A biomarker is defined as a characteristic that is objectively measured and evaluated as an indicator of normal biological processes as well as pathogenic ones. Here is where our strength lies, translating biologically relevant markers in research at cell/tissue level onto markers that can be measured and confidently assessed in humans or animals through methodological validation so that these biomarkers can be applied to wider areas of research.

The biomarker measurements, as well as the sample processing we provide are, in the majority of the cases, outside the routine measurements performed by hospital clinical/biochemistry labs.

• Novel biomarkers: from cell culture to humans
• Novel sources of material: from humans to animals
• Methodological validation:
  • Detection limits, coefficients of variation
  • Dilutions, sensitivity
• Epidemiological scaling: From single sample to 384-well plates.
• Protein assays:
  • Serum/plasma/blood cells/culture supernatants
  • Sandwich ELISA, 96-well and 384-well plate capability
  • Oxidative Damage
  • Enzymatic activity (e.g. telomerase)
• RNA and Gene expression analysis:
  • RT-qPCR, 384-well capacity
  • TaqMan Gene expression assays
  • TaqMan MicroRNA assays
• DNA and Genotyping:
  • Genotyping of Mice from Ear Notches (agarose gels)
  • Genotyping by qPCR (inc. TaqMan™ Genotyping), ApoE, SNPs
  • Telomere length by qPCR