Background

I manage the Electron Microscopy Research Services unit which provides an electron microscopy service to students and researchers throughout the University as well as to companies and individuals both nationally and internationally.

I am a Chartered Scientist registered through IST.

I am a mentor for Newcastle University and The Royal Microscopical Society.

Fellow of The Royal Microscopical Society.

Member of the Volume EM International Community.

Teaching

MRES Module

Enabling Technologies and Methodologies for Biomedical Research - MMB8053 

Training Courses

Transmission EM

Training packages are available for researchers which will reduce costs in the long term.

The TEM course is held over 3 days and covers ultra-microtomy and use of the transmission electron microscope. The course can be tailored to suit the individual.

Scanning EM

This is for groups who may have a high throughput of samples to be analysed. Once competent, the researchers would be allowed to use the microscope themselves.

School workshops  

We welcome visits from key stage 5 pupils and their teachers to the electron microscopy laboratory at Newcastle University's Medical School. During their 1.5-2 hour visit they will learn how specimens are prepared for both scanning and transmission EM and see the electron microscopes in action. Visits are suitable for both year 12 and year 13, though numbers are restricted (min 7, max 14).

Publications

• Articles

  • McGorum BC, Davey T, Dosi MCM, Keen JA, Morrison LR, Pirie RS, Shaw DJ, Harris JB. Equine grass sickness is associated with major abnormalities in the ultrastructure of skeletal neuromuscular junctions. Equine Veterinary Journal 2024, Epub ahead of print.
  • Powell J, Powell S, Mather MW, Beck L, Nelson A, Palmowski P, Porter A, Coxhead J, Hedley A, Scott J, Rostron AJ, Hellyer T, Zaidi F, Davey T, Garnett JP, Agbeko R, Ward C, Stewart CJ, Taggart CC, Brodlie M, Simpson AJ. Tracheostomy in children is associated with neutrophilic airway inflammation. Thorax 2023, Epub ahead of print.
  • Kurzawa-Akanbi M, Whitfield P, Burte F, Bertelli PM, Pathak V, Doherty M, Hilgen B, Gliaudelyte L, Platt M, Queen R, Coxhead J, Porter A, Oberg M, Fabrikova D, Davey T, Beh CS, Georgiou M, Collin J, Boczonadi V, Hartlova A, Taggart M, Al-Aama J, Korolchuk VI, Morris CM, Guduric-Fuchs J, Steel DH, Medina RJ, Armstrong L, Lako M. Retinal pigment epithelium extracellular vesicles are potent inducers of age-related macular degeneration disease phenotype in the outer retina. Journal of Extracellular Vesicles 2022, 11(12), 12295.
  • Rozanska A, Cerna R, Queen R, Collin J, Zerti D, Dorgau B, Beh C, Davey T, Coxhead J, Hussain R, Alaama J, Steel D, Benvenisty N, Armstrong L, Parulekar M, Lako M. pRB-depleted pluripotent stem cell retinal organoids recapitulate cell state transitions of retinoblastoma development and suggest an important role for pRB in retinal cell differentiation. Stem Cell Translational Medicine 2022, 11(4), 415-433.
  • Dorgau B, Georgiou M, Chaudhary A, Molina M, Collin J, Queen R, Hilgen G, Davey T, Hewitt P, Schmitt M, Kustermann S, Pognan F, Steel D, Sernagor E, Armstrong L, Lako M. Human Retinal Organoids Provide a Suitable Tool for Toxicological Investigations: A Comprehensive Validation Using Drugs and Compounds Affecting the Retina. Stem Cell Translational Medicine 2022, 11(2), 159-177.
  • Dyson NJ, Kattner N, Honkanen-Scott M, Hunter B, Doyle JA, White K, Davey TS, Ploeg RJ, Bury YA, Tiniakos DG, Shaw JAM, Scott WE. Development and Application of a Semi quantitative Scoring Method for Ultrastructural Assessment of Acute Stress in Pancreatic Islets. Transplantation Direct 2022, 8(1), e1271.
  • Georgiou M, YAng C, Atkinson R, Pan K, Buskin A, Molina M, Collin C, Alaama J, Goertler F, Ludwig S, Davey T, Luhrmann R, Grellscheid S, Johnson C, Ali R, Armstring L, Korolchuk V, Urlaub H, Mozzafari J, LAko M. Activation of autophagy reverses progressive and deleterious protein aggregation in PRPF31 patient iPSC-derived retinal pigment epithelium cells. Clinical and Translational Medicine 2022, 12(3), e759.
  • Mather MW, Verdon B, Botting RA, Engelbert J, Delpiano L, Xu X, Hatton C, Davey T, Lisgo S, Yates P, Dawe N, Bingle CD, Haniffa M, Powell J, Ward C. Development of a physiological model of human middle ear epithelium. Laryngoscope Investigative Otolaryngology 2021, 6(5), 1167-1174.
  • Hatton CF, Botting RA, Duenas ME, Haq IJ, Verdon B, Thompson BJ, Spegarova JS, Gothe F, Stephenson E, Gardner AI, Murphy S, Scott J, Garnett JP, Carrie S, Powell J, Khan CMA, Huang L, Hussain R, Coxhead J, Davey T, Simpson AJ, Haniffa M, Hambleton S, Brodlie M, Ward C, Trost M, Reynolds G, Duncan CJA. Delayed induction of type I and III interferons mediates nasal epithelial cell permissiveness to SARS-CoV-2. Nature Communications 2021, 12(1), 7092.
  • Faitg J, Lacefield C, Davey T, White K, Laws R, Kosmidis S, Reeve AK, Kandel ER, Vincent AE, Picard M. 3D neuronal mitochondrial morphology in axons, dendrites, and somata of the aging mouse hippocampus. Cell Reports 2021, 36, 108509.
  • Spendiff S, Howarth R, McMacken G, Davey T, Quinlan K, O'Connor E, Slater C, Hettwer S, Mader A, Roos A, Horvath R, Lochmuller H. Modulation of the Acetylcholine Receptor Clustering Pathway Improves Neuromuscular Junction Structure and Muscle Strength in a Mouse Model of Congenital Myasthenic Syndrome. Frontiers in Molecular Neuroscience 2020, 13, 594220.
  • Faitg J, Davey T, Turnbull DM, White K, Vincent AE. Mitochondrial morphology and function: two for the price of one!. Journal of Microscopy 2020, 278(2), 89-106.
  • Kattner N, Dyson N, Bury Y, Tiniakos D, White K, Davey T, Eliasson L, Tindale L, Wagner B, Honkanen-Scott MM, Doyle J, Ploeg RJ, Shaw JAM, Scott III WE. Development and validation of a quantitative electron microscopy score to assess acute cellular stress in the human exocrine pancreas. Journal of Pathology: Clinical Research 2020, 7(2), 173-187.
  • Vincent AE, White K, Davey T, Philips J, Ogden RT, Lawless C, Warren C, Hall MG, Ng YS, Falkous G, Holden T, Deehan D, Taylor RW, Turnbull DM, Picard M. Quantitative 3D Mapping of the Human Skeletal Muscle Mitochondrial Network. Cell Reports 2019, 26(4), 996-1009.e4.
  • Vincent AE, Rosa HS, Pabis K, Lawless C, Chen C, Grünewald A, Rygiel K, Rocha MC, Reeve AK, Falkous G, Perissi V, White K, Davey T, Petrof BJ, Sayer AA, Cooper C, Deehan D, Taylor RW, Turnbull DM, Picard M. Subcellular origin of mitochondrial DNA deletions in human skeletal muscle. Annals of Neurology 2018, 84(2), 289-301.
  • Oláhová M, Thompson K, Hardy SA, Barbosa IA, Besse A, Anagnostou ME, White K, Davey T, Simpson MA, Champion M, Enns G, Schelley S, Lightowlers RN, Chrzanowska-Lightowlers ZMA, McFarland R, Deshpande C, Bonnen PE, Taylor RW. Pathogenic variants in HTRA2 cause an early-onset mitochondrial syndrome associated with 3-methylglutaconic aciduria. Journal of Inherited Metabolic Disease 2017, 40(1), 121-130.
  • Hall EA, Nahorski MS, Murray LM, Shaheen R, Perkins E, Dissanayake KN, Kristaryanto Y, Jones RA, Vogt J, Rivagorda M, Handley MT, Mali GR, Quidwai T, Soares DC, Keighren MA, McKie L, Mort RL, Gammoh N, Garcia-Munoz A, Davey T, Vermeren M, Walsh D, Budd P, Aligianis IA, Faqeih E, Quigley AJ, Jackson IJ, Kulathu Y, Jackson M, Ribchester RR, von Kriegsheim A, Alkuraya FS, Woods CG, Maher ER, Mill P. PLAA Mutations Cause a Lethal Infantile Epileptic Encephalopathy by Disrupting Ubiquitin-Mediated Endolysosomal Degradation of Synaptic Proteins. American Journal of Human Genetics 2017, 100(5), 706-724.
  • Vincent AE, Ng YS, White K, Davey T, Mannella C, Falkous G, Feeney C, Schaefer AM, McFarland R, Gorman GS, Taylor RW, Turnbull DM, Picard M. The Spectrum of Mitochondrial Ultrastructural Defects in Mitochondrial Myopathy. Scientific Reports 2016, 6, 30610.
  • McGorum BC, Scholes S, Milne EM, Eaton SL, Wishart TM, Poxton IR, Moss S, Wernery U, Davey T, Harris JB, Pirie RS. Equine grass sickness, but not botulism, causes autonomic and enteric neurodegeneration and increases soluble N-ethylmaleimide-sensitive factor attachment receptor protein expression within neuronal perikarya. Equine Veterinary Journal 2016, 48(6), 786-791.
  • Zhou YS, Webb S, Lettice L, Tardif S, Kilanowski F, Tyrrell C, MacPherson H, Semple F, Tennant P, Baker T, Hart A, Devenney P, Perry P, Davey T, Barran P, Barratt CL, Dorin JR. Partial Deletion of Chromosome 8 β-defensin Cluster Confers Sperm Dysfunction and Infertility in Male Mice. PLoS Genetics 2013, 9(10), e1003826.
  • Dunican DS, Cruickshanks HA, Suzuki M, Semple CA, Davey T, Arceci RJ, Greally J, Adams IR, Meehan RR. Lsh regulates LTR retrotransposon repression independently of Dnmt3b function. Genome Biology 2013, 14(10), R146.
  • Hall EA, Keighren M, Ford MJ, Davey T, Jarman AP, Smith LB, Jackson IJ, Mill P. Acute Versus Chronic Loss of Mammalian Azi1/Cep131 Results in Distinct Ciliary Phenotypes. PLoS Genetics 2013, 9(12), e1003928.
  • Hart AJ, Hodgson WC, Scott-Davey T, Harris JB. Neuromuscular toxicology of the venom of Collett's snake (Pseudechis colletti): A histopathological study. Muscle and Nerve 2011, 43(4), 552-559.
  • Hart A, Scott-Davey T, Harris J. Venom of Collett's snake (Pseudechis colletti) blocks the binding of α-bungarotoxin to acetylcholine receptors at chick but not human neuromuscular junctions: A histochemical study. Toxicon 2008, 52(5), 647-650.

• Conference Proceedings (inc. Abstracts)

  • Dyson N, Kattner N, Carey S, Honkanen-Scott M, Hunter B, Davey T, Shaw JA, Scott WE. P.112: Ultrastructural Assessment of the Associations of Obesity and Established Diabetes in Human Pancreata. In: 18th World Congress of the International Pancreas and Islet Transplantation Association (IPITA 2021). 2021, Virtual: Lippincott Williams & Wilkins.
  • Bury Y, Kattner K, Dyson N, Jones C, Ness T, Coulthard R, Davey T, Eliasson L, Honkanen-Scott M, Doyle J, Ploeg R, Klöppel G, Tiniakos D, Shaw J, Scott W. Standardized pathology reporting in donor pancreata within the quality and safety in organ donation (QUOD) tissue bank: a new resource for pancreatic research. In: European Congress of Pathology. 2020. In Preparation.
  • Speight RA, Davey T, White K, Kirby JA, Mansfield JC. Activation of the bile acid receptor, farnesoid-x receptor, maintains gut epithelial cell morphology, possibly via inhibition of myosin light chain kinase expression. In: 2nd Digestive Disorders Federation Conference 2015. 2015, London, UK: BMJ Group.

• Review

  • Harris JB, Scott-Davey T. Secreted Phospholipases A₂ of Snake Venoms: Effects on the Peripheral Neuromuscular System with Comments on the Role of Phospholipases A₂ in Disorders of the CNS and Their Uses in Industry. Toxins 2013, 5(12), 2533-2571.