Current Events and Research Seminars

Monday 6 June 2022, Dr J. Bernadette Moore, University of Leeds

TEA AND COFFEE WILL BE AVAILABE FROM 1230HRS. PLEASE REGISTER YOUR ATTENDANCE HERE TO ASSIST WITH CATERING NUMBERS.

Speaker: Dr J. Bernadette Moore, Ph.D. Associate Professor of Obesity, Head of Graduate School, Faculty of Environment, University of Leeds, School of Food Science & Nutrition
Title of talk: "From NAFLD to MAFLD: New Directions in Fatty Liver Disease Research"

Venue: MED.David Shaw Lecture Theatre

Synopsis:
This seminar will introduce and give an overview of non-alcoholic fatty liver disease (NAFLD), which is now the most common of liver disease affecting an estimated 25-30% of adults and 10% of children in the UK and worldwide. In the context of dissecting the roles of genetics, obesity and dietary patterns in the development and progression of NAFLD, the rationale for both a name change to ‘metabolic associated fatty liver disease; MAFLD’, and a move to positive diagnostic criteria will be explained. Novel molecular mechanisms underpinning the beneficial effects of diet and exercise in NAFLD treatment will be highlighted. Specifically, separate new data suggesting roles for intrahepatic mucosal associated invariant T (MAIT) cells and vitamin D regulated miRNAs in NAFLD pathogenesis will be discussed.

Biography:
Dr J Bernadette Moore, Associate Professor of Obesity, University of Leeds. Dr Moore earned her Ph.D. in Nutritional Sciences from the University of Florida and subsequently earned the prestigious Christine Mirzayan Science Policy fellowship to the National Academy of Sciences in Washington DC where her interests in science policy and childhood obesity were fostered. Prior to her recruitment to the University of Leeds in 2016, Dr Moore was Senior Lecturer in Molecular Nutrition at the University of Surrey, where she had started her first laboratory in 2007. She is currently the Head of the Graduate School for the Faculty of Environment, which encompasses ~575 postgraduate researchers. Research in Dr Moore’s laboratory for the last ten years has been largely focused on the role of hepatic nutrient metabolism in healthy ageing, obesity and non-alcoholic fatty liver disease (NAFLD). To date, she has raised over 2.9 million pounds in research funding and been supported by the: BBSRC, EPSRC, Children’s Liver Disease Foundation, and the Universities of Surrey and Leeds. Her research employs a variety of genomic, proteomic, and systems biology tools alongside nutritional intervention studies. Current active strands include clinical and public health nutrition aspects related to dietary assessment and the prevention and management of NAFLD and obesity in children and adults. She has published >50 peer-reviewed papers, editorials and book chapters. Dr Moore was the recipient of the 2018 Nutrition Society Silver Medal for Research Excellence in a Young Investigator, and her work on the high sugar content of yogurts received significant international media interest, notably in the top 1% of ~20 million Altmetric tracked publications.

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