Control, Fludrocortisone or Midodrine for the treatment of Orthostatic Hypotension: A Randomised Controlled Trial

• Status: Recruiting
• Sponsor: The Newcastle upon Tyne Hospitals NHS Foundation Trust
• Funder: NIHR HTA
• Therapeutic area: Cardiovascular
• Type of study: CTIMP

Aim: This trial will evaluate the clinical and cost effectiveness of three different treatment strategies for orthostatic hypotension.

Primary outcome:

To determine whether the treatment strategies of conservative management plus fludrocortisone, and conservative management plus midodrine improve symptoms of OH compared to conservative management alone.

• Clinical Phase: IV
• Population: Adults
• Design: RCT Adaptive
• Setting: Secondary Care
• Planned Sample Size: 366