BMS3020 : Chronic Disease
- Offered for Year: 2018/19
- Module Leader(s): Dr Catherine Meplan
- Lecturer: Professor Andrew Mellor, Dr Julian Rutherford, Dr Lei Huang, Professor Quentin Anstee, Professor Neil Sheerin, Dr Steven Masson, Professor Ioakim Spyridopoulos, Professor Mark Walker
- Owning School: Biomedical Sciences
- Teaching Location: Newcastle City Campus
|Semester 1 Credit Value:||20|
The aims of the module are to study chronic diseases within three sub-categories and to illustrate the basic background knowledge within each section with selected disease examples. The disease selection reflects areas in which Newcastle University has a very active research community.
1. To provide an understanding of the biochemistry and biology of metal toxicity and the clinical consequences using specific examples
2. To provide an understanding of the relationship between nutrition and disease and to illustrate this with specific examples
3. To provide an understanding of the role of inflammation and immune function in the development of chronic disorders.
The module is designed on the principle that the basic understanding will provide information which applies to a range of chronic diseases. The selected examples simply illustrate these principles which are transferrable to other diseases. The cumulative effect should enable students to have a better understanding of disease pathogenesis across a wider range of different human diseases and stimulate further reading.
Outline Of Syllabus
The module will include 3 sections all related to chronic disease:
• Metal toxicity and chronic disease
• Nutrition and chronic disease
• Inflammation and immune function
Each section will include lectures on the basic biology and biochemistry underpinning each sub-section including the key systems and normal functioning of those systems. Each section will also include lectures and seminars/tutorials on specific disease examples.
Metal toxicity and chronic disease
This section will consist of a series of lectures and a seminar. The lectures will cover metallo-biology in general (briefly) and copper and iron homeostasis in humans,dealing specifically with the uptake and distribution of these metals and what we know about the regulation of these processes. They will also cover the clinical aspects of Wilson’s disease and haemachromatosis. The seminar will involve an open session with a Wilson’s disease patient (who has volunteered to do this) who will discuss the clinical aspect of the disease and the impact of the disease in their life.
Nutrition and chronic disease
This section discusses the relationship between nutrition factors and genetic variations in the development of age-related chronic diseases and described selected examples of diseases in which nutrition plays a key role (e.g. cancer, cardiovascular disease, type 2 diabetes and non-alcoholic fatty liver disease and alcoholic liver disease). This section is supported by a seminar on data analysis.
Inflammation and immune function
This section will start with lectures on the basic principles including an overview of infection, allergy and autoimmunity will describe the role of inflammation and inflammatory signalling in chronic diseases.
|Guided Independent Study||Assessment preparation and completion||1||30:00||30:00||The assessment preparation and revision for the assessment.|
|Scheduled Learning And Teaching Activities||Lecture||21||1:00||21:00||Lectures will be used as the primary method for knowledge transfer.|
|Scheduled Learning And Teaching Activities||Small group teaching||1||1:00||1:00||Working in groups students will be asked to come prepared to discuss Wilson’s disease.|
|Scheduled Learning And Teaching Activities||Small group teaching||1||1:00||1:00||Seminar - Students will be asked to perform some data analysis.|
|Guided Independent Study||Reflective learning activity||1||107:00||107:00||Reading on subject using references from lecturers and other sources.|
|Guided Independent Study||Reflective learning activity||1||40:00||40:00||Writing and reflecting on lectures|
Teaching Rationale And Relationship
Lectures are used to impart new information in a concise manner regarding basic biology and biochemistry underpinning chronic disease, as well as expanded examples of chronic diseases. Students will have an opportunity to consider and discuss real disease examples in the tutorial/seminars and perform some data analysis. The lectures should stimulate the students to reflect and do further reading and the seminar/ tutorials should stimulate the students to reflect and critically consider the subject and the societal challenges it raises.
The format of resits will be determined by the Board of Examiners
|Written Examination||120||2||A||80||Unseen Essay Examination|
Assessment Rationale And Relationship
The written examinations test the student’s knowledge and understanding of the subject. The exam questions are designed to enable the students to critically evaluate the information they have accrued during the module and demonstrate the scope of their reading and the extent to which they have been able to understand it. The extended essay will enable students to demonstrate critical thinking and reading in the subject area. Feedback on the extended essay will help improve student's writing skills for the final exams.
FMS Schools offering Semester One modules available as ‘Study Abroad’ will, where required, provide an alternative assessment time for examinations that take place after the Christmas vacation. Coursework with submissions dates after the Christmas vacation will either be submitted at an earlier date or at the same time remotely.
The form of assessment will not vary from the original.