Dr Seva Telezhkin
- Email: firstname.lastname@example.org
- Telephone: +441912088240
- Address: Level 7; Room 7.001,
School of Dental Sciences
Newcastle upon Tyne
1998 Specialist in Biology-Biophysics (BSc), Taras Shevchenko Kiev State University
2003 Doctor of Biological Sciences (PhD) in Biophysics, Bogomoletz Institute of Physiology
2016 Fellow of Higher Education Academy, Cardiff University
2017 Lecturer in Physiology, School of Dental Sciences, Newcastle University
2012 Senior Research Fellow, School of Biosciences, Cardiff University
2009 Research Associate, Research Department of Neuroscience, Physiology and Pharmacology, University College London
2007 Research Associate in the School of Biosciences, Cardiff University
2006 Research Associate, Department of Pharmacy and Pharmacology, University of Bath
2004 Research Associate, Department of Obstetrics and Gynaecology, College of Medicine, University of Vermont
Regular Member of European Huntington’s Disease Network
Member of The Physiological Society
Regular Member of Biophysical Society
Visitor at University College London and Cardiff University
I study physiological aspects of neuronal differentiation, maturation and degeneration.
Besides that, I am interested in orofacial post traumatic pain management, e.g. post-endodontic pain subsequent to the root canal treatment, peripheral painful traumatic or inflammatory trigeminal neuropathy, atypical facial pain, etc.
I am also interested in phospholipid regulation of ion channels and role of calcium-sensing receptor (CaSR) in dentinogenesis, reparative and mineralization process in the odontoblasts.
The aim of my research is to generate the data that provide rational basis for selecting drugs which may be useful for enhancing neuronal function in patients with neurodegenerative disorders, post traumatic and neuropathic pain and dental tissue revitalization.
- Young F, Telezhkin V, Youde SJ, Langley MS, Stack M, Kemp PJ, Waddington RJ, Sloan AJ, Song B. Clonal Heterogeneity in the Neuronal and Glial Differentiation of Dental Pulp Stem/Progenitor Cells. Stem Cells International 2016, 2016, 1290561.
- Telezhkin V, Schnell C, Yarova P, Yung S, Cope E, Hughes A, Thompson BA, Sanders P, Geater C, Hancock JM, Joy S, Badder L, Connor-Robson N, Comella A, Straccia M, Bombau G, Brown JT, Canals JM, Randall AD, Allen ND, Kemp PJ. Forced cell cycle exit and modulation of GABAA, CREB, and GSK3β signaling promote functional maturation of induced pluripotent stem cell-derived neurons. American Journal of Physiology - Cell Physiology 2016, 310(7), C520-C541.
- Brazier SP, Telezhkin V, Kemp PJ. Functional Interactions between BKCaα-Subunit and Annexin A5: Implications in Apoptosis. Oxidative Medicine and Cellular Longevity 2016, 2016, 1607092.
- Kemp PJ, Rushton DJ, Yarova PL, Schnell C, Geater C, Hancock JM, Wieland A, Hughes A, Badder L, Cope E, Riccardi D, Randall AD, Brown JT, Allen ND, Telezhkin V. Improving and accelerating the differentiation and functional maturation of human stem cell-derived neurons: role of extracellular calcium and GABA. The Journal of Physiology 2016, 594(22), 6583-6594.
- Zhang G, Edmundson M, Telezhkin V, Gu Y, Wei X, Kemp PJ, Song B. The Role of Kv1.2 Channel in Electrotaxis Cell Migration. Journal of Cellular Physiology 2016, 231(6), 1375–1384.
- Hänggi P, Telezhkin V, Kemp PJ, Schmugge M, Gassmann M, Goede JS, Speer O, Bogdanova A. Functional plasticity of the N-methyl-D-aspartate receptor in differentiating human erythroid precursor cells. American Journal of Physiology: Cell Physiology 2015, 308(12), C993–C1007.
- Kemp PJ, Telezhkin V. Oxygen sensing by the carotid body: is it all just rotten eggs?. Antioxidants & Redox Signaling 2014, 20(5), 794-804.
- Telezhkin V, Thomas AM, Harmer SC, Tinker A, Brown DA. A basic residue in the proximal C-terminus is necessary for efficient activation of the M-channel subunit Kv7.2 by PI(4,5)P₂. Pflügers Archiv - European Journal of Physiology 2013, 465(7), 945-953.
- Reilly JM, Telezhkin V, Passmore GM, Marsh SJ, Brown DA. Kv7/M-type potassium channels in rat skin keratinocytes. Pflügers Archiv - European Journal of Physiology 2013, 465(9), 1371-1381.
- Telezhkin V, Brown DA, Gibb AJ. Distinct subunit contributions to the activation of M-type potassium channels by PI(4,5)P2. The Journal of General Physiology 2012, 140(1), 41-53.
- Telezhkin V, Reilly JM, Thomas AM, Tinker A, Brown DA. Structural requirements of membrane phospholipids for M-type potassium channel activation and binding. The Journal of Biological Chemistry 2012, 287(13), 10001-10012.
- Telezhkin V, Brazier SP, Mears R, Müller CT, Riccardi D, Kemp PJ. Cysteine residue 911 in C-terminal tail of human BKCaα channel subunit is crucial for its activation by carbon monoxide. Pflügers Archiv - European Journal of Physiology 2011, 461(6), 665-675.
- Telezhkin V, Brazier SP, Cayzac S, Wilkinson WJ, Riccardi D, Kemp PJ. Mechanism of inhibition by hydrogen sulfide of native and recombinant BKCa channels. Respiratory Physiology & Neurobiology 2010, 172(3), 169-178.
- Brazier SP, Telezhkin V, Mears R, Müller CT, Riccardi D, Kemp PJ. Cysteine residues in the C-terminal tail of the human BKCaα subunit are important for channel sensitivity to carbon monoxide. Advances in Experimental Medicine and Biology 2009, 648, 49-56.
- Kemp PJ, Telezhkin V, Wilkinson WJ, Mears R, Hanmer SB, Gadenberg HC, Müller CT, Riccardi D, Brazier SP. Enzyme-linked oxygen sensing by potassium channels. Annals of the New York Academy of Sciences 2009, 1177, 112–118.
- Telezhkin V, Brazier SP, Cayzac S, Muller CT, Riccardi D, Kemp PJ. Hydrogen sulfide inhibits human BKCaα channels. Advances in Experimental Medicine and Biology 2009, 648, 65-72.
- Williams SE, Brazier SP, Baban N, Telezhkin V, Müller CT, Riccardi D, Kemp PJ. A structural motif in the C-terminal tail of slo1 confers carbon monoxide sensitivity to human BKCa channels. Pflügers Archiv - European Journal of Physiology 2008, 456(3), 561-572.
- Telezhkin V, Goecks T, Bonev A, Osol G, Gokina NI. Decreased function of voltage-gated potassium channels contributes to augmented myogenic tone of uterine arteries in late pregnancy. American Journal of Physiology - Heart and Circulatory Physiology 2008, 294(1), H272-H284.