Newcastle Clinical Trials Unit



Trial of Proton Pump Inhibitors in Throat Symptoms

Study Stage: Closed
Sponsor: The Newcastle upon Tyne Hospitals NHS Foundation Trust
Funder: NIHR HTA
Therapeutic area: Ear, Nose and Throat
Type of study: CTIMP

Aim: To compare the symptomatic response in patients with persistent throat symptoms at the end of four months (16 weeks) therapy of treatment with lansoprazole versus placebo

Primary Outcome:  The change in Reflux Symptom Index (RSI) at four months in the treatment and placebo groups in an intention to treat analysis.

Clinical Phase: III
Population: Adult
Design: RCT
Setting: Secondary Care
Planned Sample Size: 332