A single-centre, experimental medicine study investigating the route of delivery and efficacy of autologous tolerogenic dendritic cell (tolDC) therapy for Rheumatoid Arthritis.

• Study stage: Set-up
• Sponsor: The Newcastle upon Tyne Hospitals NHS Foundation Trust
• Funder: Versus Arthritis
• Therapeutic area: Musculoskeletal
• Type of study: ATIMP

Aim: Demonstrate safety of tolDC administration for intra-articular, intra-dermal and intra-nodal routes.
Identify optimal route of administration to ensure tolDC reaches secondary lymphoid tissue.

• Population: Adults
• Clinical Phase: IIa
• Design: Randomised Control Trial (RCT)
• Setting: Secondary Care