Stroke
Stabilise - Closed
Stroke: an evaluation of Thrombectomy in the Ageing Brain - [including] where IV thromboLysis IS contraindicated
- Study stage: Closed
- Sponsor: The Newcastle upon Tyne Hospitals NHS Foundation Trust
- Funder: NIHR BRC/Microvention Inc
- Therapeutic area: Stroke
- Type of study: CE marked device
Aim: To determine if a novel thrombectomy device can be utilized safely and successfully in the heterogeneous population presenting with large vessel occlusion (LVO) acute ischaemic stroke
Primary Outcome:
The proportion of patients with favourable angiographic outcome based on independent core lab assessment measured by STIR II modification of TICI scale.
- Population: Adult
- Design: RCT
- Setting: Tertiary care
- Planned Sample Size: 80
Topsat 2 - Closed
Treatment of Poor-grade SubArachnoid haemorrhage Trial 2
- Study stage: Closed
- Sponsor: The Newcastle upon Tyne Hospitals NHS Foundation Trust
- Funder: NIHR EME
- Therapeutic area: Stroke
- Type of study: Clinical Intervention
Aim: To establish the efficacy of a strategy of early aneurysm treatment (within 72 hours of ictus) in a population of World Federation of Neurosurgical Societies grade 4-5 (high grade) aneurysmal subarachnoid haemorrhage (aSAH) patients in comparison with the conventional strategy of treatment of aneurysm after neurological improvement (to WFNS grade 1-3).
Primary outcome:
Functional outcome at 12 months determined by ordinal analysis of modified Rankin Score (mRS).
- Population: Adult
- Design: RCT
- Setting: Tertiary care
- Planned Sample Size: 346