Muscle research at the NMRC
Magnetic resonance provides several important tools for the investigation of human muscle, allowing assessment of structure, metabolism and function. The Centre has developed advanced methodology for measuring tissue energetics at rest and during periods of muscle exercise (31P MRS) together with 13C measures of muscle glycogen as well as conventional images to measure structure and muscle fat infiltration. These techniques are being applied to a wide range of studies ranging from investigating healthy controls through to patient groups with genetic mutations.
These studies are supported by a variety of funders including the MRC, the NIHR Biomedical Research Centre and Diabetes UK.
Muscle Projects at the MR Centre
- A randomised, active comparator, double-blind, multi centre, parallel, synovial biopsy and imaging mechanism of action, phase 2a trial of anti-IL-20 (NNC0109-0012) in subjects with rheumatoid arthritis on MTX
Project Leader(s): Professor John Isaacs
- The impact of sucrose ingestion during exercise on liver and muscle glycogen content
Project Leader(s): Professor Mike Trenell, Dr Emma Stevenson, Professor Luc van Loon
- An international natural history study of dysferlinopathy
Project Leader(s): Professor Kate Bushby/Professor Volker Straub
- A phase IIb, open-label study to assess the efficacy, safety, pharmacodynamics and pharmacokinetics of multiple doses of PRO045 in subjects with Duchenne muscular dystrophy
Project Leader(s): Professor Volker Straub
- Skeletal muscle mitochondrial function in Pulmonary Arterial Hypertension
Project Leader(s): Professor Paul Corris, Sasi Sithamparanathan
- The effect of exercise on metabolism and liver lipid in people with Type 2 Diabetes
Project Leader(s): Dr Mike Trenell
Muscle Publications from the MR Centre
- Sinha A, Hollingsworth KG, Ball S, Cheetham T. Improving the vitamin d status of vitamin d deficient adults is associated with improved mitochondrial oxidative function in skeletal muscle.
J Clin Endocrinol Metab. 2013 Mar;98(3):E509-13. doi: 10.1210/jc.2012-3592. Epub 2013 Feb 7.
- He J, Hollingsworth KG, Newton JL, Blamire AM. Cerebral vascular control is associated with skeletal muscle pH in chronic fatigue syndrome patients both at rest and during dynamic stimulation. NeuroImage 2013 Jan 5;2:168-73. doi: 10.1016/j.nicl.2012.12.006. PubMed PMID: 24179772.
- Ford AH, Duncan GW, Firbank MJ, Yarnall AJ, Khoo TK, Burn DJ, O'Brien JT.Rapid eye movement sleep behavior disorder in Parkinson's disease: Magnetic resonance imaging study. Mov Disord. 2013 Feb 28. doi: 10.1002/mds.25367. [Epubahead of print] PubMed PMID: 23450684.
- Kinali M, Arechavala-Gomeza V, Cirak S, Glover A, Guglieri M, Feng L, Hollingsworth KG, Hunt D, Junbluth H, Roper HP, Quinlivin RM, Gosalakkal JA, Jayawant S, Nadeau A, Hughes-Carre L, Manzur AY, Mercuri E, Morgan JE, Straub V, Bushby K, Sewry C, Rutherford M, Muntoni F. Muscle histology va MRI in Duchenne muscular dystrophy. Neurology. 2011 Jan 25;76(4):346-53.
- Hallsworth K, Fattakhova G, Hollingsworth KG, Thoma C, Moore S, Taylor R ,Day CP, Trenell MI. Resistance exercise reduces liver fat and its mediators in non-alcoholic fatty liver disease independent of weight loss. Hepatology Gut 2011;60:1278e1283. doi:10.1136/gut.2011.242073.
- Yu-Wai-Man P, Trenell MI, Hollingsworth KG, Griffiths PG, PF. C. OPA1 mutations impair mitochondrial function in both pure and complicated dominant optic atrophy Brain. 2011; Apr;134(Pt 4):e164.Epub 2010 Oct 14.
- Klein A, Jungbluth H, Clement E, Lillis S, Abbs S, Munot P, Pane M, Wraige E, Schara U, Straub V, Mercuri E and Muntoni F. Muscle Magnetic Resonance Imaging in Congenital Myopathies Due to Ryanodine Receptor Type 1 Gene Mutations, Archives of Neurology, 2011, 68(9), pp. 1171-1179.
- Jones D, Hollingsworth K, Taylor R, Blamire A, Newton J. Abnormalities in pH Handling by Peripheral Muscle and Potential Regulation by the Autonomic Nervous System in Chronic Fatigue Syndrome. Journal of Internal Medicine 2010; 267(4):394-401.
- Hollingsworth KG, Newton JL, Robinson L, Taylor R, Blamire AM, Jones DE. Loss of capacity to recover from acidosis in repeat exercise is strongly associated with fatigue in Primary Biliary Cirrhosis J Hepatol 2010;53:155-161.
- Yu-Wai-Man P, Trenell MI, Hollingsworth KG, Griffiths PG, PF. C. OPA1 mutations impair mitochondrial function in both pure and complicated dominant optic atrophy Brain. 2010(Oct. 14).
- Garrood P, Hollingsworth K, Eagle M, Aribisala B, Birchall D, Bushby K, et al. MR imaging in Duchenne muscular dystrophy: quantification of T1-weighted signal, contrast uptake and the effects of exercise. Journal of Magnetic Resonance Imaging. 2009 Nov;30(5):1130-8.
- Stevenson EJ TP, Thomas K, Smith F, Brand-Miller J, Trenell MI. Dietary glycemic index influences lipid oxidation but not muscle or liver glycogen oxidation during exercise. Am J Physiol Endocrinol Metab 2009; 296(5):E1140-7. Epub 2009 Feb 17.
- Trenell MI, Thelwall P, Thomas K, Stevenson E. Effect of high and low glycaemic index diets on skeletal muscle and liver substrate storage and utilisation during exercise Diabetologia 2008;51 248.
- Hollingsworth KG, Newton JL, Taylor R, McDonald C, Palmer JM, Blamire AM, et al. Pilot study of peripheral muscle function in primary biliary cirrhosis: potential implications for fatigue pathogenesis. Clin Gastroenterol Hepatol. 2008 Sep;6(9):1041-8.
- Trenell MI, Stevenson E, Stockmann K, Brand-Miller J. Effect of high and low glycaemic index recovery diets on intramuscular lipid oxidation during aerobic exercise. British Journal of Nutrition. 2008 Feb;99(2):326-32. Epub 2007 Aug 15.
- Garrood P, Hollingsworth K, Thelwall P, Birchall D, Eagle M, Bushby K, et al. MRI in Duchenne muscular dystrophy: Quantification of fat infiltration and gadolinium uptake using whole-muscle regions of interest. Neuromuscular Disorders 2007; 17(9-10):816-7.