Trial of Proton Pump Inhibitors in Throat Symptoms

• Study Stage: Closed
• Sponsor: The Newcastle upon Tyne Hospitals NHS Foundation Trust
• Funder: NIHR HTA
• Therapeutic area: Ear, Nose and Throat
• Type of study: CTIMP

Aim: To compare the symptomatic response in patients with persistent throat symptoms at the end of four months (16 weeks) therapy of treatment with lansoprazole versus placebo

Primary Outcome:  The change in Reflux Symptom Index (RSI) at four months in the treatment and placebo groups in an intention to treat analysis.

• Clinical Phase: III
• Population: Adult
• Design: RCT
• Setting: Secondary Care
• Planned Sample Size: 332