Staff Profile
Dr Alison Howard
Lecturer
- Email: alison.howard@ncl.ac.uk
- Telephone: +44 (0) 191 208 3476
- Address: Institute for Cell and Molecular Biosciences
Newcastle University
Medical School
Framlington Place
Newcastle upon Tyne
NE2 4HH
Teaching
Lecturer and Senior Tutor in School of Biomedical, Nutritional and Sports Sciences; completed CASAP modules 1 and 2 and received the Newcastle Teaching Award and Fellowship of the Higher Education Academy in October 2018.
Module leader: PSC1002 Physiology, CMB1006 Practical Skills in Cell and Molecular Biosciences 2
Teach on modules: CMB1005, PSC1002, CMB1006, PSC2018
Project supervisor for CMB3001
Supervisor, examiner and assessor of Phd, Masters and BSc projects.
Publications
- Mowbray C, Howard A, Hirst BH. Quantitative PCR in the assessment of novel hepatic cell models. European Pharmaceutical Review 2015, 20(3), 8-14.
- Ogo OA, Tyson J, Cockell SJ, Howard A, Valentine RA, Ford D. The zinc finger protein ZNF658 regulates the transcription of genes involved in zinc homeostasis and affects ribosome biogenesis through the zinc transcriptional regulatory element (ZTRE). Molecular and Cell Biology 2015, 35(6), 977-987.
- Fultang L, Howard A, Hirst B. Expression of the glycine transporter type 1 (GlyT-1A) is upregulated by ATF-4 following physiological stress in human intestinal epithelial cells. In: Experimental Biology 2014. 2014, San Diego: Federation of American Societies for Experimental Biology.
- Bell S, Howard A, Wilson JA, Abbot EL, Smith WD, Townes CL, Hirst BH, Hall J. Streptococcus pyogenes infection of tonsil explants is associated with a human β-defensin 1 response from control but not recurrent acute tonsillitis patients. Molecular Oral Microbiology 2012, 27(3), 160-171.
- Howard A, Hirst BH. Regulation of GLYT1 and xCT in human intestinal cells by ATF4 but not XBP1 or ATF6. In: Experimental Biology Meeting 2011. 2011, Walter E Washington Convention Center, Washington, DC: Federation of American Societies for Experimental Biology.
- Howard A, Hirst BH. The glycine transporter GLYT1 in human intestine: expression and function. Biological and Pharmaceutical Bulletin 2011, 34(6), 784-788.
- Mowbray CA, Howard A, Morsman J, Hirst BH. Differentiation of HepG2 and Huh7 cells using dimethyl sulfoxide. In: FASEB JOURNAL. 2010, 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA: FEDERATION AMER SOC EXP BIOL.
- Howard A, Townes C, Milona P, Nile CJ, Michailidis G, Hall J. Expression and functional analyses of liver expressed antimicrobial peptide-2 (LEAP-2) variant forms in human tissues. Cellular Immunology 2010, 261(2), 128-133.
- Howard A, Tahir I, Javed S, Waring SM, Ford D, Hirst BH. Glycine transporter GLYT1 is essential for glycine-mediated protection human intestinal epithelial cells against oxidative damage. Journal of Physiology 2010, 588(6), 995–1009.
- Hirst BH, Howard A, Javed S. [Meeting Abstract] Protection of intestinal cells against oxidative stress: A role for GLYT1-mediated transport. Journal of Physiological Sciences 2009, 59(s1), 247.
- Javed S, Howard A, Hirst B. Protection of intestinal cells against reactive oxygen species (ROS) by amino acids. In: Mutagenesis: 31st Annual Meeting of the United Kingdom Environmental Mutagen Society. 2009, University of Northumbria, Newcastle upon Tyne, UK: Oxford University Press.
- Anderson CMH, Howard A, Walters JRF, Ganapathy V, Thwaites DT. Taurine uptake across the human intestinal brush-border membrane is via two transporters: H+-coupled PAT1 (SLC36A1) and Na+- and Cl--dependent TauT (SLC6A6). Journal of Physiology 2009, 587(4), 731-744.
- Ball SL, Siou GP, Wilson JA, Howard A, Hirst BH, Hall J. Expression and immunolocalisation of antimicrobial peptides within human palatine tonsils. Journal of Laryngology and Otology 2007, 121(10), 973-978.
- Tahir I, Howard A, Ford D, Hirst BH. Role of glycine pre-treatment and transport in intestinal cell protection. In: FASEB Journal: Experimental Biology 2005 Meeting. 2005, San Diego, California, USA: Federation of American Societies for Experimental Biology.
- Ball SL, Siou GP, Howard A, Hall J, Wilson JA, Hirst BH. Antimicrobial peptide expression in human tonsils. Clinical Otolaryngology & Allied Sciences 2004, 29(4), 427.
- Howard A, Goodlad RA, Walters JRF, Ford D, Hirst BH. Increased expression of specific intestinal amino acid and peptide transporter mRNA in rats fed by TPN is reversed by GLP-2. Journal of Nutrition 2004, 134(11), 2957-2964.
- Wilson V, Howard A, Ford D, Hirst BH. EGF enhanced transcription of the amino acid transporter hATB(0) in COS-7 cells. In: Journal of Physiology: Conference of the Physiological Society. 2002, Liverpool: Wiley-Blackwell Publishing Ltd.
- Howard A, Goodlad RA, Ford D, Walters JRF, Hirst BH. Glucagon-like peptide 2 (GLP-2) abrogates the effect of total parenteral nutrition (TPN) on intestinal amino acid and peptide transporters in rats. In: Journal of Physiology: Conference of the Physiological Society. 2002, Liverpool: Wiley-Blackwell Publishing Ltd.
- Christie GR, Ford D, Howard A, Clark M Ann, Hirst BH. Glycine supply to human enterocytes mediated by high-affinity basolateral GLYT1. Gastroenterology 2001, 120(2), 439-448.
- Howard A, Rugg-Gunn P, Goodlad RL, Walters JRF, Ford D, Hirst BH. Regional differences in small intestinal nutrient transporter transcript expression during total parenteral nutrition. In: FASEB Journal. 2001, Federation of American Societies for Experimental Biology.
- Howard A, Jordinson M, Goodlad RA, Walters JR, Ford D, Hirst BH. Changes in expression of intestinal peptide and amino acid transporters in rats fed by total parenteral nutrition. In: GASTROENTEROLOGY. 2000.