Bioimaging Unit

Publications

Please tell us about your recent publications that make use of our facility, its equipment and staff.  This can be done through email or via our online booking system.

To justify investment in us, we are assessed on the quantity and quality of publications that we facilitate as well as the number of usage hours and costs we recover. It is therefore important that you acknowledge us and inform us of your publications.

 

2017

1. Barbier-Torres L, Iruzubieta P, Fernández-Ramos D, Delgado TC, Taibo D, Guitiérrez-de-Juan V, Varela-Rey M, Azkargorta M, Navasa N, Fernández-Tussy P, Zubiete-Franco I, Simon J, Lopitz-Otsoa F, Lachiondo-Ortega S, Crespo J, Masson S, McCain MV, Villa E, Reeves H, Elortza F, Lucena MI, Hernández-Alvarez MI, Zorzano A, Andrade RJ, Lu SC, Mato JM, Anguita J, Rincón M, Martínez-Chantar ML. The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury. Nat Commun. 2017 Dec 12;8(1):2068. doi: 10.1038/s41467-017-01970-x. PubMed PMID: 29233977; PubMed Central PMCID: PMC5727217.

2. Miotto M, Gouveia R, Abidin FZ, Figueiredo F, Connon CJ. Developing aContinuous Bioprocessing Approach to Stromal Cell Manufacture. ACS Appl MaterInterfaces. 2017 Nov 29;9(47):41131-41142. doi: 10.1021/acsami.7b09809. Epub 2017Nov 17. PubMed PMID: 29145726.

3. Day AM, Herrero-de-Dios CM, MacCallum DM, Brown AJP, Quinn J. Stress-inducednuclear accumulation is dispensable for Hog1-dependent gene expression andvirulence in a fungal pathogen. Sci Rep. 2017 Oct 30;7(1):14340. doi:10.1038/s41598-017-14756-4. PubMed PMID: 29085028; PubMed Central PMCID:PMC5662626.

4. Barter MJ, Gomez R, Hyatt S, Cheung K, Skelton AJ, Xu Y, Clark IM, Young DA.The long non-coding RNA ROCR contributes to SOX9 expression and chondrogenicdifferentiation of human mesenchymal stem cells. Development. 2017 Dec15;144(24):4510-4521. doi: 10.1242/dev.152504. Epub 2017 Oct 30. PubMed PMID:29084806; PubMed Central PMCID: PMC5769619.

5. Niklison-Chirou MV, Erngren I, Engskog M, Haglöf J, Picard D, Remke M, McPolinPHR, Selby M, Williamson D, Clifford SC, Michod D, Hadjiandreou M, Arvidsson T,Pettersson C, Melino G, Marino S. TAp73 is a marker of glutamine addiction inmedulloblastoma. Genes Dev. 2017 Sep 1;31(17):1738-1753. doi:10.1101/gad.302349.117. Epub 2017 Sep 26. PubMed PMID: 28971956; PubMed CentralPMCID: PMC5666673.

6. Chichagova V, Hallam D, Collin J, Buskin A, Saretzki G, Armstrong L,Yu-Wai-Man P, Lako M, Steel DH. Human iPSC disease modelling reveals functionaland structural defects in retinal pigment epithelial cells harbouring the
m.3243A > G mitochondrial DNA mutation. Sci Rep. 2017 Sep 26;7(1):12320. doi:10.1038/s41598-017-12396-2. PubMed PMID: 28951556; PubMed Central PMCID:MC5615077.

7. Alzu'bi A, Lindsay SJ, Harkin LF, McIntyre J, Lisgo SN, Clowry GJ. TheTranscription Factors COUP-TFI and COUP-TFII have Distinct Roles in Arealisationand GABAergic Interneuron Specification in the Early Human Fetal Telencephalon.Cereb Cortex. 2017 Oct 1;27(10):4971-4987. doi: 10.1093/cercor/bhx185. PubMedPMID: 28922831; PubMed Central PMCID: PMC5903418.

8. Hallam D, Collin J, Bojic S, Chichagova V, Buskin A, Xu Y, Lafage L, Otten EG,Anyfantis G, Mellough C, Przyborski S, Alharthi S, Korolchuk V, Lotery A,Saretzki G, McKibbin M, Armstrong L, Steel D, Kavanagh D, Lako M. An InducedPluripotent Stem Cell Patient Specific Model of Complement Factor H (Y402H)Polymorphism Displays Characteristic Features of Age-Related Macular Degenerationand Indicates a Beneficial Role for UV Light Exposure. Stem Cells. 2017Nov;35(11):2305-2320. doi: 10.1002/stem.2708. Epub 2017 Oct 9. Erratum in: StemCells. 2018 Apr;36(4):630. PubMed PMID: 28913923; PubMed Central PMCID:PMC5698780.

9. Moad M, Hannezo E, Buczacki SJ, Wilson L, El-Sherif A, Sims D, Pickard R,Wright NA, Williamson SC, Turnbull DM, Taylor RW, Greaves L, Robson CN, SimonsBD, Heer R. Multipotent Basal Stem Cells, Maintained in Localized ProximalNiches, Support Directed Long-Ranging Epithelial Flows in Human Prostates. CellRep. 2017 Aug 15;20(7):1609-1622. doi: 10.1016/j.celrep.2017.07.061. PubMed PMID:28813673; PubMed Central PMCID: PMC5565638.

10. Crucean A, Alqahtani A, Barron DJ, Brawn WJ, Richardson RV, O'Sullivan J,Anderson RH, Henderson DJ, Chaudhry B. Re-evaluation of hypoplastic left heartsyndrome from a developmental and morphological perspective. Orphanet J Rare Dis.2017 Aug 10;12(1):138. doi: 10.1186/s13023-017-0683-4. PubMed PMID: 28793912;PubMed Central PMCID: PMC5551014.

11. Zou D, Wang W, Lei D, Yin Y, Ren P, Chen J, Yin T, Wang B, Wang G, Wang Y.Penetration of blood-brain barrier and antitumor activity and nerve repair inglioma by doxorubicin-loaded monosialoganglioside micelles system. Int J Nanomedicine. 2017 Jul 7;12:4879-4889. doi: 10.2147/IJN.S138257. eCollection 2017. PubMed PMID: 28744122; PubMed Central PMCID: PMC5511015.

12. Munkley J, McClurg UL, Livermore KE, Ehrmann I, Knight B, Mccullagh P, Mcgrath J, Crundwell M, Harries LW, Leung HY, Mills IG, Robson CN, Rajan P,Elliott DJ. The cancer-associated cell migration protein TSPAN1 is under controlof androgens and its upregulation increases prostate cancer cell migration. SciRep. 2017 Jul 12;7(1):5249. doi: 10.1038/s41598-017-05489-5. PubMed PMID:28701765; PubMed Central PMCID: PMC5507901.

13. Fearn A, Situmorang GR, Fox C, Oakley F, Howarth R, Wilson CL, Kiosia A,Robson MG, Mann DA, Moles A, Sheerin NS. The NF-κB1 is a key regulator of acutebut not chronic renal injury. Cell Death Dis. 2017 Jun 15;8(6):e2883. doi:10.1038/cddis.2017.233. PubMed PMID: 28617440; PubMed Central PMCID: PMC5584573.

14. Ogrodnik M, Miwa S, Tchkonia T, Tiniakos D, Wilson CL, Lahat A, Day CP, BurtA, Palmer A, Anstee QM, Grellscheid SN, Hoeijmakers JHJ, Barnhoorn S, Mann DA,Bird TG, Vermeij WP, Kirkland JL, Passos JF, von Zglinicki T, Jurk D. Cellularsenescence drives age-dependent hepatic steatosis. Nat Commun. 2017 Jun13;8:15691. doi: 10.1038/ncomms15691. PubMed PMID: 28608850; PubMed CentralPMCID: PMC5474745.

15. Carroll B, Nelson G, Rabanal-Ruiz Y, Kucheryavenko O, Dunhill-Turner NA,Chesterman CC, Zahari Q, Zhang T, Conduit SE, Mitchell CA, Maddocks ODK, Lovat P,von Zglinicki T, Korolchuk VI. Persistent mTORC1 signaling in cell senescence results from defects in amino acid and growth factor sensing. J Cell Biol. 2017 Jul 3;216(7):1949-1957. doi: 10.1083/jcb.201610113. Epub 2017 May 31. PubMed MID: 28566325; PubMed Central PMCID: PMC5496614.

16. Yang C, Xu Y, Yu M, Lee D, Alharti S, Hellen N, Ahmad Shaik N, Banaganapalli B, Sheikh Ali Mohamoud H, Elango R, Przyborski S, Tenin G, Williams S, O'Sullivan J, Al-Radi OO, Atta J, Harding SE, Keavney B, Lako M, Armstrong L. Induced pluripotent stem cell modelling of HLHS underlines the contribution of dysfunctional NOTCH signalling to impaired cardiogenesis. Hum Mol Genet. 2017 Aug 15;26(16):3031-3045. doi: 10.1093/hmg/ddx140. PubMed PMID: 28521042; PubMed Central PMCID: PMC5886295.

17. Milne P, Bigley V, Bacon CM, Néel A, McGovern N, Bomken S, Haniffa M, Diamond EL, Durham BH, Visser J, Hunt D, Gunawardena H, Macheta M, McClain KL, Allen C, Abdel-Wahab O, Collin M. Hematopoietic origin of Langerhans cell histiocytosis and Erdheim-Chester disease in adults. Blood. 2017 Jul 13;130(2):167-175. doi: 10.1182/blood-2016-12-757823. Epub 2017 May 16. PubMed PMID: 28512190; PubMed Central PMCID: PMC5524529.

18. Redgrave RE, Tual-Chalot S, Davison BJ, Singh E, Hall D, Amirrasouli MM, Gilchrist D, Medvinsky A, Arthur HM. Cardiosphere-Derived Cells Require Endoglin for Paracrine-Mediated Angiogenesis. Stem Cell Reports. 2017 May
9;8(5):1287-1298. doi: 10.1016/j.stemcr.2017.04.015. PubMed PMID: 28494939; PubMed Central PMCID: PMC5425789.

19. Elias MS, Long HA, Newman CF, Wilson PA, West A, McGill PJ, Wu KC, Donaldson MJ, Reynolds NJ. Proteomic analysis of filaggrin deficiency identifies molecular signatures characteristic of atopic eczema. J Allergy Clin Immunol. 2017 Nov;140(5):1299-1309. doi: 10.1016/j.jaci.2017.01.039. Epub 2017 May 4. PubMed PMID: 28479159; PubMed Central PMCID: PMC5667587.

20. Miwa S, Saretzki G. Telomerase and mTOR in the brain: the mitochondria connection. Neural Regen Res. 2017 Mar;12(3):358-361. doi: 10.4103/1673-5374.202922. Review. PubMed PMID: 28469639; PubMed Central PMCID: PMC5399702.

21. Ibrahim SH, Turner MJ, Saint-Criq V, Garnett J, Haq IJ, Brodlie M, Ward C, Borgo C, Salvi M, Venerando A, Gray MA. CK2 is a key regulator of SLC4A2-mediated Cl(-)/HCO(3)(-) exchange in human airway epithelia. Pflugers Arch. 2017 Sep;469(9):1073-1091. doi: 10.1007/s00424-017-1981-3. Epub 2017 Apr 28. PubMed PMID: 28455748; PubMed Central PMCID: PMC5554290.

22. Hase Y, Craggs L, Hase M, Stevenson W, Slade J, Lopez D, Mehta R, Chen A, Liang D, Oakley A, Ihara M, Horsburgh K, Kalaria RN. Effects of environmental enrichment on white matter glial responses in a mouse model of chronic cerebral hypoperfusion. J Neuroinflammation. 2017 Apr 11;14(1):81. doi: 10.1186/s12974-017-0850-5. PubMed PMID: 28399892; PubMed Central PMCID: PMC5387261.

23. Shaharuddin B, Ahmad S, Md Latar N, Ali S, Meeson A. A Human Corneal Epithelial Cell Line Model for Limbal Stem Cell Biology and Limbal Immunobiology. Stem Cells Transl Med. 2017 Mar;6(3):761-766. doi: 10.5966/sctm.2016-0175. Epub 2016 Oct 14. PubMed PMID: 28297580; PubMed Central PMCID: PMC5442771.

24. Barker CE, Thompson S, O'Boyle G, Lortat-Jacob H, Sheerin NS, Ali S, Kirby JA. CCL2 nitration is a negative regulator of chemokine-mediated inflammation. Sci Rep. 2017 Mar 14;7:44384. doi: 10.1038/srep44384. PubMed PMID: 28290520; PubMed Central PMCID: PMC5349559.

25. Bonifacio MA, Gentile P, Ferreira AM, Cometa S, De Giglio E. Insight into halloysite nanotubes-loaded gellan gum hydrogels for soft tissue engineering applications. Carbohydr Polym. 2017 May 1;163:280-291. doi: 10.1016/j.carbpol.2017.01.064. Epub 2017 Jan 20. PubMed PMID: 28267508.

26. Zummo FP, Cullen KS, Honkanen-Scott M, Shaw JAM, Lovat PE, Arden C. Glucagon-Like Peptide 1 Protects Pancreatic β-Cells From Death by Increasing Autophagic Flux and Restoring Lysosomal Function. Diabetes. 2017
May;66(5):1272-1285. doi: 10.2337/db16-1009. Epub 2017 Feb 23. PubMed PMID: 28232493.

27. Wiessner M, Roos A, Munn CJ, Viswanathan R, Whyte T, Cox D, Schoser B, Sewry C, Roper H, Phadke R, Marini Bettolo C, Barresi R, Charlton R, Bönnemann CG, Abath Neto O, Reed UC, Zanoteli E, Araújo Martins Moreno C, Ertl-Wagner B, Stucka R, De Goede C, Borges da Silva T, Hathazi D, Dell'Aica M, Zahedi RP, Thiele S, Müller J, Kingston H, Müller S, Curtis E, Walter MC, Strom TM, Straub V, Bushby K, Muntoni F, Swan LE, Lochmüller H, Senderek J. Mutations in INPP5K, Encoding a Phosphoinositide 5-Phosphatase, Cause Congenital Muscular Dystrophy with Cataracts and Mild Cognitive Impairment. Am J Hum Genet. 2017 Mar 2;100(3):523-536. doi: 10.1016/j.ajhg.2017.01.024. Epub 2017 Feb 9. PubMed PMID: 28190456; PubMed Central PMCID: PMC5339217.

28. Savage MA, McQuade R, Thiele A. Segregated fronto-cortical and midbrain connections in the mouse and their relation to approach and avoidance orienting behaviors. J Comp Neurol. 2017 Jun 1;525(8):1980-1999. doi: 10.1002/cne.24186. Epub 2017 Mar 20. PubMed PMID: 28177526; PubMed Central PMCID: PMC5396297.

29. Neganova I, Chichagova V, Armstrong L, Lako M. A critical role for p38MAPK signalling pathway during reprogramming of human fibroblasts to iPSCs. Sci Rep. 2017 Feb 3;7:41693. doi: 10.1038/srep41693. PubMed PMID: 28155868; PubMed Central PMCID: PMC5290526.

30. Petropoulos E, Dolfing J, Davenport RJ, Bowen EJ, Curtis TP. Developing cold-adapted biomass for the anaerobic treatment of domestic wastewater at low temperatures (4, 8 and 15 °C) with inocula from cold environments. Water Res. 2017 Apr 1;112:100-109. doi: 10.1016/j.watres.2016.12.009. Epub 2016 Dec 10. PubMed PMID: 28142091.

31. Zeybel M, Luli S, Sabater L, Hardy T, Oakley F, Leslie J, Page A, Moran Salvador E, Sharkey V, Tsukamoto H, Chu DCK, Singh US, Ponzoni M, Perri P, Di Paolo D, Mendivil EJ, Mann J, Mann DA. A Proof-of-Concept for Epigenetic Therapy of Tissue Fibrosis: Inhibition of Liver Fibrosis Progression by 3-Deazaneplanocin A. Mol Ther. 2017 Jan 4;25(1):218-231. doi: 10.1016/j.ymthe.2016.10.004. Epub 2017 Jan 4. PubMed PMID: 28129116; PubMed Central PMCID: PMC5363305.

32. Li J, Dang N, Wood DJ, Huang JY. The kinetochore-dependent and -independent formation of the CDC20-MAD2 complex and its functions in HeLa cells. Sci Rep. 2017 Jan 23;7:41072. doi: 10.1038/srep41072. PubMed PMID: 28112196; PubMed Central PMCID: PMC5253641.

33. Gouveia RM, González-Andrades E, Cardona JC, González-Gallardo C, Ionescu AM, Garzon I, Alaminos M, González-Andrades M, Connon CJ. Controlling the 3D architecture of Self-Lifting Auto-generated Tissue Equivalents (SLATEs) for optimized corneal graft composition and stability. Biomaterials. 2017 Mar;121:205-219. doi: 10.1016/j.biomaterials.2016.12.023. Epub 2016 Dec 23. PubMed PMID: 28092777; PubMed Central PMCID: PMC5267636.

34. Gretenkord S, Rees A, Whittington MA, Gartside SE, LeBeau FE. Dorsal vs. ventral differences in fast Up-state-associated oscillations in the medial prefrontal cortex of the urethane-anesthetized rat. J Neurophysiol. 2017 Mar
1;117(3):1126-1142. doi: 10.1152/jn.00762.2016. Epub 2016 Dec 21. PubMed PMID: 28003411; PubMed Central PMCID: PMC5340880.

35. Alzu'bi A, Lindsay S, Kerwin J, Looi SJ, Khalil F, Clowry GJ. Distinct cortical and sub-cortical neurogenic domains for GABAergic interneuron precursor transcription factors NKX2.1, OLIG2 and COUP-TFII in early fetal human
telencephalon. Brain Struct Funct. 2017 Jul;222(5):2309-2328. doi: 10.1007/s00429-016-1343-5. Epub 2016 Nov 30. PubMed PMID: 27905023; PubMed Central PMCID: PMC5504260.

36. McClurg UL, Cork DMW, Darby S, Ryan-Munden CA, Nakjang S, Mendes Côrtes L, Treumann A, Gaughan L, Robson CN. Identification of a novel K311 ubiquitination site critical for androgen receptor transcriptional activity. Nucleic Acids Res. 2017 Feb 28;45(4):1793-1804. doi: 10.1093/nar/gkw1162. PubMed PMID: 27903893; PubMed Central PMCID: PMC5389688.

37. Mavin E, Nicholson L, Rafez Ahmed S, Gao F, Dickinson A, Wang XN. Human Regulatory T Cells Mediate Transcriptional Modulation of Dendritic Cell Function. J Immunol. 2017 Jan 1;198(1):138-146. Epub 2016 Nov 28. PubMed PMID: 27895173.

38. Hunt NC, Hallam D, Karimi A, Mellough CB, Chen J, Steel DHW, Lako M. 3D culture of human pluripotent stem cells in RGD-alginate hydrogel improves retinal tissue development. Acta Biomater. 2017 Feb;49:329-343. doi:
10.1016/j.actbio.2016.11.016. Epub 2016 Nov 5. PubMed PMID: 27826002.

39. Werner A, Patti M, Zinad HS, Fearn A, Laude A, Forster I. Molecular determinants of transport function in zebrafish Slc34a Na-phosphate transporters. Am J Physiol Regul Integr Comp Physiol. 2016 Dec 1;311(6):R1213-R1222. doi: 10.1152/ajpregu.00020.2016. Epub 2016 Oct 26. PubMed PMID: 27784684.

40. Eleftheriou CG, Zimmermann JB, Kjeldsen HD, David-Pur M, Hanein Y, Sernagor E. Carbon nanotube electrodes for retinal implants: A study of structural and functional integration over time. Biomaterials. 2017 Jan;112:108-121. doi: 10.1016/j.biomaterials.2016.10.018. Epub 2016 Oct 11. PubMed PMID: 27760395; PubMed Central PMCID: PMC5123641.

41. Oláhová M, Thompson K, Hardy SA, Barbosa IA, Besse A, Anagnostou ME, White K, Davey T, Simpson MA, Champion M, Enns G, Schelley S, Lightowlers RN, Chrzanowska-Lightowlers ZM, McFarland R, Deshpande C, Bonnen PE, Taylor RW. Pathogenic variants in HTRA2 cause an early-onset mitochondrial syndrome associated with 3-methylglutaconic aciduria. J Inherit Metab Dis. 2017 Jan;40(1):121-130. doi: 10.1007/s10545-016-9977-2. Epub 2016 Sep 30. PubMed PMID: 27696117; PubMed Central PMCID: PMC5203855.

42. Lin H, Patel S, Affleck VS, Wilson I, Turnbull DM, Joshi AR, Maxwell R, Stoll EA. Fatty acid oxidation is required for the respiration and proliferation of malignant glioma cells. Neuro Oncol. 2017 Jan;19(1):43-54. doi:
10.1093/neuonc/now128. Epub 2016 Jun 29. PubMed PMID: 27365097; PubMed Central PMCID: PMC5193020.

43. Hill RM, Kuijper S, Lindsey JC, Petrie K, Schwalbe EC, Barker K, Boult JK, Williamson D, Ahmad Z, Hallsworth A, Ryan SL, Poon E, Robinson SP, Ruddle R, Raynaud FI, Howell L, Kwok C, Joshi A, Nicholson SL, Crosier S, Ellison DW, Wharton SB, Robson K, Michalski A, Hargrave D, Jacques TS, Pizer B, Bailey S, Swartling FJ, Weiss WA, Chesler L, Clifford SC. Combined MYC and P53 defects emerge at medulloblastoma relapse and define rapidly progressive, therapeutically targetable disease. Cancer Cell. 2015 Jan 12;27(1):72-84. doi: 10.1016/j.ccell.2014.11.002. Epub 2014 Dec 18. PubMed PMID: 25533335; PubMed Central PMCID: PMC4297293.

44. Margolis BL, Stein JH. The renal circulation. Int Anesthesiol Clin. 1984 Spring;22(1):35-63. Review. PubMed PMID: 6392112.

45. Worwood M. Iron and haemochromatosis. J Inherit Metab Dis. 1983;6 Suppl 1:63-9. PubMed PMID: 6413777.

46. Finnegan RA, Knutson D. Additional examples of a novel photo-decarboxylation process; the preparation of some hindered aryl ketones. Chem Ind. 1965 Oct 30;44:1837-8. PubMed PMID: 5842035.

 

2018

1. Molinari E, Ramsbottom SA, Sammut V, Hughes FEP, Sayer JA. Using zebrafish to study the function of nephronophthisis and related ciliopathy genes. Version 2. F1000Res. 2018 Jul 25 [revised 2018 Jan 1];7:1133. doi: 10.12688/f1000research.15511.2. eCollection 2018. PubMed PMID: 30254740; PubMed Central PMCID: PMC6127739.

2. Hill D, Chen L, Snaar-Jagalska E, Chaudhry B. Embryonic zebrafish xenograft assay of human cancer metastasis. Version 2. F1000Res. 2018 Oct 22 [revised 2018 Jan 1];7:1682. doi: 10.12688/f1000research.16659.2. eCollection 2018. PubMed PMID: 30473782; PubMed Central PMCID: PMC6234738.

3. Cipriani S, Phan V, Médard JJ, Horvath R, Lochmüller H, Chrast R, Roos A, Spendiff S. Neuromuscular Junction Changes in a Mouse Model of Charcot-Marie-Tooth Disease Type 4C. Int J Mol Sci. 2018 Dec 17;19(12). pii:
E4072. doi: 10.3390/ijms19124072. PubMed PMID: 30562927; PubMed Central PMCID: PMC6320960.

4. Carr-Wilkinson J, Prathalingam N, Pal D, Moad M, Lee N, Sundaresh A, Forgham H, James P, Herbert M, Lako M, Tweddle DA. Differentiation of Human Embryonic Stem Cells to Sympathetic Neurons: A Potential Model for Understanding Neuroblastoma Pathogenesis. Stem Cells Int. 2018 Nov 1;2018:4391641. doi: 10.1155/2018/4391641. eCollection 2018. PubMed PMID: 30515222; PubMed Central PMCID: PMC6236576.

5. Cartwright TN, Worrell JC, Marchetti L, Dowling CM, Knox A, Kiely P, Mann J, Mann DA, Wilson CL. HDAC1 interacts with the p50 NF-?B subunit via its nuclear localization sequence to constrain inflammatory gene expression. Biochim Biophys Acta Gene Regul Mech. 2018 Oct;1861(10):962-970. doi: 10.1016/j.bbagrm.2018.09.001. Epub 2018 Sep 10. PubMed PMID: 30496041.

6. Reis M, Mavin E, Nicholson L, Green K, Dickinson AM, Wang XN. Mesenchymal Stromal Cell-Derived Extracellular Vesicles Attenuate Dendritic Cell Maturation and Function. Front Immunol. 2018 Nov 9;9:2538. doi: 10.3389/fimmu.2018.02538. eCollection 2018. PubMed PMID: 30473695; PubMed Central PMCID: PMC6237916.

7. Ramsbottom SA, Molinari E, Srivastava S, Silberman F, Henry C, Alkanderi S, Devlin LA, White K, Steel DH, Saunier S, Miles CG, Sayer JA. Targeted exon skipping of a CEP290 mutation rescues Joubert syndrome phenotypes in vitro and in a murine model. Proc Natl Acad Sci U S A. 2018 Dec 4;115(49):12489-12494. doi: 10.1073/pnas.1809432115. Epub 2018 Nov 16. PubMed PMID: 30446612; PubMed Central PMCID: PMC6298104.

8. Del Molino Del Barrio I, Wilkins GC, Meeson A, Ali S, Kirby JA. Breast Cancer: An Examination of the Potential of ACKR3 to Modify the Response of CXCR4 to CXCL12. Int J Mol Sci. 2018 Nov 14;19(11). pii: E3592. doi: 10.3390/ijms19113592. PubMed PMID: 30441765; PubMed Central PMCID: PMC6274818.

9. Vento-Tormo R, Efremova M, Botting RA, Turco MY, Vento-Tormo M, Meyer KB, Park JE, Stephenson E, Polański K, Goncalves A, Gardner L, Holmqvist S, Henriksson J, Zou A, Sharkey AM, Millar B, Innes B, Wood L, Wilbrey-Clark A, Payne RP, Ivarsson MA, Lisgo S, Filby A, Rowitch DH, Bulmer JN, Wright GJ, Stubbington MJT, Haniffa M, Moffett A, Teichmann SA. Single-cell reconstruction of the early maternal-fetal interface in humans. Nature. 2018 Nov;563(7731):347-353. doi: 10.1038/s41586-018-0698-6. Epub 2018 Nov 14. PubMed PMID: 30429548.

10. Buskin A, Zhu L, Chichagova V, Basu B, Mozaffari-Jovin S, Dolan D, Droop A, Collin J, Bronstein R, Mehrotra S, Farkas M, Hilgen G, White K, Pan KT, Treumann A, Hallam D, Bialas K, Chung G, Mellough C, Ding Y, Krasnogor N, Przyborski S, Zwolinski S, Al-Aama J, Alharthi S, Xu Y, Wheway G, Szymanska K, McKibbin M, Inglehearn CF, Elliott DJ, Lindsay S, Ali RR, Steel DH, Armstrong L, Sernagor E, Urlaub H, Pierce E, Lührmann R, Grellscheid SN, Johnson CA, Lako M. Disrupted alternative splicing for genes implicated in splicing and ciliogenesis causes PRPF31 retinitis pigmentosa. Nat Commun. 2018 Oct 12;9(1):4234. doi: 10.1038/s41467-018-06448-y. PubMed PMID: 30315276; PubMed Central PMCID: PMC6185938.

11. Ishaq A, Dufour D, Cameron K, von Zglinicki T, Saretzki G. Metabolic memory of dietary restriction ameliorates DNA damage and adipocyte size in mouse visceral adipose tissue. Exp Gerontol. 2018 Nov;113:228-236. doi:
10.1016/j.exger.2018.10.008. Epub 2018 Oct 10. PubMed PMID: 30312736.

12. Alkanderi S, Molinari E, Shaheen R, Elmaghloob Y, Stephen LA, Sammut V, Ramsbottom SA, Srivastava S, Cairns G, Edwards N, Rice SJ, Ewida N, Alhashem A, White K, Miles CG, Steel DH, Alkuraya FS, Ismail S, Sayer JA. ARL3 Mutations Cause Joubert Syndrome by Disrupting Ciliary Protein Composition. Am J Hum Genet. 2018 Oct 4;103(4):612-620. doi: 10.1016/j.ajhg.2018.08.015. Epub 2018 Sep 27. PubMed PMID: 30269812; PubMed Central PMCID: PMC6174286.

13. Dodds RM, Davies K, Granic A, Hollingsworth KG, Warren C, Gorman G, Turnbull DM, Sayer AA. Mitochondrial respiratory chain function and content are preserved in the skeletal muscle of active very old men and women. Exp Gerontol. 2018 Nov;113:80-85. doi: 10.1016/j.exger.2018.09.020. Epub 2018 Sep 25. PubMed PMID: 30266472; PubMed Central PMCID: PMC6224654.

14. Ndeh D, Munoz Munoz J, Cartmell A, Bulmer D, Wills C, Henrissat B, Gray J. The human gut microbe Bacteroides thetaiotaomicron encodes the founding member of a novel glycosaminoglycan-degrading polysaccharide lyase family PL29. J Biol Chem. 2018 Nov 16;293(46):17906-17916. doi: 10.1074/jbc.RA118.004510. Epub 2018 Sep 27. PubMed PMID: 30262663; PubMed Central PMCID: PMC6240882.

15. Salam N, Toumpaniari S, Gentile P, Marina Ferreira A, Dalgarno K, Partridge S. Assessment of Migration of Human MSCs through Fibrin Hydrogels as a Tool for Formulation Optimisation. Materials (Basel). 2018 Sep 19;11(9). pii: E1781. doi: 10.3390/ma11091781. PubMed PMID: 30235852; PubMed Central PMCID: PMC6164849.

16. Jeong M, O'Reilly M, Kirkwood NK, Al-Aama J, Lako M, Kros CJ, Armstrong L. Generating inner ear organoids containing putative cochlear hair cells from human pluripotent stem cells. Cell Death Dis. 2018 Sep 11;9(9):922. doi: 10.1038/s41419-018-0967-1. PubMed PMID: 30206231; PubMed Central PMCID: PMC6134051.

17. Hunt NC, Hallam D, Chichagova V, Steel DH, Lako M. The Application of Biomaterials to Tissue Engineering Neural Retina and Retinal Pigment Epithelium. Adv Healthc Mater. 2018 Dec;7(23):e1800226. doi: 10.1002/adhm.201800226. Epub 2018 Sep 2. Review. PubMed PMID: 30175520.

18. Bojic S, Hallam D, Alcada N, Ghareeb A, Queen R, Pervinder S, Buck H, Amitai Lange A, Figueiredo G, Rooney P, Stojkovic M, Shortt A, Figueiredo FC, Lako M. CD200 Expression Marks a Population of Quiescent Limbal Epithelial Stem Cells with Holoclone Forming Ability. Stem Cells. 2018 Nov;36(11):1723-1735. doi: 10.1002/stem.2903. Epub 2018 Oct 1. PubMed PMID: 30157305.

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20. Stathopoulou C, Gangaplara A, Mallett G, Flomerfelt FA, Liniany LP, Knight D, Samsel LA, Berlinguer-Palmini R, Yim JJ, Felizardo TC, Eckhaus MA, Edgington-Mitchell L, Martinez-Fabregas J, Zhu J, Fowler DH, van Kasteren SI,
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21. Riley JS, Quarato G, Cloix C, Lopez J, O'Prey J, Pearson M, Chapman J, Sesaki H, Carlin LM, Passos JF, Wheeler AP, Oberst A, Ryan KM, Tait SW. Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis. EMBO J. 2018 Sep 3;37(17). pii: e99238. doi: 10.15252/embj.201899238. Epub 2018 Jul 26. PubMed PMID: 30049712; PubMed Central PMCID: PMC6120664.

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27. Eley L, Alqahtani AM, MacGrogan D, Richardson RV, Murphy L, Salguero-Jimenez A, Sintes Rodriguez San Pedro M, Tiurma S, McCutcheon L, Gilmore A, de La Pompa JL, Chaudhry B, Henderson DJ. A novel source of arterial valve cells linked to bicuspid aortic valve without raphe in mice. Elife. 2018 Jun 29;7. pii: e34110. doi: 10.7554/eLife.34110. PubMed PMID: 29956664; PubMed Central PMCID: PMC6025960.

28. Wilson R, Ahmmed AA, Poll A, Sakaue M, Laude A, Sieber-Blum M. Human peptidergic nociceptive sensory neurons generated from human epidermal neural crest stem cells (hEPI-NCSC). PLoS One. 2018 Jun 28;13(6):e0199996. doi: 10.1371/journal.pone.0199996. eCollection 2018. PubMed PMID: 29953534; PubMed Central PMCID: PMC6023242.

29. Fearn A, Allison B, Rice SJ, Edwards N, Halbritter J, Bourgeois S, Pastor-Arroyo EM, Hildebrandt F, Tasic V, Wagner CA, Hernando N, Sayer JA, Werner A. Clinical, biochemical, and pathophysiological analysis of SLC34A1 mutations. Physiol Rep. 2018 Jun;6(12):e13715. doi: 10.14814/phy2.13715. PubMed PMID: 29924459; PubMed Central PMCID: PMC6010730.

30. Issop Y, Hathazi D, Khan MM, Rudolf R, Weis J, Spendiff S, Slater CR, Roos A, Lochmüller H. GFPT1 deficiency in muscle leads to myasthenia and myopathy in mice. Hum Mol Genet. 2018 Sep 15;27(18):3218-3232. doi: 10.1093/hmg/ddy225. PubMed PMID: 29905857; PubMed Central PMCID: PMC6121184.

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39. Burns DT, Donkervoort S, Müller JS, Knierim E, Bharucha-Goebel D, Faqeih EA, Bell SK, AlFaifi AY, Monies D, Millan F, Retterer K, Dyack S, MacKay S, Morales-Gonzalez S, Giunta M, Munro B, Hudson G, Scavina M, Baker L, Massini TC, Lek M, Hu Y, Ezzo D, AlKuraya FS, Kang PB, Griffin H, Foley AR, Schuelke M, Horvath R, Bönnemann CG. Variants in EXOSC9 Disrupt the RNA Exosome and Result in Cerebellar Atrophy with Spinal Motor Neuronopathy. Am J Hum Genet. 2018 May 3;102(5):858-873. doi: 10.1016/j.ajhg.2018.03.011. PubMed PMID: 29727687; PubMed Central PMCID: PMC5986733.

40. Tarragó MG, Chini CCS, Kanamori KS, Warner GM, Caride A, de Oliveira GC, Rud M, Samani A, Hein KZ, Huang R, Jurk D, Cho DS, Boslett JJ, Miller JD, Zweier JL, Passos JF, Doles JD, Becherer DJ, Chini EN. A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD(+) Decline. Cell Metab. 2018 May 1;27(5):1081-1095.e10. doi: 10.1016/j.cmet.2018.03.016. PubMed PMID: 29719225; PubMed Central PMCID: PMC5935140.

41. Dean P, Sendra KM, Williams TA, Watson AK, Major P, Nakjang S, Kozhevnikova E, Goldberg AV, Kunji ERS, Hirt RP, Embley TM. Transporter gene acquisition and innovation in the evolution of Microsporidia intracellular parasites. Nat Commun. 2018 Apr 27;9(1):1709. doi: 10.1038/s41467-018-03923-4. PubMed PMID: 29703975; PubMed Central PMCID: PMC5923384.

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43. Boczonadi V, Meyer K, Gonczarowska-Jorge H, Griffin H, Roos A, Bartsakoulia M, Bansagi B, Ricci G, Palinkas F, Zahedi RP, Bruni F, Kaspar B, Lochmüller H, Boycott KM, Müller JS, Horvath R. Mutations in glycyl-tRNA synthetase impair mitochondrial metabolism in neurons. Hum Mol Genet. 2018 Jun 15;27(12):2187-2204. doi: 10.1093/hmg/ddy127. PubMed PMID: 29648643; PubMed Central PMCID: PMC5985729.

44. Gan EH, Robson W, Murphy P, Pickard R, Pearce S, Oldershaw R. Isolation of a multipotent mesenchymal stem cell-like population from human adrenal cortex. Endocr Connect. 2018 May;7(5):617-629. doi: 10.1530/EC-18-0067. Epub 2018 Apr 5. PubMed PMID: 29622661; PubMed Central PMCID: PMC5919938.

45. Richardson GD, Sage A, Bennaceur K, Al Zhrany N, Coelho-Lima J, Dookun E, Draganova L, Saretzki G, Breault DT, Mallat Z, Spyridopoulos I. Telomerase Mediates Lymphocyte Proliferation but Not the Atherosclerosis-Suppressive Potential of Regulatory T-Cells. Arterioscler Thromb Vasc Biol. 2018 Jun;38(6):1283-1296. doi: 10.1161/ATVBAHA.117.309940. Epub 2018 Mar 29. PubMed PMID: 29599138; PubMed Central PMCID: PMC5965929.

46. Yang Y, Denton H, Davies OR, Smith-Jackson K, Kerr H, Herbert AP, Barlow PN, Pickering MC, Marchbank KJ. An Engineered Complement Factor H Construct for Treatment of C3 Glomerulopathy. J Am Soc Nephrol. 2018 Jun;29(6):1649-1661. doi: 10.1681/ASN.2017091006. Epub 2018 Mar 27. PubMed PMID: 29588430; PubMed Central PMCID: PMC6054357.

47. Parrish RR, Grady J, Codadu NK, Trevelyan AJ, Racca C. Simultaneous profiling of activity patterns in multiple neuronal subclasses. J Neurosci Methods. 2018 Jun 1;303:16-29. doi: 10.1016/j.jneumeth.2018.03.012. Epub 2018 Mar 26. PubMed PMID: 29588195.

48. Boczonadi V, King MS, Smith AC, Olahova M, Bansagi B, Roos A, Eyassu F, Borchers C, Ramesh V, Lochmüller H, Polvikoski T, Whittaker RG, Pyle A, Griffin H, Taylor RW, Chinnery PF, Robinson AJ, Kunji ERS, Horvath R. Mitochondrial oxodicarboxylate carrier deficiency is associated with mitochondrial DNA depletion and spinal muscular atrophy-like disease. Genet Med. 2018 Oct;20(10):1224-1235. doi: 10.1038/gim.2017.251. Epub 2018 Mar 8. Erratum in: Genet Med. 2019 Sep;21(9):2163-2164. PubMed PMID: 29517768; PubMed Central PMCID: PMC6004311.

49. McMacken G, Cox D, Roos A, Müller J, Whittaker R, Lochmüller H. The beta-adrenergic agonist salbutamol modulates neuromuscular junction formation in zebrafish models of human myasthenic syndromes. Hum Mol Genet. 2018 May 1;27(9):1556-1564. doi: 10.1093/hmg/ddy062. PubMed PMID: 29462491; PubMed Central PMCID: PMC5905648.

50. O'Connor E, Phan V, Cordts I, Cairns G, Hettwer S, Cox D, Lochmüller H, Roos A. MYO9A deficiency in motor neurons is associated with reduced neuromuscular agrin secretion. Hum Mol Genet. 2018 Apr 15;27(8):1434-1446. doi: 10.1093/hmg/ddy054. PubMed PMID: 29462312; PubMed Central PMCID: PMC5991207.

51. Sarkozy A, Torelli S, Mein R, Henderson M, Phadke R, Feng L, Sewry C, Ala P, Yau M, Bertoli M, Willis T, Hammans S, Manzur A, Sframeli M, Norwood F, Rakowicz W, Radunovic A, Vaidya SS, Parton M, Walker M, Marino S, Offiah C, Farrugia ME, Mamutse G, Marini-Bettolo C, Wraige E, Beeson D, Lochmüller H, Straub V, Bushby K, Barresi R, Muntoni F. Mobility shift of beta-dystroglycan as a marker of GMPPB gene-related muscular dystrophy. J Neurol Neurosurg Psychiatry. 2018 Jul;89(7):762-768. doi: 10.1136/jnnp-2017-316956. Epub 2018 Feb 3. PubMed PMID: 29437916.

52. Russell OM, Fruh I, Rai PK, Marcellin D, Doll T, Reeve A, Germain M, Bastien J, Rygiel KA, Cerino R, Sailer AW, Lako M, Taylor RW, Mueller M, Lightowlers RN, Turnbull DM, Helliwell SB. Preferential amplification of a human mitochondrial DNA deletion in vitro and in vivo. Sci Rep. 2018 Jan 29;8(1):1799. doi: 10.1038/s41598-018-20064-2. PubMed PMID: 29379065; PubMed Central PMCID: PMC5789095.

53. Melguizo-Sanchis D, Xu Y, Taheem D, Yu M, Tilgner K, Barta T, Gassner K, Anyfantis G, Wan T, Elango R, Alharthi S, El-Harouni AA, Przyborski S, Adam S, Saretzki G, Samarasinghe S, Armstrong L, Lako M. iPSC modeling of severe aplastic anemia reveals impaired differentiation and telomere shortening in blood progenitors. Cell Death Dis. 2018 Jan 26;9(2):128. doi: 10.1038/s41419-017-0141-1. PubMed PMID: 29374141; PubMed Central PMCID: PMC5833558.

54. Cao Y, Su B, Chinnaraj S, Jana S, Bowen L, Charlton S, Duan P, Jakubovics NS, Chen J. Nanostructured titanium surfaces exhibit recalcitrance towards Staphylococcus epidermidis biofilm formation. Sci Rep. 2018 Jan 18;8(1):1071. doi: 10.1038/s41598-018-19484-x. PubMed PMID: 29348582; PubMed Central PMCID: PMC5773551.

55. Carroll B, Otten EG, Manni D, Stefanatos R, Menzies FM, Smith GR, Jurk D, Kenneth N, Wilkinson S, Passos JF, Attems J, Veal EA, Teyssou E, Seilhean D, Millecamps S, Eskelinen EL, Bronowska AK, Rubinsztein DC, Sanz A, Korolchuk VI. Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis. Nat Commun. 2018 Jan 17;9(1):256. doi: 10.1038/s41467-017-02746-z. PubMed PMID: 29343728; PubMed Central PMCID: PMC5772351.

56. Kamarudin TA, Bojic S, Collin J, Yu M, Alharthi S, Buck H, Shortt A, Armstrong L, Figueiredo FC, Lako M. Differences in the Activity of Endogenous Bone Morphogenetic Protein Signaling Impact on the Ability of Induced Pluripotent Stem Cells to Differentiate to Corneal Epithelial-Like Cells. Stem Cells. 2018 Mar;36(3):337-348. doi: 10.1002/stem.2750. Epub 2017 Dec 21. PubMed PMID: 29226476; PubMed Central PMCID: PMC5839253.

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2019


1. Müller S, Nicholson L, Al Harbi N, Mancuso E, Jones E, Dickinson A, Wang XN, Dalgarno K. Osteogenic potential of heterogeneous and CD271-enriched mesenchymal stromal cells cultured on apatite-wollastonite 3D scaffolds. BMC Biomed Eng. 2019 Jun 19;1:16. doi: 10.1186/s42490-019-0015-y. PubMed PMID: 32002516; PubMed Central PMCID: PMC6992429.

2. Martens A, Schmid B, Akintola O, Saretzki G. Telomerase Does Not Improve DNA Repair in Mitochondria upon Stress but Increases MnSOD Protein under Serum-Free Conditions. Int J Mol Sci. 2019 Dec 19;21(1). pii: E27. doi:10.3390/ijms21010027. PubMed PMID: 31861522; PubMed Central PMCID: PMC6981674.

3. Erskine D, Reeve AK, Polvikoski T, Schaefer AM, Taylor RW, Lax NZ, El-Agnaf O, Attems J, Gorman GS, Turnbull DM, Ng YS. Lewy body pathology is more prevalent in older individuals with mitochondrial disease than controls. Acta Neuropathol. 2020 Jan;139(1):219-221. doi: 10.1007/s00401-019-02105-w. Epub 2019 Nov 28. PubMed PMID: 31781911; PubMed Central PMCID: PMC6942000.

4. Damala M, Swioklo S, Koduri MA, Mitragotri NS, Basu S, Connon CJ, Singh V. Encapsulation of human limbus-derived stromal/mesenchymal stem cells for biological preservation and transportation in extreme Indian conditions for clinical use. Sci Rep. 2019 Nov 18;9(1):16950. doi: 10.1038/s41598-019-53315-x. PubMed PMID: 31740778; PubMed Central PMCID: PMC6861256.

5. Vucicevic L, Misirkic M, Ciric D, Martinovic T, Jovanovic M, Isakovic A, Markovic I, Saponjic J, Foretz M, Rabanal-Ruiz Y, Korolchuk VI, Trajkovic V. Transcriptional block of AMPK-induced autophagy promotes glutamate excitotoxicity in nutrient-deprived SH-SY5Y neuroblastoma cells. Cell Mol Life Sci. 2019 Nov 12. doi: 10.1007/s00018-019-03356-2. [Epub ahead of print] PubMed PMID: 31720741.

6. Wadkin LE, Orozco-Fuentes S, Neganova I, Bojic S, Laude A, Lako M, Parker NG, Shukurov A. Seeding hESCs to achieve optimal colony clonality. Sci Rep. 2019 Oct  25;9(1):15299. doi: 10.1038/s41598-019-51897-0. PubMed PMID: 31653933; PubMed Central PMCID: PMC6814789.

7. Victorelli S, Lagnado A, Halim J, Moore W, Talbot D, Barrett K, Chapman J, Birch J, Ogrodnik M, Meves A, Pawlikowski JS, Jurk D, Adams PD, van Heemst D, Beekman M, Slagboom PE, Gunn DA, Passos JF. Senescent human melanocytes drive skin ageing via paracrine telomere dysfunction. EMBO J. 2019 Dec 2;38(23):e101982. doi: 10.15252/embj.2019101982. Epub 2019 Oct 21. PubMed PMID: 31633821; PubMed Central PMCID: PMC6885734.

8. Cao Y, Jana S, Bowen L, Tan X, Liu H, Rostami N, Brown J, Jakubovics NS, Chen  J. Hierarchical Rose Petal Surfaces Delay the Early-Stage Bacterial Biofilm Growth. Langmuir. 2019 Nov 12;35(45):14670-14680. doi: 10.1021/acs.langmuir.9b02367. Epub 2019 Nov 4. PubMed PMID: 31630525.

9. Davies HR, Hodgson K, Schwalbe E, Coxhead J, Sinclair N, Zou X, Cockell S, Husain A, Nik-Zainal S, Rajan N. Epigenetic modifiers DNMT3A and BCOR are recurrently mutated in CYLD cutaneous syndrome. Nat Commun. 2019 Oct 17;10(1):4717. doi: 10.1038/s41467-019-12746-w. PubMed PMID: 31624251; PubMed Central PMCID: PMC6797807.

10. Dhayal S, Zummo FP, Anderson MW, Thomas P, Welters HJ, Arden C, Morgan NG. Differential effects of saturated and unsaturated fatty acids on autophagy in pancreatic β-cells. J Mol Endocrinol. 2019 Nov;63(4):285-296. doi: 10.1530/JME-19-0096. PubMed PMID: 31614336.

11. Scalzone A, Ferreira AM, Tonda-Turo C, Ciardelli G, Dalgarno K, Gentile P. The interplay between chondrocyte spheroids and mesenchymal stem cells boosts cartilage regeneration within a 3D natural-based hydrogel. Sci Rep. 2019 Oct 10;9(1):14630. doi: 10.1038/s41598-019-51070-7. PubMed PMID: 31601910; PubMed Central PMCID: PMC6787336.

12. Burman RJ, Selfe JS, Lee JH, van den Berg M, Calin A, Codadu NK, Wright R, Newey SE, Parrish RR, Katz AA, Wilmshurst JM, Akerman CJ, Trevelyan AJ, Raimondo  JV. Excitatory GABAergic signalling is associated with benzodiazepine resistance  in status epilepticus. Brain. 2019 Nov 1;142(11):3482-3501. doi: 10.1093/brain/awz283. PubMed PMID: 31553050; PubMed Central PMCID: PMC6904319.

13. Olthof BMJ, Rees A, Gartside SE. Multiple Nonauditory Cortical Regions Innervate the Auditory Midbrain. J Neurosci. 2019 Nov 6;39(45):8916-8928. doi: 10.1523/JNEUROSCI.1436-19.2019. Epub 2019 Sep 20. PubMed PMID: 31541020; PubMed Central PMCID: PMC6832679.

14. Karlsson JKG, Laude A, Hall MJ, Harriman A. Photo-isomerization of the Cyanine Dye Alexa-Fluor 647 (AF-647) in the Context of dSTORM Super-Resolution Microscopy. Chemistry. 2019 Nov 22;25(65):14983-14998. doi: 10.1002/chem.201904117. Epub 2019 Oct 24. PubMed PMID: 31515919.

15. Cowell IG, Ling EM, Swan RL, Brooks MLW, Austin CA. The Deubiquitinating Enzyme Inhibitor PR-619 is a Potent DNA Topoisomerase II Poison. Mol Pharmacol. 2019 Nov;96(5):562-572. doi: 10.1124/mol.119.117390. Epub 2019 Sep 12. PubMed PMID: 31515282; PubMed Central PMCID: PMC6776009.

16. Ivanova IG, Perkins ND. Hypoxia induces rapid, STAT3 and ROS dependent, mitochondrial translocation of RelA(p65) and IκBα. Biosci Rep. 2019 Sep 16;39(9). pii: BSR20192101. doi: 10.1042/BSR20192101. Print 2019 Sep 30. PubMed PMID: 31484794; PubMed Central PMCID: PMC6746997.

17. Chichagova V, Dorgau B, Felemban M, Georgiou M, Armstrong L, Lako M. Differentiation of Retinal Organoids from Human Pluripotent Stem Cells. Curr Protoc Stem Cell Biol. 2019 Sep;50(1):e95. doi: 10.1002/cpsc.95. PubMed PMID: 31479596.

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21. Atwal M, Swan RL, Rowe C, Lee KC, Lee DC, Armstrong L, Cowell IG, Austin CA.  Intercalating TOP2 Poisons Attenuate Topoisomerase Action at Higher Concentrations. Mol Pharmacol. 2019 Oct;96(4):475-484. doi: 10.1124/mol.119.117259. Epub 2019 Aug 9. PubMed PMID: 31399497; PubMed Central PMCID: PMC6744389.

22. O'Connor E, Cairns G, Spendiff S, Burns D, Hettwer S, Mäder A, Müller J, Horvath R, Slater C, Roos A, Lochmüller H. Modulation of Agrin and RhoA Pathways  Ameliorates Movement Defects and Synapse Morphology in MYO9A-Depleted Zebrafish.  Cells. 2019 Aug 7;8(8). pii: E848. doi: 10.3390/cells8080848. PubMed PMID: 31394789; PubMed Central PMCID: PMC6721702.

23. Molinari E, Ramsbottom SA, Srivastava S, Booth P, Alkanderi S, McLafferty SM, Devlin LA, White K, Gunay-Aygun M, Miles CG, Sayer JA. Targeted exon skipping rescues ciliary protein composition defects in Joubert syndrome patient fibroblasts. Sci Rep. 2019 Jul 25;9(1):10828. doi: 10.1038/s41598-019-47243-z. PubMed PMID: 31346239; PubMed Central PMCID: PMC6658666.

24. Ladak SS, Roebuck E, Powell J, Fisher AJ, Ward C, Ali S. The Role of miR-200b-3p in Modulating TGF-β1-induced Injury in Human Bronchial Epithelial Cells. Transplantation. 2019 Nov;103(11):2275-2286. doi: 10.1097/TP.0000000000002845. PubMed PMID: 31283671.

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33. Gouveia RM, Vajda F, Wibowo JA, Figueiredo F, Connon CJ. YAP, ΔNp63, and β-Catenin Signaling Pathways Are Involved in the Modulation of Corneal Epithelial Stem Cell Phenotype Induced by Substrate Stiffness. Cells. 2019 Apr 12;8(4). pii: E347. doi: 10.3390/cells8040347. PubMed PMID: 31013745; PubMed Central PMCID: PMC6523807.

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35. Gouveia RM, Lepert G, Gupta S, Mohan RR, Paterson C, Connon CJ. Assessment of corneal substrate biomechanics and its effect on epithelial stem cell maintenance and differentiation. Nat Commun. 2019 Apr 3;10(1):1496. doi: 10.1038/s41467-019-09331-6. PubMed PMID: 30944320; PubMed Central PMCID: PMC6447573.

36. Walaszczyk A, Dookun E, Redgrave R, Tual-Chalot S, Victorelli S, Spyridopoulos I, Owens A, Arthur HM, Passos JF, Richardson GD. Pharmacological clearance of senescent cells improves survival and recovery in aged mice following acute myocardial infarction. Aging Cell. 2019 Jun;18(3):e12945. doi: 10.1111/acel.12945. Epub 2019 Mar 28. PubMed PMID: 30920115; PubMed Central PMCID: PMC6516151.

37. Mellough CB, Collin J, Queen R, Hilgen G, Dorgau B, Zerti D, Felemban M, White K, Sernagor E, Lako M. Systematic Comparison of Retinal Organoid Differentiation from Human Pluripotent Stem Cells Reveals Stage Specific, Cell Line, and Methodological Differences. Stem Cells Transl Med. 2019 Jul;8(7):694-706. doi: 10.1002/sctm.18-0267. Epub 2019 Mar 27. PubMed PMID: 30916455; PubMed Central PMCID: PMC6591558.

38. Alzu'bi A, Clowry GJ. Expression of ventral telencephalon transcription factors ASCL1 and DLX2 in the early fetal human cerebral cortex. J Anat. 2019 Sep;235(3):555-568. doi: 10.1111/joa.12971. Epub 2019 Mar 12. PubMed PMID: 30861584; PubMed Central PMCID: PMC6704271.

39. Bailey KE, MacGowan GA, Tual-Chalot S, Phillips L, Mohun TJ, Henderson DJ, Arthur HM, Bamforth SD, Phillips HM. Disruption of embryonic ROCK signaling reproduces the sarcomeric phenotype of hypertrophic cardiomyopathy. JCI Insight.  2019 Mar 5;5. pii: 125172. doi: 10.1172/jci.insight.125172. PubMed PMID: 30835717; PubMed Central PMCID: PMC6538384.

40. Oldershaw R, Owens WA, Sutherland R, Linney M, Liddle R, Magana L, Lash GE, Gill JH, Richardson G, Meeson A. Human Cardiac-Mesenchymal Stem Cell-Like Cells,  a Novel Cell Population with Therapeutic Potential. Stem Cells Dev. 2019 May 1;28(9):593-607. doi: 10.1089/scd.2018.0170. Epub 2019 Apr 3. PubMed PMID: 30803370; PubMed Central PMCID: PMC6486668.

41. Kucheryavenko O, Nelson G, von Zglinicki T, Korolchuk VI, Carroll B. The mTORC1-autophagy pathway is a target for senescent cell elimination. Biogerontology. 2019 Jun;20(3):331-335. doi: 10.1007/s10522-019-09802-9. Epub 2019 Feb 23. PubMed PMID: 30798505; PubMed Central PMCID: PMC6535413.

42. Schönauer R, Petzold F, Lucinescu W, Seidel A, Müller L, Neuber S, Bergmann C, Sayer JA, Werner A, Halbritter J. Evaluating pathogenicity of SLC34A3-Ser192Leu, a frequent European missense variant in disorders of renal phosphate wasting. Urolithiasis. 2019 Dec;47(6):511-519. doi:10.1007/s00240-019-01116-2. Epub 2019 Feb 23. PubMed PMID: 30798342; PubMed
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43. Ferreras L, Moles A, Situmorang GR, El Masri R, Wilson IL, Cooke K, Thompson E, Kusche-Gullberg M, Vivès RR, Sheerin NS, Ali S. Heparan sulfate in chronic kidney diseases: Exploring the role of 3-O-sulfation. Biochim Biophys Acta GenSubj. 2019 May;1863(5):839-848. doi: 10.1016/j.bbagen.2019.02.009. Epub 2019 Feb 19. PubMed PMID: 30794825.

44. Ahmed SS, Whritenour J, Ahmed MM, Bibby L, Darby L, Wang XN, Watson J, Dickinson AM. Evaluation of a human in vitro skin test for predicting drug hypersensitivity reactions. Toxicol Appl Pharmacol. 2019 Apr 15;369:39-48. doi:10.1016/j.taap.2019.02.005. Epub 2019 Feb 12. PubMed PMID: 30768973.

45. Seibert M, Krüger M, Watson NA, Sen O, Daum JR, Slotman JA, Braun T, Houtsmuller AB, Gorbsky GJ, Jacob R, Kracht M, Higgins JMG, Schmitz ML. CDK1-mediated phosphorylation at H2B serine 6 is required for mitotic chromosome segregation. J Cell Biol. 2019 Apr 1;218(4):1164-1181. doi:10.1083/jcb.201806057. Epub 2019 Feb 14. PubMed PMID: 30765437; PubMed Central PMCID: PMC6446833.

46. Levasseur MD, Thomas C, Davies OR, Higgins JMG, Madgwick S. Aneuploidy in Oocytes Is Prevented by Sustained CDK1 Activity through Degron Masking in Cyclin B1. Dev Cell. 2019 Mar 11;48(5):672-684.e5. doi: 10.1016/j.devcel.2019.01.008. Epub 2019 Feb 7. PubMed PMID: 30745144; PubMed Central PMCID: PMC6416240.

47. Hepburn AC, Steele RE, Veeratterapillay R, Wilson L, Kounatidou EE, Barnard A, Berry P, Cassidy JR, Moad M, El-Sherif A, Gaughan L, Mills IG, Robson CN, Heer R. The induction of core pluripotency master regulators in cancers defines poor clinical outcomes and treatment resistance. Oncogene. 2019 May;38(22):4412-4424. doi: 10.1038/s41388-019-0712-y. Epub 2019 Feb 11. Erratum in: Oncogene. 2019 May 8. PubMed PMID: 30742096; PubMed Central PMCID: PMC6546609.

48. Roger M, Fullard N, Costello L, Bradbury S, Markiewicz E, O'Reilly S, Darling N, Ritchie P, Määttä A, Karakesisoglou I, Nelson G, von Zglinicki T, Dicolandrea  T, Isfort R, Bascom C, Przyborski S. Bioengineering the microanatomy of human skin. J Anat. 2019 Apr;234(4):438-455. doi: 10.1111/joa.12942. Epub 2019 Feb 10.  PubMed PMID: 30740672; PubMed Central PMCID: PMC6422806.

49. Dorgau B, Felemban M, Hilgen G, Kiening M, Zerti D, Hunt NC, Doherty M, Whitfield P, Hallam D, White K, Ding Y, Krasnogor N, Al-Aama J, Asfour HZ, Sernagor E, Lako M. Decellularised extracellular matrix-derived peptides from neural retina and retinal pigment epithelium enhance the expression of synaptic markers and light responsiveness of human pluripotent stem cell derived retinal organoids. Biomaterials. 2019 Apr;199:63-75. doi:10.1016/j.biomaterials.2019.01.028. Epub 2019 Jan 22. PubMed PMID: 30738336.

50. Anderson R, Lagnado A, Maggiorani D, Walaszczyk A, Dookun E, Chapman J, Birch J, Salmonowicz H, Ogrodnik M, Jurk D, Proctor C, Correia-Melo C, Victorelli S, Fielder E, Berlinguer-Palmini R, Owens A, Greaves LC, Kolsky KL, Parini A, Douin-Echinard V, LeBrasseur NK, Arthur HM, Tual-Chalot S, Schafer MJ, Roos CM, Miller JD, Robertson N, Mann J, Adams PD, Tchkonia T, Kirkland JL, Mialet-Perez J, Richardson GD, Passos JF. Length-independent telomere damage drives post-mitotic cardiomyocyte senescence. EMBO J. 2019 Mar 1;38(5). pii: e100492. doi: 10.15252/embj.2018100492. Epub 2019 Feb 8. PubMed PMID: 30737259; PubMed Central PMCID: PMC6396144.

51. Hase Y, Ding R, Harrison G, Hawthorne E, King A, Gettings S, Platten C, Stevenson W, Craggs LJL, Kalaria RN. White matter capillaries in vascular and neurodegenerative dementias. Acta Neuropathol Commun. 2019 Feb 7;7(1):16. doi: 10.1186/s40478-019-0666-x. PubMed PMID: 30732655; PubMed Central PMCID: PMC6366070.

52. Anzilotti C, Swan DJ, Boisson B, Deobagkar-Lele M, Oliveira C, Chabosseau P,  Engelhardt KR, Xu X, Chen R, Alvarez L, Berlinguer-Palmini R, Bull KR, Cawthorne  E, Cribbs AP, Crockford TL, Dang TS, Fearn A, Fenech EJ, de Jong SJ, Lagerholm BC, Ma CS, Sims D, van den Berg B, Xu Y, Cant AJ, Kleiner G, Leahy TR, de la Morena MT, Puck JM, Shapiro RS, van der Burg M, Chapman JR, Christianson JC, Davies B, McGrath JA, Przyborski S, Santibanez Koref M, Tangye SG, Werner A, Rutter GA, Padilla-Parra S, Casanova JL, Cornall RJ, Conley ME, Hambleton S. An,essential role for the Zn(2+) transporter ZIP7 in B cell development. Nat mmunol. 2019 Mar;20(3):350-361. doi: 10.1038/s41590-018-0295-8. Epub 2019 Feb 4. PubMed PMID: 30718914; PubMed Central PMCID: PMC6561116.

53. Smith-Jackson K, Yang Y, Denton H, Pappworth IY, Cooke K, Barlow PN, Atkinson JP, Liszewski MK, Pickering MC, Kavanagh D, Cook HT, Marchbank KJ. Hyperfunctional complement C3 promotes C5-dependent atypical hemolytic uremic syndrome in mice. J Clin Invest. 2019 Mar 1;129(3):1061-1075. doi: 10.1172/JCI99296. Epub 2019 Feb 4. PubMed PMID: 30714990; PubMed Central PMCID:PMC6391106.

54. Mellough CB, Bauer R, Collin J, Dorgau B, Zerti D, Dolan DWP, Jones CM, Izuogu OG, Yu M, Hallam D, Steyn JS, White K, Steel DH, Santibanez-Koref M, Elliott DJ, Jackson MS, Lindsay S, Grellscheid S, Lako M. An integrated transcriptional analysis of the developing human retina. Development. 2019 Jan 29;146(2). pii: dev169474. doi: 10.1242/dev.169474. PubMed PMID: 30696714; PubMed Central PMCID: PMC6361134.

55. Chan F, Lax NZ, Voss CM, Aldana BI, Whyte S, Jenkins A, Nicholson C, Nichols  S, Tilley E, Powell Z, Waagepetersen HS, Davies CH, Turnbull DM, Cunningham MO. The role of astrocytes in seizure generation: insights from a novel in vitro seizure model based on mitochondrial dysfunction. Brain. 2019 Feb 1;142(2):391-411. doi: 10.1093/brain/awy320. PubMed PMID: 30689758; PubMed Central PMCID: PMC6519661.

56. Collin J, Zerti D, Queen R, Santos-Ferreira T, Bauer R, Coxhead J, Hussain R, Steel D, Mellough C, Ader M, Sernagor E, Armstrong L, Lako M. CRX Expression in Pluripotent Stem Cell-Derived Photoreceptors Marks a Transplantable Subpopulation of Early Cones. Stem Cells. 2019 May;37(5):609-622. doi: 10.1002/stem.2974. Epub  2019 Jan 30. PubMed PMID: 30681766; PubMed Central PMCID: PMC6519156.

57. Wood MJ, Leckenby A, Reynolds G, Spiering R, Pratt AG, Rankin KS, Isaacs JD, Haniffa MA, Milling S, Hilkens CM. Macrophage proliferation distinguishes 2 subgroups of knee osteoarthritis patients. JCI Insight. 2019 Jan 24;4(2). pii: 125325. doi: 10.1172/jci.insight.125325. [Epub ahead of print] PubMed PMID: 30674730; PubMed Central PMCID: PMC6413777.

58. Ehrmann I, Crichton JH, Gazzara MR, James K, Liu Y, Grellscheid SN, Curk T, de Rooij D, Steyn JS, Cockell S, Adams IR, Barash Y, Elliott DJ. An ancient germ  cell-specific RNA-binding protein protects the germline from cryptic splice site poisoning. Elife. 2019 Jan 24;8. pii: e39304. doi: 10.7554/eLife.39304. PubMed PMID: 30674417; PubMed Central PMCID: PMC6345566.

59. Alzu'bi A, Homman-Ludiye J, Bourne JA, Clowry GJ. Thalamocortical Afferents Innervate the Cortical Subplate much Earlier in Development in Primate than in Rodent. Cereb Cortex. 2019 Apr 1;29(4):1706-1718. doi: 10.1093/cercor/bhy327. Erratum in: Cereb Cortex. 2019 Dec 17;29(12):5316. PubMed PMID: 30668846; PubMed  Central PMCID: PMC6418397.

60. Ogrodnik M, Zhu Y, Langhi LGP, Tchkonia T, Krüger P, Fielder E, Victorelli S, Ruswhandi RA, Giorgadze N, Pirtskhalava T, Podgorni O, Enikolopov G, Johnson KO,  Xu M, Inman C, Palmer AK, Schafer M, Weigl M, Ikeno Y, Burns TC, Passos JF, von Zglinicki T, Kirkland JL, Jurk D. Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis. Cell Metab. 2019 May 7;29(5):1061-1077.e8. doi: 10.1016/j.cmet.2018.12.008. Epub 2019 Jan 3. Erratum in: Cell Metab. 2019 May 7;29(5):1233. PubMed PMID: 30612898; PubMed Central PMCID: PMC6509403.

61. Kolli S, Bojic S, Ghareeb AE, Kurzawa-Akanbi M, Figueiredo FC, Lako M. The Role of Nerve Growth Factor in Maintaining Proliferative Capacity, Colony-Forming Efficiency, and the Limbal Stem Cell Phenotype. Stem Cells. 2019 Jan;37(1):139-149. doi: 10.1002/stem.2921. PubMed PMID: 30599086; PubMed Central  PMCID: PMC6334532.

62. Collin J, Queen R, Zerti D, Dorgau B, Hussain R, Coxhead J, Cockell S, Lako M. Deconstructing Retinal Organoids: Single Cell RNA-Seq Reveals the Cellular Components of Human Pluripotent Stem Cell-Derived Retina. Stem Cells. 2019 May;37(5):593-598. doi: 10.1002/stem.2963. Epub 2019 Jan 12. PubMed PMID: 30548510; PubMed Central PMCID: PMC6519347.

63. Olthof BMJ, Gartside SE, Rees A. Puncta of Neuronal Nitric Oxide Synthase (nNOS) Mediate NMDA Receptor Signaling in the Auditory Midbrain. J Neurosci. 2019 Jan 30;39(5):876-887. doi: 10.1523/JNEUROSCI.1918-18.2018. Epub 2018 Dec 7. PubMed PMID: 30530507; PubMed Central PMCID: PMC6382984.

64. Neganova I, Cotts L, Banks P, Gassner K, Shukurov A, Armstrong L, Ladds G, Lako M. Endothelial Differentiation G Protein-Coupled Receptor 5 Plays an Important Role in Induction and Maintenance of Pluripotency. Stem Cells. 2019 Mar;37(3):318-331. doi: 10.1002/stem.2954. Epub 2019 Feb 7. PubMed PMID: 30512203; PubMed Central PMCID: PMC6446721.

65. Phan V, Cox D, Cipriani S, Spendiff S, Buchkremer S, O'Connor E, Horvath R, Goebel HH, Hathazi D, Lochmüller H, Straka T, Rudolf R, Weis J, Roos A. SIL1 deficiency causes degenerative changes of peripheral nerves and neuromuscular junctions in fish, mice and human. Neurobiol Dis. 2019 Apr;124:218-229. doi: 10.1016/j.nbd.2018.11.019. Epub 2018 Nov 20. PubMed PMID: 30468864.

66. Correia-Melo C, Birch J, Fielder E, Rahmatika D, Taylor J, Chapman J, Lagnado A, Carroll BM, Miwa S, Richardson G, Jurk D, Oakley F, Mann J, Mann DA, Korolchuk VI, Passos JF. Rapamycin improves healthspan but not inflammaging in nfκb1(-/-) mice. Aging Cell. 2019 Feb;18(1):e12882. doi: 10.1111/acel.12882. Epub 2018 Nov 23. PubMed PMID: 30468013; PubMed Central PMCID: PMC6351839.

67. da Silva PFL, Ogrodnik M, Kucheryavenko O, Glibert J, Miwa S, Cameron K, Ishaq A, Saretzki G, Nagaraja-Grellscheid S, Nelson G, von Zglinicki T. The bystander effect contributes to the accumulation of senescent cells in vivo. Aging Cell. 2019 Feb;18(1):e12848. doi: 10.1111/acel.12848. Epub 2018 Nov 21. PubMed PMID: 30462359; PubMed Central PMCID: PMC6351849.

68. Paganini C, Monti L, Costantini R, Besio R, Lecci S, Biggiogera M, Tian K, Schwartz JM, Huber C, Cormier-Daire V, Gibson BG, Pirog KA, Forlino A, Rossi A. Calcium activated nucleotidase 1 (CANT1) is critical for glycosaminoglycan biosynthesis in cartilage and endochondral ossification. Matrix Biol. 2019 Aug;81:70-90. doi: 10.1016/j.matbio.2018.11.002. Epub 2018 Nov 12. PubMed PMID: 30439444; PubMed Central PMCID: PMC6598859.

69. Verykiou S, Alexander M, Edwards N, Plummer R, Chaudhry B, Lovat PE, Hill DS. Harnessing autophagy to overcome mitogen-activated protein kinase kinase inhibitor-induced resistance in metastatic melanoma. Br J Dermatol. 2019 Feb;180(2):346-356. doi: 10.1111/bjd.17333. Epub 2018 Nov 25. PubMed PMID: 30339727.

70. Hayhurst H, Anagnostou ME, Bogle HJ, Grady JP, Taylor RW, Bindoff LA, McFarland R, Turnbull DM, Lax NZ. Dissecting the neuronal vulnerability underpinning Alpers' syndrome: a clinical and neuropathological study. Brain Pathol. 2019 Jan;29(1):97-113. doi: 10.1111/bpa.12640. Epub 2018 Oct 9. PubMed PMID: 30021052.

 

2020

  1.  E Singh, H M Phillips, H M Arthur. Dynamic changes in endoglin expression in the developing mouse heart. Gene Expr Patterns. 2020 Dec 26;39:119165. doi: 10.1016/j.gep.2020.119165. Online ahead of print.

  2. David Hill, Ioana Cosgarea, Nick Reynolds, Penny Lovat, Jane Armstrong. Research Techniques Made Simple: Analysis of Autophagy in the Skin. J Invest Dermatol. 2021 Jan;141(1):5-9.e1. doi: 10.1016/j.jid.2020.10.004.

  3. Clare Tweedy, Nathan Kindred, Joshua Curry, Christopher Williams, John-Paul Taylor, Peter Atkinson, Fiona Randall, Daniel Erskine, Christopheer M Morris, Amy K Reeve, Gavin J Clowry, Fiona E N LeBeau. Hippocampal network hyperexcitability in young transgenic mice expressing human mutant alpha-synuclein. Neurobiol Dis. 2020 Dec 30;149:105226. doi: 10.1016/j.nbd.2020.105226.

  4. Jack Leslie, Marina García Macia, Saimir Luli, Julie C Worrell, William J Reilly, Hannah L Paish, Amber Knox, Ben S Barksby, Lucy M Gee, Marco Y W Zaki, Amy L Collins, Rachel A Burgoyne, Rainie Cameron, Charlotte Bragg, Xin Xu, Git W Chung, Colin D A Brown, Andrew D Blanchard, Carmel B Nanthakumar, Morten Karsdal, Stuart M Robinson, Derek M Manas, Gourab Sen, Jeremy French, Steven A White, Sandra Murphy, Matthias Trost, Johannes L Zakrzewski, Ulf Klein, Robert F Schwabe, Ingmar Mederacke, Colin Nixon, Tom Bird, Laure-Anne Teuwen, Luc Schoonjans, Peter Carmeliet, Jelena Mann, Andrew J Fisher, Neil S Sheerin, Lee A Borthwick, Derek A Mann, Fiona Oakley. c-Rel orchestrates energy-dependent epithelial and macrophage reprogramming in fibrosis. Nat Metab. 2020 Nov;2(11):1350-1367. doi: 10.1038/s42255-020-00306-2. Epub 2020 Nov 9.

  5. Lei Zhang, Anna Evans, Chris von Ruhland, Mohd Shazli Draman, Sarah Edkins, Amy E Vincent, Rolando Berlinguer-Palmini, D Aled Rees, Anjana S Haridas, Dan Morris, Andrew R Tee, Marian Ludgate, Doug M Turnbull, Fredrik Karpe, Colin M Dayan.Distinctive Features of Orbital Adipose Tissue (OAT) in Graves' Orbitopathy. Int J Mol Sci. 2020 Nov 30;21(23):9145. doi: 10.3390/ijms21239145.

  6. Irene Carmagnola, Valeria Chiono, Gerardina Ruocco, Annachiara Scalzone, Piergiorgio Gentile, Paola Taddei, Gianluca Ciardelli. PLGA Membranes Functionalized with Gelatin through Biomimetic Mussel-Inspired Strategy. Nanomaterials (Basel). 2020 Nov 2;10(11):2184. doi: 10.3390/nano10112184.

  7. Matthew Zorkau, Yasmin Proctor-Kent, Rolando Berlinguer-Palmini, Andrew Hamilton, Zofia M Chrzanowska-Lightowlers, Robert N Lightowlers. Visualizing Mitochondrial Ribosomal RNA and Mitochondrial Protein Synthesis in Human Cell Lines. Methods Mol Biol. 2021; 2192:159-181. doi: 10.1007/978-1-0716-0834-0_13.

  8. Prendergast L, McClurg UL, Hristova R, Berlinguer-Palmini R, Greener S, Veitch K, Hernandez I, Pasero P, Rico D, Higgins JMG, Gospodinov A, Papamichos-Chronakis M. Resolution of R-loops by INO80 promotes DNA replication and maintains cancer cell proliferation and viability. Nat Commun. 2020 Sep 10;11(1):4534. doi: 10.1038/s41467-020-18306-x.PMID: 32913330

  9. Saint-Criq V, Delpiano L, Casement J, Onuora JC, Lin J, Gray MA.Choice of Differentiation Media Significantly Impacts Cell Lineage and Response to CFTR Modulators in Fully Differentiated Primary Cultures of Cystic Fibrosis Human Airway Epithelial Cells. Cells. 2020 Sep 21;9(9):E2137. doi: 10.3390/cells9092137.PMID: 32967385

  10. Fielder E, Tweedy C, Wilson C, Oakley F, LeBeau FEN, Passos JF, Mann DA, von Zglinicki T, Jurk D.Anti-inflammatory treatment rescues memory deficits during aging in nfkb1(-/-) mice. Aging Cell. 2020 Sep 11:e13188. doi: 10.1111/acel.13188. Online ahead of print.PMID: 32915495

  11. Dookun E, Walaszczyk A, Redgrave R, Palmowski P, Tual-Chalot S, Suwana A, Chapman J, Jirkovsky E, Donastorg Sosa L, Gill E, Yausep OE, Santin Y, Mialet-Perez J, Andrew Owens W, Grieve D, Spyridopoulos I, Taggart M, Arthur HM, Passos JF, Richardson GD. Clearance of senescent cells during cardiac ischemia-reperfusion injury improves recovery. Aging Cell. 2020 Sep 29:e13249. doi: 10.1111/acel.13249. Online ahead of print.PMID: 32996233

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  13. Cerniauskas E, Kurzawa-Akanbi M, Xie L, Hallam D, Moya-Molina M, White K, Steel D, Doherty M, Whitfield P, Al-Aama J, Armstrong L, Kavanagh D, Lambris JD, Korolchuk VI, Harris C, Lako M. Complement modulation reverses pathology in Y402H-retinal pigment epithelium cell model of age-related macular degeneration by restoring lysosomal function. Stem Cells Transl Med. 2020 Aug 20. doi: 10.1002/sctm.20-0211. Online ahead of print.PMID: 32815311

  14. Singh E, Redgrave RE, Phillips HM, Arthur HM. Arterial endoglin does not protect against arteriovenous malformations.Angiogenesis. 2020 Nov;23(4):559-566. doi: 10.1007/s10456-020-09731-z. Epub 2020 Jun 6.PMID: 32506200

  15. Hatton C, Reeve A, Lax NZ, Blain A, Ng YS, El-Agnaf O, Attems J, Taylor JP, Turnbull D, Erskine D. Complex I reductions in the nucleus basalis of Meynert in Lewy body dementia: the role of Lewy bodies. Acta Neuropathol Commun. 2020 Jul 9;8(1):103. doi: 10.1186/s40478-020-00985-8.PMID: 32646480

  16. Dobson PF, Dennis EP, Hipps D, Reeve A, Laude A, Bradshaw C, Stamp C, Smith A, Deehan DJ, Turnbull DM, Greaves LC. Mitochondrial dysfunction impairs osteogenesis, increases osteoclast activity, and accelerates age related bone loss. Sci Rep. 2020 Jul 15;10(1):11643. doi: 10.1038/s41598-020-68566-2.PMID: 32669663

  17. K Mistry, B van der Steen, T Clifford, F van Holthoon, A Kleinnijenhuis, J Prawitt, M Labus, B Vanhoecke, P E Lovat, A McConnell. Potentiating cutaneous wound healing in young and aged skin with nutraceutical collagen peptides. Clin Exp Dermatol. 2021 Jan;46(1):109-117. doi: 10.1111/ced.14392. Epub 2020 Sep 14.

  18. Thompson ER, Bates L, Ibrahim IK, Sewpaul A, Stenberg B, McNeill A, Figueiredo R, Girdlestone T, Wilkins GC, Wang L, Tingle SJ, Scott WE 3rd, de Paula Lemos H, Mellor AL, Roobrouck VD, Ting AE, Hosgood SA, Nicholson ML, Fisher AJ, Ali S, Sheerin NS, Wilson CH. Novel delivery of cellular therapy to reduce ischemia reperfusion injury in kidney transplantation. Am J Transplant. 2020 Jun 7. doi: 10.1111/ajt.16100. Online ahead of print.PMID: 32506663

  19. Gardner AI, Haq IJ, Simpson AJ, Becker KA, Gallagher J, Saint-Criq V, Verdon B, Mavin E, Trigg A, Gray MA, Koulman A, McDonnell MJ, Fisher AJ, Kramer EL, Clancy JP, Ward C, Schuchman EH, Gulbins E, Brodlie M. Recombinant Acid Ceramidase Reduces Inflammation and Infection in Cystic Fibrosis. Am J Respir Crit Care Med. 2020 Jun 22. doi: 10.1164/rccm.202001-0180OC. Online ahead of print.PMID: 32569477

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  25. Watson NA, Cartwright TN, Lawless C, Cámara-Donoso M, Sen O, Sako K, Hirota T, Kimura H, Higgins JMG. Kinase inhibition profiles as a tool to identify kinases for specific phosphorylation sites. Nat Commun. 2020 Apr 3;11(1):1684. doi: 10.1038/s41467-020-15428-0.

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  27. Sarah E Gartside, Abdurrahman Ercan Yurttaser, Amy L Burns, Nebojša Jovanović, Katie J Smith, Nana Shika Amegashiti, Bas M J Olthof. A role for nitric oxide in serotonin neurons of the midbrain raphe nuclei. Eur J Neurosci. 2020 May;51(9):1881-1899. doi: 10.1111/ejn.14713. Epub 2020 Mar 13.

  28. Anastasia C Hepburn, Emma L Curry, Mohammad Moad, Rebecca E Steele, Omar E Franco, Laura Wilson, Parmveer Singh, Adriana Buskin, Susan E Crawford, Luke Gaughan, Ian G Mills, Simon W Hayward, Craig N Robson, Rakesh Heer. Propagation of human prostate tissue from induced pluripotent stem cells. Stem Cells Transl Med. 2020 Jul;9(7):734-745. doi: 10.1002/sctm.19-0286. Epub 2020 Mar 14.

  29. Ronny Rosner, Ghaith Tarawneh, Veronika Lukyanova, Jenny C A Read. Binocular responsiveness of projection neurons of the praying mantis optic lobe in the frontal visual field. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2020 Mar;206(2):165-181. doi: 10.1007/s00359-020-01405-x. Epub 2020 Feb 22.

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  32. Daniele Pierantozzi, Annachiara Scalzone, Swati Jindal, Liga Stipniece, Kristine Salma-Ancane, Kenny Dalgarno, Piergiorgio Gentile, Elena Mancuso. 3D printed Sr-containing composite scaffolds: Effect of structural design and material formulation towards new strategies for bone tissue engineering. Composites Science and Technology, doi.org/10.1016/j.compscitech.2020.108069. Volume 191, 3 May 2020, 108069.

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2021

1. Darin Zerti, Marina Moya Molina, Birthe Dorgau, Sarah Mearns, Roman Bauer, Jumana Al-Aama, Majlinda Lako. IGFBPs mediate IGF-1's functions in retinal lamination and photoreceptor development during pluripotent stem cell differentiation to retinal organoids. Stem Cells. 021 Apr;39(4):458-466. doi: 10.1002/stem.3331. Epub 2021 Jan 14.

2. Gary Reynolds, Peter Vegh, James Fletcher, Elizabeth F M Poyner, Emily Stephenson, Issac Goh, Rachel A Botting, Ni Huang, Bayanne Olabi, Anna Dubois, David Dixon, Kile Green, Daniel Maunder, Justin Engelbert, Mirjana Efremova, Krzysztof Polański, Laura Jardine, Claire Jones, Thomas Ness, Dave Horsfall, Jim McGrath, Christopher Carey, Dorin-Mirel Popescu, Simone Webb, Xiao-Nong Wang, Ben Sayer, Jong-Eun Park, Victor A Negri, Daria Belokhvostova, Magnus D Lynch, David McDonald, Andrew Filby, Tzachi Hagai, Kerstin B Meyer, Akhtar Husain, Jonathan Coxhead, Roser Vento-Tormo, Sam Behjati, Steven Lisgo, Alexandra-Chloé Villani, Jaume Bacardit, Philip H Jones, Edel A O'Toole, Graham S Ogg, Neil Rajan, Nick J Reynolds, Sarah A Teichmann, Fiona M Watt, Muzlifah Haniffa. Developmental cell programs are co-opted in inflammatory skin disease. Science. 2021 Jan 22;371(6527):eaba6500. doi: 10.1126/science.aba6500

3. Gema Dura, Maria Crespo-Cuadrado, Helen Waller, Daniel T Peters, Ana Marina Ferreira, Jeremy H Lakey, David A Fulton. Hydrogels of engineered bacterial fimbriae can finely tune 2D human cell culture. Biomater Sci. 2021 Apr 7;9(7):2542-2552. doi: 10.1039/d0bm01966f. Epub 2021 Feb 11.

4. Rabanal-Ruiz Y, Byron A, Wirth A, Madsen R, Sedlackova L, Hewitt G, Nelson G, Stingele J, Wills JC, Zhang T, Zeug A, Fässler R, Vanhaesebroeck B, Maddocks ODK, Ponimaskin E, Carroll B, Korolchuk VI. mTORC1 activity is supported by spatial association with focal adhesions. J Cell Biol. 2021 May 3;220(5):e202004010. doi: 10.1083/jcb.202004010.

5. Craig Stamp, Julia C Whitehall, Anna L M Smith, David Houghton, Carla Bradshaw, Elizabeth A Stoll, Alasdair P Blain, Doug M Turnbull, Laura C Greaves. Age-associated mitochondrial complex I deficiency is linked to increased stem cell proliferation rates in the mouse colon. Aging Cell. 2021 Mar;20(3):e13321. doi: 10.1111/acel.13321. Epub 2021 Feb 24.

6. Matthew Zorkau, Christin A Albus, Rolando Berlinguer-Palmini, Zofia M A Chrzanowska-Lightowlers, Robert N Lightowlers. High-resolution imaging reveals compartmentalization of mitochondrial protein synthesis in cultured human cells. Proc Natl Acad Sci U S A 2021 Feb 9;118(6):e2008778118. doi: 10.1073/pnas.2008778118.

7. Rachel Addison, Sophie C Weatherhead, Anandika Pawitri, Graham R Smith, Ashley Rider, Henry J Grantham, Simon J Cockell, Nick J Reynolds. Therapeutic wavelengths of ultraviolet B radiation activate apoptotic, circadian rhythm, redox signalling and key canonical pathways in psoriatic epidermis. Redox Biol.  2021 May;41:101924. doi: 10.1016/j.redox.2021.101924. Epub 2021 Mar 10.

8. Valentina Mengoli, Katarzyna Jonak, Oleksii Lyzak, Mahdi Lamb, Lisa M Lister, Chris Lodge, Julie Rojas, Ievgeniia Zagoriy, Mary Herbert, Wolfgang Zachariae. Deprotection of centromeric cohesin at meiosis II requires APC/C activity but not kinetochore tension. EMBO J. 2021 Apr 1;40(7):e106812. doi: 10.15252/embj.2020106812. Epub 2021 Mar 1.

9. Anthony Lagnado, Jack Leslie, Marie-Helene Ruchaud-Sparagano, Stella Victorelli, Petra Hirsova, Mikolaj Ogrodnik, Amy L Collins, Maria Grazia Vizioli, Leena Habiballa, Gabriele Saretzki, Shane A Evans, Hanna Salmonowicz, Adam Hruby, Daniel Geh, Kevin D Pavelko, David Dolan, Helen L Reeves, Sushma Grellscheid, Colin H Wilson, Sanjay Pandanaboyana, Madison Doolittle, Thomas von Zglinicki, Fiona Oakley, Suchira Gallage, Caroline L Wilson, Jodie Birch, Bernadette Carroll, James Chapman, Mathias Heikenwalder, Nicola Neretti, Sundeep Khosla, Claudio Akio Masuda, Tamar Tchkonia, James L Kirkland, Diana Jurk, Derek A Mann, João F Passos. Neutrophils induce paracrine telomere dysfunction and senescence in ROS-dependent manner. EMBO J 2021 May 3;40(9):e106048. doi: 10.15252/embj.2020106048. Epub 2021 Mar 25.

10. Darin Zerti, Gerrit Hilgen, Birthe Dorgau, Joseph Collin, Marius Ader, Lyle Armstrong, Evelyne Sernagor, Majlinda Lako. Transplanted pluripotent stem cell-derived photoreceptor precursors elicit conventional and unusual light responses in mice with advanced retinal degeneration. Stem Cells. 2021 Jul;39(7):882-896. doi: 10.1002/stem.3365. Epub 2021 Mar 6.

11. Joseph Collin, Rachel Queen, Darin Zerti, Sanja Bojic, Birthe Dorgau, Nicky Moyse, Marina Moya Molina, Chunbo Yang, Sunanda Dey, Gary Reynolds, Rafiqul Hussain, Jonathan M Coxhead, Steven Lisgo, Deborah Henderson, Agatha Joseph, Paul Rooney, Saurabh Ghosh, Lucy Clarke, Che Connon, Muzlifah Haniffa, Francisco Figueiredo, Lyle Armstrong, Majlinda Lako. A single cell atlas of human cornea that defines its development, limbal progenitor cells and their interactions with the immune cells. Ocul Surf. 2021 Apr 16;S1542-0124(21)00021-5. doi: 10.1016/j.jtos.2021.03.010. Online ahead of print.

12. Dan J Hayman, Tamara Modebadze, Sarah Charlton, Kat Cheung, Jamie Soul, Hua Lin, Yao Hao, Colin G Miles, Dimitra Tsompani, Robert M Jackson, Michael D Briggs, Katarzyna A Piróg, Ian M Clark, Matt J Barter, Gavin J Clowry, Fiona E N LeBeau, David A Young. Increased hippocampal excitability in miR-324-null mice. Sci Rep. 2021 May 17;11(1):10452. doi: 10.1038/s41598-021-89874-1.

13. Ulrike Boehm, Glyn Nelson, Claire M Brown, Steve Bagley, Peter Bajcsy, Johanna Bischof, Aurelien Dauphin, Ian M Dobbie, John E Eriksson, Orestis Faklaris, Julia Fernandez-Rodriguez, Alexia Ferrand, Laurent Gelman, Ali Gheisari, Hella Hartmann, Christian Kukat, Alex Laude, Miso Mitkovski, Sebastian Munck, Alison J North, Tobias M Rasse, Ute Resch-Genger, Lucas C Schuetz, Arne Seitz, Caterina Strambio-De-Castillia, Jason R Swedlow, Roland Nitschke. QUAREP-LiMi: a community endeavor to advance quality assessment and reproducibility in light microscopy. Nat Methods. 2021 May 21. doi: 10.1038/s41592-021-01162-y. Online ahead of print.

14. Chun Chen, David McDonald, Alasdair Blain, Ashwin Sachdeva, Laura Bone, Anna L M Smith, Charlotte Warren, Sarah J Pickett, Gavin Hudson, Andrew Filby, Amy E Vincent, Doug M Turnbull, Amy K Reeve. Imaging mass cytometry reveals generalised deficiency in OXPHOS complexes in Parkinson's disease. NPJ Parkinsons Dis.  2021 May 12;7(1):39. doi: 10.1038/s41531-021-00182-x.

15. Tommaso Cavazza, Yuko Takeda, Antonio Z Politi, Magomet Aushev, Patrick Aldag, Clara Baker, Meenakshi Choudhary, Jonas Bucevičius, Gražvydas Lukinavičius, Kay Elder, Martyn Blayney, Andrea Lucas-Hahn, Heiner Niemann, Mary Herbert, Melina Schuh. Parental genome unification is highly error-prone in mammalian embryos. Cell. 2021 May 27;184(11):2860-2877.e22. doi: 10.1016/j.cell.2021.04.013. Epub 2021 May 7.

16. K Mistry, B van der Steen , T Clifford 1 , F van Holthoon , A Kleinnijenhuis , J Prawitt , M Labus , B Vanhoecke , P E Lovat , A McConnell. Potentiating cutaneous wound healing in young and aged skin with nutraceutical collagen peptides. Clin Exp Dermatol. 2021 Jan;46(1):109-117. doi: 10.1111/ced.14392.

17.Matthew Zorkau , Yasmin Proctor-Kent , Rolando Berlinguer-Palmini , Andrew Hamilton , Zofia M Chrzanowska-Lightowlers , Robert N Lightowlers. Visualizing Mitochondrial Ribosomal RNA and Mitochondrial Protein Synthesis in Human Cell Lines. Methods Mol Biol. 2021;2192:159-181. doi: 10.1007/978-1-0716-0834-0_13.

18.David Hill, Ioana Cosgarea, Nick Reynolds, Penny Lovat, Jane Armstrong. Research Techniques Made Simple: Analysis of Autophagy in the Skin. J Invest Dermatol. 2021 Jan;141(1):5-9.e1. doi: 10.1016/j.jid.2020.10.004.

19.Clare Tweedy, Nathan Kindred, Joshua Curry, Christopher Williams, John-Paul Taylor, Peter Atkinson, Fiona Randall, Daniel Erskine, Christopheer M Morris, Amy K Reeve, Gavin J Clowry, Fiona E N LeBeau. Hippocampal network hyperexcitability in young transgenic mice expressing human mutant alpha-synuclein. Neurobiol Dis. 2021 Feb;149:105226. doi: 10.1016/j.nbd.2020.105226.

20. Emily R Thompson, Lucy Bates, Ibrahim K Ibrahim, Avinash Sewpaul, Ben Stenberg, Andrew McNeill, Rodrigo Figueiredo, Tom Girdlestone, Georgina C Wilkins, Lu Wang, Samuel J Tingle, William E Scott 3rd, Henrique de Paula Lemos, Andrew L Mellor, Valerie D Roobrouck, Anthony E Ting, Sarah A Hosgood, Michael L Nicholson, Andrew J Fisher, Simi Ali, Neil S Sheerin, Colin H Wilson. Novel delivery of cellular therapy to reduce ischemia reperfusion injury in kidney transplantation. Am J Transplant.  2021 Apr;21(4):1402-1414. doi: 10.1111/ajt.16100.

21. Francesco P Zummo, Stanislaus I Krishnanda, Merilin Georgiou, Finbarr Pm O'Harte, Vadivel Parthsarathy, Kirsty S Cullen, Minna Honkanen-Scott, James Am Shaw, Penny E Lovat, Catherine Arden. Exendin-4 stimulates autophagy in pancreatic β-cells via the RAPGEF/EPAC-Ca 2+-PPP3/calcineurin-TFEB axis. Autophagy. 2021 Aug 2;1-17. doi: 10.1080/15548627.2021.1956123.

22. Sviatlana Shashkova, Thomas Nyström, Mark C Leake, Adam J M Wollman. Correlative single-molecule fluorescence barcoding of gene regulation in Saccharomyces cerevisiae. Methods. 2021 Sep;193:62-67. doi: 10.1016/j.ymeth.2020.10.009.

23. Cornelia Roesl, Elizabeth R. Evans, Kosala N. Dissanayake, Veronika Boczonadi, Ross A. Jones ,Graeme R. Jordan ,Leire Ledahawsky ,Guy C. C. Allen ,Molly Scott ,Alanna Thomson ,Thomas M. Wishart ,David I. Hughes ,Richard J. Mead ,Clifford C. Shone ,Clarke R. Slater ,Thomas H. Gillingwater ,Paul A. Skehel , Richard R. Ribchester. Confocal Endomicroscopy of Neuromuscular Junctions Stained with Physiologically Inert Protein Fragments of Tetanus Toxin. Biomolecules. 2021 Oct 12;11(10):1499. doi: 10.3390/biom11101499.

24. Christin A. Albus , Rolando Berlinguer-Palmini,Caroline Hewison ,Fiona McFarlane ,Elisabeta-Ana Savu ,Robert N. Lightowlers ,Zofia M. Chrzanowska-Lightowlers and Matthew Zorkau. Mitochondrial Translation Occurs Preferentially in the Peri-Nuclear Mitochondrial Network of Cultured Human Cells. Biology 2021, 10(10), 1050; https://doi.org/10.3390/biology10101050.

25.Diana Papini, Mark D Levasseur, Jonathan M G Higgins. The Aurora B gradient sustains kinetochore stability in anaphase. Cell Rep. 2021 Nov 9;37(6):109818. doi: 10.1016/j.celrep.2021.109818.

26. Mathias Hammer, Maximiliaan Huisman, Alessandro Rigano, Ulrike Boehm, James J. Chambers, Nathalie Gaudreault, Alison J. North, Jaime A. Pimentel, Damir Sudar, Peter Bajcsy, Claire M. Brown, Alexander D. Corbett, Orestis Faklaris, Judith Lacoste, Alex Laude, Glyn Nelson, Roland Nitschke, Farzin Farzam, Carlas S. Smith, David Grunwald & Caterina Strambio-De-Castillia. Towards community-driven metadata standards for light microscopy: tiered specifications extending the OME model. Nature Methods volume 18, pages1427–1440 (2021).

27. Alessandro Rigano, Shannon Ehmsen, Serkan Utku Öztürk, Joel Ryan, Alexander Balashov, Mathias Hammer, Koray Kirli, Ulrike Boehm, Claire M. Brown, Karl Bellve, James J. Chambers, Andrea Cosolo, Robert A. Coleman, Orestis Faklaris, Kevin E. Fogarty, Thomas Guilbert, Anna B. Hamacher, Michelle S. Itano, Daniel P. Keeley, Susanne Kunis, Judith Lacoste, Alex Laude, Willa Y. Ma, Marco Marcello, Paula Montero-Llopis, Glyn Nelson, Roland Nitschke, Jaime A. Pimentel, Stefanie Weidtkamp-Peters, Peter J. Park, Burak H. Alver, David Grunwald & Caterina Strambio-De-Castillia. Micro-Meta App: an interactive tool for collecting microscopy metadata based on community specifications. Nature Methods volume 18, pages1489–1495 (2021).

 

 

 

 

 

 

2022

1. McLeod F, Dimtsi A, Marshall AC, Lewis-Smith D, Thomas R, Clowry GJ, Trevelyan AJ. Altered synaptic connectivity in an in vitro human model of STXBP1 encephalopathy. Brain. 2022 Oct 31:awac396. doi: 10.1093/brain/awac396. Online ahead of print. PMID: 36315647

2. Scalzone A, Cerqueni G, Wang XN, Ferreira-Duarte A, Dalgarno K, Mattioli-Belmonte M, Gentile P. An In Vitro Engineered Osteochondral Model as Tool to Study Osteoarthritis Environment. Adv Healthc Mater. 2022 Oct 27:e2202030. doi: 10.1002/adhm.202202030. Online ahead of publication.

3. Smith LA, Erskine D, Blain A, Taylor RW, McFarland R, Lax NZ. Delineating selective vulnerability of inhibitory interneurons in Alpers' syndrome. Neuropathol Appl Neurobiol. 2022 Oct;48(6):e12833. doi: 10.1111/nan.12833. Epub 2022 Jul 19.PMID: 35790454 

4. Saha S, Rundle S, Kotsopoulos IC, Begbie J, Howarth R, Pappworth IY, Mukhopadhyay A, Kucukmetin A, Marchbank KJ, Curtin N. Determining the Potential of DNA Damage Response (DDR) Inhibitors in Cervical Cancer Therapy. Cancers (Basel). 2022 Sep 1;14(17):4288. doi: 10.3390/cancers14174288.PMID: 36077823 

5. Jackson RM, Hatton CF, Spegarova JS, Georgiou M, Collin J, Stephenson E, Verdon B, Haq IJ, Hussain R, Coxhead JM, Mudhar HS, Wagner B, Hasoon M, Davey T, Rooney P, Khan CMA, Ward C, Brodlie M, Haniffa M, Hambleton S, Armstrong L, Figueiredo F, Queen R, Duncan CJA, Lako M. Conjunctival epithelial cells resist productive SARS-CoV-2 infection. Stem Cell Reports. 2022 Jul 12;17(7):1699-1713. doi: 10.1016/j.stemcr.2022.05.017. Epub 2022 Jun 23.PMID: 35750043.

6. Cartwright TN, Harris RJ, Meyer SK, Mon AM, Watson NA, Tan C, Marcelot A, Wang F, Zinn-Justin S, Traktman P, Higgins JMG. Dissecting the roles of Haspin and VRK1 in histone H3 phosphorylation during mitosis. Sci Rep. 2022 Jul 1;12(1):11210. doi: 10.1038/s41598-022-15339- 8.PMID: 35778595.

7. Yu X, Arden C, Berlinguer-Palmini R, Chen C, Bradshaw C, Smith AL, Whitehall J, White M, Anderson S, Kattner N, Shaw J, Turnbull D, Greaves LC, Walker M. Mitochondrial complex I subunit deficiency promotes pancreatic α-cell proliferation. Mol Metab. 2022 Jun;60:101489. doi: 10.1016/j.molmet.2022.101489. Epub 2022 Apr 4.PMID: 35390502

8. Kotlarz M, Ferreira AM, Gentile P, Dalgarno K. Bioprinting of Cell-Laden Hydrogels onto Titanium Alloy Surfaces to Produce a Bioactive Interface. Macromol Biosci. 2022 Jun;22(6):e2200071. doi: 10.1002/mabi.202200071. Epub 2022 Apr 11.PMID: 35365963

9. Hatton C, Ghanem SS, Koss DJ, Abdi IY, Gibbons E, Guerreiro R, Bras J; International DLB Genetics Consortium, Walker L, Gelpi E, Heywood W, Outeiro TF, Attems J, McFarland R, Forsyth R, El-Agnaf OM, Erskine D. Prion-like α-synuclein pathology in the brain of infants with Krabbe disease. Brain. 2022 May 24;145(4):1257-1263. doi: 10.1093/brain/awac002.PMID: 34999780

10. Scalzone A, Cerqueni G, Bonifacio MA, Pistillo M, Cometa S, Belmonte MM, Wang XN, Dalgarno K, Ferreira AM, De Giglio E, Gentile P. Valuable effect of Manuka Honey in increasing the printability and chondrogenic potential of a naturally derived bioink. Mater Today Bio. 2022 May 13;14:100287. doi: 10.1016/j.mtbio.2022.100287. eCollection 2022 Mar.PMID: 35647514

11. Derrick CJ, Santos-Ledo A, Eley L, Paramita IA, Henderson DJ, Chaudhry B. Sequential action of JNK genes establishes the embryonic left-right axis. Development. 2022 May 1;149(9):dev200136. doi: 10.1242/dev.200136. Epub 2022 May 3.PMID: 35352808

12. Hipps D, Dobson PF, Warren C, McDonald D, Fuller A, Filby A, Bulmer D, Laude A, Russell O, Deehan DJ, Turnbull DM, Lawless C. Detecting respiratory chain defects in osteoblasts from osteoarthritic patients using imaging mass cytometry. Bone. 2022 May;158:116371. doi: 10.1016/j.bone.2022.116371. Epub

13. Govaere O, Petersen SK, Martinez-Lopez N, Wouters J, Van Haele M, Mancina RM, Jamialahmadi O, Bilkei-Gorzo O, Lassen PB, Darlay R, Peltier J, Palmer JM, Younes R, Tiniakos D, Aithal GP, Allison M, Vacca M, Göransson M, Berlinguer-Palmini R, Clark JE, Drinnan MJ, Yki-Järvinen H, Dufour JF, Ekstedt M, Francque S, Petta S, Bugianesi E, Schattenberg JM, Day CP, Cordell HJ, Topal B, Clément K, Romeo S, Ratziu V, Roskams T, Daly AK, Anstee QM, Trost M, Härtlova A. Macrophage scavenger receptor 1 mediates lipid-induced inflammation in non-alcoholic fatty liver disease. J Hepatol. 2022 May;76(5):1001-1012. doi: 10.1016/j.jhep.2021.12.012. Epub 2021 Dec 21.PMID: 34942286

14. Rozanska A, Cerna-Chavez R, Queen R, Collin J, Zerti D, Dorgau B, Beh CS, Davey T, Coxhead J, Hussain R, Al-Aama J, Steel DH, Benvenisty N, Armstrong L, Parulekar M, Lako M. pRB-Depleted Pluripotent Stem Cell Retinal Organoids Recapitulate Cell State Transitions of Retinoblastoma Development and Suggest an Important Role for pRB in Retinal Cell Differentiation. Stem Cells Transl Med. 2022 Apr 29;11(4):415-433. doi: 10.1093/stcltm/szac008.PMID: 35325233 

15. Sachdeva A, Hart CA, Carey CD, Vincent AE, Greaves LC, Heer R, Oliveira P, Brown MD, Clarke NW, Turnbull DM. Automated quantitative high-throughput multiplex immunofluorescence pipeline to evaluate OXPHOS defects in formalin-fixed human prostate tissue. Sci Rep. 2022 Apr 22;12(1):6660. doi: 10.1038/s41598-022-10588-z.PMID: 35459777

16. Zummo FP, Krishnanda SI, Georgiou M, O'Harte FP, Parthsarathy V, Cullen KS, Honkanen-Scott M, Shaw JA, Lovat PE, Arden C. Exendin-4 stimulates autophagy in pancreatic β-cells via the RAPGEF/EPAC-Ca2+-PPP3/calcineurin-TFEB axis. Autophagy. 2022 Apr;18(4):799-815. doi: 10.1080/15548627.2021.1956123. Epub 2021 Aug 2. PMID: 34338148 

17. Dorgau B, Georgiou M, Chaudhary A, Moya-Molina M, Collin J, Queen R, Hilgen G, Davey T, Hewitt P, Schmitt M, Kustermann S, Pognan F, Steel DH, Sernagor E, Armstrong L, Lako M. Human Retinal Organoids Provide a Suitable Tool for Toxicological Investigations: A Comprehensive Validation Using Drugs and Compounds Affecting the Retina.  Stem Cells Transl Med. 2022 Mar 17;11(2):159-177. doi: 10.1093/stcltm/szab010.PMID: 35298655.

18. Georgiou M, Yang C, Atkinson R, Pan KT, Buskin A, Molina MM, Collin J, Al-Aama J, Goertler F, Ludwig SEJ, Davey T, Lührmann R, Nagaraja-Grellscheid S, Johnson CA, Ali R, Armstrong L, Korolchuk V, Urlaub H, Mozaffari-Jovin S, Lako M. Activation of autophagy reverses progressive and deleterious protein aggregation in PRPF31 patient-induced pluripotent stem cell-derived retinal pigment epithelium cells. Clin Transl Med. 2022 Mar;12(3):e759. doi: 10.1002/ctm2.759.PMID: 35297555.

19. Hilgen G, Kartsaki E, Kartysh V, Cessac B, Sernagor E. A novel approach to the functional classification of retinal ganglion cells. Open Biol. 2022 Mar;12(3):210367. doi: 10.1098/rsob.210367. Epub 2022 Mar 9.PMID: 35259949.

20. Gillani SQ, Reshi I, Nabi N, Un Nisa M, Sarwar Z, Bhat S, Roberts TM, Higgins JMG, Andrabi S. PCTAIRE1 promotes mitotic progression and resistance against antimitotic and apoptotic signals. J Cell Sci. 2022 Feb 1;135(3):jcs258831. doi: 10.1242/jcs.258831. Epub 2022 Feb 9.PMID: 35044463.

21. Luo M, Yang W, Cartwright TN, Higgins JMG, Chen J. Simultaneous Measurement of Single-Cell Mechanics and Cell-to-Materials Adhesion Using Fluidic Force Microscopy. Langmuir. 2022 Jan 18;38(2):620-628. doi: 10.1021/acs. langmuir.1c01973. Epub 2022 Jan 4. PMID: 34981921

22. Gee LMV, Barron-Millar B, Leslie J, Richardson C, Zaki MYW, Luli S, Burgoyne RA, Cameron RIT, Smith GR, Brain JG, Innes B, Jopson L, Dyson JK, McKay KRC, Pechlivanis A, Holmes E, Berlinguer-Palmini R, Victorelli S, Mells GF, Sandford RN, Palmer J, Kirby JA, Kiourtis C, Mokochinski J, Hall Z, Bird TG, Borthwick LA, Morris CM, Hanson PS, Jurk D, Stoll EA, LeBeau FEN, Jones DEJ, Oakley F. Anti-Cholestatic Therapy with Obeticholic Acid Improves Short-Term Memory in Bile Duct Ligated Mice. Am J Pathol. 2022 Oct 13:S0002-9440(22)00312-1. doi: 10.1016/j.ajpath.2022.09.005. Online ahead of print.PMID: 36243043

23. Zaaimi B, Turnbull M, Hazra A, Wang Y, Gandara C, McLeod F, McDermott EE, Escobedo-Cousin E, Idil AS, Bailey RG, Tardio S, Patel A, Ponon N, Gausden J, Walsh D, Hutchings F, Kaiser M, Cunningham MO, Clowry GJ, LeBeau FEN, Constandinou TG, Baker SN, Donaldson N, Degenaar P, O'Neill A, Trevelyan AJ, Jackson A. Closed-loop optogenetic control of the dynamics of neural activity in non-human primates. Nat Biomed Eng. 2022 Oct 20. doi: 10.1038/s41551-022-00945-8. Online ahead of print.PMID: 36266536

24. Hammer M, Huisman M, Rigano A, Boehm U, Chambers JJ, Gaudreault N, North AJ, Pimentel JA, Sudar D, Bajcsy P, Brown CM, Corbett AD, Faklaris O, Lacoste J, Laude A, Nelson G, Nitschke R, Farzam F, Smith CS, Grunwald D, Strambio-De-Castillia C. Author Correction: Towards community-driven metadata standards for light microscopy: tiered specifications extending the OME model. Nat Methods. 2022 Feb;19(2):255. doi: 10.1038/s41592-021-01386-y.PMID: 34980906

25. Rigano A, Ehmsen S, Öztürk SU, Ryan J, Balashov A, Hammer M, Kirli K, Boehm U, Brown CM, Bellve K, Chambers JJ, Cosolo A, Coleman RA, Faklaris O, Fogarty KE, Guilbert T, Hamacher AB, Itano MS, Keeley DP, Kunis S, Lacoste J, Laude A, Ma WY, Marcello M, Montero-Llopis P, Nelson G, Nitschke R, Pimentel JA, Weidtkamp-Peters S, Park PJ, Alver BH, Grunwald D, Strambio-De-Castillia C. Author Correction: Micro-Meta App: an interactive tool for collecting microscopy metadata based on community specifications. Nat Methods. 2022 Feb;19(2):256. doi: 10.1038/s41592-021-01388-w.PMID: 34952955

26. Rico D, Kent D, Karataraki N, Mikulasova A, Berlinguer-Palmini R, Walker BA, Javierre BM, Russell LJ, Brackley CA. High-resolution simulations of chromatin folding at genomic rearrangements in malignant B cells provide mechanistic insights into proto-oncogene deregulation. Genome Res. 2022 Jul 21;32(7):1355-66. doi: 10.1101/gr.276028.121. Online ahead of print.PMID: 35863900