Global Opportunities

CHY2103 : Medicinal Chemistry and Drug Design (Inactive)

Semesters
Semester 1 Credit Value: 10
ECTS Credits: 5.0

Aims

To equip students with:
• knowledge and understanding of drug-receptor interactions, enzyme chemistry and the
principles of drug design and action
• understand the basic concepts and uses of computational chemistry
• appreciate the validity of results based on appropriateness of theory levels
• be able to use ChemDraw as an interface to the GAMESS package
• know how to generate theoretical spectroscopic data for an arbitrary compound

Outline Of Syllabus

Principles of Medicinal Chemistry and Enzyme Action
Dr C Cano

* Principles of medicinal chemistry. Pharmacokinetics; Lipinski’s rule of five;
Pharmacodynamics; Drug-receptor interactions
* Enzymes. What are enzymes?; How do they work?; Mechanisms of enzyme catalysis;
Enzyme inhibition and co-enzyme catalysis
* Physicochemical properties of drugs. Ionisation constants; Aqueous solubility;
Fick’s Law of diffusion; The cell membrane and lipophilicity; Partition and
distribution coefficients
* Isosterism and bioisosterism. Functional group modifications
* Case studies – Design of small molecule enzyme inhibitors

Drug Design
Dr I Hardcastle

* Drug discovery and SARs
* Lead optimisation
* Mechanisms of enzyme inhibition
* Case studies in drug discovery
* Introduction to Structure Based Drug Design using CCP4 Molecular Graphics including
a computer workshop with hands on ligand-bound protein crystal structures)

Teaching Methods

Teaching Activities
Category Activity Number Length Student Hours Comment
Structured Guided LearningLecture materials20:301:00Online module introduction and familiarisation with the module topics and delivery
Structured Guided LearningLecture materials161:0016:00Online - A combination of short recordings of lecture material and text published on VLE each week
Guided Independent StudyAssessment preparation and completion17:007:00Formative online coursework (0%)
Scheduled Learning And Teaching ActivitiesLecture111:0011:00Office hour drop in sessions
Guided Independent StudyDirected research and reading160:308:00Online - students will receive relevant reading for module topics throughout the semester
Structured Guided LearningAcademic skills activities14:004:00Online - ChemDraw and CCP4MG tutorials and practice
Guided Independent StudyIndependent study210:0020:002 x Online coursework (50% each)
Guided Independent StudyIndependent study130:3030:30Background reading and research
Scheduled Learning And Teaching ActivitiesModule talk40:302:00Online - feedback on formative coursework, case studies, student's Q+A
Scheduled Learning And Teaching ActivitiesModule talk10:300:30Module introduction by module team
Total100:00
Jointly Taught With
Code Title
CHY2003Topics in Chemistry
Teaching Rationale And Relationship

Students acquire knowledge and understanding through online lectures and materials. Problem solving skills are introduced and practised.

Assessment Methods

The format of resits will be determined by the Board of Examiners

Other Assessment
Description Semester When Set Percentage Comment
Written exercise1M50Alternate online assessment
Written exercise1M50Alternate online assessment
Formative Assessments
Description Semester When Set Comment
Written exercise1MFormitive coursework
Assessment Rationale And Relationship

The two pieces of summative coursework and one formative piece will test the student's knowledge and understanding of both the medicinal and the modelling lecture material.

Study Abroad students to take their exam before the semester 1 exam period, in which case the format of the paper may differ from that shown in the MOF. Study Abroad students should contact the school to discuss this.

Reading Lists

Timetable