Newcastle Preclinical In Vivo Imaging Facility


Find a list of our publications, and guidelines for acknowledging PIVI's role in your own research.

 At current rates, PIVI users pay a fraction of our costs. This is thanks largely to faculty subsidy and more accurate yearly capacity figures.

Even without any specific assistance from our members, the reason the instruments are in good working order is because of their efforts and expertise.

Find out how to acknowledge PIVI's role in your research.


The following publications resulted from research projects which acknowledge the use of the Preclinical In Vivo Imaging (PIVI) Facility.


Leslie J, Robinson SM, Oakley F, Luli S. Non-invasive synchronous monitoring of neutrophil migration using whole body near-infrared fluorescence-based imaging. Sci Rep. 2021 Jan 14;11(1):1415. doi: 10.1038/s41598-021-81097-8. PMID: 33446811; PMCID: PMC7809207.(Luli S - last / corresponding author)


Leslie J, Macia MG, Luli S, et al. c-Rel orchestrates energy-dependent epithelial and macrophage reprogramming in fibrosis [published correction appears in Nat Metab. 2021 Jan;3(1):118-119]. Nat Metab. 2020;2(11):1350-1367. doi:10.1038/s42255-020-00306-2

Simon Tual-Chalot, Maria Garcia-Collado , Rachael E Redgrave, Esha Singh , Benjamin Davison, Catherine Park , Hua Lin, Luli S, Yi Jin , Yixin Wang , Allan Lawrie, Lars Jakobsson , Helen M Arthur. Loss of Endothelial Endoglin Promotes High-Output Heart Failure Through Peripheral Arteriovenous Shunting Driven by VEGF Signaling. Circ Res. 2020;126(2):243-257. doi:10.1161/CIRCRESAHA.119.315974

Madgwick S, Sellier S, Luli S, Leslie J, Moore AJ, Corbin EK, Kenneth NS, Chiremba R, Oakley F, Perkins ND and Hunter JE* “Claspin haploinsufficiency leads to non-alcoholic fatty liver disease and defects in fertility and meiosis” Submitted to Wellcome Open Research June 2020

Jack Leslie, Ben J.M. Millar, Alicia del Carpio Pons, Rachel A. Burgoyne, Joseph D. Frost,1 Ben S. Barksby, Luli S, Jon Scott, A. John Simpson, Jack Gauldie, Lynne A. Murray, Donna K. Finch, Alan M. Carruthers, John Ferguson, Matthew A. Sleeman, David Rider, Rachel Howarth, Christopher Fox, Fiona Oakley, Andrew J. Fisher, Derek A. Mann, and Lee A. Borthwick

K Szoltysek, H Blair, R Tirtakusuma, S Nakjang, E Law, L McKenzie, J Vormoor, D Pal, O Heidenreich. Whole-genome CRISPR screen as a tool to identify mechanism of relapse and potential targets for novel drug combinations. conference abstarct Klin Padiatr 2020; 232(03): e3 DOI: 10.1055/s-0040-1709771

Dookun E, Walaszczyk A, Redgrave R, Palmowski P, Tual-Chalot S, Suwana A, Chapman J, Jirkovsky E, Donastorg Sosa L, Gill E, Yausep O, Santin Y, Mialet-Perez J, Owens WA, Grieve D, Spyridopoulos I, Taggart T, Arthur H, Passos J, Richardson GD. Clearance of senescent cells during cardiac ischemia-reperfusion injury improves heart recovery following myocardial infarction.

Ramsbottom SA, Thelwall PE, Wood KM, Clowry GJ, Devlin LA, Silbermann F, Spiewak HL, Shril S, Molinari E, Hildebrandt F, Gunay-Aygun M, Saunier S, Cordell HJ, Sayer JA, Miles CG. Mouse genetics reveals Barttin as a genetic modifier of Joubert syndrome. Proc Natl Acad Sci U S A. 2020 Jan 14;117(2):1113-1118. doi: 10.1073/pnas.1912602117. Epub 2019 Dec 26.


Dr. Dumitru Sirbu, Dr. Saimir Luli, Dr. Jack Leslie, Prof. Fiona Oakley Prof. Andrew C. Benniston. Enhanced in vivo Optical Imaging of the Inflammatory Response to Acute Liver Injury in C57BL/6 Mice Using a Highly Bright Near‐Infrared BODIPY Dye. ChemMedChem 2019,14,995 –999

Eva Moran-Salvador , Marina Garcia-Macia, Ashwin Sivaharan, Laura Sabater, Marco Y W Zaki, Fiona Oakley, Amber Knox, Agata Page, Luli S, Jelena Mann, Derek A Mann . Fibrogenic Activity of MECP2 Is Regulated by Phosphorylation in Hepatic Stellate Cells. Gastroenterology. 2019;157(5):1398-1412.e9. doi:10.1053/j.gastro.2019.07.029

Roughan JV, Sevenoaks T. Welfare and Scientific Considerations of Tattooing and Ear Tagging for Mouse Identification. J Am Assoc Lab Anim Sci. 2019 Mar 1;58(2):142-153. doi: 10.30802/AALAS-JAALAS-18-000057. Epub 2019 Feb 27. PMID: 30813985; PMCID: PMC6433351.  (Luli S acknowledged)

Neal MA, Pippard BJ, Simpson AJ, Thelwall PE. Dynamic susceptibility contrast 19 F-MRI of inhaled perfluoropropane: a novel approach to combined pulmonary ventilation and perfusion imaging. Magn Reson Med. 2020 Feb;83(2):452-461. doi: 10.1002/mrm.27933. Epub 2019 Aug 29. PMID: 31468589; PMCID: PMC6899496.  (Luli S acknowledged)

Anderson R, Lagnado A, Maggiorani D, Walaszczyk A, Dookun E, Chapman J, Birch J, Salmonowicz H, Ogrodnik M, Jurk D, Proctor C, Correia-Melo C, Victorelli S, Fielder E, Berlinguer-Palmini R, Owens WA, Greaves L, Kolsky K, Parini A, Douin-Echinard V, LeBrasseur N, Arthur H, Tual-Chalot S, Schafer M, Roos C, Miller J, Robertson N, Mann N, Adams P, Tchkonia T, Kirkland J, Mialet-Perez J, Richardson GD*, Passos J*. Length-independent telomere damage drives cardiomyocyte senescence. EMBO J, Jan 2019, doi:10.15252/embj.2018100492.

Walaszczyk A, Dookun D, Redgrave R, Tual-Chalot S, Victorelli S, Spyridopoulos I, Owens WA, Arthur HM, Passos JF, Richardson GD*. Pharmacological clearance of senescent cells improves survival and recovery in aged mice following acute myocardial infarction. Aging Cell, 2019 doi:10.1111/acel.12945.


Dr Lynsey McKenzie, Hasan Issa, Sandeep Potluri, Dr Helen Blair, Asmida Isa, Dr Ricky Tirtakusuma, Dan Coleman, Dr Sirintra Nakjang, Dr Victoria Forster, Dr Mojgan Reza, Dr Edward Law, Philip Berry, Dr Simon Bomken, Dr Deepali Pal, Professor James Allan, Professor Gareth Veal, Professor Olaf Heidenreich. The Oncogenic Transcription Factor RUNX1/ETO Corrupts Cell Cycle Regulation to Drive Leukemic Transformation. Cancer Cell 34, 626–642, October 8, 2018

Sarah E. Fordham, Helen J. Blair, Claire J. Elstob, Ruth Plummer, Yvette Drew, Nicola J. Curtin, Olaf Heidenreich, Deepali Pal, David Jamieson, Catherine Park, John Pollard,2 Scott Fields, Paul Milne, Graham H. Jackson, Helen J. Marr, Tobias Menne, Gail L. Jones, and James M. Allan. Inhibition of ATR acutely sensitizes acute myeloid leukemia cells to nucleoside analogs that target ribonucleotide reductase. Blood Advances. 2018 May 22;2(10):1157-1169.

Paul. B. Sinclair, Helen H. Blair, Sarra L. Ryan, Lars Buechler, Joanna Cheng, Jake Clayton, Rebecca Hanna, Shaun Hollern, Zoe Hawking, Matthew Bashton, Claire J. Schwab, Lisa Jones, Lisa J. Russell, Helen Marr, Peter Carey, Christina Halsey, Olaf Heidenreich, Anthony V. Moorman, Christine J. Harrison. Dynamic Clonal Progression In Xenografts Of Acute Lymphoblastic Leukemia With Intrachromosomal Amplification Of Chromosome 21. Haematologica April 2018 103: 634-644;


Zeybel M, Luli S, Sabater L, Hardy T, Oakley F, Leslie J, Page A, Moran Salvador E, Sharkey V, Tsukamoto H, Chu DCK, Singh US, Ponzoni M, Perri P, Di Paolo D, Mendivil EJ, Mann J, Mann DA. A Proof-of-Concept for Epigenetic Therapy of Tissue Fibrosis: Inhibition of Liver Fibrosis Progression by 3-Deazaneplanocin A. Mol Ther. 2017 Jan 4;25(1):218-231. doi: 10.1016/j.ymthe.2016.10.004. Epub 2017 Jan 4. PMID: 28129116; PMCID: PMC5363305. (Luli S - Joint 1st Authour

Elder, Bomken S, Wilson I, Blair HJ, Cockell S, Ponthan F, Dormon K1, Pal D, Heidenreich O, Vormoor J.Abundant and equipotent founder cells establish and maintain acute lymphoblastic leukaemia. Leukemia. 2017 Dec;31(12):2577-2586. doi: 10.1038/leu.2017.140. Epub 2017 May 10.

McCormick A, Earp E, Elliot K, Cuthbert G, O'Donnell R, Wilson BT, Sutton R, Leeson C, Thomas HD, Blair H, Fordham S, Lunec J, Allan J, Edmondson RJ. Functional characterisation of a novel ovarian cancer cell line, NUOC-1. Oncotarget. 2017, 8(16), 26832-26844.

Noble RA, Bell N, Blair H, Sikka A, Thomas H, Phillips N, Nakjang S, Miwa S, Crossland R, Rand V, Televantou D, Long A, Keun HC, Bacon CM, Bomken S, Critchlow SE, Wedge SR. Inhibition of monocarboxyate transporter 1 by AZD3965 as a novel therapeutic approach for diffuse large B-cell lymphoma and burkitt lymphoma. Haematologica. 2017, 102(7), 1247-1257.

Meyer SK, Probert PM, Lakey AF,  Axon AR, Williams FM, Jowsey PA, Blain PG, Kass GE, Wright MC.  Hepatic effects of tartrazine (E 102) are independent of oestrogen receptor interactions in the mouse.  Toxicol Letts, In press (2017).

Vormoor B, Schlosser YT, Blair H, Sharma A, Wilkinson S, Newell DR, Curtin N. Sensitizing Ewing sarcoma to chemo- and radiotherapy by inhibition of the DNA-repair enzymes DNA protein kinase (DNA-PK) and poly-ADP-ribose polymerase (PARP) 1/2. Oncotarget. 2017 Sep 28;8(69):113418-113430. doi: 10.18632/oncotarget.21300. PMID: 29371919; PMCID: PMC5768336.

Lin H, Patel S, Affleck VS, Wilson I, Turnbull DM, Joshi AR, Maxwell R, Stoll EA. Fatty acid oxidation is required for the respiration and proliferation of malignant glioma cells. Neuro-Oncology 2017, 19(1), 43-54


Luli S, Di Paolo D, Perri P, Brignole C, Hill SJ, Brown H, et al. A new fluorescence-based optical imaging method to non-invasively monitor hepatic myofibroblasts in vivo. J Hepatol. 2016. Epub 2016/04/14. doi: 10.1016/j.jhep.2016.03.021. IF 11.336 (Luli S - 1st Author)

Pal D, Blair HJ, Elder A, Dormon K, Rennie KJ, Coleman DJ, et al. Long-term in vitro maintenance of clonal abundance and leukaemia-initiating potential in acute lymphoblastic leukaemia. Leukemia. 2016. PubMed PMID: 27109511. IF 10.431

Fox C, Cocchiaro P, Oakley F, Howarth R, Callaghan K, Leslie J, Luli S, Wood KM, Genovese F, Sheerin NS, Moles A. Inhibition of lysosomal protease cathepsin D reduces renal fibrosis in murine chronic kidney disease. Sci Rep. 2016 Feb 2;6:20101. doi: 10.1038/srep20101. PMID: 26831567; PMCID: PMC4735715.

Roughan JV, Bertrand HG, Isles HM. Meloxicam prevents COX-2-mediated post-surgical inflammation but not pain following laparotomy in mice. Eur J Pain. 2016;20(2):231-40. PubMed PMID: 25908253. IF 3.218

Moles A, Butterworth JA, Sanchez A, Hunter JE, Leslie J, Sellier H, et al. A RelA(p65) Thr505 phospho-site mutation reveals an important mechanism regulating NF-kappaB-dependent liver regeneration and cancer. Oncogene 2016. PubMed PMID: 26853469. IF 8.459

Miller, A., Burson, H., Söling, A. and Roughan, J. V. Welfare assessment following heterotopic or orthotopic inoculation of bladder cancer in C57BL/6. PLOS ONE 2016. Submitted. IF 3.234


Wilson CL, Jurk D, Fullard N, Banks P, Page A, Luli S, et al. NFkappaB1 is a suppressor of neutrophil-driven hepatocellular carcinoma. Nat Commun. 2015;6:6818. PubMed PMID: 25879839. IF 11.47

Hunter JE, Butterworth JA, Zhao B, Sellier H, Campbell KJ, Thomas HD, et al. The NF-kappaB subunit c-Rel regulates Bach2 tumour suppressor expression in B-cell lymphoma. Oncogene. 2015. PubMed PMID: 26522720. IF 8.459


Scherr M, Elder A, Battmer K, Barzan D, Bomken S, Ricke-Hoch M, et al. Differential expression of miR-17~92 identifies BCL2 as a therapeutic target in BCR-ABL-positive B-lineage acute lymphoblastic leukemia. Leukemia. 2014;28(3):554-65. PubMed PMID: 24280866. IF 10.431

Vormoor B, Knizia HK, Batey MA, Almeida GS, Wilson I, Dildey P, et al. Development of a preclinical orthotopic xenograft model of ewing sarcoma and other human malignant bone disease using advanced in vivo imaging.PLoS One. 2014;9(1):e85128. PubMed PMID: 24409320. IF 3.234


Moles A, Sanchez AM, Banks PS, Murphy LB, Luli S, Borthwick L, Fisher A, O'Reilly S, van Laar JM, White SA, Perkins ND, Burt AD, Mann DA, Oakley F. Inhibition of RelA-Ser536 phosphorylation by a competing peptide reduces mouse liver fibrosis without blocking the innate immune response. Hepatology. 2013 Feb;57(2):817-28. doi: 10.1002/hep.26068. Epub 2013 Jan 8. PMID: 22996371; PMCID: PMC3807604.

Bomken S, Buechler L, Rehe K, Ponthan F, Elder A, Blair H, et al. Lentiviral marking of patient-derived acute lymphoblastic leukaemic cells allows in vivo tracking of disease progression. Leukemia. 2013;27(3):718-21. PubMed PMID: 22858908. IF 10.431

Robinson SM, Mann DA, Manas DM, Oakley F, Mann J, White SA. The potential contribution of tumour-related factors to the development of FOLFOX-induced sinusoidal obstruction syndrome. Br J Cancer. 2013;109(9):2396-403. PubMed PMID: 24113143. IF 4.836