Newcastle Magnetic Resonance Centre

Brain Ageing

Brain Ageing Research

We are involved in studies of the ageing brain using advanced imaging methodology. These studies include a range of clinical conditions associated with brain ageing.

Brain ageing publications


  • Bohr I, McDonald C, He J, Kerr S, Newton JL, Blamire AM. Brain oxygenation responses to an autonomic challenge: a quantitative fMRI investigation of the Valsalva manoeuver. Age 2015 Oct;37(5):9833. doi: 10.1007/s11357-015-9833-6. Epub 2015 Aug 29. PMID: 26318855. In Press.
  • Parikh J, Thrippleton M, Murray C, Harris B, Wardlaw J, Deary I, Andrews P, Starr J, Marshall I, Proton spectroscopic imaging of brain metabolities in basal ganalia of healthy older adults. MAGMA 2015 Jun;28(3):251-7. doi: 10.1007/s10334-014-0465-0. Epub 2014 Oct 14.


  • McDonald C, Firbank M, Pearce M, Blamire AM, Newton JL, Kerr S. Symptoms during carotid sinus massage, not hemodynamic change, are associated with white matter hyperintensity volume on magnetic resonance imaging. J Am Geriatr Soc. 2014 Oct;62(10):1988-9. doi: 10.1111/jgs.13031. PMID: 25333538.


  • Duncan GW, Firbank MJ, O'Brien JT, Burn DJ. Magnetic resonance imaging: A biomarker for cognitive impairment in Parkinson's disease? Mov Disord. 2013 Feb 28. doi: 10.1002/mds.25352. [Epub ahead of print] PubMed PMID: 23450518.
  • O'Donovan J, Watson R, Colloby SJ, Firbank MJ, Burton EJ, Barber R, Blamire AM, O'Brien JT. Does posterior cortical atrophy on MRI discriminate between Alzheimer's disease, dementia with Lewy bodies, and normal aging? Int Psychogeriatr. 2013 Jan;25(1):111-9. doi: 10.1017/S1041610212001214. Epub 2012 Jul 19.
  • Bohr IJ, Kenny E, Blamire A, O'Brien JT, Thomas A, Richardson J, Kaiser M. Resting-state functional connectivity in late-life depression: higher global connectivity and more long distance connections. Front. Psychiatry, Jan. 2013, doi: 10.3389/fpsyt.2012.00116.
  • Tryambake D, He J, Firbank MJ, O’Brien JT, Blamire AM, Ford GA. Intensive Blood Pressure Lowering increases Cerebral Blood Flow in Older Subjects with Hypertension. Hypertension, in press (2013).


  • Vasudev A, Saxby BK, OʼBrien JT, Colloby SJ, Firbank MJ, Brooker H, Wesnes K, Thomas AJ. Relationship Between Cognition, Magnetic Resonance White MatterHyperintensities, and Cardiovascular Autonomic Changes in Late-Life Depression.Am J Geriatr Psychiatry. 2012 20(8):691-699. PubMed PMID: 22609766.
  • Colloby SJ, Firbank MJ, He J, Thomas AJ, Vasudev A, Parry SW and O'Brien, JT. Regional cerebral blood flow in late-life depression: arterial spin labelling magnetic resonance study , Br J Psychiatry. 2012 Feb;200(2):150-5. Epub 2011 Dec 22. PubMed PMID: 22194184.


  • Colloby SJ, Firbank MJ, Vasudev A, Parry SW, Thomas AJ, O'Brien JT. Cortical thickness and VBM-DARTEL in late-life depression. J Affect Disord. 2011; 133(1-2):158-64.
  • Colloby SJ, Vasudev A, O'Brien JT, Firbank MJ, Parry SW, Thomas AJ. Relationship of orthostatic blood pressure to white matter hyperintensities and subcortical volumes in late-life depression. Br J Psychiatry. 2011. Nov;199(5):404-10. Epub 2011 Sep 8. PubMed PMID: 21903666.
  • Colloby SJ, Firbank MJ, Thomas AJ, Vasudev A, Parry SW, O'Brien JT. White matter changes in late-life depression: a diffusion tensor imaging study. J Affect Disord. 2011 Dec;135(1-3):216-20. Epub 2011 Aug 20. PubMed PMID: 21862137.


  • Firbank MJ, Narayan SK, Saxby BK, Ford GA, JT OB. Homocysteine is associated with hippocampal and white matter atrophy in older subjects with mild hypertension International Psychogeriatrics. 2010; 22(5):804-11.
  • Kenny ER, O’Brien JT, Cousins D, Richardson J, Thomas A, Firbank MJ, Blamire AM. Functional Connectivity in Late-life Depression using Resting-state Functional Magnetic Resonance Imaging. Am J Geriatric Psychiatry 2010; 18(7):643-51.