Newcastle Clinical Trials Unit



The ENHANCE-D Study – ENHANCing smoking cEssation interventions in Dentistry

  • Study stage: Recruiting
  • Sponsor: The Newcastle upon Tyne Hospitals NHS Foundation Trust
  • Funder: NIHR HTA
  • Therapeutic area: Oral
  • Type of study: CTIMP


To compare smoking abstinence at 6 months of Nicotine Replacement Therapy (NRT)  and  E-cigarette (EC) to usual care and to each other.

Primary Outcome:

Biochemically verified smoking abstinence at 6 months

  • Clinical Phase: IIII
  • Population: Adults
  • Design: RCT
  • Setting: Primary care (NHS Dental Care)
  • Planned Sample Size: 1460