Newcastle Clinical Trials Unit



Control, Fludrocortisone or Midodrine for the treatment of Orthostatic Hypotension: A Randomised Controlled Trial

Status: Closedown/Analysis
Sponsor: The Newcastle upon Tyne Hospitals NHS Foundation Trust
Funder: NIHR HTA
Therapeutic area: Cardiovascular
Type of study: CTIMP

Aim: This trial will evaluate the clinical and cost effectiveness of three different treatment strategies for orthostatic hypotension.

Primary outcome:

To determine whether the treatment strategies of conservative management plus fludrocortisone, and conservative management plus midodrine improve symptoms of OH compared to conservative management alone.

Clinical Phase: IV
Population: Adults
Design: RCT Adaptive
Setting: Secondary Care
Planned Sample Size: 366