Bacteria are the most abundant and diverse group of organisms on Earth. Bacteria play vital roles in the environment (such as recycling nutrients) and even in the human body where they aid normal gut function. Bacteria are also exploited in industry (for example in chemical production) and as tools in biotechnology and medical research. However, pathogenic bacteria are the cause of many human diseases including tuberculosis, meningitis and pneumonia.
Bacteria are relatively simple, single-cell organisms, yet many of the cellular processes in bacteria are comparable to those in human cells. This makes bacteria ideal experimental models for unravelling the complexity of crucial cellular mechanisms.
For example, scientists in Newcastle are using bacteria to:
Advances in our understanding of bacterial cell biology are also being used to develop new antibiotics and novel tools for molecular biology and biomedical research. Proteins found in the cell wall (cell envelope) of bacteria determine how bacteria interact with host organisms (such as humans) and often influence the pathogenicity of bacteria.
The cell wall is essential for bacterial survival and many antibiotics target proteins that are found in the cell wall. Newcastle scientists are investigating how the cell wall is made and how cell wall proteins are processed. Researchers are also exploring how bacteria sense their surroundings and respond to environmental stress, viral infection and host cells.
Find out more about our research areas