Centre for Synthetic Biology and the Bioeconomy

Staff Profile

Dr Michael Hall

Senior Lecturer in Organic and Biological Chemistry

Background

Background

After finishing my DPhil with Dr. Jeremy Robertson (Oxford) entitled "Silicon Tethered Ene and Allyl Transfer Reactions", I moved to Dublin for a postdoctoral position with Dr. Donal O'Shea (UCD) where I worked on the synthesis of switchable photodynamic therapy agents. I then moved to Paris to work with Professor Janine Cossy and Dr Christophe Meyer (ESPCI) on the total synthesis of Phoslactomycin. I subsequently was appointed as a Lecturer in 2007 and then Senior Lecturer in Organic Chemistry in 2016 at Newcastle University.

Area of Expertise

Organic and Biological Chemistry

Prizes and Awards

  • Dave Kelly Cup, Gregynog Synthesis Meeting, 2019
  • Newcastle University Innovator of the Year, 2014
  • BioNow Awards, Medical Project of the Year, 2013
  • Medical Futures Innovation Awards, invited finalist 2011

Qualifications

  • DPhil, Linacre College, Oxford, 2003
  • MChem, Brasenose College, Oxford, 1999

Previous Positions

  • CNRS Postdoctoral Research Fellow, ESPCI, Paris, 2006
  • Postdoctoral Research Assistant, CSCB, University College Dublin, 2003-2005

Google Scholar




Research

Research Interests

Synthetic organic chemistry: Natural Products, Bioactive molecules

Current Work

Current work is divided into three research areas; isolation, characterisation and synthesis of biologically active natural products, new synthetic methodology based on multicomponent "one pot" reactions and the development of new fluorophores for application in bioimaging and sensing.

Recent Funding

2019

Northern Accelerator CCF (PoC): Robot Assisted Micro-crystallisation Platform for Polymorph Screening and Structural Solution – Prototype Workflow Development, Industrial Demonstrations and Market Development, £48,683

MICA: Novel mode of RNA polymerase inhibition by a new natural rifamycin, which is active against rifampicin-resistant RNA polymerase, Medical Research Council (MRC), £603,841

Industrial Demonstration of Newcastle High Throughput Crystallisation Screening Platform, Higher Education Innovation Fund (HEIF), £11,845

N8 - High throughput structural elucidation of plant natural products and agrochemical metabolites, N8 Research Partnership, £31,580

2018

Metabolomics by Automated Crystallography (MbAC): Solving the Structural Elucidation Bottleneck in Natural Product Discovery and Bioengineering through Automated Crystallisation and Single Crystal X-Ray Diffraction, NPRONET, Biotechnology and Biological Sciences Research Council (BBSRC), £43,843

2017

Bill toScale-up and Structural Elucidation of Novel Natural Product Antibiotics from the Demuris Actinomycete Collection, NPRONET, Biotechnology and Biological Sciences Research Council (BBSRC), £10,000

2016

Studying the development of a new natural product antibiotic for the treatment of ESKAPE infections, Rosetrees Trust, £54,171

2014

A New Antibiotic for Gram Positive Bacterial Infections, Medical Research Council (MRC), £29,282

2013

A Novel Crosslinking Strategy for MS Structural Biology, Biotechnology and Biological Sciences Research Council (BBSRC), £116,056

2012

Probing the Mechanisms of dSTORM Reporters, Biotechnology and Biological Sciences Research Council (BBSRC), £118,521

2010

Towards commercial application of a novel method to prevent and remove bacterial biofilms, Natural Environment Research Council (NERC), £137,802

Diels-Alder/Ene Reactions for the Multi-Component Synthesis, Engineering and Physical Sciences Research Council (EPSRC), £96,013

Total: £1,301,637


Teaching

Undergraduate Teaching

CHY2101 - Organic Chemistry: Heteroaromatic Chemistry
CHY3108 - Advanced Organic Chemistry (Module leader)
CHY3105 - Advanced Organic Chemistry DL - (Module leader)
CHY8422 - Further Organic Chemistry (Module leader)

Postgraduate Teaching

CHY8824 - Methods and Techniques for Drug Chemistry
MChem and MSc project supervision

Admissions Tutor  - MSc Drug Chemistry and MSc Chemistry

Publications