Staff Profile
Dr Peter Taylor
UKRI Future Leaders Fellow
- Email: peter.taylor@ncl.ac.uk
- Personal Website: www.cnnp-lab.com
- Address: School of Computing,
Room 5.016, Urban Sciences Building,
Science Central,
Newcastle University,
Newcastle upon Tyne,
NE5 5TG
Background
Introduction
I trained in computer science and software engineering before doing a masters degree in computational molecular biology in Manchester. I completed my PhD in 2013, studying dynamical systems theory and computational modelling in epilepsy with Gerold Baier. I have since undertaken postdoctoral work at NTU Singapore, MGH Boston, and in Newcastle before starting a faculty fellowship in Newcastle in 2015. I began an open-ended lectureship in in 2018 and secured a UKRI Future Leaders Fellowship in 2020. I have also held an honorary position at University College London since 2016. I am Associate Editor at PLoS Computational Biology.
Research
My research is focused on using computational methods to understand brain function and in the case of disease, brain dysfunction. I use methods from mathematical modelling, dynamical systems and graph theory to investigate complex brain network dynamics. I use functional data such as EEG, MEG and fMRI in addition to structural data derived from MRI and diffusion MRI.
Primarily I work on epilepsy and traumatic brain injury.
Environment
I am based in the School of Computing Science, in the Interdisciplinary Computing and Complex BioSystems (ICOS) group and I co-lead the CNNP Lab.
Links
Area of expertise: Computer modelling, Neuroimaging, Complex networks, EEG, Epilepsy, Brain injury
Research
Primarily I work on epilepsy and traumatic brain injury.
Research
My research is focused on using computational methods to understand brain function and in the case of disease, brain dysfunction. I use methods from mathematical modelling, dynamical systems and graph theory to investigate complex brain network dynamics. I use functional data such as EEG, MEG and fMRI in addition to structural data derived from MRI and diffusion MRI.Primarily I work on epilepsy and traumatic brain injury.
Publications
- Sinha N, Peternell N, Schroeder GM, de Tisi J, Vos SB, Winston GP, Duncan JS, Wang Y, Taylor PN. Focal to bilateral tonic–clonic seizures are associated with widespread network abnormality in temporal lobe epilepsy. Epilepsia 2021, 62(3), 729-741.
- Wang Y, Leiberg K, Ludwig T, Little B, Necus JH, Winston G, Vos SB, Tisi JD, Duncan JS, Taylor PN, Mota B. Independent components of human brain morphology. NeuroImage 2021, 226, 117546.
- Sinha N, Wang Y, da Silva NM, Miserocchi A, McEvoy AW, de Tisi J, Vos SB, Winston GP, Duncan JS, Taylor PN. Structural brain network abnormalities and the probability of seizure recurrence after epilepsy surgery. Neurology 2021, 96(5), e758-e771.
- Kreilkamp BAK, McKavanagh A, Alonazi B, Bryant L, Das K, Wieshmann UC, Marson AG, Taylor PN, Keller SS. Altered structural connectome in non-lesional newly diagnosed focal epilepsy: Relation to pharmacoresistance. NeuroImage: Clinical 2021, 29, 102564.
- Ramaraju S, Reichert S, Wang Y, Forsyth R, Taylor PN. Carbogen inhalation during Non-Convulsive Status Epilepticus: A quantitative exploratory analysis of EEG recordings. PLoS one 2021, 16(2), e0240507.
- Ramaraju S, Wang Y, Sinha N, McEvoy AW, Miserocchi A, de Tisi J, Duncan JS, Rugg-Gunn F, Taylor PN. Removal of Interictal MEG-Derived Network Hubs Is Associated With Postoperative Seizure Freedom. Frontiers in Neurology 2020, 11, 563847.
- Schroeder GM, Diehl B, Chowdhury FA, Duncan JS, de Tisi J, Trevelyan A, Forsyth R, Jackson A, Taylor PN, Wang Y. Seizure pathways change on circadian and slower timescales in individual patients with focal epilepsy. Proceedings of the National Academy of Sciences of the United States of America 2020, 117(20), 11048-11058.
- Wang Y, Sinha N, Schroeder GM, Ramaraju S, McEvoy AW, Miserocchi A, de Tisi J, Chowdhury FA, Diehl B, Duncan JS, Taylor PN. Interictal intracranial electroencephalography for predicting surgical success: The importance of space and time. Epilepsia 2020, 61(7), 1417-1426.
- da Silva NM, Forsyth R, McEvoy AW, Miserocchi A, de Tisi J, Vos S, Winston G, Duncan J, Wang Y, Taylor PN. Network reorganisation following anterior temporal lobe resection and relation with post-surgery seizure relapse: a longitudinal study. Neuroimage: Clinical 2020, 27, 102320.
- Hatton SN, Huynh KH, Bonilha L, Abela E, Alhusaini S, Altmann A, Alvim MKM, Balachandra AR, Bartolini E, Bender B, Bernasconi N, Bernasconi A, Bernhardt B, Bargallo N, Caldairou B, Caligiuri ME, Carr SJA, Cavalleri GL, Cendes F, Concha L, Davoodi-bojd E, Desmond PM, Devinsky O, Doherty CP, Domin M, Duncan JS, Focke NK, Foley SF, Gambardella A, Gleichgerrcht E, Guerrini R, Hamandi K, Ishikawa A, Keller SS, Kochunov PV, Kotikalapudi R, Kreilkamp BAK, Kwan P, Labate A, Langner S, Lenge M, Liu M, Lui E, Martin P, Mascalchi M, Moreira JCV, Morita-Sherman ME, O’Brien TJ, Pardoe HR, Pariente JC, Ribeiro LF, Richardson MP, Rocha CS, Rodríguez-Cruces R, Rosenow F, Severino M, Sinclair B, Soltanian-Zadeh H, Striano P, Taylor PN, Thomas RH, Tortora D, Velakoulis D, Vezzani A, Vivash L, Podewils FV, Vos SB, Weber B, Winston GP, Yasuda CL, Zhu AH, Thompson PM, Whelan CD, Jahanshad N, Sisodiya SM, McDonald CR. White matter abnormalities across different epilepsy syndromes in adults: an ENIGMA-Epilepsy study. Brain 2020, 143(8), 2454–2473.
- Sisodiya SM, Whelan CD, Hatton SN, Huynh K, Altmann A, Ryten M, Vezzani A, Caligiuri ME, Labate A, Gambardella A, Ives-Deliperi V, Meletti S, Munsell BC, Bonilha L, Tondelli M, Rebsamen M, Rummel C, Vaudano AE, Wiest R, Balachandra AR, Bargallo N, Bartolini E, Bernasconi A, Bernasconi N, Bernhardt B, Caldairou B, Carr SJA, Cavalleri GL, Cendes F, Concha L, Desmond PM, Domin M, Duncan JS, Focke NK, Guerrini R, Hamandi K, Jackson GD, Jahanshad N, Kalviainen R, Keller SS, Kochunov P, Kowalczyk MA, Kreilkamp BAK, Kwan P, Lariviere S, Lenge M, Lopez SM, Martin P, Mascalchi M, Moreira JCV, Morita-Sherman ME, Pardoe HR, Pariente JC, Raviteja K, Rocha CS, Rodriguez-Cruces R, Seeck M, Semmelroch MKHG, Sinclair B, Soltanian-Zadeh H, Stein DJ, Striano P, Taylor PN, Thomas RH, Thomopoulos SI, Velakoulis D, Vivash L, Weber B, Yasuda CL, Zhang J, Thompson PM, McDonald CR. The ENIGMA-Epilepsy working group: Mapping disease from large data sets. Human Brain Mapping 2022, 43(1), 113-128.
- Carmon J, Heege J, Necus JH, Owen TW, Pipa G, Kaiser M, Taylor PN, Wang Y. Reliability and comparability of human brain structural covariance networks. NeuroImage 2020, 220, 117104.
- da Silva NM, Cowie C, Blamire AM, Forsyth R, Taylor PN. Investigating brain network changes and their association with cognitive recovery after Traumatic Brain Injury: a longitudinal analysis. Frontiers Neurology 2020, 11, 369.
- Papasavvas CA, Schroeder GM, Diehl B, Baier G, Taylor PN, Wang Y. Band power modulation through intracranial EEG stimulation and its cross-session consistency. Journal of Neural Engineering 2020, 17(5), 054001.
- Sinha N, Wang Y, Dauwels J, Kaiser M, Thesene T, Forsyth R, Taylor PN. Computer modelling of connectivity change suggests epileptogenesis mechanisms in idiopathic generalised epilepsy. NeuroImage: Clinical 2019, 21, 101655.
- Taylor PN, da Silva NM, Blamire A, Wang Y, Forsyth RJ. Early deviation from normal structural connectivity: A novel intrinsic severity score for mild TBI. Neurology 2019, 94(10), e1021-e1026.
- Wang Y, Necus J, Peraza Rodriguez L, Taylor PN, Mota B. Human cortical folding across regions within individual brains follows universal scaling law. Communications Biology 2019, 2, 191.
- Necus J, Sinha N, Smith FE, Thelwall PE, Flowers CJ, Taylor PN, Blamire AM, Cousins DA, Wang Y. White matter microstructural properties in bipolar disorder in relationship to the spatial distribution of lithium in the brain. Journal of Affective Disorders 2019, 253, 224-231.
- Necus J, Smith FE, Thelwall PE, Flowers CJ, Sinha N, Taylor PN, Blamire AM, Wang Y, Cousins DA. Quantification of brain proton longitudinal relaxation (T1) in lithium‐treated and lithium‐naïve patients with bipolar disorder in comparison to healthy controls. Bipolar Disorders 2019, 23(1), 41-48.
- Taylor PN, Sinha N, Wang Y, Vos SB, deTisi J, Miserocchi A, McEvoy AW, Winston GP, Duncan JS. The impact of epilepsy surgery on the structural connectome and its relation to outcome. NeuroImage: Clinical 2018, 18, 202-214.
- Baier G, Taylor PN, Wang Y. Understanding Epileptiform After-Discharges as Rhythmic Oscillatory Transients. Frontiers in Computational Neuroscience 2017, 11, 25.
- Wang Y, Trevelyan AJ, Valentin A, Alarcon G, Taylor PN, Kaiser M. Mechanisms underlying different onset patterns of focal seizures. PLoS Computational Biology 2017, 13(5), e1005475.
- Taylor PN, Wang Y, Kaiser M. Within brain area tractography suggests local modularity using high resolution connectomics. Scientific Reports 2017, 7, 39859.
- Sinha N, Dauwels J, Kaiser M, Cash SS, Westover BM, Wang Y, Taylor PN. Reply: Computer models to inform epilepsy surgery strategies: Prediction of postoperative outcome. Brain 2017, 140(5), e31.
- Sinha N, Dauwels J, Kaiser M, Cash SS, Westover MB, Wang Y, Taylor PN. Predicting neurosurgical outcomes in focal epilepsy patients using computational modelling. Brain 2017, 140(2), 319-332.
- Baier G, Rosch R, Taylor PN, Wang Y. Design principle for a population-based model of epileptic dynamics. In: Complexity and Synergetics. Berlin: Springer International Publishing, 2017, pp.333-347.
- Taylor PN, Forsyth R. Heterogeneity of trans-callosal structural connectivity and effects on resting state subnetwork integrity may underlie both wanted and unwanted effects of therapeutic corpus callostomy. NeuroImage: Clinical 2016, 12, 341-347.
- Hutchings F, Han CE, Keller SS, Weber B, Taylor PN, Kaiser M. Predicting Surgery Targets in Temporal Lobe Epilepsy through Structural Connectome Based Simulations. PLoS Computational Biology 2015, 11(12), e1004642.
- Basu A, Taylor PN, Lowther E, Forsyth EO, Blamire A, Forsyth R. Structural connectivity in a paediatric case of anarchic hand syndrome. BMC Neurology 2015, 15, 234.
- Taylor PN, Thomas J, Sinha N, Dauwels J, Kaiser M, Thesen T, Ruths J. Optimal control based seizure abatement using patient derived connectivity. Frontiers in Neuroscience 2015, 9, 202.
- Taylor PN, Han CE, Schoene-Bake J-C, Weber B, Kaiser M. Structural connectivity changes in temporal lobe epilepsy: Spatial features contribute more than topological measures. NeuroImage: Clinical 2015, 8, 322-328.
- Taylor PN, Wang Y, Goodfellow M, Dauwels J, Moeller F, Stephani U, Baier G. A Computational Study of Stimulus Driven Epileptic Seizure Abatement. PLoS ONE 2014, 9(12), e114316.
- Taylor PN, Kaiser M, Dauwels J. Structural connectivity based whole brain modelling in epilepsy. Journal of Neuroscience Methods 2014, 236, 51-57.
- Sinha N, Dauwels J, Wang Y, Cash SS, Taylor PN. An in silico approach for pre-surgical evaluation of an epileptic cortex. In: 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). 2014, Chicago, IL, USA: IEEE.
- Wang Y, Goodfellow M, Taylor PN, Baier G. Dynamic Mechanisms of Neocortical Focal Seizure Onset. PLoS Computational Biology 2014, 10(8), e1003787.
- Taylor PN, Goodfellow M, Wang Y, Baier G. Towards a large-scale model of patient-specific epileptic spike-wave discharges. Biological Cybernetics 2013, 107(1), 83-94.
- Sinha N, Taylor PN, Dauwels J, Ruths J. Development of optimal stimuli in a heterogeneous model of epileptic spike-wave oscillations. In: IEEE International Conference on Systems, Man and Cybernetics (SMC). 2014, San Diego, CA, USA: IEEE.
- Taylor PN, Baier G, Cash SS, Dauwels J, Slotine JJ, Wang Y. A model of stimulus induced epileptic spike-wave discharges. In: IEEE Computational Intelligence, Cognitive Algorithms, Mind, and Brain (CCMB). 2013, Singapore: IEEE.
- Goodfellow M, Taylor PN, Wang Y, Garry DJ, Baier G. Modelling the role of tissue heterogeneity in epileptic rhythms. European Journal of Neuroscience 2012, 36(2), 2178-2187.
- Wang Y, Goodfellow M, Taylor PN, Baier G. Phase space approach for modeling of epileptic dynamics. Physical Review E 2012, 85(6), 061918.
- Geenen S, Taylor PN, Snoep JL, Wilson ID, Kenna JG, Westerhoff HV. Systems biology tools for toxicology. Archives of Toxicology 2012, 86(8), 1251-1271.
- Baier G, Goodfellow M, Taylor PN, Wang Y, Garry DJ. The importance of modeling epileptic seizure dynamics as spatio-temporal patterns. Frontiers in Physiology 2012, 3, 281.
- Taylor PN, Baier G. A spatially extended model for macroscopic spike-wave discharges. Journal of Computational Neuroscience 2011, 31(3), 679-684.
- McKavanagh A, Kreilkamp AK, Chen Y, Denby C, Bracewell M, Das K, De Bezenac C, Marson AG, Taylor PN, Keller SS. Altered Structural Brain Networks in Refractory and Nonrefractory Idiopathic Generalized Epilepsy. Brain Connectivity 2022, 12(6), 549-560.
- Panagiotopoulou M, Papasavvas CA, Schroeder GM, Thomas RH, Taylor PN, Wang Y. Fluctuations in EEG band power at subject-specific timescales over minutes to days explain changes in seizure evolutions. Human Brain Mapping 2022, 43(8), 2460-2477.
- Papasavvas C, Taylor PN, Wang Y. Long-term changes in functional connectivity improve prediction of responses to intracranial stimulation of the human brain. Journal of Neural Engineering 2022, 19(2), 026006.
- Schroeder GM, Chowdhury FA, Cook MJ, Diehl B, Duncan JS, Karoly PJ, Taylor PN, Wang Y. Multiple mechanisms shape the relationship between pathway and duration of focal seizures. Brain Communications 2022, 4(4), fcac173.
- Taylor PN, Papasavvas CA, Owen TW, Schroeder GM, Hutchings FE, Chowdhury FA, Diehl B, Duncan JS, McEvoy AW, Miserocchi A, De Tisi J, Vos SB, Walker MC, Wang Y. Normative brain mapping of interictal intracranial EEG to localize epileptogenic tissue. Brain 2022, 145(3), 939-949.
- Horsley JJ, Schroeder GM, Thomas RH, de Tisi J, Vos SB, Winston GP, Duncan JS, Wang Y, Taylor PN. Volumetric and structural connectivity abnormalities co-localise in TLE. NeuroImage: Clinical 2022, 35, 103105.
- Gleichgerrcht E, Munsell BC, Alhusaini S, Alvim MKM, Bargalló N, Bender B, Bernasconi A, Bernasconi N, Bernhardt B, Blackmon K, Caligiuri ME, Cendes F, Concha L, Desmond PM, Devinsky O, Doherty CP, Domin M, Duncan JS, Focke NK, Gambardella A, Gong B, Guerrini R, Hatton SN, Kälviäinen R, Keller SS, Kochunov P, Kotikalapudi R, Kreilkamp BAK, Labate A, Langner S, Larivière S, Lenge M, Lui E, Martin P, Mascalchi M, Meletti S, O'Brien TJ, Pardoe HR, Pariente JC, Xian Rao J, Richardson MP, Rodríguez-Cruces R, Rüber T, Sinclair B, Soltanian-Zadeh H, Stein DJ, Striano P, Taylor PN, Thomas RH, Vaudano AE, Vivash L, von Podewills F, Vos SB, Weber B, Yao Y, Lin Yasuda C, Zhang J, Thompson PM, Sisodiya SM, McDonald CR, Bonilha L. Artificial intelligence for classification of temporal lobe epilepsy with ROI-level MRI data: A worldwide ENIGMA-Epilepsy study. Neuroimage: Clinical 2021, 31, 102765.
- Owen TW, de Tisi J, Vos SB, Winston GP, Duncan JS, Wang Y, Taylor PN. Multivariate white matter alterations are associated with epilepsy duration. European Journal of Neuroscience 2021, 53(8), 2788-2803.