Your programme is made up of credits, the total differs on programme to programme.
| Semester 1 Credit Value: | 10 |
| ECTS Credits: | 5.0 |
| European Credit Transfer System | |
To equip students with:
• knowledge and understanding of drug-receptor interactions, enzyme chemistry and the
principles of drug design and action
• understand the basic concepts and uses of computational chemistry
• appreciate the validity of results based on appropriateness of theory levels
• be able to use ChemDraw as an interface to the GAMESS package
• know how to generate theoretical spectroscopic data for an arbitrary compound
Principles of Medicinal Chemistry and Enzyme Action
Dr C Cano
* Principles of medicinal chemistry. Pharmacokinetics; Lipinski’s rule of five;
Pharmacodynamics; Drug-receptor interactions
* Enzymes. What are enzymes?; How do they work?; Mechanisms of enzyme catalysis;
Enzyme inhibition and co-enzyme catalysis
* Physicochemical properties of drugs. Ionisation constants; Aqueous solubility;
Fick’s Law of diffusion; The cell membrane and lipophilicity; Partition and
distribution coefficients
* Isosterism and bioisosterism. Functional group modifications
* Case studies – Design of small molecule enzyme inhibitors
Drug Design
Dr I Hardcastle
* Drug discovery and SARs
* Lead optimisation
* Mechanisms of enzyme inhibition
* Case studies in drug discovery
* Introduction to Structure Based Drug Design using CCP4 Molecular Graphics including
a computer workshop with hands on ligand-bound protein crystal structures)
| Category | Activity | Number | Length | Student Hours | Comment |
|---|---|---|---|---|---|
| Guided Independent Study | Assessment preparation and completion | 1 | 7:00 | 7:00 | Formative online coursework (0%) |
| Structured Guided Learning | Lecture materials | 16 | 1:00 | 16:00 | Online - A combination of short recordings of lecture material and text published on VLE each week |
| Structured Guided Learning | Lecture materials | 2 | 0:30 | 1:00 | Online module introduction and familiarisation with the module topics and delivery |
| Scheduled Learning And Teaching Activities | Lecture | 11 | 1:00 | 11:00 | Office hour drop in sessions |
| Structured Guided Learning | Academic skills activities | 1 | 4:00 | 4:00 | Online - ChemDraw and CCP4MG tutorials and practice |
| Guided Independent Study | Directed research and reading | 16 | 0:30 | 8:00 | Online - students will receive relevant reading for module topics throughout the semester |
| Guided Independent Study | Independent study | 1 | 30:30 | 30:30 | Background reading and research |
| Guided Independent Study | Independent study | 2 | 10:00 | 20:00 | 2 x Online coursework (50% each) |
| Scheduled Learning And Teaching Activities | Module talk | 1 | 0:30 | 0:30 | Module introduction by module team |
| Scheduled Learning And Teaching Activities | Module talk | 4 | 0:30 | 2:00 | Online - feedback on formative coursework, case studies, student's Q+A |
| Total | 100:00 |
| Code | Title |
|---|---|
| CHY2003 | Topics in Chemistry |
Students acquire knowledge and understanding through online lectures and materials. Problem solving skills are introduced and practised.
The format of resits will be determined by the Board of Examiners
| Description | Semester | When Set | Percentage | Comment |
|---|---|---|---|---|
| Written exercise | 1 | M | 50 | Alternate online assessment |
| Written exercise | 1 | M | 50 | Alternate online assessment |
Formative Assessment is an assessment which develops your skills in being assessed, allows for you to receive feedback, and prepares you for being assessed. However, it does not count to your final mark.
| Description | Semester | When Set | Comment |
|---|---|---|---|
| Written exercise | 1 | M | Formitive coursework |
The two pieces of summative coursework and one formative piece will test the student's knowledge and understanding of both the medicinal and the modelling lecture material.
Study Abroad students to take their exam before the semester 1 exam period, in which case the format of the paper may differ from that shown in the MOF. Study Abroad students should contact the school to discuss this.