Newcastle Magnetic Resonance Centre

Reversing Type 2 Diabetes

Reversing Type 2 Diabetes and ongoing remission

Public Information

Hear all about from Professor Roy Taylor the 5 minute summary.

•   Type 2 diabetes is a potentially reversible condition
•   If a person has type 2 diabetes, they have become too heavy for their own body (nothing to do with the arbitrary concept of obesity)
•   Weight loss of around 15kg is necessary for most people
•   This can be achieved using a simple 3-step method: the 1, 2, 3 of diabetes reversal
•   Type 2 diabetes is most easily reversed to normal in the early years after diagnosis
•   How and why type 2 diabetes happens can now be understood

Read Richard Doughty's personal story Type 2 diabetes and the diet that cured me on the Guardian website, including a video interview of another personal story. You can also read an update from Richard, I reversed my diabetes in just 11 days, on the Mail Online.

Information for your doctor

Download our Information for Doctors (PDF: 227KB).  Even though doctors do not like downloaded information from the web, this comes from an internationally recognised diabetes research centre. It is now being put into practice by both NHS England and NHS Scotland. The American Diabetes Association recognises remission of diabetes as an appropriate aim of management.

Publications

Publications relating to reversing diabetes can be found on this page.

The Shakes

The shakes can be found here

 

Background

All this work has depended upon a breakthrough in understanding.

Reversing the twin cycles of Type 2 diabetes  was that too much fat within liver builds up as a vicious cycle. This overspills to the rest of the body, including the pancreas. This starts up a second vicious cycle in the pancreas which prevents normal production of insulin.

Proof of the hypothesis was published in 2011 as the Counterpoint‌.

Further studies showed that once the vicious cycles of type 2 diabetes had been reversed, the remission of diabetes was durable – as long as weight was not regained. very low calorie diet and 6 months of weight stability in Type 2 diabetes

Different people have different levels of tolerance of fat within liver and pancreas. If you have type 2 diabetes, you have crossed your ‘personal fat thresholds’. But if you lose weight and go below your personal fat threshold, type 2 diabetes will disappear.

Watch Professor Taylor's Newcastle University Public Lecture on reversing type 2 diabetes (4th November 2014).

 

DiRECT

DIabetes REmissions Clinical Trial – understanding why significant weight loss results in remission of Type 2 diabetes is at the heart of DiRECT.

DiRECT is a collaboration between Professor Roy Taylor, Newcastle University and Professor Mike Lean, University of Glasgow.

  • One third of all people taking part were free of diabetes at 2 years.
  • Around three quarters of everyone who were in remission at 1 year stayed in remission at 2 years.
  • The group who embarked on rapid weight loss had fewer serious medical problems in the second year of DiRECT.

DiRECT results: Direct results at 2 years (PDF: 627KB) full paper and the online DiRECT Appendix (PDF: 499KB) are now available. 

View details at:

Watch Professor Taylor’s interview: Has DiRECT and Type 2 diabetes remission gone mainstream? (Medscape, 8 March 2019) 

Media coverage and press releases:

Further information on the Hairy Dieters programme including experts' hints and tips and regular updates on the Hairy Dieters' progress can be seen on the BBC website. The programme promoted the University's aim to help us all live healthy, longer lives 

Get sample recipes and meal plans (PDF: 385KB) devised by Alison Barnes, Senior Diabetes Dietitian, Newcastle University and Tom Crame, Dietitian Intern, Newcastle University.
Guoda Karoblyte, Human Nutrition placement student at Newcastle University has also devised some 'More vegetable recipes'.

More information on low calorie diets is available from the Diabetes UK website and the British Heart Foundation provide advice on weight loss.

Life Without Diabetes

Read the whole story of what happens to your food inside your body.  And how this understanding led to reversing the Twin Cycles of type 2 diabetes.

Contents:
Foreward by Professor Sir George Alberti
A personal note: Dave Myers, Hairy Biker
How to use this book
Introduction
1. What is type 2 diabetes?
2. Energy for life: the dual fual
3. How your body deals with food
4. Type 2 diabetes: a bad case of food poisoning
5. A murder mystery and the Twin Cycles
6. The Personal Fat Threshold
7. Escaping from type 2 diabetes
8. Enjoying life and staying away from diabetes
9. Don't be fooled
Recipes

 

The book can be purchased from a number of online providers and bookshops from 26 December 2019.
It will also be available as audiobook (Narrated by Prof Roy Taylor) and e-Book version.

The following are suitable liquid replacement meals as described in Life Without Diabetes:

These all provide 200 calories per meal:

Exante, Slim and Save, Kee Diet and New You Plan.  Also suitable, when made up with skimmed milk, are Asda,GreatShape and Tesco, Ultraslim.

 

Scientific Information

The information on this page is for doctors and scientists. It includes slides on various aspects of the reversal of Type 2 diabetes as well as published papers.

Download our slides on:

Further information

In 2008, we published the Twin Cycle Hypothesis to explain the cause of Type 2 diabetes. This hypothesis predicted that diet could entirely reverse Type 2 diabetes. Read the scientific review, Pathogenesis of type 2 diabetes (PDF: 471KB) on the US National Library of Medicine website.

The Counterpoint study designed to test the hypothesis was funded by Diabetes UK. The results were very clear. Weight loss averaging 15kg (2 stone 5lb) achieved over 8 weeks caused two distinct sets of changes. Within seven days, liver fat had fallen by 30%, liver insulin sensitivity had returned to normal and fasting blood glucose had become normal. By eight weeks, pancreas fat content had returned to normal and insulin secretion by the pancreas had returned to normal. Read the full scientific paper, Reversal of Type 2 diabetes (PDF: 195KB) and the related Newcastle University Press Release, Diet Reverses Type 2 Diabetes.

This new understanding of what causes Type 2 diabetes and how it can be completely reversed has been used by individuals worldwide, a report has been published documenting practical management of Type 2 diabetes in respect of reversal (PDF: 85KB).  A review describing the beta cell de-differentiation (PDF: 1081KB) explains why the condition is reversible. Under the endoplasmic reticulum stress caused by excess intracytoplasmic fat, the cell goes into a survival mode and switches off specialised gene expression. Removal of the fat permits re-differentiation.  See the more recent reviews:  Diabetologia Review 2017 a discussion of practical aspects of achieving remission.

Professor Taylor was awarded the 2012 Banting Lectureship of Diabetes UK. Read his lecture Reversing the twin cycles of Type 2 diabetes (PDF: 543KB).

Scientists and doctors with access to the journal Diabetes Care, can read a full review of the science underlying this matter: Type 2 diabetes: etiology and reversibility (PDF: 363KB).

The pathophysiological basis of reversal of type 2 diabetes is described in 3 major papers: