Staff Profile

Roles and Responsibilities

FMS Director of Equality, Diversity and Inclusion

Teaching and supervision of students within the lab.

Qualifications

Bsc Hons in Neuroscience from Edinburgh University.
PhD entitled ‘The molecular Basis of Neurodegeneration – the role of mitochondrial DNA mutations’.

Research Interests

My primary research interest lies in investigating  the effects of mitochondrial dysfunction on substantia nigra neurons with ageing and Parkinson's disease. The main focus of my research is studying the how neurons might respond to mitochondrial dysfunction and how changes with age affect this process. Ultimately i hope to be able to find new drugs which might help neurons to be able to tolerate mitochondrial dysfunction and survive into later life.

Current Work

Relationship between alpha-synuclein accumulation and mitochondrial dysfunction.

Response of neurons to mitochondrial dysfunction.

Models of mitochondrial dysfunction in neurons.

BMS3013 Diseases of the Human Nervous System

MMB8034 Mitochondrial Biology and Medicine

MMB8020 Scientific Basis of Neurological Disease

• Chen C, Vincent AE, Blain AP, Smith AL, Turnbull DM, Reeve AK. Investigation of mitochondrial biogenesis defects in single substantia nigra neurons using post-mortem human tissues. Neurobiology of Disease 2020, 134, 104631.
• Erskine D, Reeve AK, Polvikoski T, Schaefer AM, Taylor RW, Lax NZ, El-Agnaf O, Attems J, Gorman GS, Turnbull DM, Ng YS. Lewy body pathology is more prevalent in older individuals with mitochondrial disease than controls. Acta Neuropathologica 2020, 139, 219-221.
• Lehmann D, Tuppen HAL, Campbell G, Alston CL, Lawless C, Rosa HS, Rocha MC, Reeve AK, Nicholls TJ, Deschauer M, Zierz S, Taylor RW, Turnbull DM, Vincent AE. Understanding mitochondrial DNA maintenance disorders at the single muscle fibre level. Nucleic Acids Research 2019, 47(14), 7430–7443.
• Robson E, Tweedy C, Manzanza N, Taylor J-P, Atkinson P, Randall F, Reeve A, Clowry GJ, LeBeau FEN. Impaired Fast Network Oscillations and Mitochondrial Dysfunction in a Mouse Model of Alpha-synucleinopathy (A30P). Neuroscience 2018, 377, 161-173.
• Reeve AK, Grady JP, Cosgrave EM, Bennison E, Chen C, Hepplewhite PD, Morris CM. Mitochondrial dysfunction within the synapses of substantia nigra neurons in Parkinson’s disease. npj Parkinson's Disease 2018, 4, 9.
• Russell OM, Fruh I, Rai PK, Marcellin D, Doll T, Reeve A, Germain M, Bastien J, Rygiel KA, Cerino R, Sailer AW, Lako M, Taylor RW, Mueller M, Lightowlers RN, Turnbull DM, Helliwell SB. Preferential amplification of a human mitochondrial DNA deletion in vitro and in vivo. Scientific Reports 2018, 8(1), 1799.
• Vincent AE, Rosa HS, Pabis K, Lawless C, Chen C, Grünewald A, Rygiel K, Rocha MC, Reeve AK, Falkous G, Perissi V, White K, Davey T, Petrof BJ, Sayer AA, Cooper C, Deehan D, Taylor RW, Turnbull DM, Picard M. Subcellular origin of mitochondrial DNA deletions in human skeletal muscle. Annals of Neurology 2018, 84(2), 289-301.
• Simcox EM, Reeve AK. An introduction to mitochondria, their structure and functions. In: Reeve AK; Simcox EM; Duchen MR; Turnbull DM, ed. Mitochondrial Dysfunction in Neurodegenerative Disorders: Second Edition. Cham: Springer International Publishing, 2016, pp.3-30.
• Rygiel KA, Tuppen HA, Grady JP, Vincent A, Blakely EL, Reeve AK, Taylor RW, Picard M, Miller J, Turnbull DM. Complex mitochondrial DNA rearrangements in individual cells from patients with sporadic inclusion body myositis. Nucleic Acids Research 2016, 44(11), 5313-5329.
• Reeve AK, Simcox E, Duchen MR, Turnbull DM. Mitochondrial dysfunction in neurodegenerative disorders: Second edition. Cham: Springer International Publishing, 2016.
• Reeve AK, Simcox E, Duchen MR, Turnbull DM. Preface. In: Reeve A; Simcox E; Duchen M; Turnbull D, ed. Mitochondrial Dysfunction in Neurodegenerative Disorders: Second Edition. Cham: Springer International Publishing, 2016, pp.v-v.
• Reeve AK. Summary and conclusions. In: Reeve A; Simcox E; Duchen M; Turnbull D, ed. Mitochondrial Dysfunction in Neurodegenerative Disorders: Second Edition. Cham: Springer International Publishing, 2016, pp.373-376.
• Reeve, AK, Ludtmann, MHR, Angelova, PR, Simcox, EM, Horrocks, MH, Klenerman, D, Gandhi, S, Turnbull DM, Abramov, AY. Aggregated α-synuclein and complex I deficiency: exploration of their relationship in differentiated neurons. Cell Death & Disease 2015, 6, e1820.
• Reeve A, Simcox E, Turnbull D. Ageing and Parkinson's disease: Why is advancing age the biggest risk factor?. Ageing Research Reviews 2014, 14, 19-30.
• Campbell GR, Reeve A, Ziabreva I, Polvikoski TM, Taylor RW, Reynolds R, Turnbull DM, Mahad DJ. Mitochondrial DNA deletions and depletion within paraspinal muscles. Neuropathology and Applied Neurobiology 2013, 39(4), 377-389.
• Simcox EM, Reeve A, Turnbull D. Monitoring mitochondrial dynamics and complex I dysfunction in neurons: implications for Parkinson's disease. Biochemical Society Transactions 2013, 41(6), 1618-1624.
• Campbell GR, Reeve AK, Ziabreva I, Reynolds R, Turnbull DM, Mahad DJ. No excess of mitochondrial DNA deletions within muscle in progressive multiple sclerosis. Multiple Sclerosis Journal 2013, 19(14), 1858-1866.
• Reeve A, Meagher M, Lax N, Simcox E, Hepplewhite P, Jaros E, Turnbull D. The Impact of Pathogenic Mitochondrial DNA Mutations on Substantia Nigra Neurons. Journal of Neuroscience 2013, 33(26), 10790-10801.
• Lax NZ, Hepplewhite PD, Reeve AK, Nesbitt V, McFarland R, Jaros E, Taylor RW, Turnbull DM. Cerebellar Ataxia in Patients With Mitochondrial DNA Disease: A Molecular Clinicopathological Study. Journal of Neuropathology and Experimental Neurology 2012, 71(2), 148-161.
• Campbell GR, Kraytsberg Y, Krishnan KJ, Ohno N, Ziabreva I, Reeve A, Trapp BD, Newcombe J, Reynolds R, Lassmann H, Khrapko K, Turnbull DM, Mahad DJ. Clonally expanded mitochondrial DNA deletions within the choroid plexus in multiple sclerosis. Acta Neuropathologica 2012, 124(2), 209-220.
• Lax NZ, Campbell GR, Reeve AK, Ohno N, Zambonin J, Blakely EL, Taylor RW, Bonilla E, Tanji K, DiMauro S, Jaros E, Lassmann H, Turnbull DM, Mahad DJ. Loss of Myelin-Associated Glycoprotein in Kearns-Sayre Syndrome. Archives of Neurology 2012, 69(4), 490-499.
• Lax NZ, Pienaar IS, Reeve AK, Hepplewhite PD, Jaros E, Taylor RW, Kalaria RN, Turnbull DM. Microangiopathy in the cerebellum of patients with mitochondrial DNA disease. Brain 2012, 135(6), 1736-1750.
• Reeve AK, Park TK, Jaros E, Campbell GR, Lax NZ, Hepplewhite PD, Krishnan KJ, Elson JL, Morris CM, McKeith IG, Turnbull DM. Relationship Between Mitochondria and α-Synuclein: A Study of Single Substantia Nigra Neurons. Archives of Neurology 2012, 69(3), 385-393.
• Lax NZ, Whittaker RG, Hepplewhite PD, Reeve AK, Blakely EL, Jaros E, Ince PG, Taylor RW, Fawcett PR, Turnbull DM. Sensory neuronopathy in patients harbouring recessive polymerase γ mutations. Brain 2012, 135(1), 62-71.
• Campbell GR, Ziabreva I, Reeve AK, Krishnan KJ, Reynolds R, Howell O, Lassmann H, Turnbull DM, Mahad DJ. Mitochondrial DNA Deletions and Neurodegeneration in Multiple Sclerosis. Annals of Neurology 2011, 69(3), 481-492.
• Lax NZ, Turnbull DM, Reeve AK. Mitochondrial mutations: newly discovered players in neuronal degeneration. Neuroscientist 2011, 17(6), 645-648.
• Betts-Henderson J, Jaros E, Krishnan KJ, Perry RH, Reeve AK, Schaefer AM, Taylor RW, Turnbull DM. Alpha-synuclein pathology and Parkinsonism associated with POLG1 mutations and multiple mitochondrial DNA deletions. Neuropathology and Applied Neurobiology 2009, 35(1), 120-124.
• Reeve AK, Krishnan KJ, Taylor G, Elson JL, Bender A, Taylor RW, Morris CM, Turnbull DM. The low abundance of clonally expanded mitochondrial DNA point mutations in aged substantia nigra neurons. Aging Cell 2009, 8(4), 496-498.
• Reeve AK, Krishnan KJ, Elson JL, Morris CM, Bender A, Lightowlers RN, Turnbull DM. Nature of Mitochondrial DNA Deletions in Substantia Nigra Neurons. American Journal of Human Genetics 2008, 82(1), 228-235.
• Krishnan KJ, Reeve AK, Samuels DC, Chinnery PF, Blackwood JK, Taylor RW, Wanrooij S, Spelbrink JN, Lightowlers RN, Turnbull DM. What causes mitochondrial DNA deletions in human cells?. Nature Genetics 2008, 40(3), 275-279.
• Bender A, Krishnan KJ, Morris CM, Taylor GA, Reeve AK, Perry RH, Jaros E, Hersheson JS, Betts J, Klopstock T, Taylor RW, Turnbull DM. High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease. Nature Genetics 2006, 38(5), 515-517.