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Chemistry Mass Spectrometry

We develop small molecule analysis methods to fit your needs.

The chemistry mass spectrometry laboratory was established in 2018, following investment of over £300k, to consolidate chemistry and chemical biology mass spectrometry capability into a single facility. We provide mass spectrometry analysis for isolated small organic and inorganic molecules (e.g. synthetic molecules, natural products, small peptides, drugs and drug precursors) as well as mixtures (e.g. reaction monitoring, biological metabolites).

Isolated small molecules can be studied directly by a range of mass spectrometry techniques. We have a suite of mass analysers that can provide rapid low resolution mass, high resolution accurate mass, elemental composition and structural information via fragmentation analysis (MSn).

Small molecule mixtures are typically analysed using liquid chromatography mass spectrometry (LC-MS), one of the most widespread and efficient analytical techniques for the separation and analysis of chemical mixtures. The chemistry mass spectrometry laboratory employs modern UPLC-MS methods for the separation and detection of compounds in a wide range complex chemical and biological samples.

Additional liquid chromatography instrumentation is also available capable of normal and reverse phase separations (analytical and semi-preparative) with UV/vis, diode array and fluorescence detectors.

Drawing on our expert mass spectrometry knowledge and access to a wide range of HPLC techniques, we are confident that we can develop small molecule analysis methods to fit your needs.


Our staff

  • Dr Alex Charlton, Senior Analytical Technician
  • Karina Scurupa Machado, Senior Analytical Technician

Contact us

To request a quote, or ask us a question, you can complete our analytical services general enquiry form below.

If you’re a Newcastle University staff member or student, you can visit the internal Research and Analytical Services' intranet page.