Staff Profile
Dr Christina Elliott
Lecturer in Biochemistry
- Email: christina.elliott@ncl.ac.uk
- Telephone: 01912084388
Qualifications
BSc (hons) Biochemistry, University of York
PhD Neuroimmunology, University of Glasgow
PGCert Academic Practice, University of Glasgow
Previous Academic Positions
2020-2022: Lecturer, University of Glasgow
2018-2020: Research Fellow, University of Bergen
2015-2018: Postdoctoral Researcher, King's College London
2011-2015: Research Associate, University of Glasgow
Professional Societies
Royal Society of Biology
British Pharmacological Society
Other roles
Editorial board, BMC research notes
Review editor, Frontiers in Pharmacology
Member, Deep Dementia Phenotyping Network (DEMON)
Organising team/ Guest/ Contributor #LTHEchat (learning and teaching in HE tweetchat)
I am the module leader for the following modules:
BMS3016, Science Communication
PED1003, Pharmacology
I also am involved in teaching across several modules including:
CMB1004, Cell Biology
CMB1005/6, Practical Skills in Biomedical & Biomolecular Sciences
PED1003, Pharmacology
BMS2002, Cell Biology & Disease
BMS3016, Science Communication
Student Supervision
Supervision of undergraduate and postgraduate research project students
Teaching & Scholarship Interests
Feedback standardisation and student feeback literacy
Digital education/ technology enhanced learning
Gamification and games-based learning
My current research interests focus on elucidating the molecular mechanisms that underpin neurodegenerative diseases and how this knowledge can be leveraged to provide novel therapeutic strategies.
- Functional genomics / transcriptomics
- Drug repositioning / discovery
- Disease modelling in vitro
- Target identification and validation
- Assay development and high-throughput compound screening
- Glennon EB, Lau DHW, Gabriele RMC, Taylor MF, Troakes C, Opie-Martin S, Elliott C, Killick R, Hanger DP, Perez-Nievas BG, Noble W. Bridging integrator 1 protein loss in Alzheimer’s disease promotes synaptic tau accumulation and disrupts tau release. Brain Communications 2020, 2(1), fcaa011.
- Elliott C, Rojo A, Ribe E, Broadstock M, Xia W, Morin P, Semenov M, Baillie G, Cuadrado A, Al-Shawi R, Ballard CG, Simons P, Killick R. A role for APP in Wnt signalling links synapse loss with β-amyloid production. Translational Psychiatry 2018, 8, 179.
- Sellers KJ, Elliott C, Jackson J, Ghosh A, Ribe E, Rojo-Sanchís A, Jarosz-Griffiths HH, Watson IA, Xia W, Semenov M, Morin P, Hooper NM, Porter R, Preston J, Al-Shawi R, Baillie GS, Lovestone S, Cuadrado A, Harte M, Simons P, Srivastava DP, Killick R. Amyloid β synaptotoxicity is Wnt-PCP dependent and blocked by fasudil. Alzheimer’s and Dementia 2018, 14(3), 306-317.
- Yalla K, Elliott C, Day JP, Findlay J, Barratt S, Hughes ZA, Wilson L, Whiteley E, Popiolek M, Li Y, Dunlop J, Killick R, Adams DR, Brandon NJ, Houslay MD, Hao B, Baillie GS. FBXW7 regulates DISC1 stability via the ubiquitin-proteosome system. Molecular Psychiatry 2018, 23, 1278-1286.
- Engelhardt B, Holze J, Elliott C, Baillie GS, Kschischo M, Frohlich H. Modelling and Mathematical Analysis of the M2-Receptor Dependent Joint Signaling and Secondary Messenger Network in CHO Cells. Mathematical Medicine & Biology 2018, 35(3), 279-297.
- Ashton NJ, Hye A, Leckey CA, Jones AR, Gardner A, Elliott C, Wetherell JL, Lenze EJ, Killick R, Marchant NL. Plasma REST: a novel candidate biomarker of Alzheimer’s disease is modified by psychological intervention in an at risk population. Translational Psychiatry 2017, 7(6), e1148.
- Al-Nimer F, Elliott C, Bergman J, Khademi M, Dring AM, Aeinehband S, Bergenheim TR, Christensen J, Sellebjerg F, Svenningsson A, Linington C, Olsson T, Piehl F. Lipocalin-2 is increased in progressive multiple sclerosis and inhibits remyelination. Neurology – Neuroimmunology & Neuroinflammation 2016, 3(1), e191.
- Dachtler J, Elliott C, Rodgers RJ, Baillie GS, Clapcote SJ. Missense mutation in DISC1 C-terminal coiled-coil has GSK3β signaling and sex-dependent behavioral effects in mice. Scientific Reports 2016, 6, 18748.
- Roscoe RB, Elliott C, Zarros A, Baillie GS. Non-genetic therapeutic approaches to Canavan disease. Journal of the Neurological Sciences 2016, 366, 116-124.
- Allan D, Fairlie-Clarke K, Elliott C, Schuh C, Barnett SC, Lassmann H, Linington C, Jiang H. Role of IL-33 and ST2 signalling pathway in multiple sclerosis: expression by oligodendrocytes and inhibition of myelination in central nervous system. Acta Neuropathologica Communications 2016, 4(1), 75.
- McGirr A, Lipina TV, Mun H, Georgiou J, Al-Amri AH, Ng E, Zhai D, Elliott C, Cameron RT, Mullins JGL, Liu F, Baillie GS, Clapcote SJ, Roder JC. Specific Inhibition of Phosphodiesterase-4B Results in Anxiolysis and Facilitates Memory Acquisition. Neuropsychopharmacology 2016, 41(4), 1080-1092.
- Tankou S, Ishii K, Elliott C, Yalla KC, Day JP, Furukori K, Kubo K, Brandon NJ, Tang Q, Hayward G, Nakajima K, Houslay MD, Kamiya A, Baillie GS, Ishizuka K, Sawa A. SUMOylation of DISC1: A Potential Role in Neural Progenitor Proliferation in the Developing Cortex. Molecular Neuropsychiatry 2016, 2(1), 20-27.
- Lindner M, Thuemmler K, Arthur A, Brunner S, Elliott C, McElroy D, Mohan H, Williams A, Edgar JM, Schuh C, Stadelmann C, Barnett SC, Lassmann H, Muecklisch S, Mudaliar M, Schaeren-Wiemers N, Meinl E, Linington C. Fibroblast growth factor signalling in multiple sclerosis: inhibition of myelination and induction of proinflammatory environment by FGF9. Brain 2015, 138(7), 1875-1893.
- Byrne AM, Elliott C, Hoffmann R, Baillie GS. The activity of cAMP-phosphodiesterase 4D7 (PDE4D7) is regulated by protein kinase A-dependent phosphorylation within its unique N-terminus. FEBS Letters 2015, 589(6), 750-755.
- Martin TP, Hortigon-Vinagre M, Findlay JE, Elliott C, Currie S, Baillie GS. Targeted disruption of the heat shock protein 20-phosphodiesterase 4D (PDE4D) interaction protects against pathological cardiac remodelling in a mouse model of hypertrophy. FEBS Open Bio 2014, 4(1), 923-927.
- Mohan H, Friese A, Albrecht S, Krumbholz M, Elliott CL, Arthur A, Menon R, Farina C, Junker A, Stadelmann C, Barnett SC, Huitinga I, Wekerle H, Hohlfeld R, Lassmann H, Kuhlmann T, Linington C, Meinl E. Transcript profiling of different types of multiple sclerosis lesions yields FGF1 as a promoter of remyelination. Acta Neuropathologica Communications 2014, 2(1), 178.
- Elliott C, Lindner M, Arthur A, Brennan K, Jarius S, Hussey J, Chan A, Stroet A, Olsson T, Willison H, Barnett SC, Meinl E, Linington C. Functional identification of pathogenic autoantibody responses in patients with multiple sclerosis. Brain 2012, 135(6), 1819-1833.
- Brennan KM, Galban-Horcajo F, Rinaldi S, O'Leary CP, Goodyear CS, Kalna G, Arthur A, Elliott C, Barnett S, Linington C, Bennett JL, Owens GP, Willison HJ. Lipid arrays identify myelin-derived lipids and lipid complexes as prominent targets for oligoclonal band antibodies in multiple sclerosis. Journal of Neuroimmunology 2011, 238(1).