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Modules

Modules

CHY3306 : Advanced Inorganic Chemistry

Semesters
Semester 2 Credit Value: 30
ECTS Credits: 15.0

Aims

To introduce the fundamental principles and reactions of organometallic chemistry; to introduce concepts of homogeneous catalysis; to demonstrate the diverse chemistry of the s- and p-elements; to introduce inorganic aspects of biological systems and metals in biomedicine. To practise and develop skills in practical inorganic chemistry and in writing reports.

Outline Of Syllabus

Organometallic Chemistry
Dr S Doherty

Background and introduction
The 18-Electron rule
Important ligand types; carbonyl (bonding and binary carbonyls)
Pi-ligands, hydrides, phosphines
The synthesis of organometallic compounds
Organometallic reaction mechanisms 1. Reaction at the metal: ligand substitution, oxidative addition and reductive elimination
Organometallic reaction mechanisms 2: Reactions involving the ligand: migratory insertion, reductive elimination and nucleophilic additions and abstractions
Transition metal carbene complexes: synthesis, structure and reactivity
Homogeneous catalysis: an introduction

Comparative Main Group Chemistry
Dr KJ Izod

General principles. Complexes of the s-elements: macrocycles and the macrocyclic effect, alkalides and electrides
Organometallics of the electropositive metals: an introduction to electron-deficient compounds
More electron-deficient compounds: boranes and carboranes, Zintl ions
Low oxidation states of the p-block elements (groups 13 and 14)
E=E bonds (groups 14 and 15); synthesis and reactions. Phosphorus (V) ylides and related compounds
E=E’ bonds – stability, synthesis and reactions

Bioinorganic Chemistry
Professor A Houlton

An introduction to bioinorganic chemistry; the essential metals, metal ion overload-deficiency and treatments.
An introduction to metalloproteins. Protein structure, metal ion binding groups, protein function and role of metal ions.
Myoglobin– protein structure and function, haem group, oxidation and spin states of the metal centre before and after oxygen coordination
Haemoglobin – protein structure and function, comparison with Mb, the cooperative nature of oxygen binding in haemoglobin
Metallo-enzymes – details of the structure and function of Zn and Fe-containing systems
Metal ion binding in DNA. Discovery of metal-containing anti-tumour drugs. mode of action, side effects. Metal-based drugs

Inorganic Chemistry Laboratory Course
Dr J Eriksson

Each student is assigned five experiments from the following list:

Vanadium Chemistry: Coordination Chemistry and Catalysis
Early Transition –Metal Polyoxoanions: Metal Oxide Chemistry in Organic Solvents
Ferrocene (•5-C5H5)2Fe, and its Derivatives
Tris Chelate Complexes: Stoichiometry of [Fe(phen)3]2+ Resolution and Optical Activity of [Co(en)3]3+
Use of Liquid Ammonia as a Solvent – Synthesis of a Diphosphine

Teaching Methods

Teaching Activities
Category Activity Number Length Student Hours Comment
Guided Independent StudyAssessment preparation and completion46:0024:00Writing practical reports
Guided Independent StudyAssessment preparation and completion420:5035:00Revision for end of semester examination
Guided Independent StudyAssessment preparation and completion13:003:00End of semester examination
Scheduled Learning And Teaching ActivitiesLecture421:0042:00N/A
Scheduled Learning And Teaching ActivitiesPractical510:0050:005x10h Practical sessions take place over 5 weeks
Guided Independent StudyIndependent study1146:00146:00Background reading and practice past paper examination questions
Total300:00
Jointly Taught With
Code Title
CHY3301Advanced Inorganic Chemistry
Teaching Rationale And Relationship

The lectures will provide students with the material required for an understanding of advanced inorganic chemistry. The revision sessions will be used to assist the students with parts of the course that they find more demanding and for providing problems associated with the module.

In the practical classes competencies in practical procedures, observation, record-keeping and report writing, will be taught and learnt.

Assessment Methods

The format of resits will be determined by the Board of Examiners

Exams
Description Length Semester When Set Percentage Comment
Written Examination1802A67N/A
Exam Pairings
Module Code Module Title Semester Comment
2N/A
CHY3305Advanced Inorganic Chemistry (Distance Learning)2N/A
1N/A
Other Assessment
Description Semester When Set Percentage Comment
Practical/lab report1M33composed of several individual laboratory reports as specified in the practical course handbook
Assessment Rationale And Relationship

The written examination will test the student's knowledge and understanding of the content of the module.
The laboratory component practical involves the assessment of a complex selection of skills learnt in about 4 experiments per student, spread over the major areas of inorganic chemistry.

Reading Lists

Timetable