Treatment of Poor-grade SubArachnoid haemorrhage Trial 2

• Study stage: Closed
• Sponsor: The Newcastle upon Tyne Hospitals NHS Foundation Trust
• Funder: NIHR EME
• Therapeutic area: Stroke
• Type of study: Clinical Intervention

Aim: To establish the efficacy of a strategy of early aneurysm treatment (within 72 hours of ictus) in a population of World Federation of Neurosurgical Societies grade 4-5 (high grade) aneurysmal subarachnoid haemorrhage (aSAH) patients in comparison with the conventional strategy of treatment of aneurysm after neurological improvement (to WFNS grade 1-3).

Primary outcome:

Functional outcome at 12 months determined by ordinal analysis of modified Rankin Score (mRS).

• Population: Adult
• Design: RCT
• Setting: Tertiary care
• Planned Sample Size: 346