Background

Qualifications

BSc, National Chung Hsing University, Taiwan

MSc, National Taiwan University, Taiwan

PhD, University of Nottingham, UK

PgCert in Learning and Teaching (Higher Education), Anglia Ruskin University, UK

Professional History

Lecturer in Microbiology, University of Bradford, UK

Assistant Professor, Heriot-Watt University, UK

Honours and Awards

Fellow of the Higher Education Academy (Advance HE, 2020)

Daiwa Adrian Prize (co-awardee, Daiwa Anglo-Japanese Foundation UK, 2007)

Overseas Research Scholarship (Universities UK, 2002)

Google Scholar

Chang Lab

Research

Understanding how simple gene regulatory events and biochemical processes become complex decision-making machines in individuals or at population levels is a key challenge in biology. The research in our group is to address fundamental questions concerning:

1) how bacterial cells sense their surroundings and coordinate their responses in population to survive or to cause infection e.g. quorum sensing; surface sensing.

2) how bacterial cells interact with other microbes or host cells in complex and diverse communities in health and diseases e.g. multi-species biofilm in oral environments; biofilm-associated infections.

3) how to harness microbial cells/communities for therapeutical or biotechnological purposes e.g. quorum quenching.

Also, we are interested in exploring the broad bio-diversities in various environmental habitats to discover novel microorganisms and biocatalysts and to study their potential roles for anti-infectious and biotechnological applications. We have established several national and international research collaborations including in Bradford, Nottingham, Malaysia, and China.

We are welcoming anyone interested in microbes to join us and to explore their good, their bad, and their useful. 

Current Research Team

Dr Halah Ahmed (PDRA)

Pavlos Trus (PhD student)

Mandy Fengyi Wang (PhD student)

Pisit Charoenwongwatthana (PhD student)

Angeliki Marouli (PhD student)

Oslovenya Caroline (MRes student)

Athalia Levinna (MRes student)

Jason Chow (MRes student)

Charlotte Norton (MRes student)

Jack Kiggins (BSc student)

Previous Group Members

PhD

Dr Paul Norton

MSc/MRes

Alina Novikova

Bonolo Phinius

Emma Dobson

Nadhira Azzahra

BSc

Ferdos Ali

Daniel Clucas

Georgina Young

Teaching

Stage 1 BDS

Metabolism & Homeostasis (Course Lead)

Orientation and Study Skills

Cellular Physiology - Gastrointestinal Tract

Stage 2 BDS

Microbiology for Dentistry

Publications

• Articles

  • Liu Z, Jiang X, Li J, Ji W, Zhou H, Gong X, Miao B, Meng S, Duan L, Shi Q, Han X, Gao P, Chang C, Dong A, Li J. Molecular characteristics and antibiotic resistance mechanisms of clindamycin-resistant Streptococcus agalactiae isolates in China. Frontiers in Microbiology 2023, 14, 1138039.
  • Wong SY, Hook AL, Gardner W, Chang C-Y, Mei Y, Davies MC, Williams P, Alexander MR, Ballabio D, Muir BW, Winkler DA, Pigram PJ. Exploring the relationship between polymer surface chemistry and bacterial attachment using ToF-SIMS and self-organizing maps. Advanced Materials Interfaces 2023, 10(9), 2202334.
  • Dubern JF, Hook AL, Carabelli AM, Chang C-Y, Lewis-Lloyd CA, Luckett JC, Burroughs L, Dundas AA, Humes DJ, Irvine DJ, Alexander MR, Williams P. Discovery of a polymer resistant to bacterial biofilm, swarming, and encrustation. Sciences Advances 2023, 9(4), eadd7474.
  • Jin Z, Li J, Zhou J, Wang Z, Yi L, Liu N, Du J, Chang C-Y, Ji W. Serotype Distribution, Virulence Determinants and Antimicrobial Susceptibility of Streptococcus agalactiae Isolated from Young Infants. Pathogens 2022, 11, 1355.
  • Chua K-O, Norton P, Trus P, Katsikogianni M, Thornton MJ, Chan K-G, Chang C-Y. Draft Genome Sequence of the Multiple Antibiotic Resistant Pseudomonas aeruginosa PAO1-UB Subline. Microbiology Resource Announcements 2022, 11(9), e00646-22.
  • Norton P, Chua K-O, Katsikogianni M, Thornton MJ, Chan K-G, Chang C-Y. Draft Genome Sequence of a Multiple Antibiotic Resistant Staphylococcus aureus NCTC 6571-UB Laboratory Strain. Microbiology Resource Announcements 2022, 11(9), e00448-22.
  • Chua K-O, Fatima I, Lau YY, Hong KW, Yin W-F, Mardaryev A, Chan K-G, Chang C-Y. Bacterial microbiome of faecal samples of naked mole-rat collected from the toilet chamber. BMC Research Notes 2022, 15, 107.
  • Huang L, Gao K, Chen G, Zhong H, Li Z, Guan X, Deng Q, Xie Y, Ji W, McIver DJ, Chang C-Y, Liu H. Rapid Classification of Multilocus Sequence Subtype for Group B Streptococcus Based on MALDI-TOF Mass Spectrometry and Statistical Models. Frontiers in Cellular and Infection Microbiology 2021, 10, 77031.
  • Gao K, Gao C, Huang L, Guan X, Ji W, Chang CY, McIver DJ, Deng Q, Zhong H, Xie Y, Deng L, Gao F, Zeng L, Liu H. Predominance of III/ST19 and Ib/ST10 Lineages With High Multidrug Resistance in Fluoroquinolone-Resistant Group B Streptococci Isolates in Which a New Integrative and Conjugative Element Was Identified. Frontiers in Microbiology 2021, 11, 609526.
  • Gao K, Deng Q, Huang L, Chang C-Y, Zhong H, Xie Y, Guan X, Liu H. Diagnostic Performance of Various Methodologies for Group B Streptococcus Screening in Pregnant Woman in China. Frontiers in Cellular and Infection Microbiology 2021, 11, 651968.
  • Chang C-Y, Chan K-G. Underestimation of co-infections in COVID-19 due to non-discriminatory use of antibiotics. Journal of Infection 2020, 81(3), e29-e30.
  • Li J, Ji W, Gao K, Zhou H, Zhang L, Mu X, Yuan C, Guan X, Deng Q, Zhang L, Zhong H, Gao X, Gao F, Long Y, Chang C-Y, McIver DJ, Liu H. Molecular characteristics of group B Streptococcus isolates from infants in southern mainland China. BMC Infectious Diseases 2019, 19, 812.
  • Gao K, Fu J, Guan X, Zhu S, Zeng L, Xu X, Chang C-Y, Liu H. Incidence, Bacterial Profiles, And Antimicrobial Resistance Of Culture-Proven Neonatal Sepsis In South China. Infection and Drug Resistance 2019, 12, 3797-3805.
  • Shepherd J, Swift T, Chang C-Y, Boyne JR, Rimmer S, Martin WHC. Highly branched poly(N-isopropyl acrylamide) functionalized with an inducer molecule suppresses quorum sensing in Chromobacterium violaceum. Chemical Communications 2019, 55(66), 9765-9768.
  • Chang C-Y. Surface Sensing for Biofilm Formation in Pseudomonas aeruginosa. Frontiers in Microbiology 2018, 8, 2671.
  • Chen J-W, Lau YY, Krishnan T, Chan K-G, Chang C-Y. Recent Advances in Molecular Diagnosis of Pseudomonas aeruginosa Infection by State-of-the-Art Genotyping Techniques. Frontiers in Microbiology 2018, 9, 1104.
  • Guan X, Mu X, Ji W, Yuan C, He P, Zhang L, Huang Y, Li J, Chen J, Zhong H, Pang S, Tan N, Deng Q, Gao K, Huang Y-P, Chang C-Y, Liu H. Epidemiology of invasive group B streptococcal disease in infants from urban area of South China, 2011–2014. BMC Infectious Diseases 2018, 18, 14.
  • Gao K, Guan X, Zeng L, Qian J, Zhu S, Deng Q, Zhong H, Pang S, Gao F, Wang J, Long Y, Chang C-Y, Liu H. An increasing trend of neonatal invasive multidrug-resistant group B streptococcus infections in southern China, 2011–2017. Infection and Drug Resistance 2018, 11, 2561-2569.
  • Chan X-Y, Chen J-W, Adrian T-G, Hong K-W, Chang C-Y, Yin W-F, Chan K-G. Whole-Genome Sequence and Fosfomycin Resistance of Bacillus sp. Strain G3(2015) Isolated from Seawater off the Coast of Malaysia. Genome Announcements 2017, 5(13), e00067-17.
  • Chan K-G, Priya K, Chang C-Y, Abdul Rahman AY, Tee KK, Yin W-F. Transcriptome analysis of Pseudomonas aeruginosa PAO1 grown at both body and elevated temperatures. PeerJ 2016, 2016(7), e2223.
  • Adlington K, Nguyen NT, Eaves E, Yang J, Chang C-Y, Li J, Gower AL, Stimpson A, Anderson DG, Langer R, Davies MC, Hook AL, Williams P, Alexander MR, Irvine DJ. Application of Targeted Molecular and Material Property Optimization to Bacterial Attachment-Resistant (Meth)acrylate Polymers. Biomacromolecules 2016, 17(9), 2830-2838.
  • Tan WS, Yin WF, Chang CY, Chan KG. Whole-genome sequencing analysis of quorum-sensing Aeromonas hydrophila strain M023 from freshwater. Genome Announcements 2015, 3(1), e01548-14.
  • Chan KG, Chen JW, Tee KK, Chang CY, Yin WF, Chan XY. Whole-genome analysis of quorum-sensing Burkholderia sp. strain A9. Genome Announcements 2015, 3(2), e00063-15.
  • Tan WS, Chang CY, Yin WF, Chan KG. Understanding the quorum-sensing bacterium Pantoea stewartii strain M009 with whole-genome sequencing analysis. Genome Announcements 2015, 3(1), e01509-14.
  • Yong D, Ee R, Lim YL, Chang CY, Yin WF, Chan KG. Insights on quorum-quenching properties of Lysinibacillus fusiformis strain RB21, a Malaysian municipal solid-waste landfill soil isolate, via complete genome sequence analysis. Genome Announcements 2015, 3(3), e00409-15.
  • Chan KG, Tan WS, Chang CY, Yin WF, Yunos NYM. Genome sequence analysis reveals evidence of quorum-sensing genes present in Aeromonas hydrophila strain M062, isolated from freshwater. Genome Announcements 2015, 3(2), e00100-15.
  • Tan KH, Sheng KY, Chang CY, Yin WF, Chan KG. Draft genome sequence of a quorum-sensing bacterium, Dickeya sp. strain 2B12, isolated from a freshwater lake. Genome Announcements 2015, 3(1), e01542-14.
  • Chan KG, Chen JW, Chang CY, Yin WF, Chan XY. Draft genome sequence of Lysinibacillus sp. strain A1, isolated from Malaysian tropical soil. Genome Announcements 2015, 3(2), e00095-15.
  • Chan KG, Chin PS, Tee KK, Chang CY, Yin WF, Sheng KY. Draft genome sequence of Aeromonas caviae strain L12, a quorum-sensing strain isolated from a freshwater lake in Malaysia. Genome Announcements 2015, 3(2), e00079-15.
  • Sanni O, Chang CY, Anderson DG, Langer R, Davies MC, Williams PM, Williams P, Alexander MR, Hook AL. Bacterial Attachment to Polymeric Materials Correlates with Molecular Flexibility and Hydrophilicity. Advanced Healthcare Materials 2015, 4(5), 695-701.
  • Mohamad NI, Tan WS, Chang CY, Tee KK, Yin WF, Chan KG. Analysis of quorum-sensing Pantoea stewartii strain M073a through whole-genome sequencing. Genome Announcements 2015, 3(1), e00022-15.
  • Chan KG, Kher HL, Chang CY, Yin WF, Tan KH. Analysis of pectate lyase genes in Dickeya chrysanthemi strain L11, isolated from a recreational lake in Malaysia: a draft genome sequence perspective. Genome Announcements 2015, 3(2), e00145-15.
  • Chan KG, Yin WF, Tee KK, Chang CY, Priya K. Pandoraea sp. Strain E26: Discovery of Its Quorum-Sensing Properties via Whole-Genome Sequence Analysis. Genome Announcements 2015, 3(3), e00565-15.
  • Hook AL, Chang C-Y, Scurr DJ, Langer R, Anderson DG, Williams P, Davies MC, Alexander MR. Thermally Switchable Polymers Achieve Controlled Escherichia coli Detachment. Advanced Healthcare Materials 2014, 3(7), 1020-1025.
  • Chang CY, Krishnan T, Wang H, Chen Y, Yin WF, Chong YM, Tan LY, Chong TM, Chan KG. Non-antibiotic quorum sensing inhibitors acting against N-acyl homoserine lactone synthase as druggable target. Scientific Reports 2014, 4, 7245.
  • Epa VC, Hook AL, Chang C, Yang J, Langer R, Anderson DG, Williams P, Davies MC, Alexander MR, Winkler DA. Modelling and Prediction of Bacterial Attachment to Polymers. Advanced Functional Materials 2014, 24(14), 2085-2093.
  • Chan X-Y, Chang C-Y, Hong KW, Tee KK, Yin WF, Chan KG. Insights of biosurfactant producing Serratia marcescens strain W2.3 isolated from diseased tilapia fish: a draft genome analysis. Gut Pathogens 2013, 5, 29.
  • Hook AL, Chang C-Y, Yang J, Atkinson S, Langer R, Anderson DG, Davies MC, Williams P, Alexander MR. Discovery of novel materials with broad resistance to bacterial attachment using combinatorial polymer microarrays. Advanced Materials 2013, 25(18), 2542-2547.
  • Chang C-Y, Koh C-L, Sam C-K, Chan X-Y, Yin WF, Chan KG. Unusual Long-Chain N-Acyl Homoserine Lactone Production by and Presence of Quorum Quenching Activity in Bacterial Isolates from Diseased Tilapia Fish. PLoS ONE 2012, 7(8), e44034.
  • Hook AL, Chang C-Y, Yang J, Scurr D, Langer R, Anderson DG, Atkinson S, Williams P, Davies MC, Alexander MR. Polymer microarrays for high throughput discovery of biomaterials. Journal of Visualized Experiments 2012, 59, e3636.
  • Hook AL, Chang C-Y, Yang J, Luckett J, Cockayne A, Atkinson S, Mei Y, Bayston R, Irvine DJ, Langer R, Anderson DG, Williams P, Davies MC, Alexander MR. Combinatorial discovery of polymers resistant to bacterial attachment. Nature Biotechnology 2012, 30, 868-875.
  • Chang C-Y, Hobley L, Till R, Capeness M, Kanna M, Burtt W, Jagtap P, Aizawa S-I, Sockett RE. The Bdellovibrio bacteriovorus twin-arginine transport system has roles in predatory and prey-independent growth. Microbiology 2011, 157(11), 3079-3093.
  • Atkinson S, Goldstone RJ, Joshua GWP, Chang C-Y, Patrick HL, Cámara M, Wren B, Williams P. Biofilm development on Caenorhabditis elegans by Yersinia is facilitated by quorum sensing-dependent repression of type III secretion. PLoS Pathogens 2011, 7(1), e1001250.
  • Lambert C, Chang C-Y, Capeness MJ, Sockett RE. The First Bite - Profiling the Predatosome in the Bacterial Pathogen Bdellovibrio. PLoS One 2010, 5, e8599.
  • Atkinson S, Chang C-Y, Patrick HL, Buckley CMF, Wang Y, Sockett RE, Cámara M, Williams P. Functional interplay between the Yersinia pseudotuberculosis YpsRI and YtbRI quorum sensing systems modulates swimming motility by controlling expression of flhDC and fliA. Molecular Microbiology 2008, 69, 137.
  • Sockett L, Hobley L, Fenton A, Woods R, Lambert C, Chang C-Y, Atterbury R, Till R, Whitworth M, Capeness M, Fung R, Ahmad R, Milner D, Lerner T, King S. An inside job: Bdellovibrio bacteriovorus. Microbiology Today 2008, 35, 184-187.
  • Atkinson S, Chang C-Y, Sockett RE, Cámara M, Williams P. Quorum sensing in Yersinia enterocolitica controls swimming and swarming motility. Journal of Bacteriology 2006, 181, 2823.
  • Lambert C, Morehouse KA, Chang C-Y, Sockett RE. Bdellovibrio: Growth and development during the predatory cycle. Current Opinion in Microbiology 2006, 9(6), 639-644.

• Book Chapters

  • Lazenby J, Chang C-Y. Pathogens. In: Randall, MD, ed. Medical Sciences at a Glance. John Wiley & Sons, Inc, 2014, pp.130-133.
  • Lambert C, Hobley L, Chang C-Y, Fenton A, Capeness M, Sockett RE. A predatory patchwork: membrane and surface structures of Bdellovibrio bacteriovorus. In: Poole, RK, ed. Advances in Microbial Physiology. 2009, pp.313-361.

• Reviews

  • Liu YC, Chan KG, Chang CY. Modulation of Host Biology by Pseudomonas aeruginosa Quorum Sensing Signal Molecules: Messengers or Traitors. Frontiers in Microbiology 2015, 6, 1226.
  • Chan KG, Liu YC, Chang CY. Inhibiting N-acyl-homoserine lactone synthesis and quenching Pseudomonas quinolone quorum sensing to attenuate virulence. Frontiers in Microbiology 2015, 6, 1173.