Staff Profile
Dr Christopher Bacon
Senior Lecturer and Honorary Consultant in Haematopathology
- Email: chris.bacon@ncl.ac.uk
- Telephone: +44 (0) 191 208 4404
- Fax: +44 (0) 191 208 4301
- Address: Northern Institute for Cancer Research
Paul O'Gorman Building
Newcastle University
Framlington Place
Newcastle upon Tyne
NE2 4HH
Publications
- Offor UT, Bacon C, Gennery A, Reinhardt Z, Bomken S. Cardiac transplantation for congenital heart disease is associated with an increased risk of post-transplant lymphoproliferative disorder (PTLD) in children: a single centre experience. In: 58th Annual Scientific Meeting of the British Society for Haematology. 2018, Liverpool, United Kingdom: British Journal of Haematology.
- Coulter TI, Chandra A, Bacon CM, Babar J, Curtis J, Screaton N, Goodlad JR, Farmer G, Steele CL, Leahy TR, Doffinger R, Baxendale H, Bernatoniene J, Edgar JDM, Longhurst HJ, Ehl S, Speckmann C, Grimbacher B, Sediva A, Milota T, Faust SN, Williams AP, Hayman G, Kucuk ZY, Hague R, French P, Brooker R, Forsyth P, Herriot R, Cancrini C, Palma P, Ariganello P, Conlon N, Feighery C, Gavin PJ, Jones A, Imai K, Ibrahim MAA, Markelj G, Abinun M, Rieux-Laucat F, Latour S, Pellier I, Fischer A, Touzot F, Casanova J-L, Durandy A, Burns SO, Savic S, Kumararatne DS, Moshous D, Kracker S, Vanhaesebroeck B, Okkenhaug K, Picard C, Nejentsev S, Condliffe AM, Cant AJ. Clinical spectrum and features of activated phosphoinositide 3-kinase δ syndrome: A large patient cohort study. Journal of Allergy and Clinical Immunology 2017, 139(2), 597-606.e4.
- Milne P, Bigley V, Bacon CM, Néel A, McGovern N, Bomken S, Haniffa M, Diamond EL, Durham BH, Visser J, Hunt D, Gunawardena H, Macheta M, McClain KL, Allen C, Abdel-Wahab O, Collin M. Hematopoietic origin of Langerhans cell histiocytosis and Erdheim Chester disease in adults. Blood 2017, 130(2), 167-175.
- Noble RA, Bell N, Blair H, Sikka A, Thomas H, Phillips N, Nakjang S, Miwa S, Crossland R, Rand V, Televantou D, Long A, Keun HC, Bacon CM, Bomken S, Critchlow SE, Wedge SR. Inhibition of monocarboxyate transporter 1 by AZD3965 as a novel therapeutic approach for diffuse large B-cell lymphoma and burkitt lymphoma. Haematologica 2017, 102(7), 1247-1257.
- Coulter T, Chandra A, Nejentsev S, Okkenhaug K, Babar J, Bacon CM, Cant AJ, Condliffe AM. Activated PI3-kinase Delta Syndrome (APDS): Genetics, Immunodeficiency, Diagnosis and Related Pathology. In: 205th Meeting of the Pathological Society of Great Britain & Ireland. 2016, London, UK: John Wiley & Sons Ltd.
- Hunter JE, Butterworth JA, Zhao B, Sellier H, Campbell KJ, Thomas HD, Bacon CM, Cockell SJ, Gewurz BE, Perkins ND. The NF-κB subunit c-Rel regulates Bach2 tumour suppressor expression in B-cell lymphoma. Oncogene 2016, 35(26), 3476-3484.
- Wade MA, Sunter NJ, Fordham SE, Long A, Masic D, Russell J, Harrison CJ, Rand V, Elstob C, Bown N, Rowe D, Lowe C, Cuthbert G, Bennett S, Crosier S, Bacon CM, Onel K, Scott K, Scott D, Travis LB, May FEB, Allan JM. c-MYC is a radiosensitive locus in human breast cells. Oncogene 2015, 34, 4985-4994.
- Savic S, Parry D, Carter C, Johnson C, Logan C, Gutierrez BM, Thomas JE, Bacon CM, Cant A, Hambleton S. A new case of Fas-associated death domain protein deficiency and update on treatment outcomes. Journal of Allergy and Clinical Immunology 2015, 136(2), 502-505.
- Coulter T, Chandra A, Bacon CM, Babar J, Curtis J, Farmer G, Steele CL, Leahy TR, Doffinger R, Baxendale H, Bernatoniene J, Edgar JDM, Longhurst HJ, Ehl S, Speckmann C, Grimbacher B, Sediva A, Faust SN, Williams AP, Hayman G, Kucuk ZY, Brooker R, Forsyth P, Herriot R, Cancrini C, Palma P, Ariganello P, Feighery C, Gavin PJ, Jones A, Ibrahim MAA, Markelj G, Abinun M, Touzot F, Rieux-Laucat F, Latour S, Moshous D, Pellier I, Fischer A, Casanova JL, Durandy A, Burns SO, Savic S, Kumararatne DS, Kracker S, Vanhaesebroeck B, Okkenhaug K, Picard C, Nejentsev S, Condliffe AM, Cant AJ. Activated PI3-Kinase Delta Syndrome: Clinical, Radiological And Laboratory Features Of A Large Cohort. In: UKPIN 2015 Meeting. 2015, Belfast, Northern Ireland: Wiley-Blackwell Publishing Ltd.
- Crossland RE, Green K, Bacon C, Rand V. Direct digital profiling of multiplexed mRNA expression from degraded formalin fixed paraffin embedded aggressive paediatric B-cell lymphoma tumour tissue. In: Fifth International Symposium on Childhood, Adolescent and Young Adult Non-Hodgkin Lymphoma. 2015, Varese, Italy: Wiley.
- Zhou P, Newman AM, Van Noorden S, Banda K, Chagaluka G, Lampert I, Erhorn A, Bacon C, Bailey S, Molyneux E, Rand V. Investigation of prognostic markers in endemic Burkitt lymphoma. In: Fifth International Symposium on Childhood Adolescent and Young Adult Non-Hodgkin Lymphoma. 2015, Varese, Italy: Wiley-Blackwell Publishing Ltd.
- Milne P, Collin M, Bigley V, Bacon CM, McGovern N, Windebank K, Allen C, McClain K, Haniffa M. Mapping the BRAFV600E Hematopoietic Clone of Adult Multi-System Langerhans Cell Histiocytosis. In: 30th Annual Meeting of the Histiocyte Society. 2015, Toronto, Ontario, Canada: Wiley-Blackwell.
- Carey CD, Gusenleitner D, Chapuy B, Kovach AE, Kluk MJ, Sun HH, Crossland RE, Bacon CM, Rand V, Dal Cin P, Le LP, Neuberg D, Sohani AR, Shipp MA, Monti S, Rodig SJ. Molecular Classification of MYC-Driven B-Cell Lymphomas by Targeted Gene Expression Profiling of Fixed Biopsy Specimens. Journal of Molecular Diagnostics 2015, 17(1), 19-30.
- Mather MW, Hayhurst H, Bacon CM, Cole TS, Pan-Hammarstrom Q, Misbah S, Gennery AR. Mutation of TNFRSF13B in a child with 22q11 deletion syndrome associated with granulomatous lymphoproliferation. Journal of Allergy and Clinical Immunology 2015, 135(2), 559-561.
- Bell N, Blair H, Noble R, Price L, Wood K, Vormoor J, Bacon C, Rand V, Heidenreich O, Wedge S, Bomken S. Patient-derived xenograft and in vivo bioluminescent modelling of B-cell NHL. In: Fifth International Symposium on Childhood, Adolescent and Young Adult Non-Hodgkin Lymphoma. 2015, Varese, Italy: Wiley-Blackwell.
- Vormoor B, Knizia HK, Batey MA, Almeida GS, Wilson I, Dildey P, Sharma A, Blair H, Hide IG, Heidenreich O, Vormoor J, Maxwell RJ, Bacon CM. Development of a Preclinical Orthotopic Xenograft Model of Ewing Sarcoma and Other Human Malignant Bone Disease Using Advanced In Vivo Imaging. PLoS ONE 2014, 9(1), e85128.
- Bell N, Blair HJ, Vormoor J, Bacon C, Rand V, Heidenreich O, Bomken S. Development of in Vivo Models of Paediatric Burkitt Lymphoma Allowing Therapeutic Target Analysis and Drug Testing. In: 56th ASH Annual Meeting and Exposition. 2014, San Francisco, CA: American Society of Hematology.
- Aljefri K, Wang XN, Husain A, Bacon C, Long A, Pagan S, Collin M, Haniffa M. Factor XIIIa identifies macrophages and cells of mesenchymal origin in the human skin. In: British Society of Investigative Dermatology Annual Meeting. 2014, Newcastle upon Tyne: Wiley-Blackwell Publishing Ltd.
- Hamadeh F, MacNamara S, Bacon CM, Sohani AR, Swerdlow SH, Cook JR. Gamma Heavy Chain Disease Lacks the MYD88 L265p Mutation Associated with Lymphoplasmacytic Lymphoma. Haematologica 2014, 99(9), E154-E155.
- Hamadeh F, MacNamara S, Bacon CM, Sohani AR, Swerdlow SH, Cook JR. Gamma Heavy Chain Disease Lacks the MYD88 L265P Mutation Associated with Lymphoplasmacytic Lymphoma. In: USCAP 103rd Annual Meeting. 2014, San Diego, C.A, U.S.A: Nature Publishing Group.
- Crossland RE, Mainou-Fowler T, Sieniawski M, Bacon C, Rand V. High BACH2 gene Expression Is an Indicator of Poor Prognosis in Adult Diffuse Large B-Cell Lymphoma Treated with R-CHOP. In: 56th ASH Annual Meeting and Exposition. 2014, San Francisco, CA: American Society of Hematology.
- McCann LJ, McPartland J, Barge D, Strain L, Bourn D, Calonje E, Verbov J, Riordan A, Kokai G, Bacon CM, Wright M, Abinun M. Phenotypic Variations of Cartilage Hair Hypoplasia: Granulomatous Skin Inflammation and Severe T Cell Immunodeficiency as Initial Clinical Presentation in Otherwise Well Child with Short Stature. Journal of Clinical Immunology 2014, 34(1), 42-48.
- Coulter TI, Chandra A, Leahy TR, Curtis J, Bacon CM, Babar J, Farmer G, Savic S, Burns SO, Jones AM, Gavin PJ, Feighery CF, Forsyth P, Herriot R, Edgar JD, Abinun M, Markelj G, Ibrahim M, Baxendale H, Doffinger R, Kumararatne D, Condliffe AM, Cant AJ, Nejentsev S. The Clinical Manifestations, Management and Outcomes of Activated PI3K-Delta Syndrome (APDS) in UK and Ireland Cohort. In: European Society for Immunodeficiencies. 2014, Prague, Czech Republic: Springer.
- Dickinson RE, Milne P, Jardine L, Zandi S, Swierczek SI, McGovern N, Cookson S, Ferozepurwalla Z, Langridge A, Pagan S, Gennery A, Heiskanen-Kosma T, Hamalainen S, Seppanen M, Helbert M, Tholouli E, Gambineri E, Reykdal S, Gottfreosson M, Thaventhiran JE, Morris E, Hirschfield G, Richter AG, Jolles S, Bacon CM, Hambleton S, Haniffa M, Bryceson Y, Allen C, Prchal JT, Dick JE, Bigley V, Collin M. The evolution of cellular deficiency in GATA2 mutation. Blood 2014, 123(6), 863-874.
- Bacon CM, Wilkinson SJ, Spickett GP, Barge D, Lucraft HH, Jackson G, Rand V, Gennery AR. Epstein-Barr virus-independent diffuse large B-cell lymphoma in DNA ligase 4 deficiency. Journal of Allergy and Clinical Immunology 2013, 131(4), 1237-1239.
- Łastowska M, Al-Afghani H, Al-Balool HH, Sheth H, Mercer E, Coxhead JM, Redfern CPF, Peters H, Burt AD, Santibanez-Koref M, Bacon CM, Chesler L, Rust AG, Adams DJ, Williamson D, Clifford SC, Jackson MS. Identification of a neuronal transcription factor network involved in medulloblastoma development. Acta Neuropathologica Communications 2013, 1, 35.
- Perry AM, Warnke RA, Hu QL, Gaulard P, Copie-Bergman C, Alkan S, Wang HY, Cheng JX, Bacon CM, Delabie J, Ranheim E, Kucuk C, Hu XZ, Weisenburger DD, Jaffe ES, Chan WC. Indolent T-cell lymphoproliferative disease of the gastrointestinal tract. Blood 2013, 122(22), 3599-3606.
- Bomken S, Buechler L, Rehe K, Ponthan F, Elder A, Blair H, Bacon CM, Vormoor J, Heidenreich O. Lentiviral marking of patient-derived acute lymphoblastic leukaemic cells allows in vivo tracking of disease progression. Leukemia 2013, 27(3), 718-721.
- Bieliauskas S, Tubbs RR, Bacon CM, Eshoa C, Foucar K, Gibson SE, Kroft SH, Sohani AR, Swerdlow SH, Cook JR. Gamma Heavy-chain Disease: Defining the Spectrum of Associated Lymphoproliferative Disorders Through Analysis of 13 Cases. American Journal of Surgical Pathology 2012, 36(4), 534-543.
- McCann LJ, McPartland J, Barge D, Strain L, Calonje E, Verbov J, Riordan A, Bourn D, Wright M, Bacon C, Kokai G, Abinun M. Granulomatous inflammation at presentation of severe T cell immunodeficiency due to RMRP mutation (cartilage-hair hypoplasis). In: 15th Biennial Meeting European Society for Immunodeficiency (ESID). 2012, Florence, Italy: Springer.
- Wilkinson S, Van Noorden S, Bradburn A, Banda K, Chagaluka G, Griffin B, Lampert I, Bailey S, Bacon C, Molyneux E, Rand V. High-resolution genome-wide analysis of endemic Burkitt Lymphoma using DNA extracted from fine-needle aspirates preserved at ambient temperature. In: 4th International Symposium on Childhood, Adolescent and Young Adult Non-Hodgkins Lymphoma. 2012, New York, USA: Wiley-Blackwell Publishing Ltd.
- Hambleton S, Salem S, Bustamente J, Bigley V, Boisson-Dupuis S, Azevedo J, Fortin A, Haniffa M, Ceron-Gutierrez C, Bacon CM, Menon G, Trouillet C, McDonald D, Carey P, Ginhoux F, Alsina L, Zumwalt TJ, Kong X, Kumararatne D, Butler K, Hubeau M, Feinberg J, Al-Muhsen S, Cant A, Abel L, Chaussabel D, Doffinger R, Talesnik E, Grumach A, Duarte A, Abarca K, Moraes-Vasconcelos D, Burk D, Berghuis A, Geissmann F, Collin M, Casanova J-L, Gros P. IRF8 Mutations and Human Dendritic-Cell Immunodeficiency. New England Journal of Medicine 2011, 365(2), 127-138.
- Payne K, Wright P, Grant JW, Huang Y, Hamoudi R, Bacon CM, Du MQ, Liu H. BIOMED-2 PCR assays for IGK gene rearrangements are essential for B-cell clonality analysis in follicular lymphoma. British Journal of Haematology 2011, 155(1), 84-92.
- Vela-Chávez T, Adam P, Kremer M, Bink K, Bacon CM, Menon G, Ferry JA, Fend F, Jaffe ES, Quintanilla-Martínez L. Cyclin D1 positive diffuse large B-cell lymphoma is a post-germinal center-type lymphoma without alterations in the CCND1 gene locus. Leukemia and Lymphoma 2011, 52(3), 458-466.
- Bedwell C, Rowe D, Moulton D, Jones G, Bown N, Bacon CM. Cytogenetically complex SEC31A-ALK fusions are recurrent in ALK-positive large B-cell lymphomas. Haematologica 2011, 96(2), 343-346.
- Sturgess K, Slatter M, Bigley V, Haniffa M, Wang XN, Dickinson R, McGovern N, Jardine L, Pagan S, Chua I, Wallis J, Lordan J, Morgan C, Cant A, Gennery A, Edmondson R, Bacon C, Black F, Kirkham N, Jackson GH, Hambleton S, Collin MP. Reduced Intensity Hematopoietic Stem Cell Transplant Rescues Immune Function and Corrects Pulmonary Alveolar Proteinosis in DCML Deficiency/GATA 2 Mutation. In: Blood: 53rd Annual Meeting and Exposition of the American Society of Hematology (ASH). 2011, San Diego, California, USA: American Society of Hematology.