Current Research Projects
- A 4D flow-sensitive Magnetic Resonance Study of Patent Foramen Ovale
Project Leader(s): Professor Gary Ford and Dr Louise Coats - A cancer research UK phase I trial of AZD3965, a monocarboxylate transporter 1 inhibitor (MCT1) in patients with advanced cancer (Non-Hodgkins Lymphoma. MCT1 Inhibitor study)
Project Leader(s): Professor Ruth Plummer - A Multi-center, Longitudinal, Observational Study of Patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD) to Establish the Rate, Characteristics, and Determinants of Disease Progression
Project Leader(s): Dr John Sayer - A neuropsychological approach to dissect face perception and perceptual expertise
Project Leader(s): Dr Quoc Vuong - A non invasive detection of disease processes in the CNS using multi parametric MRI and magnetic resonance spectroscopy MRS
Project Leader(s): Professor A Blamire - A single-center, double-blind, randomised, placebo-controlled, parallel-group study to assess the effect of 24 weeks of treatment with vildagliptin on insulin sensitivity and its underlying mechanisms in patients with type 2 diabetes treated with metform
Project Leader(s): Professor Roy Taylor - Amyloid imaging for phenotyping lewy body dementia
Project Leader(s): Professor John O'Brien and Dr Robert Barber - An international natural history study of dysferlinopathy
Project Leader(s): Professor Kate Bushby/Professor Volker Straub - Antiglucocorticoid augmentation of antidepressants in depression
Project Leader(s): Professor I N Ferrier - Biomedical and quality of life assessment in individuals with type 1 diabetes mellitus before and after insulin pump therapy or transplantation of kidney, pancreas or islets.
Project Leader(s): Dr Jim Shaw/Dr Mike Trenell - Cardiac energetic and function in normal human ageing
Project Leader(s): Dr Guy MacGowan - Characterisation of the principle determinants of long term reversal of type 2 diabetes
Project Leader(s): Professor Roy Taylor and Dr Sarah Steven - Efficacy and safety of 3 doses of S 38093 (2, 5 and 20 mg/day) versus placebo, in co-administration with donepezil (10 mg/day) in patients with moderate Alzheimer’s Disease. A 24-week international, multi-centre, randomised, double-blind, placebo-control
Project Leader(s): Dr Andrew Byrne - Efficacy of Switch to Lopinavir/r in Improving Cognitive function in Efavirenz treated patients
Project Leader(s): Dr Ashley Price - Exploring how sight and sound interact in recognition
Project Leader(s): Dr Quoc Vuong - fMRI Studies
- Highly accelerated quantitative MRI of skeletal and cardiac muscle
Project Leader(s): Dr Kieren Hollingsworth - How intensively should we treat blood pressure in established cerebral small vessel disease?
Project Leader(s): Professor Gary Ford - Human neurophysiological and neurochemical correlates of tinnitus: the GABA-gamma hypothesis
Project Leader(s): Dr William Sedley - In vivo monitoring of liver oxidative stress defences by magnetic resonance measurements of glutathione turnover
Project Leader(s): Dr Pete Thelwall - Incidence of Cognitive Impairment in Cohorts with Longitudinal Evaluation. Predicting Dementia in Parkinson's Disease-a Genotypic and Phenotypic study
Project Leader(s): Professor David Burn - Increased physical activity and glucose control: Developing a framework for clinical application in Type 2 diabetes.
Project Leader(s): Dr Mike Trenell and Professor Roy Taylor - Investigating attentional function and cognitive fluctuations in Lewy body disease: a functional magnetic imaging and electrophysiological study.
Project Leader(s): Dr J P Taylor, Professor John O'Brien and Ms Alison Killen - Investigating Spatial Memory in Major Depressive Disorder
Project Leader(s): Dr Jonna Nilsson, Prof J McAllister-Williams,Prof I N Ferrier - Ketamine augmentation of ECT to improve outcomes in depression
Project Leader(s): Dr Hamish McAllister-Williams - MRS Validation Study - Developing a protocol to determine tumour pH using phosphorus magnetic resonance spectroscopy (MRS)
Project Leader(s): Professor Ruth Plummer - Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Two Year Study to Evaluate the Effect of Subcutaneous RO4909832 on Cognition and Function in Prodromal Alzheimer's Disease (WN25203)
Project Leader(s): Dr Robert Barber - Neuroimaging of evolutionary precursors to language
Project Leader(s): Dr Chris Petkov - Pathobiology of hepatic encephalopathy in man - determination of the cerebral effects of induced hyperammonaemia and ammonia lowering strategies by MRI and spectroscopy
Project Leader(s): Dr C Record and Dr H Mardini - Preservation of cognitive functioning in older adults and mood disorders: neuropsychological and neuroimaging correlates - healthy volunteer pilot study
Project Leader(s): Dr Yvonne Lai - Randomised pilot trial of Blood pressure Rapid Intensive Lowering And Normal Treatment for Mood and Cognition in Persistent Depression
Project Leader(s): Dr Alan Thomas - Rituximab for the treatment of fatigue in primary biliary cirrhosis
Project Leader(s): Professor David Jones - The development and evaluation of a monitoring device to assess psychosocial and function impairment in older adults with major depression
Project Leader(s): Professor John O'Brien and Professor Nicol Ferrier - The effect of exercise on active liver injury, inflammation and liver lipid in people with non-alcoholic steatohepatitis
Project Leader(s): Professor Mike Trenell - The effect of exercise on metabolism and liver lipid in people with non-alcoholic fatty liver disease
Project Leader(s): Dr Mike Trenell - The effect of exercise on metabolism and liver lipid in people with Type 2 Diabetes
Project Leader(s): Dr Mike Trenell - The impact of attention on the neuronal mechanisms of adaptation
Project Leader(s): Dr Chris Petkov - The role of skeletal muscle function and energetics in the symptoms and metabolic characteristics of Growth Hormone deficiency: a functional NMR approach
Project Leader(s): Dr Tim Cheetman and Akash Sinha - Understanding the pathogenesis of autonomic dysfunction in chronic fatigue syndrome and its relationship with cognitive impairment
Project Leader(s): Professor Julia Newton
