Staff Profile

I am currently a Future Leaders Fellow in the School of Computing at Newcastle University.

The majority of my work is on mathematical/computational modelling and advanced data analytics in neurological disorders (primarily epilepsy).

My wider research interests currently also include neuroimaging and neuromorphology in health and disease.

Area of expertise: Computational Neurology

Google Scholar: Click here.

The majority of my work is on mathematical/computational modelling and advanced data analytics in neurological disorders (primarily epilepsy).

My wider research interests currently also include neuroimaging and neuromorphology in health and disease.

For more details please see my personal website.

• Articles

  • Taylor PN, Wang Y, Simpson C, Janiukstyte V, Horsley J, Leiberg K, Little B, Clifford H, Adler S, Vos SB, Winston GP, McEvoy AW, Miserocchi A, de Tisi J, Duncan JS. The Imaging Database for Epilepsy And Surgery (IDEAS). Epilepsia 2025, 66(2), 471-481.
  • Hall GR, Gascoigne SJ, Horsley JJ, Wang Y, Kozma C, De Tisi J, Vos SB, Winston GP, Duncan JS, Taylor PN. Superficial and deep white matter abnormalities in temporal lobe epilepsy. Brain Communications 2025, 7(5), fcaf305.
  • Horsley J, Hall G, Simpson C, Kozma C, Thomas R, Wang Y, de Tisi J, Miserocchi A, McEvoy A, Vos S, Winston G, Duncan J, Taylor PN. Seizure freedom after surgical resection of diffusion-weighted magnetic resonance imaging abnormalities. Epilepsia 2025, 66(9), 3480-3490.
  • Leiberg K, Blattner T, Little B, Mello VBB, de Moraes FHP, Rummel C, Taylor PN, Mota B, Wang Y. Multiscale cortical morphometry reveals pronounced regional and scale-dependent variations across the lifespan. Cerebral Cortex 2025, 35(6), bhaf154.
  • Woodhouse H, Hall G, Simpson C, Kozma C, Turner F, Schroeder GM, Diehl B, Duncan JS, Mo J, Zhang K, Chari A, Tisdall M, Moeller F, Petkov C, Howard MA, Ibrahim GM, Donner E, Warsi NM, Ahmed R, Taylor PN, Wang Y. Multi-centre normative brain mapping of intracranial EEG lifespan patterns in the human brain. Brain Structure and Function 2025, 230(7), 138.
  • Smith BC, Thornton C, Stirling RE, Besne GM, Gascoigne SJ, Evans N, Taylor PN, Leiberg K, Karoly PJ, Wang Y. More variable circadian rhythms in epilepsy captured by long-term heart rate recordings from wearable sensors. Epilepsia 2025, 66(8), 2754-2765.
  • Ding T, Nye TMW, Wang Y. Manifold-valued models for analysis of EEG time series data. Computational Statistics and Data Analysis 2025, 209, 108168.
  • Clifford HJ, Fenske S, Horsley J, Simpson C, Evans N, Wang Y, da Silva Costa T, Thomas RH, Iqbal S, Elliott CA, Duncan JS, Taylor PN. Hippocampal abnormality and response to vagus nerve stimulation in epilepsy. Epilepsia 2025, 66(12), e268-e275.
  • Woodhouse H, Gascoigne SJ, Hall G, Simpson C, Evans N, Schroeder GM, Taylor PN, Wang Y. From Bedside to Desktop: A Data Protocol for Normative Intracranial EEG and Abnormality Mapping. Bio-protocol 2025, 15(10), e5321.
  • Simpson C, Horsley Jonathan, Janiukstyte V, Tisi J, Miserocchi A, McEvoy A, Wang Y, Duncan J, Taylor P. Do Larger Resections Cut It? Relating Temporal Lobe Epilepsy Surgery and Seizure Outcome. In: 47th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2025). 2025, Copenhagen, Denmark: IEEE.
  • Kozma C, Horsley J, Hall G, Simpson C, de Tisi J, Miserocchi A, McEvoy AW, Vos SB, Winston GP, Wang Y, Duncan JS, Taylor PN. Combined impact of gray and superficial white matter abnormalities: Implications for epilepsy surgery. Epilepsia 2025, 66(10), 3688-3699.
  • Little B, Alyas N, Surtees A, Winston GP, Duncan JS, Cousins DA, Taylor J-P, Taylor P, Leiberg K, Wang Y. Brain morphology normative modelling platform for abnormality and centile estimation: Brain MoNoCle. Imaging Neuroscience 2025, 3, imag_a_00438.
  • Simpson C, Hall G, Duncan JS, Wang Y, Taylor PN. Automated generation of epilepsy surgery resection masks: The RAMPS pipeline. Imaging Neuroscience 2025, 3, IMAG.a.147.
  • Besne GM, Evans N, Panagiotopoulou M, Smith B, Chowdhury FA, Diehl B, Duncan JS, McEvoy AW, Miserocchi A, de Tisi J, Walker MC, Taylor PN, Thornton C, Wang Y. Anti-seizure medication tapering correlates with daytime delta band power reduction in the cortex. Brain Communications 2025, 7(1), fcaf020.
  • Horsley J, Wang Y, Simpson C, Janiukstyte V, Leiberg K, Little B, de Tisi J, Duncan J, Taylor PN. Status epilepticus and thinning of the entorhinal cortex. Epilepsy and Behavior 2024, 160, 110016.
  • Wang Y, Leiberg K, Kindred N, Madan CR, Poirier C, Petkov CI, Taylor PN, Mota B. Neuro-evolutionary evidence for a universal fractal primate brain shape. eLife 2024, 12, RP92080.
  • Little B, Flowers C, Blamire AM, Thelwall PE, Taylor JP, Gallagher P, Cousins DA, Wang Y. Multivariate brain-cognition associations in euthymic bipolar disorder. Bipolar Disorders 2024, 26(6), 604-616.
  • Gascoigne SJ, Evans N, Hall G, Kozma C, Panagiotopoulou M, Schroeder GM, Simpson C, Thornton C, Turner F, Woodhouse H, Blickwedel J, Chowdhury F, Diehl B, Duncan JS, Faulder R, Thomas RH, Wilson K, Taylor PN, Wang Y. Incomplete resection of the intracranial electroencephalographic seizure onset zone is not associated with postsurgical outcomes. Epilepsia 2024, 65(9), e163-e169.
  • Kozma C, Schroeder G, Owen T, de Tisi J, McEvoy AW, Miserocchi A, Duncan J, Wang Y, Taylor PN. Identifying epileptogenic abnormality by decomposing intracranial EEG and MEG power spectra. Journal of Neuroscience Methods 2024, 408, 110180.
  • Thornton C, Panagiotopoulou M, Chowdhury FA, Diehl B, Duncan JS, Gascoigne SJ, Besne G, McEvoy AW, Miserocchi A, Smith BC, de Tisi J, Taylor PN, Wang Y. Diminished circadian and ultradian rhythms of human brain activity in pathological tissue in vivo. Nature Communications 2024, 15, 8527.
  • Janiukstyte V, Kozma C, Owen TW, Chaudhary UJ, Diehl B, Lemieux L, Duncan JS, Rugg-Gunn F, De Tisi J, Wang Y, Taylor PN. Alpha rhythm slowing in temporal lobe epilepsy across scalp EEG and MEG. Brain Communications 2024, 6(6), fcae439.
  • Wang Y, Schroeder GM, Horsley JJ, Panagiotopoulou M, Chowdhury FA, Diehl B, Duncan JS, McEvoy AW, Miserocchi A, de Tisi J, Taylor PN. Temporal stability of intracranial electroencephalographic abnormality maps for localizing epileptogenic tissue. Epilepsia 2023, 64(8), 2070-2080.
  • Ramantani G, Westover MB, Gliske S, Sarnthein J, Sarma S, Wang Y, Baud MO, Stacey WC, Conrad EC. Passive and active markers of cortical excitability in epilepsy. Epilepsia 2023, 64(S3), S25-S36.
  • Owen TW, Schroeder GM, Janiukstyte V, Hall GR, McEvoy A, Miserocchi A, de Tisi J, Duncan JS, Rugg-Gunn F, Wang Y, Taylor PN. MEG abnormalities and mechanisms of surgical failure in neocortical epilepsy. Epilepsia 2023, 64(3), 692-704.
  • Owen TW, Janiukstyte V, Hall GR, Chowdhury FA, Diehl B, McEvoy A, Miserocchi A, de Tisi J, Duncan JS, Rugg-Gunn F, Wang Y, Taylor PN. Interictal magnetoencephalography abnormalities to guide intracranial electrode implantation and predict surgical outcome. Brain Communications 2023, 5(6).
  • Hall GR, Hutchings F, Horsley J, Simpson CM, Wang Y, de Tisi J, Miserocchi A, McEvoy AW, Vos SB, Winston GP, Duncan JS, Taylor PN. Epileptogenic networks in extra temporal lobe epilepsy. Network Neuroscience 2023, 7(4), 1351-1362.
  • Leiberg K, de Tisi J, Duncan JS, Little B, Taylor PN, Vos SB, Winston GP, Mota B, Wang Y. Effects of anterior temporal lobe resection on cortical morphology. Cortex 2023, 166, 233-242.
  • Horsley JJ, Thomas RH, Chowdhury FA, Diehl B, McEvoy AW, Miserocchi A, de Tisi J, Vos SB, Walker MC, Winston GP, Duncan JS, Wang Y, Taylor PN. Complementary structural and functional abnormalities to localise epileptogenic tissue. eBioMedicine 2023, 97, 104848.
  • Zaaimi B, Turnbull M, Hazra A, Wang Y, Gandara C, McLeod F, McDermott EE, Escobedo-Cousin E, Idil AS, Bailey RG, Tardio S, Patel A, Ponon N, Gausden J, Walsh D, Hutchings F, Kaiser M, Cunningham MO, Clowry GJ, LeBeau FEN, Constandinou TG, Baker SN, Donaldson N, Degenaar P, O'Neill A, Trevelyan AJ, Jackson A. Closed-loop optogenetic control of the dynamics of neural activity in non-human primates. Nature Biomedical Engineering 2023, 7, 559-575.
  • Zaaimi B, Turnbull M, Hazra A, Wang Y, Gandara C, McLeod F, McDermott EE, Escobedo-Cousin E, Shah Idil A, Bailey RG, Tardio S, Patel A, Ponon N, Walsh D, Hutchings F, Kaiser M, Cunningham MO, Clowry GJ, LeBeau FEN, Constandinou TG, Baker SN, Donaldson N, Degenaar P, O'Neill A, Trevelyan AJ, Jackson A. Closed-loop optogenetic control of the dynamics of neural activity in non-human primates. Nature Biomedical Engineering 2023, 7, 559-575.
  • Schroeder GM, Karoly PJ, Maturana M, Panagiotopoulou M, Taylor PN, Cook MJ, Wang Y. Chronic intracranial EEG recordings and interictal spike rate reveal multiscale temporal modulations in seizure states. Brain Communications 2023, 5(5), fcad205.
  • Kindred N, Carella S, van der Heuvel MP, Balezeau F, Wang Y, Poirier C. AutoMacq: an automatic pipeline to analyse macaque structural MRI data. bioRXiv 2023.
  • Jiruska P, Freestone D, Gnatkovsky V, Wang Y. An update on the seizures beget seizures theory. Epilepsia 2023, 64(S3), S13-S14.
  • Gascoigne SJ, Waldmann L, Schroeder GM, Panagiotopoulou M, Blickwedel J, Chowdhury F, Cronie A, Diehl B, Duncan JS, Falconer J, Faulder R, Guan Y, Leach V, Livingstone S, Papasavvas C, Thomas RH, Wilson K, Taylor PN, Wang Y. A library of quantitative markers of seizure severity. Epilepsia 2023, 64(4), 1074-1086.
  • Horsley JJ, Schroeder GM, Thomas RH, de Tisi J, Vos SB, Winston GP, Duncan JS, Wang Y, Taylor PN. Volumetric and structural connectivity abnormalities co-localise in TLE. NeuroImage: Clinical 2022, 35, 103105.
  • Taylor PN, Papasavvas CA, Owen TW, Schroeder GM, Hutchings FE, Chowdhury FA, Diehl B, Duncan JS, McEvoy AW, Miserocchi A, De Tisi J, Vos SB, Walker MC, Wang Y. Normative brain mapping of interictal intracranial EEG to localize epileptogenic tissue. Brain 2022, 145(3), 939-949.
  • Schroeder GM, Chowdhury FA, Cook MJ, Diehl B, Duncan JS, Karoly PJ, Taylor PN, Wang Y. Multiple mechanisms shape the relationship between pathway and duration of focal seizures. Brain Communications 2022, 4(4), fcac173.
  • Papasavvas C, Taylor PN, Wang Y. Long-term changes in functional connectivity improve prediction of responses to intracranial stimulation of the human brain. Journal of Neural Engineering 2022, 19(2), 026006.
  • Sinha N, Wang Y, da Silva NM, Miserocchi A, McEvoy AW, de Tisi J, Vos SB, Winston GP, Duncan JS, Taylor PN. Structural brain network abnormalities and the probability of seizure recurrence after epilepsy surgery. Neurology 2021, 96(5), e758-e771.
  • Owen TW, de Tisi J, Vos SB, Winston GP, Duncan JS, Wang Y, Taylor PN. Multivariate white matter alterations are associated with epilepsy duration. European Journal of Neuroscience 2021, 53(8), 2788-2803.
  • Wang Y, Leiberg K, Ludwig T, Little B, Necus JH, Winston G, Vos SB, Tisi JD, Duncan JS, Taylor PN, Mota B. Independent components of human brain morphology. NeuroImage 2021, 226, 117546.
  • Sinha N, Peternell N, Schroeder GM, de Tisi J, Vos SB, Winston GP, Duncan JS, Wang Y, Taylor PN. Focal to bilateral tonic–clonic seizures are associated with widespread network abnormality in temporal lobe epilepsy. Epilepsia 2021, 62(3), 729-741.
  • Ramaraju S, Reichert S, Wang Y, Forsyth R, Taylor PN. Carbogen inhalation during Non-Convulsive Status Epilepticus: A quantitative exploratory analysis of EEG recordings. PLoS one 2021, 16(2), e0240507.
  • Schroeder GM, Diehl B, Chowdhury FA, Duncan JS, de Tisi J, Trevelyan A, Forsyth R, Jackson A, Taylor PN, Wang Y. Seizure pathways change on circadian and slower timescales in individual patients with focal epilepsy. Proceedings of the National Academy of Sciences of the United States of America 2020, 117(20), 11048-11058.
  • Ramaraju S, Wang Y, Sinha N, McEvoy AW, Miserocchi A, de Tisi J, Duncan JS, Rugg-Gunn F, Taylor PN. Removal of Interictal MEG-Derived Network Hubs Is Associated With Postoperative Seizure Freedom. Frontiers in Neurology 2020, 11, 563847.
  • Carmon J, Heege J, Necus JH, Owen TW, Pipa G, Kaiser M, Taylor PN, Wang Y. Reliability and comparability of human brain structural covariance networks. NeuroImage 2020, 220, 117104.
  • Wang Y, Sinha N, Schroeder GM, Ramaraju S, McEvoy AW, Miserocchi A, de Tisi J, Chowdhury FA, Diehl B, Duncan JS, Taylor PN. Interictal intracranial electroencephalography for predicting surgical success: The importance of space and time. Epilepsia 2020, 61(7), 1417-1426.
  • Papasavvas CA, Trevelyan AJ, Kaiser M, Wang Y. Divisive gain modulation enables flexible and rapid entrainment in a neocortical microcircuit model. Journal of Neurophysiology 2020, 123(3), 1133-1143.
  • Papasavvas CA, Schroeder GM, Diehl B, Baier G, Taylor PN, Wang Y. Band power modulation through intracranial EEG stimulation and its cross-session consistency. Journal of Neural Engineering 2020, 17(5), 054001.
  • Necus J, Sinha N, Smith FE, Thelwall PE, Flowers CJ, Taylor PN, Blamire AM, Cousins DA, Wang Y. White matter microstructural properties in bipolar disorder in relationship to the spatial distribution of lithium in the brain. Journal of Affective Disorders 2019, 253, 224-231.
  • Necus J, Smith FE, Thelwall PE, Flowers CJ, Sinha N, Taylor PN, Blamire AM, Wang Y, Cousins DA. Quantification of brain proton longitudinal relaxation (T₁) in lithium‐treated and lithium‐naïve patients with bipolar disorder in comparison to healthy controls. Bipolar Disorders 2019, 23(1), 41-48.
  • Wang Y, Necus J, Peraza Rodriguez L, Taylor PN, Mota B. Human cortical folding across regions within individual brains follows universal scaling law. Communications Biology 2019, 2, 191.
  • Taylor PN, da Silva NM, Blamire A, Wang Y, Forsyth RJ. Early deviation from normal structural connectivity: A novel intrinsic severity score for mild TBI. Neurology 2019, 94(10), e1021-e1026.
  • Sinha N, Wang Y, Dauwels J, Kaiser M, Thesene T, Forsyth R, Taylor PN. Computer modelling of connectivity change suggests epileptogenesis mechanisms in idiopathic generalised epilepsy. NeuroImage: Clinical 2019, 21, 101655.
  • Uddin M, Wang Y, Woodbury-Smith MR. Artificial intelligence for precision medicine in neurodevelopmental disorders. npj Digital Medicine 2019, 2, 112.
  • Taylor PN, Sinha N, Wang Y, Vos SB, deTisi J, Miserocchi A, McEvoy AW, Winston GP, Duncan JS. The impact of epilepsy surgery on the structural connectome and its relation to outcome. NeuroImage: Clinical 2018, 18, 202-214.
  • França LGS, Miranda JGV, Leite M, Sharma NK, Walker MC, Lemieux L, Wang Y. Fractal and Multifractal Properties of Electrographic Recordings of Human Brain Activity: Toward Its Use as a Signal Feature for Machine Learning in Clinical Applications. Frontiers in Physiology 2018, 9, 1767.
  • Taylor PN, Wang Y, Kaiser M. Within brain area tractography suggests local modularity using high resolution connectomics. Scientific Reports 2017, 7, 39859.
  • Baier G, Taylor PN, Wang Y. Understanding Epileptiform After-Discharges as Rhythmic Oscillatory Transients. Frontiers in Computational Neuroscience 2017, 11, 25.
  • Sinha N, Dauwels J, Kaiser M, Cash SS, Westover MB, Wang Y, Taylor PN. Predicting neurosurgical outcomes in focal epilepsy patients using computational modelling. Brain 2017, 140(2), 319-332.
  • Wang Y, Trevelyan AJ, Valentin A, Alarcon G, Taylor PN, Kaiser M. Mechanisms underlying different onset patterns of focal seizures. PLoS Computational Biology 2017, 13(5), e1005475.
  • Wang Y, Necus J, Kaiser M, Mota B. Universality in human cortical folding in health and disease. Proceedings of the National Academy of Sciences of the USA 2016, 113(45), 12820-12825.
  • Papasavvas CA, Wang Y, Trevelyan AJ, Kaiser M. Gain control through divisive inhibition prevents abrupt transition to chaos in a neural mass model. Physical Review E 2015, 92(3), 032723.
  • Wang Y, Goodfellow M, Taylor PN, Baier G. Dynamic Mechanisms of Neocortical Focal Seizure Onset. PLoS Computational Biology 2014, 10(8), e1003787.
  • Taylor PN, Wang Y, Goodfellow M, Dauwels J, Moeller F, Stephani U, Baier G. A Computational Study of Stimulus Driven Epileptic Seizure Abatement. PLoS ONE 2014, 9(12), e114316.
  • Taylor PN, Goodfellow M, Wang Y, Baier G. Towards a large-scale model of patient-specific epileptic spike-wave discharges. Biological Cybernetics 2013, 107(1), 83-94.
  • Baier G, Goodfellow M, Taylor PN, Wang Y, Garry DJ. The importance of modeling epileptic seizure dynamics as spatio-temporal patterns. Frontiers in Physiology 2012, 3, 281.
  • Wang Y, Goodfellow M, Taylor PN, Baier G. Phase space approach for modeling of epileptic dynamics. Physical Review E 2012, 85(6), 061918.
  • Goodfellow M, Taylor PN, Wang Y, Garry DJ, Baier G. Modelling the role of tissue heterogeneity in epileptic rhythms. European Journal of Neuroscience 2012, 36(2), 2178-2187.

• Book Chapters

  • Baier G, Rosch R, Taylor PN, Wang Y. Design principle for a population-based model of epileptic dynamics. In: Complexity and Synergetics. Berlin: Springer International Publishing, 2017, pp.333-347.
  • Wang Y, Goodfellow M, Taylor PN, Garry D, Baier G. Computational modelling of microseizures and focal seizure onset. In: Recent Advances in Predicting and Preventing Epileptic Seizures. 2013.

• Conference Proceedings (inc. Abstracts)

  • Little B, Cousins D, Wang Y, Gallagher P. The Effect of Core Cognitive Dysfunction on Memory in People with Mood Disorders. In: Annual Mid-Year Meeting of the International Neuropsychological Society. 2022, Barcelona, Spain: INS.
  • Little B, Anwyll M, Norsworthy L, Corbett L, Schultz-Froggatt M, Cousins D, Wang Y, Gallagher P. Processing speed and sustained attention in mood disorders: A systematic review and meta-analysis. In: The 24th Annual Conference of the International Society for Bipolar Disorders. 2022, (virtual): John Wiley & Sons Ltd.
  • Little B, Gallagher P, Cousins D, Wang Y. Investigating brain-cognition associations in Bipolar Disorder using Canonical Correlation Analysis (CCA). In: Organization for Human Brain Mapping Annual Meeting. 2022, Glasgow, UK: OHBM.
  • Cousins D, Smith F, Necus J, Thelwall P, Flowers C, Taylor P, Sinha N, Wang YJ, Blamire A. Imaging the distribution and effects of lithium in the brain in bipolar disorder. In: 73rd Annual Meeting of the Society of Biological Chemistry. 2018, New York: Elsevier.
  • Sinha N, Dauwels J, Wang Y, Cash SS, Taylor PN. An in silico approach for pre-surgical evaluation of an epileptic cortex. In: 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). 2014, Chicago, IL, USA: IEEE.
  • Wang Y, Taylor PN, Baier G. Computational modelling of micro-seizures and focal seizure onset. In: Twenty Second Annual Computational Neuroscience Meeting: CNS*2013. 2013, Paris, France: BioMed Central.
  • Taylor PN, Baier G, Cash SS, Dauwels J, Slotine JJ, Wang Y. A model of stimulus induced epileptic spike-wave discharges. In: IEEE Computational Intelligence, Cognitive Algorithms, Mind, and Brain (CCMB). 2013, Singapore: IEEE.

• Letter

  • Sinha N, Dauwels J, Kaiser M, Cash SS, Westover BM, Wang Y, Taylor PN. Reply: Computer models to inform epilepsy surgery strategies: Prediction of postoperative outcome. Brain 2017, 140(5), e31.

• Reviews

  • Clifford HJ, Paranathala MP, Wang Y, Thomas RH, da SilvaCosta T, Duncan JS, Taylor PN. Vagus nerve stimulation for epilepsy: A narrative review of factors predictive of response. Epilepsia 2024, 65(12), 3441-3456.
  • Wang YJ, Hutchings F, Kaiser M. Computational modeling of neurostimulation in brain diseases. Progress in Brain Research 2015, 222, 191-228.