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Publication

The following list of papers shows the range of research carried out by users of the Electron Microscopy Research Services.

We'd like to thank all those who have taken the trouble to recognise the efforts of this unit in supporting their research.

By acknowledging us in your papers, posters and talks, you will help to ensure we continue to receive faculty subsidy and continue to offer excellent access rates. 

If you have a paper published, please let us know so we can include it in this list. Email us at em.researchservices@ncl.ac.uk 

Anyone publishing data generated using the Gatan 3View system please quote BBSRC grant reference BB/M012093/1 in the acknowledgement.

Anyone publishing data generated using the Hitachi TEM please quote BBSRC grant reference BB/R013942/1 in the acknowledgement.

Published in 2024

Unit Staff as Author: 

 

Staff Acknowledged:

Machine and Unit Acknowledged:

 

 

 

Published in 2023
Published in 2022
Published in 2021
 
Published in 2020
Published in 2019

Vincent AE, White K, Davey T, Philips J, Ogden RT, Lawess C, Warren C, Hall MG, Ng YS, Falkous G, Holden T, Deehan D, Taylor RW, Turnbull DM, Picard M. Quantitative 3D Mapping of the Human Skeletal Muscle Mitochondrial Network. Cell Rep. 2019 Jan 14. pii: S2211-1247(19)30018-X. doi: 10.1016/j.celrep.2019.01.010.

Mellough CB, Bauer R, Collin J, Dorgau B, Zerti D, Dolan DWP, Jones CM, Izuogu OG, Yu M, Hallam D, Steyn JS, White K, Steel DH, Santibanez-Koref M, Elliott DJ, Jackson MS, Lindsay S, Grellscheid S, Lako M. An integrated transcriptional analysis of the developing human retina. Development. 2019 Jan 29;146(2).

Dorgau B, Felemban M, Hilgen G, Kiening M, Zerti D, Hunt NC, Doherty M, Whitfield P, Hallam D, White K, Ding Y, Krasnogor N, Al-Aama J, Asfour HZ, Sernagor E, Lako M. Decellularised extracellular matrix-derived peptides from neural retina and retinal pigment epithelium enhance the expression of synaptic markers and light responsiveness of human pluripotent stem cell derived retinal organoids. Biomaterials. 2019 Jan 22;199:63-75.

Bailey KE, MacGowan GA, Tual-Chalot S, Phillips L, Mohun TJ, Henderson DJ, Arthur HM, Bamforth SD, Phillips HM. Disruption of embryonic ROCK signaling reproduces the sarcomeric phenotype of hypertrophic cardiomyopathy. JCI Insight. 2019 Mar 5;5. pii: 125172. doi: 10.1172/jci.insight.125172.

Mellough CB, Collin J, Queen R, Hilgen G, Dorgau B, Zerti D, Felemban M, White K, Sernagor E, Lako M. Systematic Comparison of Retinal Organoid Differentiation from Human Pluripotent Stem Cells Reveals Stage Specific, Cell Line, and Methodological Differences. Stem Cells Transl Med. 2019 Mar 27. doi: 10.1002/sctm.18-0267

Ritchie AW, Cox HJ, Barrientos-Palomo SN, Sharples GJ, Badyal JPS. Bioinspired multifunctional polymer–nanoparticle–surfactant complex nanocomposite surfaces for antibacterial oil–water separation.Colloids and Surfaces A: Physicochemical and Engineering Aspects.  560:352-359, 2019.

Hernandez-Diaz I, Pan J, Ricciardi CA, Bai X, Ke J, White KE, Flaquer M, Fouli GE, Argunhan F, Hayward AE, Hou FF, Mann GE, Miao RQ, Long DA, Gnudi L. Overexpression of Circulating Soluble Nogo-B Improves Diabetic Kidney Disease by Protecting the Vasculature. Diabetes. 2019 Jun 19. pii: db190157. doi: 10.2337/db19-0157.

Cross SH, Mckie L, Keighren M, West K, Thaung C, Davey T, Soares DC, Sanchez-Pulido L, Jackson IJ. Missense Mutations in the Human Nanophthalmos Gene TMEM98 Cause Retinal Defects in the Mouse. Invest Ophthalmol Vis Sci. 2019 Jul 1;60(8):2875-2887. doi: 10.1167/iovs.18-25954.

Majumder S, Hadden MJ, Thieme K, Batchu SN, Niveditha D, Chowdhury S, Yerra VG, Advani SL, Bowskill BB, Liu Y, Vakili H, Alghamdi TA, White KE, Geldenhuys L, Siddiqi FS, Advani A. Dysregulated expression but redundant function of the long non-coding RNA HOTAIR in diabetic kidney disease. Diabetologia. 2019

Molinari E, Ramsbottom SA, Srivastava S, Booth P, Alkanderi S, McLafferty SM, Devlin LA, White K, Gunay-Aygun M, Miles CG, Sayer JA. Targeted exon skipping rescues ciliary protein composition defects in Joubert syndrome patient fibroblasts. Sci Rep. 2019 Jul 25;9(1):10828. doi: 10.1038/s41598-019-47243-z.

Oliver P. March, Thomas Lettner, Alfred Klausegger, Michael Ablinger, Julia Reichelt Gene Editing–Mediated Disruption of Epidermolytic Ichthyosis–Associated KRT10 Alleles Restores Filament Stability in Keratinocytes Journal of Investigative Dermatology, Volume 139, Issue 8, August 2019, Pages 1699-1710.e6

Peters DT, Waller H, Birch MA, Lakey JH. Engineered mosaic protein polymers; a simple route to multifunctional biomaterials. Journal of Biological Engineering 2019 13:54

Al-Wahaibi ASM, Lapinska E, Rajarajan N, Dobretsov S, Upstill-Goddard R, Burgess JG. Secretion of DNases by Marine Bacteria: A Culture Based and Bioinformatics Approach. Front Microbiol. 2019 May 7;10:969. doi: 10.3389/fmicb.2019.00969. eCollection 2019

Liddle A, Webb M, Clement N, Green S, Liddle J, German M, Holland J. Ultrasonic cement removal in cement-in-cement revision total hip arthroplasty: What is the effect on the final cement-in-cement bond? Bone Joint Res. 2019 5;8(6):246-252. doi: 10.1302/2046-3758.86.BJR-2018-0313.R1

Priscila Melo, Emma Tarrant, Thomas Swift, Anthony Townshend, Kenneth Dalgarno Short phosphate glass fiber - PLLA composite to promote bone mineralization Materials Science and Engineering: C, Volume 104, November 2019, Article 109929

McMacken GM, Spendiff S, Whittaker RG, O'Connor E, Howarth RM, Boczonadi V, Horvath R, Slater CR, Lochmüller H. Salbutamol modifies the neuromuscular junction in a mouse model of ColQ myasthenic syndrome. Hum Mol Genet. 2019 Jul 15;

Kousi K, Neagu D, Papaioannou EI, Metcalfe IS.  Endogenous Nanoparticles Strain Perovskite Host Lattice Providing Oxygen Capacity and Driving Oxygen Exchange and CH4 Conversion to Syngas  Dec 2019  Angewandt Chemie

Müller, S., Nicholson, L., Al Harbi, N. et al. Osteogenic potential of heterogeneous and CD271-enriched mesenchymal stromal cells cultured on apatite-wollastonite 3D scaffolds. BMC biomed eng 1, 16 (2019).

Published in 2018

Majumder S, Thieme K, Batchu SN, Alghamdi TA, Bowskill BB, Kabir MG, Liu Y, Advani SL, White KE, Geldenhuys L, Tennankore KK, Poyah P, Siddiqi FS, Advani A. Shifts in podocyte histone H3K27me3 regulate mouse and human glomerular disease. J Clin Invest. 128:483-499, 2018

Cocks E, Taggart M, Rind FC, White K. A guide to analysis and reconstruction of serial block face scanning electron microscopy data. J Microsc. 2018 Jan 15. doi: 10.1111/jmi.12676.

Srivastava S, Ramsbottom SA, Molinari E, Alkanderi S, Filby A, White K, Henry C, Saunier S, Miles CG, Sayer JA. A human patient-derived cellular model of Joubert syndrome reveals ciliary defects which can be rescued with targeted therapies. Hum Mol Genet. 2017 Dec 1;26(23):4657-4667. doi: 10.1093/hmg/ddx347.

Vincent AE, Rosa HS, Pabis K, Lawless C, Chen C, Grünewald A, Rygiel KA, Rocha MC, Reeve AK, Falkous G, Perissi V, White K, Davey T, Petrof BJ, Sayer AA, Cooper C, Deehan D, Taylor RW, Turnbull DM, Picard M. Sub-cellular origin of mtDNA deletions in human skeletal muscle. Ann Neurol. 2018 Jul 16. doi: 10.1002/ana.25288.

Papakrivopoulou E, Vasilopoulou E, Lindenmeyer MT, Pacheco S, Brzóska HŁ, Price KL, Kolatsi-Joannou M, White KE, Henderson DJ, Dean CH, Cohen CD, Salama AD, Woolf AS, Long DA. Vangl2, a planar cell polarity molecule, is implicated in irreversible and reversible kidney glomerular injury. J Pathol. 2018 Aug 20. doi: 10.1002/path.5158.

Alkanderi S, Molinari E, Shaheen R, Elmaghloob Y, Stephen LA, Sammut V, Ramsbottom SA, Srivastava S, Cairns G, Edwards N, Rice SJ, Ewida N, Alhashem A, White K, Miles CG, Steel DH, Alkuraya FS, Ismail S, Sayer JA. ARL3 Mutations Cause Joubert Syndrome by Disrupting Ciliary Protein Composition. Am J Hum Genet. 2018 Sep 19. pii: S0002-9297(18)30283-0. doi: 10.1016/j.ajhg.2018.08.015.

Buskin A, Zhu L, Chichagova V, Basu B, Mozaffari-Jovin S, Dolan D, Droop A, Collin J, Bronstein R, Mehrotra S, Farkas M, Hilgen G, White K, Pan KT, Treumann A, Hallam D, et al Disrupted alternative splicing for genes implicated in splicing and ciliogenesis causes PRPF31 retinitis pigmentosa. Nat Commun. 2018 Oct 12;9(1):4234. doi: 10.1038/s41467-018-06448-y. 

 Ramsbottom SA, Molinari E, Srivastava S, Silberman F, Henry C, Alkanderi S, Devlin LA, White K, Steel DH, Saunier S, Miles CG, Sayer JA. Targeted exon skipping of a CEP290 mutation rescues Joubert syndrome phenotypes in vitro and in a murine model. Proc Natl Acad Sci U S A. 2018 115(49):12489-12494.

 Santos-Beneit F, Gu JY, Stimming U, Errington J. ylmD and ylmE genes are dispensable for growth, cross-wall formation and sporulation in Streptomyces venezuelae. Heliyon. 2017 Nov 21;3(11):e00459. doi: 10.1016/j.heliyon.2017.e00459. eCollection 2017 Nov

Langton DJ, Sidaginamale RP, Joyce TJ, Meek RD, Bowsher JG, Deehan D, Nargol AVF, Holland JP. A comparison study of stem taper material loss at similar and mixed metal head-neck taper junctions. Bone Joint J. 2017 Oct;99-B(10):1304-1312. doi: 10.1302/0301-620X.99B10.BJJ-2016-1005.R1.

Papastavrou VT, Borooah S, O'Brien JM, Ray-Chaudhuri N, Dhillon B, Vieira RV, Browning AC.  Cataract surgery in patients with late-onset retinal degeneration. .  J Cataract Refract Surg. 2017 Aug;43(8):1036-1043. doi: 10.1016/j.jcrs.2017.05.041

G. Montalbano, S. Toumpaniari, A. Popov, P. Duan, A. M. Ferreira. Synthesis of bioinspired collagen/alginate/fibrin based hydrogels for soft tissue engineering. Materials Science and Engineering: C, Volume 91, 1 October 2018, Pages 236-246

Ashwin Miriyala, Sébastien Kessler, F. Claire Rind, Geraldine A. Wright. Burst Firing in Bee Gustatory Neurons Prevents Adaptation. Current Biology, Volume 28, Issue 10, 21 May 2018, Pages 1585-1594.e3 https://doi.org/10.1016/j.cub.2018.03.070

Zur Lage P, Stefanopoulou P, Styczynska-Soczka K, Quinn N, Mali G, von Kriegsheim A, Mill P, Jarman AP. Ciliary dynein motor preassembly is regulated by Wdr92 in association with HSP90 co-chaperone, R2TP. J Cell Biol. 2018 May 9. pii: jcb.201709026. doi: 10.1083/jcb.201709026

Timothy Robson, Deepan S. H. Shah, Alexandra S. Solovyova, and Jeremy H. Lakey. Modular Protein Engineering Approach to the Functionalization of Gold Nanoparticles for Use in Clinical Diagnostics. ACS Appl. Nano Mater., DOI: 10.1021/acsanm.8b00737

Hallam D, Hilgen G, Dorgau B, Zhu L, Yu M, Bojic S, Hewitt P, Schmitt M, Uteng M, Kustermann S, Steel D, Nicholds M, Thomas R, Treumann A, Porter A, Sernagor E, Armstrong L, Lako M. Human induced pluripotent stem cells generate light responsive retinal organoids with variable and nutrient dependent efficiency.Stem Cells. 2018 Jul 13. doi: 10.1002/stem.2883

Gema Dura, Helen Waller, Piergiorgio Gentile, Jeremy H. Lakey, David A. Fulton. Tuneable hydrogels of Caf1 protein fibers. Materials Science and Engineering: C,  Volume 93, Pages 88-95, 2018

Dunce JM, Dunne OM, Ratcliff M, Millán C, Madgwick S, Usón I, Davies OR. Structural basis of meiotic chromosome synapsis through SYCP1 self-assembly.Nat Struct Mol Biol. 2018 Jun 18. doi: 10.1038/s41594-018-0078-9.

Salam N, Toumpaniari S, Gentile P, Marina Ferreira A, Dalgarno K, Partridge S. Assessment of Migration of Human MSCs through Fibrin Hydrogels as a Tool for Formulation Optimisation. Materials (Basel). 2018 Sep 19;11(9). pii: E1781. doi: 10.3390/ma11091781.

Doherty S, Knight JG, Backhouse T, Abood E, Alshaikh H, Clemmet AR, Ellison JR, Bourne RA, Chamberlain TW, Stones R, Warren NJ, Fairlamb IAJ, Lovelock KRJ. Heteroatom Donor-Decorated Polymer-Immobilized Ionic Liquid Stabilized Palladium Nanoparticles: Efficient Catalysts for Room-Temperature Suzuki-Miyaura Cross-Coupling in Aqueous Media. Advanced Synthesis & Catalysis 2018 https://doi.org/10.1002/adsc.201800561

Doherty S, Knight JG, Backhouse T, Bradford A, Saunders, Bourne RA, Chamberlain TW, Stones R, Clayton A, Lovelock K. Highly efficient aqueous phase reduction of nitroarenes catalyzed by phosphine-decorated PEG-modified polymer immobilized ionic liquid stabilized PdNPs. Catalysis, Science & Technology 2018 https://doi.org/10.1039/C7CY02557B

Mohammed WK, Krasnogor N, Jakubovics NS. Streptococcus gordonii Challisin protease is required for sensing cell--cell contact with Actinomyces oris. FEMS Microbiol Ecol. 2018 May 1;94(5). doi: 10.1093/femsec/fiy043.

Cao Y, Su B, Chinnaraj S, Jana S, Bowen L, Charlton S, Duan P, Jakubovics NS, Chen J. Nanostructured titanium surfaces exhibit recalcitrance towards Staphylococcus epidermidis biofilm formation. Sci Rep. 2018 Jan 18;8(1):1071. doi: 10.1038/s41598-018-19484-x.

Bagnall AJ, Santana Vega M, Martinelli J, Djanashvili K, Cucinotta F. Mesoscopic FRET Antenna Materials by Self-Assembling Iridium(III) Complexes and BODIPY Dyes. Chemistry. 2018 Aug 14;24(46):11992-11999. doi: 10.1002/chem.201802745

da Conceicao Ribeiro R, Pal D, Ferreira AM, Gentile P, Benning M, Dalgarno K Reactive jet impingement bioprinting of high cell density gels for bone microtissue fabrication.Biofabrication. 2018 Dec 27;11(1):015014. doi: 10.1088/1758-5090/aaf625.

Arunmanee W, Heenan RK, Lakey JH. Determining the amphipol distribution within membrane-protein fibre samples using small-angle neutron scattering. Acta Crystallogr D Struct Biol. 2018 Dec 1;74(Pt 12):1192-1199.

Jeong M, O'Reilly M, Kirkwood NK, Al-Aama J, Lako M, Kros CJ, Armstrong L. Generating inner ear organoids containing putative cochlear hair cells from human pluripotent stem cells. Cell Death Dis. 2018 Sep 11;9(9):922. doi: 10.1038/s41419-018-0967-1.

Idris H, Nouioui I, Pathom-Aree W, Castro JF, Bull AT, Andrews BA, Asenjo JA, Goodfellow M. Amycolatopsis vastitatis sp. nov., an isolate from a high altitude subsurface soil on Cerro Chajnantor, northern Chile. Antonie Van Leeuwenhoek. 2018 Sep;111(9):1523-1533. doi: 10.1007/s10482-018-1039-3.

Mali GR, Yeyati PL, Mizuno S, Dodd DO, Tennant PA, Keighren MA, Zur Lage P, Shoemark A, Garcia-Munoz A, Shimada A, Takeda H, Edlich F, Takahashi S, von Kreigsheim A, Jarman AP, Mill P. ZMYND10 functions in a chaperone relay during axonemal dynein assembly. Elife. 2018 Jun 19;7. pii: e34389. doi:10.7554/eLife.34389.

Ibeyaima A, Singh AK, Lal R, Gupta S, Goodfellow M, Sarethy IP. Saccharothrix tharensis sp. nov., an actinobacterium isolated from the Thar Desert, India. Antonie Van Leeuwenhoek. 2018 Nov;111(11):2141-2147. doi: 10.1007/s10482-018-1106-9.

Mutha NVR, Mohammed WK, Krasnogor N, Tan GYA, Choo SW, Jakubovics NS. Transcriptional Responses of Streptococcus gordonii and Fusobacterium nucleatum to Coaggregation. Mol Oral Microbiol. 2018 Oct 17. doi: 10.1111/omi.12248.

Coulter J, Jakubovics NS, Preshaw PM, German MJ. An in vitro model to assess effects of a desensitising agent on bacterial biofilm formation. Acta Biomater Odontol Scand. 2018 Dec 24;5(1):1-8. doi: 10.1080/23337931.2018.1544847. eCollection 2019.