Module Catalogue

NES1301 : Molecular Biology of the Cell

  • Offered for Year: 2025/26
  • Available to incoming Study Abroad and Exchange students
  • Module Leader(s): Dr James Stach
  • Lecturer: Dr Vasilios Andriotis, Dr Maxim Kapralov, Dr Patricia Lopez-Calcagno, Dr Thomas Howard
  • Owning School: Natural and Environmental Sciences
  • Teaching Location: Newcastle City Campus
Semesters

Your programme is made up of credits, the total differs on programme to programme.

Semester 1 Credit Value: 20
ECTS Credits: 10.0
European Credit Transfer System

Aims

The module aims to provide a broad introduction to the molecular biology of the cell; workshops will provide free enquiry opportunities. Seminars introduce students to current research in each of the themes to broaden and deepen student knowledge. The assessment challenges students to produce communication materials to enhance the module’s learning aims by researching an area of their choosing within the module themes.

Outline Of Syllabus

The module is organised into 8 themes


1. Evolution of Life

- Origin of life, life without a membrane.
- Cellular evolution - the Prokaryotes, the origin of Eukaryotes
- Tree of Life - History and current basis on molecular evidence


2. Prokaryotes

- Extremophiles – early life and exobiology
- Diversity


3. Viruses

- Structure
- Replication


4. First cells and multicellularity.

- Origin of cells
- Single-celled organisms


5 - 6. Cell structure, function and specialisation

- Structure
- Organisation
- Specialist functions


7 – 8 . Gene expression and control

- Transcription control
- Repression and activation
- Operons
- Eukaryotic gene expression
- Post-translational control
- Non-coding RNAs


9. Protein evolution

- Neutral and positive substitution
- Enzyme function
- microadaptation


10. Molecular mechanism of cell specialisation

- DNA rearrangement
- DNA methylation
- Regulatory circuits


10-12. Genome evolution

- Genome duplication
- Genome reconstitution
- Plant genomes
- Synthetic genomes


13-14. Cell signalling and communication

- Reception
- Transduction
- Response

Teaching Methods

Teaching Activities
Category Activity Number Length Student Hours Comment
Scheduled Learning And Teaching ActivitiesLecture141:0014:00Present in person with supplementary material available online
Guided Independent StudyAssessment preparation and completion112:0012:00Preparation and Completion of the MCQ Inspera exam and student presentations
Scheduled Learning And Teaching ActivitiesSmall group teaching41:004:00Seminars present in person with supplementary material available online
Scheduled Learning And Teaching ActivitiesWorkshops51:005:00Present in person with supplementary material available online
Guided Independent StudyIndependent study1165:00165:00N/A
Total200:00
Teaching Rationale And Relationship

Lectures will provide the framework and theory for appreciation of the molecular biology of the cell and its evolution. Directed reading and links to further information will encourage individual learning and will contribute to greater understanding of the topics within the module. The assessments will provide team-working opportunities and student autonomy in their learning. The intention of the assessment is to help transition students from consumers of information, to researchers and communicators of knowledge.

Assessment Methods

The format of resits will be determined by the Board of Examiners

Exams
Description Length Semester When Set Percentage Comment
Digital Examination1201A70Inspera MCQ Exam
Other Assessment
Description Semester When Set Percentage Comment
Design/Creative proj1M30Group digital presentation on student-led area within module themes
Assessment Rationale And Relationship

The exam will test student understanding of the key module themes. This ensures that the key foundational concepts, which are required throughout their degree, are present and secure. The rationale for presentations is to introduce students early to autonomy in their learning, to demonstrate how to read within and beyond module content and how to communicate professionally with peers and academics.

Reading Lists

Timetable