Newcastle Clinical Trials Unit

Topsat 2

Topsat 2

Treatment of Poor-grade SubArachnoid haemorrhage Trial 2

  • Study stage: Closed
  • Sponsor: The Newcastle upon Tyne Hospitals NHS Foundation Trust
  • Funder: NIHR EME
  • Therapeutic area: Stroke
  • Type of study: Clinical Intervention

Aim: To establish the efficacy of a strategy of early aneurysm treatment (within 72 hours of ictus) in a population of World Federation of Neurosurgical Societies grade 4-5 (high grade) aneurysmal subarachnoid haemorrhage (aSAH) patients in comparison with the conventional strategy of treatment of aneurysm after neurological improvement (to WFNS grade 1-3).

Primary outcome:

Functional outcome at 12 months determined by ordinal analysis of modified Rankin Score (mRS).

  • Population: Adult
  • Design: RCT
  • Setting: Tertiary care
  • Planned Sample Size: 346