Staff Profile

To uncover pharmaceutical problems, Oisín collaborates with a wide range of disciplines, including pharmacists, pharmaceutical scientists, chemists, and engineers at internationally renowned pharmacy departments and at multinational pharmaceutical companies. This has led to a diverse range of projects built around the central theme of investigating the important pharmaceutical characteristics of solubility and mechanical behaviour which target key scientific challenges.

Oisín is keen to hear from any student (national or international) for PhD studies, or from experienced researchers who wish to pursue a postdoctoral appointment in one of my research areas. Get in touch and let me know how I can help you work at Newcastle!

• Drug solubility determinations relevant to new contexts: Despite its apparent simplicity, there is much misunderstanding around the concept of solubility. This has been discussed in a recent consensus statement which highlighted that aqueous drug solubility is often reported as a single unit and often without solution pH, ionic strength and – if you're particularly unlucky – temperature data. The solid phase remaining after these measurements is also seldom reported. As such, there is currently a lack of data exploring the solubility of drugs in solvents such as urine. My preliminary data has illustrated that this may enable the greater predictive capacity of pharmacokinetic models for crystalluria.

• Mechanistic understanding of cocrystal solubility behaviour for better PBPK prediction: Current approaches to cocrystal solubility prediction have not accounted for solution activity which would be expected to change drastically after meals. Further, there is little work exploring the effect of dose number on cocrystal behaviour. A better fundamental understanding of cocrystal behaviour in these contexts can enable better predictive capacity and may enable formulation design for new therapeutic contexts (e.g., achlorhydria).

• Enabling industrial cocrystal upscale without the need for ternary phase diagrams: Despite much commercial and scientific interest in cocrystals, methods of cocrystal synthesis are often empirically determined. Although researchers can precisely identify the optimum reaction conditions to obtain pure cocrystals via ternary phase diagrams, they are cumbersome, and therefore, synthesis is often carried out by mechanochemical methods (when possible). For cocrystals to be utilised to their full potential in the pharmaceutical industry they must fit into existing processes, which are predominantly solvent based. Notwithstanding the advantages of solution-based methods to control particle size and morphology.

• High-load, multidrug powders that can be directly compacted into tablets: The development of high-drug load, multidrug tablets is an emerging challenge in the pharmaceutical industry, particularly in the context of multidrug formulations. This is seen most critically in the antiretroviral space (which commonly employs multidrug formulations of several antiretrovirals). In collaboration with Professor Calvin Sun, I have recently illustrated that cocrystallisation can enable direct compaction to produce robust USP quality tablets with high-drug loading.

Publications: https://scholar.google.com/citations?user=ILUlsgwAAAAJ&hl=en