Staff Profile

Introduction

Prof Quentin M. Anstee is Chair of Experimental Hepatology and Deputy-Dean of Research & Innovation for the Faculty of Medical Sciences. A practising clinician, he is also an Honorary Consultant Hepatologist in the Liver Unit at the Freeman Hospital, Newcastle.

His translational research has extended from the bench to the bedside with particular focus on the pathogenesis, diagnosis and treatment of Non-Alcoholic Fatty Liver Disease & Non-Alcoholic Steatohepatitis (NAFLD/NASH), including the identification of genetic and epigenetic modifiers of Hepatic Fibrosis progression and Hepatocellular Carcinoma (HCC) risk. He is actively involved in biomarker discovery projects that will assist in the diagnosis and risk-stratification of patients with NAFLD and serves as the Chief Investigator of several ongoing clinical trials examining new medical therapies for NAFLD.

Prof Anstee leads the European NAFLD Registry and coordinates two major international research consortia, both addressing different aspects of translational research into NAFLD:

1. EPoS: Elucidating Pathways of Steatohepatitis is funded by the EU Horizon 2020 scheme (€6 million, 2015-2019). This consortium focuses on understanding the pathophysiology of NAFLD and examining the determinants of individual risk for disease progression using a "multi-omics" translational-science approach. 
2. LITMUS: Liver Investigation - Testing Marker Utility in Steatohepatitis is funded by the EU Investigative Medicines Initiative (IMI2) scheme (€47.3 million, 2017-2023). This consortium focuses on the comprehensive and robust validation/qualification of blood-based and imaging-based non-invasive biomarkers that may be used to diagnose and risk-stratify severity of NAFLD. Ultimately, this will facilitate conduct of clinical trials of new NAFLD treatments and will improve the care of patients with NAFLD by streamlining their diagnosis and management.

Further details about the projects and the membership of these consortia are available on their respective websites: EPoS and LITMUS. 

Clinical Expertise

Prof Anstee's clinical practice is based in the Regional Liver Unit at the Freeman Hospital. His particular specialist interest is the diagnosis and treatment of Non-Alcoholic Fatty Liver Disease (NAFLD), an increasingly common, progressive liver disease that is strongly associated with features of the 'metabolic syndrome' (including obesity, type 2 diabetes mellitus and dyslipidaemia). He leads the regional NAFLD specialist clinical service based at the Freeman Hospital, Newcastle.

He trained in medicine at University College London where he was awarded First Prize in Medicine in the final MB BS examination (The Philip Seth Belasco & Douglas Cree Prize, 1997). His post-graduate specialist clinical training in Hepatology/Gastroenterology & General Medicine was undertaken at hospitals in North-West London. Prior to moving his research group to Newcastle in 2010, he worked as Clinical Lecturer in Medicine & Hepatology at Imperial College London and St Mary's Hospital from 2007-2010.

He has expertise in the management of patients with a range of acute and chronic liver conditions including:

• Non-Alcoholic Fatty Liver Disease (NAFLD) & Non-Alcoholic Steatohepatitis (NASH)
• Alcoholic Liver Disease
• Chronic Viral Hepatitis
• Autoimmune hepatitis, PSC & PBC
• Cirrhosis and Portal hypertension
• Liver Transplantation

Qualifications

• BSc(Hons) - 1st Class 'Cell Pathology & Basic Medical Sciences', UCL (1994)
• MB BS with Distinction in Medicine, UCL (1997)
• MRCP(UK), Royal College of Physicians (London, 2000)
• PhD, Imperial College London (2007)
• FRCP, Fellow of the Royal College of Physicians (London, 2016)

Fellowships & Memberships of Learned Societies

• Fellow of the Royal College of Physicians (FRCP)
• Fellow of the Association of Physicians of Great Britain & Ireland (FAoP)
• Member of the British Association for the Study of the Liver, BASL
• Member of the British Society of Gastroenterology, BSG
• Member of the European Association for the Study of the Liver, EASL
• Member of the American Association for the Study of the Liver, AASLD

Esteem Indicators

Membership of Editorial Boards:

• Journal of Hepatology (Associate Editor)
• European Medical Journal - Hepatology (past)

Peer Review Activity:

• International journals including 'Nature', 'Nature Genetics', 'Nature Communications', 'Gastroenterology', 'Hepatology', 'Journal of Hepatology', 'Gut', 'Liver International', 'Journal of Viral Hepatitis', 'Mammalian Genome' & 'International Journal of Experimental Pathology'
• Grant awarding bodies including the MRC, Wellcome Trust and NIHR.

Selected Invited Lectures at Recent National & International Meetings:

• ‘The Good, the Bad, and the Ugly: Risk stratification in NAFLD’, AASLD Liver Meeting 2021, AASLD Postgraduate Course ‘Managing the Epidemic of Fatty Liver from Obesity and Alcohol’, October 2021, Virtual.
• ‘Progress in non-invasive biomarkers in NAFLD: Moving Beyond Biopsy’, UEG Week 2021, October 2021, Virtual.
• ‘Biomarkers to Support Clinical Practice & Drug Development’, EASL NASH Summit, September 2021, Virtual.
• ‘Compound Biomarkers in NASH: Integration of Multi-Omics to Clinical Applications’, Basic Science Seminar: European Association for the Study of the Liver International Liver Congress, 2021, June 2021, Virtual
• ‘European NAFLD Consortia Update: LITMUS & The European NAFLD Registry’, European Association for the Study of the Liver International Liver Congress, 2021, June 2021, Virtual
• ‘Genetic Targeting of Therapies for NASH & Cirrhosis: PNPLA3, TM6SF2 and HSD17B13’, AASLD Emerging Topic Conference: Current Challenges in Clinical Management and Drug Development in NASH, June 2021, Virtual
• ‘Non-Invasive Biomarkers in NAFLD’, European Association for the Study of the Liver 54th International Liver Congress, April 2019, Vienna, Austria. 
• ‘European NAFLD Consortia: EPoS, LITMUS & The European NAFLD Registry’, European Association for the Study of the Liver 54th International Liver Congress, April 2019, Vienna, Austria. 
• ‘Debate: “NASH Does Not Alter A Patient’s Natural History” - CON’, European Association for the Study of the Liver 54th International Liver Congress, April 2019, Vienna, Austria. 
• ‘How to Ensure the Quality of Data in a Registry for Frequent Diseases’, European Association for the Study of the Liver 54th International Liver Congress, April 2019, Vienna, Austria. 
• ‘Non-Alcoholic Fatty Liver Disease’, 23rd Advanced Gastroenterology & Hepatology Course, Royal College of Physicians of Edinburgh, January 2019, Edinburgh, UK
• ‘Second Harmonic Generation: Fully Quantitative Histopathology Assessment for NASH’, NASH-TAG, Deer Valley, Utah, USA, January 2019
• ‘Genetic Testing: Any Utility in Sub-Phenotyping or Risk Stratification in Clinical Trials’, NASH-TAG, Deer Valley, Utah, USA, January 2019
• 'NAFLD: Potential Trial Designs & Suitable Study Populations', European Medicines Agency: Stakeholder Meeting on Medicinal Products for Chronic Non-Infectious Liver Diseases, December 2018, London, UK.
• 'Non-Invasive Assessment of NAFLD & How Will We Treat NASH 5-Years From Now?', 31st Annual Scientific Meeting of the Hong Kong Association for the Study of Liver Diseases, November 2018, Hong Kong.
• 'NAFLD Natural History & Use of Large Data to Risk Stratify', 2nd EASL NASH Summit, September 2018, Geneva, Switzerland.
• 'Clinical Events: Liver-Related Outcomes', AASLD/EASL NAFLD Endpoints Conference, June 2018, Washington DC, USA.
• 'Diagnosis of NAFLD/NASH in Clinical Practice & Clinical Trials: Biomarkers & Imaging Modalities', Chinese Society of Medicine & Chinese Hepatology Association NAFLD Monothematic Meeting, June 2018, Tianjin, China.
• Contexts of Use & Implications for Study Design', NASH Biomarkers Workshop 2018, May 2018, Washington DC, USA.
• 'NASH: When do I Refer? What should I Measure?', Diabetes UK Annual Conference, March 2018, London, UK.
• 'Role of Genetics & Epigenetics in Disease Pathophysiology & Diagnosis', 2nd European Fatty Liver Conference, February 2018, Maastricht, The Netherlands. 
• 'PNPLA3 & Other Genetic Markers for Risk Stratification in NAFLD', 1st EASL NASH Summit, November 2017, Rome, Italy.
• 'NASH - Current & Emerging Therapies', AASLD Liver Meeting Postgraduate Course, 2017, Washington DC, USA.
• 'Serum-based Biomarkers to Identify NASH & Quantify Fibrosis: Current Applications & Limitations', AASLD Liver Meeting, 2017, Washington DC, USA. 
• 'Current & Future Therapies for NASH', BASL School of Hepatology, 2017 Newcastle University, UK.
• 'Serum Fibrosis Markers in NASH', AASLD Emerging Trends in NAFLD Conference, 2017, Washington DC, USA.
• 'NAFLD: The Role of Genetic Assessments', NASH Biomarkers Workshop, 2017, Washington DC, USA.
• 'Natural History & Genetics of NAFLD', 52nd International Liver Congress, European Association for the Study of the Liver, 2017, Amsterdam, The Netherlands.
• 'The Genetics of Non-Alcoholic Fatty Liver Disease', Keystone Symposia on Molecular & Cellular Biology conference on "Injury, Inflammation & Fibrosis", 2017, Snowbird, Utah, USA.
• 'Making the Best Use of CRISPR-Cas9 Technology' Co-chair of Early Morning Workshop, 51st International Liver Congress, European Association for the Study of the Liver, 2016, Barcelona, Spain.
• 'Genetics of NAFLD' International Symposium, CHOZEN Project, Kanazawa University, Japan, 2016.
• 'Steatosis and Metabolic Risk Factors: who is at risk of liver disease progression?' 11th Barcelona International Meeting on Therapy in Liver Disease, Spain, 2015.
• 'Genetics, Mechanisms & Management of NAFLD and ALD' Advanced Medicine 2015, Royal College of Physicians, London, 2015.
• 'NASH - Diagnosis & Current Management' Co-chair of Early Morning Workshop, 49th International Liver Congress, European Association for the Study of the Liver, 2014, London, UK.
• 'Genetics of NAFLD & ALD' Falk Forum on Autoimmune & Congenital Liver Disorders, 2014, London, UK.
• 'Genetics of NAFLD' & 'New Therapies for NAFLD' NAFLD: Basics to Clinical Practice - An INASL Initiative, 2014, Chandigarh, India.
• 'NAFLD: Clinical Research Update' British Society of Gastroenterology, 2013, Glasgow, UK.
• 'SNPs, GWAS & NGS - Making Sense of the Alphabet Soup of Genomics' APASL, 2013, Singapore.

Research Interests

Prof Anstee's primary research interest is the study of genetic modifiers of progressive liver disease. His translational research has extended from the bench to the bedside with particular focus on the pathogenesis, diagnosis and treatment of Non-Alcoholic Fatty Liver Disease (NAFLD/NASH), including genetic and epigenetic modifiers of Hepatic Fibrosis progression and Hepatocellular Carcinoma (HCC) risk.

Prof Anstee leads the European NAFLD Registry and was also a member of the EU FP7 funded FLIP: Fatty Liver - Inhibition of Progression consortium. He coordinates two major international research consortia, both addressing different aspects of translational research in NAFLD:

1. EPoS: Elucidating Pathways of Steatohepatitis is funded by the EU Horizon 2020 scheme (€6 million, 2015-2019). This consortium focuses on understanding the pathophysiology of NAFLD and examining the determinants of individual risk for disease progression using a translational-science "multi-omics" approach. Further details about the project and membership of the consortium are available on the consortium website: www.epos-nafld.eu
   
2. LITMUS: Liver Investigation - Testing Marker Utility in Steatohepatitis is funded by the EU Investigative Medicines Initiative (IMI2) scheme (€47.3 million, 2017-2022). This consortium focuses on the comprehensive and robust validation/qualification of blood-based and imaging-based non-invasive biomarkers that may be used to diagnose and risk-stratify severity of NAFLD. Ultimately, this will facilitate clinical trials for NAFLD and improve the care of patients with NAFLD by streamlining their diagnosis and management. Further details about the project and membership of the consortium are available on the consortium website: www.litmus-project.eu. 
   
   

Through these and other projects he has established many ongoing fruitful collaborations with academic researchers based in the UK and in numerous international universities and with industrial partners from the pharmaceutical and biomarker industries.

Prof Anstee's scientific research has employed gene-driven and phenotype‐driven ethyl-nitrosourea (ENU) mutagenesis screens and more traditional targeted genetic modification techniques such as CRISPR/Cas9 to generate and study models of complex genetic disease traits including alcohol addiction, non-alcoholic steatohepatitis, drug induced liver injury (paracetamol toxicity and antibiotic related idiosyncratic drug reactions) and liver fibrosis. He has a long-standing research collaboration with investigators at MRC Harwell and leads the Genetics of Liver Disease (UK-GoLD) network.

He is a principal investigator in ongoing clinical trials of new therapies for fatty liver disease and hepatic fibrosis.

Funding

Prof Anstee's research is supported by substantial research grant funding from the European Union (FP7, H2020 and IMI2), the Medical Research Council (MRC) and the National Institute of Health Research (NIHR). He has also received grant funding from the Wellcome Trust and Academy of Medical Sciences.

In 2010 he was awarded a HEFCE Clinical Senior Lecturer Award and has previously received an MRC Clinical Research Fellowship to study genetic modifiers of Non-Alcoholic Steatohepatitis (NASH) & Liver Fibrosis.

Undergraduate Teaching

• Medicine & Surgery MB BS Course (CSIM3): Lecturer
• Medicine & Surgery MB BS Course (NME2): Seminar Tutor
• Biomedical Sciences BSc Course (BMS3020 - Chronic Disease): Lecturer
• Biomedical Sciences BSc Course (BGM3061 - Integrated Genetics): Lecturer
• MB BS Undergraduate Tutor

Lecture topics include: 'Non-Alcoholic Fatty Liver Disease (NAFLD)', 'Alcoholic Liver Disease', 'Viral Hepatitis (hepatitis C)', 'Cirrhosis & its Complications', 'Genetics of NAFLD'.

Postgraduate Teaching 

• Medical Sciences MRes project supervisor
  
• MRes (Diabetes): Lecturer
• MClinRes (MCR8006: Designing a Research Proposal): Lecturer
• MClinRes (MCR8004: Developing Your Career in Clinical Research): Lecturer

• Articles

  • Haigh L, Kirk C, El Gendy K, Gallacher J, Errington L, Mathers JC, Anstee QM. The effectiveness and acceptability of Mediterranean diet and calorie restriction in non-alcoholic fatty liver disease (NAFLD): A systematic review and meta-analysis. Clinical Nutrition 2022, 41(9), 1913-1931.
  • Zaki MYW, Alhasan SF, Shukla R, McCain M, Laszczewska M, Geh D, Patman GL, Televantou D, Whitehead A, Mauricio JP, Barksby B, Gee LM, Paish HL, Leslie J, Younes R, Burt AD, Borthwick LA, Thomas H, Beale GS, Govaere O, Sia D, Anstee QM, Tiniakos D, Oakley F, Reeves HL. Sulfatase-2 from Cancer Associated Fibroblasts: An Environmental Target for Hepatocellular Carcinoma?. Liver Cancer 2022, 11(6), 540-557.
  • Pai RK, Jairath V, Hogan M, Zou G, Adeyi OA, Anstee QM, Aqel BA, Behling C, Carey EJ, Clouston AD, Corey K, Feagan BG, Kleiner DE, Ma C, McFarlane SC, Noureddin M, Ratziu V, Valasek MA, Younossi ZM, Harrison SA, Loomba R. Reliability of histologic assessment for NAFLD and development of an expanded NAFLD activity score. Hepatology 2022, Epub ahead of print.
  • Anstee QM, Hallsworth K, Lynch N, Hauvespre A, Mansour E, Kozma S, Marino J-P, Bottomley J, Piercy J, Higgins V. Real-world management of non-alcoholic steatohepatitis differs from clinical practice guideline recommendations and across regions. JHEP Reports 2022, 4(1), 100411.
  • Sen P, Govaere O, Sinioja T, McGlinchey A, Geng D, Ratziu V, Bugianesi E, Schattenberg JM, Vidal-Puig A, Allison M, Cockell S, Daly AK, Hyotylainen T, Anstee QM, Oresic M. Quantitative modeling of human liver reveals dysregulation of glycosphingolipid pathways in nonalcoholic fatty liver disease. iScience 2022, 25(9), 104949.
  • McPherson S, Armstrong MJ, Cobbold JF, Corless L, Anstee QM, Aspinall RJ, Barclay ST, Brennan PN, Cacciottolo TM, Goldin RD, Hallsworth K, Hebditch V, Jack K, Jarvis H, Johnson J, Li W, Mansour D, McCallum M, Mukhopadhya A, Parker R, Ross V, Rowe IA, Srivastava A, Thiagarajan P, Thompson AI, Tomlinson J, Tsochatzis EA, Yeoman A, Alazawi W. Quality standards for the management of non-alcoholic fatty liver disease (NAFLD): consensus recommendations from the British Association for the Study of the Liver and British Society of Gastroenterology NAFLD Special Interest Group. Lancet Gastroenterology and Hepatology 2022, epub ahead of print.
  • Tingle SJ, Thompson ER, Bates L, Ibrahim IK, Govaere O, Shuttleworth V, Wang L, Figueiredo R, Palmer J, Bury Y, Anstee QM, Wilson C. Pharmacological testing of therapeutics using normothermic machine perfusion: A pilot study of 2,4-dinitrophenol delivery to steatotic human livers. Artificial Organs 2022, 46(11), 2201-2214.
  • Wong VW-S, Tak WY, Goh GBB, Cheng P-N, Lawitz EJ, Younossi ZM, Vuppalanchi R, Younes Z, Alkhouri N, Wang L, Liu J, Kersey K, Myers RP, Harrison SA, Goodman Z, Trauner M, Romero-Gomez M, Anstee QM, Nguyen MH, Okanoue T. Performance of Noninvasive Tests of Fibrosis Among Asians, Hispanic, and non-Hispanic Whites in the STELLAR Trials. Clinical Gastroenterology and Hepatology 2022, Epub ahead of print.
  • Rinella M, Dufour JF, Anstee QM, Goodman Z, Younossi Z, Harrison SA, Loomba R, Sanyal AJ, Bonacci M, Trylesinski A, Natha M, Shringarpure R, Granston T, Venugopal A, Ratziu R. Noninvasive Evaluation of Response to Obeticholic Acid in Patients with NASH: Results from the REGENERATE Study. Journal of Hepatology 2022, 76(3), 536-548.
  • Martinez-Arranz I, Bruzzone C, Noureddin M, Gil-Redondo R, Minchole I, Bizkarguenaga M, Arretxe E, Iruarrizaga-Lejarreta M, Fernandez-Ramos D, Lopitz-Otsoa F, Mayo R, Embade N, Newberry E, Mittendorf B, Izquierdo-Sanchez L, Smid V, Arnold J, Iruzubieta P, Perez Castano Y, Krawczyk M, Marigorta UM, Morrison MC, Kleemann R, Martin-Duce A, Hayardeny L, Vitek L, Bruha R, Aller de la Fuente R, Crespo J, Romero-Gomez M, Banales JM, Arrese M, Cusi K, Bugianesi E, Klein S, Lu SC, Anstee QM, Millet O, Davidson NO, Alonso C, Mato JM. Metabolic subtypes of patients with NAFLD exhibit distinctive cardiovascular risk profiles. Hepatology 2022, Epub ahead of print.
  • Martínez-Arranz I, Bruzzone C, Noureddin M, Gil-Redondo R, Minchole I, Bizkarguenaga M, Arretxe E, Iruarrizaga-Lejarreta M, Fernandez-Ramos D, Lopitz-Otsoa F, Mayo R, Embade N, Newberry E, Mittendorf B, Izquierdo-Sanchez L, Smid V, Arnold J, Iruzubieta P, Castano YP, Krawczyk M, Marigorta UM, Morrison MC, Kleemann R, Martin-Duce A, Hayardeny L, Vitek L, Bruha R, AllerdelaFuente R, Crespo J, Romero-Gomez M, Banales JM, Arrese M, Cusi K, Bugianesi E, Klein S, Lu SC, Anstee QM, Millet O, Davidson NO, Alonso C, Mato JM. Metabolic subtypes of nonalcoholic fatty liver disease patients exhibit distinctive cardiovascular risk profiles. Hepatology 2022, epub ahead of pub.
  • McGlinchey AJ, Govaere O, Geng D, Ratziu V, Allison M, Bousier J, Petta S, deOliviera C, Bugianesi E, Schattenberg JM, Daly AK, Hyotylainen T, Anstee QM, Oresic M. Metabolic signatures across the full spectrum of nonalcoholic fatty liver disease. JHEP Reports 2022, 4(5), 100477.
  • Govaere O, Petersen SK, Martinez-Lopez N, Wouters J, VanHaele M, Mancina RM, Jamialahmadi O, Bilkei-Gorzo O, Lassen PB, Darlay R, Peltier J, Palmer JM, Younes R, Tiniakos D, Aithal GP, Allison M, Vacca M, Göransson M, Berlinguer-Palmini R, Clark J, Drinnan MJ, Yki-Järvinen H, Dufour JF, Ekstedt M, Francque S, Petta S, Bugianesi E, Schattenberg JM, Day CP, Cordell HJ, Topal B, Clément K, Romeo S, Ratziu V, Roskams T, Daly AK, Anstee QM, Trost M, Härtlova A. Macrophage Scavenger Receptor 1 mediates lipid-induced inflammation in non-alcoholic fatty liver disease. Journal of Hepatology 2022, 76(5), 1001-1012.
  • Loomba R, Huang DQ, Sanyal AJ, Anstee QM, Trauner M, Lawitz EJ, Ding D, Ma L, Jia C, Billin A, Huss RS, Chung C, Goodman Z, Wong VW-S, Okanoue T, Romero-Gomez M, Abdelmalek MF, Muir A, Afdhal N, Bosch J, Harrison S, Younossi ZM, Myers RP. Liver stiffness thresholds to predict disease progression and clinical outcomes in bridging fibrosis and cirrhosis. Gut 2022, (ePub ahead of Print).
  • Johnson K, Leary PJ, Govaere O, Barter MJ, Charlton SH, Cockell SJ, Tiniakos D, Zatorska M, Bedossa P, Brosnan MJ, Cobbold JF, Ekstedt M, Aithal GP, Clement K, Schattenberg JM, Boursier J, Ratziu V, Bugianesi E, Anstee QM, Daly AK, LITMUS Consortium Investigators. Increased serum miR-193a-5p during non-alcoholic fatty liver disease progression: Diagnostic and mechanistic relevance. JHEP Reports 2022, 4(2), 100409.
  • Amin NB, Darekar A, Anstee QM, Wong VW-S, Tacke F, Vourvahis M, Lee DS, Charlton M, Alkhouri N, Nakajima A, Yunis C. Efficacy and safety of an orally administered DGAT2 inhibitor alone or coadministered with a liver-targeted ACC inhibitor in adults with non-alcoholic steatohepatitis (NASH): rationale and design of the phase II, dose-ranging, dose-finding, randomised, placebo-controlled MIRNA (Metabolic Interventions to Resolve NASH with fibrosis) study. BMJ Open 2022, 12(3), e056159.
  • Labenz C, Toenges G, Zheng M-H, Ding D, Myers RP, Galle PR, Armandi A, Ampuero J, Gomez MR, Bugianesi E, Anstee QM, Schattenberg JM. Derivation and validation of the NAFLD Cirrhosis Score (NCS) to distinguish bridging fibrosis from cirrhosis. European Journal of Internal Medicine 2022.
  • Sebastiani G, Patel K, Ratziu V, Feld JJ, Neuschwander-Tetri BA, Pinzani M, Petta S, Berzigotti A, Metrakos P, Shoukry N, Brunt EM, Tang A, Cobbold JF, Ekoe J-M, Seto K, Ghali P, Chevalier S, Anstee QM, Watson H, Bajaj H, Stone J, Swain MG, Ramji A. Current considerations for clinical management and care of non-alcoholic fatty liver disease: Insights from the 1st International Workshop of the Canadian NASH Network (CanNASH). Canadian Liver Journal 2022, 5(1), 61-90.
  • Geh D, Watson R, Sen G, French JJ, Hammond J, Turner P, Hoare T, Anderson K, Mcneil M, Mcpherson S, Masson S, Dyson J, Donnelly M, Macdougal L, Patel P, Hudson M, Anstee QM, White S, Robinson S, Pandanaboyana S, Walker L, Mccain M, Bury Y, Raman S, Burt A, Parkinson D, Haugk B, Darne A, Wadd N, Asghar S, Mariappan L, Margetts J, Stenberg B, Scott J, Littler P, Manas DM, Reeves HL. COVID-19 and liver cancer: Lost patients and larger tumours. BMJ Open Gastroenterology 2022, 9(1), e000794.
  • Brunt EM, Clouston AD, Goodman Z, Guy C, Kleiner DE, Lackner C, Tiniakos DG, Wee A, Yeh M, Leow WQ, Chng E, Ren Y, Bee G, Powell EE, Rinella M, Sanyal AJ, Neuschwander-Tetri B, Younossi Z, Charlton M, Ratziu V, Harriso SA, Tai D, Anstee QM. Complexity of ballooned hepatocyte feature recognition: Defining a training atlas for artificial intelligence-based imaging in NAFLD. Journal of Hepatology 2022, 76(5), 1030-1041.
  • Vali Y, Eijk R, Hicks T, Jones WS, Suklan J, Holleboom AG, Ratziu V, Langendam MW, Anstee QM, Bossuyt PMM. Clinicians’ Perspectives on Barriers and Facilitators for the Adoption of Non-Invasive Liver Tests for NAFLD: A Mixed-Method Study. Journal of Clinical Medicine 2022, 11(10), 2707.
  • Ratziu V, Anstee QM, Wong VW-S, Schattenberg JM, Bugianesi E, Augustin S, Gheorghe L, Zambon V, Reau N. An international survey on patterns of practice in NAFLD and expectations for therapies—The POP-NEXT project. Hepatology 2022, Epub ahead of print.
  • Gallage S, Avila JEB, Ramadori P, Focaccia E, Rahbari M, Ali A, Malek NP, Anstee QM, Heikenwalder M. A researcher’s guide to preclinical mouse NASH models. Nature Metabolism 2022, 4, 1632–1649.
  • Vujkovic M, Ramdas S, Lorenz KM, Guo X, Darlay R, Cordell HJ, He J, Gindin Y, Chung C, Myers R, Schneider C, Park J, Lee K, Serper M, Carr R, Kaplan D, Haas M, MacLean M, Witschey W, Zhu X, Tcheandjieu C, Kember R, Kranzler H, Verma A, Giri A, Klarin D, Sun Y, Huang J, Huffman J, TownsendCreasy K, Hand N, Liu C, Long M, Yao J, Budoff M, Tan J, Li X, Lin H, Chen Y, Taylor K, Chang R, Krauss R, Vilarinho S, Brancale J, Nielsen J, Locke A, Jones M, Verweij N, Baras A, Reddy K, NeuschwanderTetri B, Schwimmer J, Sanyal A, Chalasani N, Ryan K, Mitchell B, Gill D, Wells A, Manduchi E, Saiman Y, Mahmud N, Miller D, Reaven P, Phillips L, Muralidhar S, DuVall S, Lee J, Assimes T, Pyarajan S, Cho K, Edwards T, Damrauer S, Wilson P, Gaziano J, ODonnell C, Khera A, Grant S, Brown C, Tsao P, Saleheen D, Lotta L, Bastarache L, Anstee QM, Daly A, Meigs J, Rotter JI, Lynch JA, Rader DJ, Voight BF, Chang KM. A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation. Nature Genetics 2022, Epub ahead of print.
  • Kozumi K, Kodama T, Murai H, Sakane S, Govaere O, Cockell S, Motooka D, Kakita N, Yamada Y, Kondo Y, Tahata Y, Yamada R, Hikita H, Sakamori R, Kamada Y, Daly AK, Anstee QM, Tatsumi T, Morii E, Takehara T. Transcriptomics Identify Thrombospondin-2 as a Biomarker for Nonalcoholic Steatohepatitis and Advanced Liver Fibrosis. Hepatology 2021, 74(5), 2452-2466.
  • Jarvis H, McPherson S, Anstee QM, Hanratty B. The pathway to better primary care for chronic liver disease. British Journal of General Practice 2021, 71(705), 180-182.
  • Lazarus JV, Mark HE, Villota-Rivas M, Palayew A, Carrieri P, Colombo M, Ekstedt M, Esmat G, George J, Marchesini G, Novak K, Ocama P, Ratziu V, Razavi H, Romero-Gómez M, Silva M, Spearman CW, Tacke F, Tsochatzis EA, Yilmaz Y, Younossi ZM, Wong VW, Zelber-Sagi S, Cortez-Pinto H, Anstee QM. The global NAFLD policy review and preparedness index: are countries ready to address this silent public health challenge?. Journal of Hepatology 2021, Epub ahead of print.
  • Lazarus JV, Palayew A, Carrieri P, Ekstedt M, Marchesini G, Novak K, Ratziu V, Romero-Gómez M, Tacke F, Zelber-Sagi S, Cortez-Pinto H, Anstee QM. The European ‘NAFLD Preparedness Index’ — is Europe ready to meet the challenge of fatty liver disease?. JHEP Reports 2021, 3(2), 100234.
  • Younossi ZM, Anstee QM, Wong VW, Trauner M, Lawitz EJ, Harrison SA, Camargo M, Kersey K, Subramanian GM, Myers RP, Stepanova M. The Association of Histologic and Non-invasive Tests with Adverse Clinical and Patient-Reported Outcomes in Patients with Advanced Fibrosis Due to Nonalcoholic Steatohepatitis. Gastroenterology 2021, 160(5), 1608-1619.e13.
  • Teo K, Abeysekera KWM, Adams L, Aigner E, Anstee QM, Banales JM, Banerjee R, Basu P, Berg T, Bhatnagar P, Buch S, Canbay A, Caprio S, Chatterjee A, Chen YD, Chowdhury A, Daly AK, Datz C, deGraciaHahn D, DiStefano JK, Dong J, Duret A, Emdin C, Fairey M, Gerhard GS, Guo X, Hampe J, Hickman M, Heintz L, Hudert C, Hunter H, Kelly M, Kozlitina J, Krawczyk M, Lammert F, Langenberg C, Lavine J, Li L, Lim HK, Loomba R, Luukkonen PK, Melton PE, Mori TA, Palmer ND, Parisinos CA, Pillai SG, Qayyum F, Reichert MC, Romeo S, Rotter JI, Im YR, Santoro N, Schafmayer C, Speliotes EK, Stender S, Stickel F, Still CD, Strnad P, Taylor KD, TybjærgHansen A, Umano GR, Utukuri M, Valenti L, Wagenknecht LE, Wareham NJ, Watanabe RM, Wattacheril J, Yaghootkar H, YkiJarvinen H, Young KA, Mann JP. rs641738C>T near MBOAT7 is associated with liver fat, ALT and fibrosis in NAFLD: A meta-analysis. Journal of Hepatology 2021, 74(1), 20-30.
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  • Boyle M, Masson S, Anstee QM. The bidirectional impacts of alcohol consumption and the metabolic syndrome: Cofactors for progressive fatty liver disease. Journal of Hepatology 2018, 68(2), 251-267.
  • Anstee QM, Mantovani A, Tilg H, Targher G. Risk of cardiomyopathy and cardiac arrhythmias in patients with nonalcoholic fatty liver disease. Nature Reviews Gastroenterology and Hepatology 2018, 15, 425-439.
  • Cobbold JF, Atkinson S, Marchesi JR, Smith A, Wai SN, Stove J, Shojaee-Moradie F, Jackson N, Umpleby AM, Fitzpatrick J, Thomas EL, Bell JD, Holmes E, Taylor-Robinson SD, Goldin RD, Yee MS, Anstee QM, Thursz MR. Rifaximin in non-alcoholic steatohepatitis: An open-label pilot study. Hepatology Research 2018, 48(1), 69-77.
  • Labenz C, Huber Y, Kalliga E, Nagel M, Ruckes C, Straub BK, Galle PR, Worns M-A, Anstee QM, Schuppan D, Schattenberg JM. Predictors of advanced fibrosis in non-cirrhotic non-alcoholic fatty liver disease in Germany. Alimentary Pharmacology and Therapeutics 2018, 48(10), 1109-1116.
  • Petta S, Sebastiani G, Bugianesi E, Viganò M, Wong VWS, Berzigotti A, Fracanzani AL, Anstee QM, Marra F, Barbara M, Calvaruso V, Cammà C, Di Marco V, Craxì A, de Ledinghen V. Noninvasive Prediction of Esophageal Varices by Stiffness and Platelet in Nonalcoholic Fatty Liver Disease Cirrhosis. Journal of Hepatology 2018, 69(4), 878-885.
  • Estes C, Anstee QM, Arias-Loste MT, Bantel H, Bellentani S, Caballeria J, Colombo M, Craxi A, Crespo J, Day CP, Geier A, Kondili LA, Lazarus JV, Loomba R, Manns MP, Marchesini G, Negro F, Petta S, Ratziu V, Romero-Gomez M, Sanyal A, Schattenberg JM, Tacke F, Trautwein C, Wei L, Zeuzem S, Razavi H. Modeling NAFLD Disease Burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016-2030. Journal of Hepatology 2018, 69(4), 896-904.
  • Mann JP, Vreugdenhil A, Socha P, Janczyk W, Baumann U, Rajwal S, Casswall T, Marcus C, van Mourik I, O'Rahilly S, Savage DB, Noble-Jamieson G, Lacaille F, Dabbas M, Dubern B, Kelly DA, Nobili V, Anstee QM. European paediatric non-alcoholic fatty liver disease registry (EU-PNAFLD): Design and rationale. Contemporary Clinical Trials 2018, 75, 67-71.
  • Siddiqui MS, Harrison SA, Abdelmalek MF, Anstee QM, Bedossa P, Castera L, Dimick-Santos L, Friedman SL, Greene K, Kleiner DE, Megnien S, Neuschwander-Tetri BA, Ratziu V, Schabel E, Miller V, Sanyal AJ. Case definitions for inclusion and analysis of endpoints in clinical trials for nonalcoholic steatohepatitis through the lens of regulatory science. Hepatology 2018, 67(5), 2001-2012.
  • Codner GF, Mianne J, Caulder A, Loeffler J, Fell R, King R, Allan AJ, Mackenzie M, Pike FJ, McCabe CV, Christou S, Joynson S, Hutchison M, Stewart ME, Kumar S, Simon MM, Agius L, Anstee QM, Volynski KE, Kullmann DM, Wells S, Teboul L. Application of long single-stranded DNA donors in genome editing: Generation and validation of mouse mutants. BMC Biology 2018, 16(1), 70.
  • Codner GF, Mianné J, Caulder A, Loeffler J, Fell R, King R, Allan AJ, Mackenzie M, Pike FJ, McCabe CV, Christou S, Joynson S, Hutchison M, Stewart ME, Kumar S, Simon MM, Agius L, Anstee QM, Volynski KE, Kullmann DM, Wells S, Teboul L. Application of long single-stranded DNA donors in genome editing: generation and validation of mouse mutants. BioMedCentral Biology 2018, 16, 70.
  • Isokuortti E, Zhou Y, Peltonen M, Bugianesi E, Clement K, Bonnefont-Rousselot D, Lacorte J-M, Gastaldelli A, Schuppan D, Schattenberg JM, Hakkarainen A, Lundbom N, Jousilahti P, Mannisto S, Keinanen-Kiukaanniemi S, Saltevo J, Anstee QM, Yki-Jarvinen H. Use of HOMA-IR to diagnose non-alcoholic fatty liver disease: a population-based and inter-laboratory study. Diabetologia 2017, 60(10), 1873-1882.
  • Liu W, Anstee QM, Wang X, Gawrieh S, Gamazon ER, Athinarayanan S, Liu Y-L, Darlay R, Cordell HJ, Daly AK, Day CP, Chalasani N. Transcriptional regulation of PNPLA3 and its impact on susceptibility to nonalcoholic fatty liver Disease (NAFLD) in humans. Aging 2017, 9(1), 26-40.
  • Govaere O, Petz M, Wouters J, Vandewynckel Y-P, Scott EJ, Topal B, Nevens F, Verslype C, Anstee QM, Van Vlierberghe H, Mikulits W, Roskams T. The PDGFRα-laminin B1-keratin 19 cascade drives tumor progression at the invasive front of human hepatocellular carcinoma. Oncogene 2017, 36, 6605-6616.
  • Donati B, Pietrelli A, Pingitore P, Dongiovanni P, Caddeo A, Walker L, Baselli G, Pelusi S, Rosso C, Vanni E, Daly A, Mancina RM, Grieco A, Miele L, Grimaudo S, Craxi A, Petta S, De Luca L, Maier S, Soardo G, Bugianesi E, Colli F, Romagnoli R, Anstee QM, Reeves HL, Fracanzani AL, Fargion S, Romeo S, Valenti L. Telomerase reverse transcriptase germline mutations and hepatocellular carcinoma in patients with nonalcoholic fatty liver disease. Cancer Medicine 2017, 6(8), 1930-1940.
  • Hardy T, Zeybel M, Day CP, Dipper C, Masson S, McPherson S, Henderson E, Tiniakos D, White S, French J, Mann DA, Anstee QM, Mann J. Plasma DNA methylation: A potential biomarker for stratification of liver fibrosis in non-alcoholic fatty liver disease. Gut 2017, 66(7), 1321-1328.
  • Adams LA, Anstee QM, Tilg H, Targher G. Non-Alcoholic fatty liver disease and its relationship with cardiovascular disease and other extrahepatic diseases. Gut 2017, 66(6), 1138-1153.
  • Mann JP, Anstee QM. NAFLD: PNPLA3 and obesity: a synergistic relationship in NAFLD. Nature Reviews Gastroenterology and Hepatology 2017, 14(9), 506-507.
  • Donati B, Dongiovanni P, Romeo S, Meroni M, McCain M, Miele L, Petta S, Maier S, Rosso C, De Luca L, Vanni E, Grimaudo S, Romagnoli R, Colli F, Ferri F, Mancina R, Iruzubieta P, Craxi A, Fracanzani A, Grieco A, Corradini S, Aghemo A, Colombo M, Soardo G, Bugianesi E, Reeves H, Anstee Q, Fargion S, Valenti L. MBOAT7 rs641738 variant and hepatocellular carcinoma in non-cirrhotic individuals. Scientific Reports 2017, 7, 4492.
  • Avery L, Exley C, McPherson S, Trenell MI, Anstee QM, Hallsworth K. Lifestyle Behavior Change in Patients With Nonalcoholic Fatty Liver Disease: A Qualitative Study of Clinical Practice. Clinical Gastroenterology and Hepatology 2017, 15(12), 1968-1971.
  • Shalapour S, Lin XJ, Bastian IN, Brain J, Burt AD, Aksenov AA, Vrbanac AF, Li W, Perkins A, Matsutani T, Zhong Z, Dhar D, Navas-Molina JA, Xu J, Loomba R, Downes M, Yu RT, Evans RM, Dorrestein PC, Knight R, Benner C, Anstee QM, Karin M. Inflammation-induced IgA⁺ cells dismantle anti-liver cancer immunity. Nature 2017, 551(7680), 340-345.
  • Luukkonen PK, Zhou Y, Nidhina Haridas PA, Dwivedi OP, Hyotylainen T, Ali A, Juuti A, Leivonen M, Tukiainen T, Ahonen L, Scott E, Palmer JM, Arola J, Orho-Melander M, Vikman P, Anstee QM, Olkkonen VM, Oresic M, Groop L, Yki-Jarvinen H. Impaired hepatic lipid synthesis from polyunsaturated fatty acids in TM6SF2 E167K variant carriers with NAFLD. Journal of Hepatology 2017, 67(1), 128-136.
  • McCabe WA, Way MJ, Ruparelia K, Knapp S, Ali MA, Anstee QM, Thomas HC, McQuillin A, Morgan MY. Genetic variation in GABRβ1 and the risk for developing alcohol dependence. Psychiatric Genetics 2017, 27(3), 110-115.
  • Houghton D, Thoma C, Hallsworth K, Cassidy S, Hardy T, Burt AD, Tiniakos D, Hollingsworth KG, Taylor R, Day CP, McPherson S, Anstee QM, Trenell MI. Exercise Reduces Liver Lipids and Visceral Adiposity in Patients With Nonalcoholic Steatohepatitis in a Randomized Controlled Trial. Clinical Gastroenterology and Hepatology 2017, 15(1), 96-102.e3.
  • Houghton D, Hallsworth K, Thoma C, Cassidy S, Hardy T, Heaps S, Hollingsworth KG, Taylor R, Day CP, Masson S, McPherson S, Anstee QM, Trenell MI. Effects of Exercise on Liver Fat and Metabolism in Alcohol Drinkers. Clinical Gastroenterology and Hepatology 2017, 15(10), 1596-1603.e3.
  • Ogrodnik M, Miwa S, Tchkonia T, Tiniakos D, Wilson CL, Lahat A, Day CP, Burt A, Palmer A, Anstee QM, Nagaraja Grellscheid S, Hoeijmakers JHJ, Barnhoorn S, Mann DA, Bird TG, Vermeij WP, Kirkland JL, Passos JF, von Zglinicki T, Jurk D. Cellular senescence drives age-dependent hepatic steatosis. Nature Communications 2017, 8, 15691.
  • Sheridan DA, Aithal G, Alazawi W, Allison M, Anstee Q, Cobbold J, Khan S, Fowell A, McPherson S, Newsome PN, Oben J, Tomlinson J, Tsochatzis E. Care standards for non-alcoholic fatty liver disease in the United Kingdom 2016: a cross-sectional survey. Frontline Gastroenterology 2017, 8(4), 252-259.
  • McPherson S, Hardy T, Dufour JF, Petta S, Romero-Gomez M, Allison M, Oliveira CP, Francque S, Van Gaal L, Schattenberg JM, Tiniakos D, Burt AD, Bugianesi E, Ratziu V, Day CP, Anstee QM. Age as a Confounding Factor for the Accurate Non-Invasive Diagnosis of Advanced NAFLD Fibrosis. American Journal of Gastroenterology 2017, 112(5), 740-751.
  • McPherson S, Wilkinson N, Tiniakos D, Wilkinson J, Burt AD, McColl E, Stocken DD, Steen N, Barnes J, Goudie N, Stewart S, Bury Y, Mann D, Anstee QM, Day CP. A randomised controlled trial of losartan as an anti-fibrotic agent in non-alcoholic steatohepatitis. PLoS One 2017, 12(4), e0175717.
  • Anstee QM, Seth D, Day CP. Genetic Factors That Affect Risk of Alcoholic and Nonalcoholic Fatty Liver Disease. Gastroenterology 2016, 150(8), 1728-1744.e7.
  • Ratziu V, Harrison SA, Francque S, Bedossa P, Lehert P, Serfaty L, Romero-Gomez M, Boursier J, Abdelmalek M, Caldwell S, Drenth J, Anstee QM, Hum D, Hanf R, Roudot A, Megnien S, Staels B, Sanyal A, GOLDEN-505 Investigator Study Group. Elafibranor, an Agonist of the Peroxisome Proliferator−Activated Receptor−α and −δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening. Gastroenterology 2016, 150(5), 1147-1159.
  • Munteanu M, Tiniakos D, Anstee Q, Charlotte F, Marchesini G, Bugianesi E, Trauner M, Romero Gomez M, Oliveira C, Day C, Dufour JF, Bellentani S, Ngo Y, Traussnig S, Perazzo H, Deckmyn O, Bedossa P, Ratziu V, Poynard T, FLIP Consortium and the FibroFrance Group Collaborators, Ratziu V, Poynard T, Castille JM, Ngo Y, Langon T, Lawlor D, Marchesini G, Marra F, Bugianesi E, Bellentani S, Dufour JF, Romero Gomez M, Sørensen T, Tribelli C, DeMinicis S, Trauner M, Oliveira C, Bedossa P, Burt AD, Gouw AS, Lackner C, Schirmacher P, Terracciano L, Tiniakos D, Brain J, Bury Y, Cabibi D, Charlotte F, David E, Losi L, Montani M, Pareja MJ, Wendum D, Wrba F, Ziol M, Poynard T, Thabut D, Moussalli J, Lebray P, Rudler M, Bismuth FI, Charlotte F, Rosmorduc O, Calmus Y, Hartemann A, Jacqueminet S, Bruckert E, Giral P, Naveau S, Perlemuter G, Varsat B, Mercadier A. Diagnostic performance of FibroTest, SteatoTest and ActiTest in patients with NAFLD using the SAF score as histological reference. Alimentary Pharmacology and Therapeutics 2016, 44(8), 877-889.
  • Weston CJ, Shepherd EL, Claridge LC, Rantakari P, Curbishley SM, Tomlinson JW, Hubscher SG, Reynolds GM, Aalto K, Anstee QM, Jalkanen S, Salmi M, Smith DJ, Day CP, Adams DH. Vascular adhesion protein-1 promotes liver inflammation and drives hepatic fibrosis. Journal of Clinical Investigation 2015, 125(2), 501-520.
  • Possamai LA, McPhail MJW, Khamri W, Wu BS, Concas D, Harrison M, Williams R, Cox RD, Cox IJ, Anstee QM, Thursz MR. The role of intestinal microbiota in murine models of acetaminophen-induced hepatotoxicity. Liver International 2015, 35(3), 764-773.
  • Hardy T, Anstee QM, Day CP. Nonalcoholic fatty liver disease: new treatments. Current Opinion in Gastroenterology 2015, 31(3), 175-183.
  • Hallsworth K, Thoma C, Hollingsworth KG, Cassidy S, Anstee QM, Day CP, Trenell MI. Modified high-intensity interval training reduces liver fat and improves cardiac function in non-alcoholic fatty liver disease: A randomised controlled trial. Clinical Science 2015, 129(12), 1097-1105.
  • McPherson S, Hardy T, Henderson E, Burt AD, Day CP, Anstee QM. Evidence of NAFLD progression from steatosis to fibrosing-steatohepatitis using paired biopsies: Implications for prognosis and clinical management. Journal of Hepatology 2015, 62(5), 1148-1155.
  • Zeybel M, Hardy T, Robinson SM, Fox C, Anstee QM, Ness T, Masson S, Mathers JC, French J, White S, Mann J. Differential DNA methylation of genes involved in fibrosis progression in non-alcoholic fatty liver disease and alcoholic liver disease. Clinical Epigenetics 2015, 7(25).
  • Liu Y-L, Reeves HL, Burt AD, Tiniakos D, McPherson S, Leathart JBS, Allison MED, Alexander GJ, Piguet A-C, Anty R, Donaldson P, Aithal GP, Francque S, VanGaal L, Clement K, Ratziu V, Dufour J-F, Day CP, Daly AK, Anstee QM. TM6SF2 rs58542926 Influences Hepatic Fibrosis Progression in Patients with Non-Alcoholic Fatty Liver Disease. Nature Communications 2014, 5, 4309.
  • McPherson S, Henderson E, Burt AD, Day CP, Anstee QM. Serum immunoglobulin levels predict fibrosis in patients with non-alcoholic fatty liver disease. Journal of Hepatology 2014, 60(5), 1055-1062.
  • Hallsworth K, Thoma C, Moore S, Ploetz T, Anstee QM, Taylor R, Day CP, Trenell MI. Non-alcoholic fatty liver disease is associated with higher levels of objectively measured sedentary behaviour and lower levels of physical activity than matched healthy controls. Frontline Gastroenterology 2014, 1-8.
  • Anty R, Tonohouan M, Ferrari-Panaia P, Piche T, Pariente A, Anstee QM, Gual P, Tran A. Low Levels of 25-Hydroxy Vitamin D are Independently Associated with the Risk of Bacterial Infection in Cirrhotic Patients. Clinical and Translational Gastroenterology 2014, 5, 1-10.
  • Aravinthan A, Mells G, Allison M, Leathart J, Kotronen A, Yki-Jarvinen H, Daly AK, Day CP, Anstee QM, Alexander G. Gene Polymorphisms of Cellular Senescence Marker P21 and Disease Progression in Non-Alcohol-Related Fatty Liver Disease. Cell Cycle 2014, 13(9), 1489-1494.
  • Liu Y-L, Patman GL, Leathart J, Piguet A-C, Burt AD, Dufour J-F, Day CP, Daly AK, Reeves HL, Anstee QM. Carriage of the PNPLA3 rs738409 C>G Polymorphism Confers an Increased Risk of Non-Alcoholic Fatty Liver Disease Associated Hepatocellular Carcinoma. Journal of Hepatology 2014, 61(1), 75-81.
  • Anstee QM, Targher G, Day CP. Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis. Nature Reviews Gastroenterology and Hepatology 2013, 10(6), 330-344.
  • Anstee QM, Knapp S, Maguire EP, Hosie AM, Thomas P, Mortensen M, Bhome R, Martinez A, Walker SE, Dixon CI, Ruparelia K, Montagnese S, Kuo YT, Herlihy A, Bell JD, Robinson I, Guerrini I, McQuillin A, Fisher EMC, Ungless MA, Gurling HMD, Morgan MY, Brown SDM, Stephens DN, Belelli D, Lambert J, Smart T, Thomas HC. Mutations in the Gabrb1 gene promote alcohol consumption through increased tonic inhibition. Nature Communications 2013, 4, 1-11.
  • Goldsworthy M, Absalom NL, Schröter D, Matthews HC, Bogani D, Moir L, Long A, Church C, Hugill A, Anstee QM, Goldin R, Thursz M, Hollfelder F, Cox RD. Mutations in Mll2, an H3K4 methyltransferase, result in insulin resistance and impaired glucose tolerance in mice. PLOS One 2013, 8(6), e61870.
  • Hallsworth K, Hollingsworth KG, Thoma C, Jakovljevic DG, MacGowan GA, Anstee QM, Taylor R, Day CP, Trenell MI. Cardiac structure and function are altered in adults with non-alcoholic fatty liver disease. Journal of Hepatology 2013, 58(4), 757-762.
  • McPherson S, Anstee QM, Henderson E, Day CP, Burt AD. Are simple noninvasive scoring systems for fibrosis reliable in patients with NAFLD and normal ALT levels?. European Journal of Gastroenterology & Hepatology 2013, 25(6), 652-658.
  • Al-Serri A, Anstee QM, Valenti L, Nobili V, Leathart JBS, Dongiovanni P, Patch J, Fracanzani A, Fargion S, Day CP, Daly AK. The SOD2 C₄₇T polymorphism influences NAFLD fibrosis severity: Evidence from case-control and intra-familial allele association studies. Journal of Hepatology 2012, 56(2), 448-454.
  • Levene AP, Kudo H, Armstrong MJ, Thursz MR, Gedroyc WM, Anstee QM, Goldin RD. Quantifying hepatic steatosis - more than meets the eye. Histopathology 2012, 60(6), 971-981.
  • Zeybel M, Hardy T, Wong YK, Mathers JC, Fox CR, Gackowska A, Oakley F, Burt AD, Wilson CL, Anstee QM, Barter MJ, Masson S, Elsharkawy AM, Mann DA, Mann J. Multigenerational epigenetic adaptation of the hepatic wound-healing response. Nature Medicine 2012, 18(9), 1369-U110.
  • Anstee QM, Day CP. A lipid to treat non-alcoholic fatty liver disease – The dawn of ‘lipo-rehabilitation’?. Journal of Hepatology 2012, 56(4), 987-989.
  • Anstee QM, Dhar A, Thursz MR. The role of hypercoagulability in liver fibrogenesis. Clinics and Research in Hepatology and Gastroenterology 2011, 35(8-9), 526-533.
  • Sauvage VR, Levene AP, Nguyen HT, Wood TC, Kudo H, Concas D, Thomas HC, Thursz MR, Goldin RD, Anstee QM, Elson DS. Multi-Excitation Fluorescence Spectroscopy for Analysis of Non-Alcoholic Fatty Liver Disease. Lasers in Surgery and Medicine 2011, 43(5), 392-400.
  • Anstee QM, McPherson S, Day CP. How big a problem is non-alcoholic fatty liver disease?. BMJ 2011, 343, d3897.
  • Possamai LA, Antoniades CG, Anstee QM, Quaglia A, Vergani D, Thursz MR, Wendon J. Role of monocytes and macrophages in experimental and human acute liver failure. World Journal of Gastroenterology 2010, 16(15), 1811-1819.
  • Cobbold JFL, Anstee QM, Thomas HC. Rational Testing: Investigating mildly abnormal serum aminotransferase values. British Medical Journal 2010, 341, c4039.
  • Anstee QM, Concas D, Kudo H, Levene A, Pollard J, Charlton P, Thomas HC, Thursz MR, Goldin RD. Impact of pan-caspase inhibition in animal models of established steatosis and non-alcoholic steatohepatitis. Journal of Hepatology 2010, 53(3), 542-550.
  • Cobbold JFL, Anstee QM, Goldin RD, Williams HRT, Matthews HC, North BV, Absalom N, Thomas HC, Thursz MR, Cox RD, Taylor-Robinson SD, Cox IJ. Phenotyping murine models of non-alcoholic fatty liver disease through metabolic profiling of intact liver tissue. Clinical Science 2009, 116(5-6), 403-413.
  • Anstee QM, Wright M, Goldin R, Thursz MR. Parenchymal extinction: coagulation and hepatic fibrogenesis. Clinics in Liver Disease 2009, 13(1), 117-126.
  • Kelly ML, Moir L, Jones L, Whitehill E, Anstee QM, Goldin RD, Hough A, Cheeseman M, Jansson JO, Peters J, Cox RD. A missense mutation in the non-neural G-protein α-subunit isoforms modulates susceptibility to obesity. International Journal of Obesity 2009, 33(5), 507-518.
  • Northup PG, Sundaram V, Fallon MB, Reddy KR, Balogun RA, Sanyal AJ, Anstee QM, Hoffman MR, Ikura Y, Caldwell H, The Coagulation in Liver Disease Group. Hypercoagulation and thrombophilia in liver disease. Journal of Thrombosis and Haemostasis 2008, 6(1), 2-9.
  • Martinelli A, Knapp S, Anstee QM, Worku M, Tommasi A, Zucoloto S, Goldin R, Thursz M. Effect of a thrombin receptor (protease-activated receptor 1, PAR-1) gene polymorphism in chronic hepatitis C liver fibrosis. Journal of Gastroenterology and Hepatology 2008, 23(9), 1403-1409.
  • Anstee QM, Goldin RD, Wright M, Martinelli A, Cox R, Thursz MR. Coagulation status modulates murine hepatic fibrogenesis: implications for the development of novel therapies. Journal of Thrombosis and Haemostasis 2008, 6(8), 1336-1343.
  • Anstee QM, Goldin RD. Mouse models in non-alcoholic fatty liver disease and steatohepatitis research. International Journal of Experimental Pathology 2006, 87(1), 1-16.
  • Anstee QM, Forbes A. The safe use of percutaneous gastrostomy for enteral nutrition in patients with Crohn's disease. European Journal of Gastroenterology & Hepatology 2000, 12(10), 1089-1093.
  • Lopes LM, Hughson E, Anstee QM, O'Neil D, Katz DR, Chain BM. Vectorial function of major histocompatibility complex class II in a human intestinal cell line. Immunology 1999, 98(1), 16-26.
  • Anstee QM, Forbes A. [Abstract] Safety of percutaneous gastrostomy (PEG) feeding in Crohn's disease. Gastroenterology 1999, 116(4 (part 2)), A662 abstract no. G2889.
  • Anstee QM, Forbes A. [Abstract] Safety of percutaneous gastrostomy (PEG) feeding in Crohn's disease. Gut 1999, 44(supplement 1), A36 abstract no. T144.

• Book Chapters

  • Bellamy C, Burt AD. The Liver in Systemic Disease. In: Burt, AD; Ferrell, LD; Hubscher, SG, ed. MacSween's Pathology of the Liver (Seventh Edition). Elsevier Inc, 2018, pp.966-1018.
  • Tiniakos DG, Anstee QM, Burt AD. Fatty Liver Disease. In: Burt, AD; Ferrell, LD; Hubscher, SG, ed. MacSween's Pathology of the Liver. Elsevier Inc, 2018, pp.308-371.
  • Anstee QM, Jones D. Liver and Biliary Tract Disease. In: Walker BR, Colledge NR, Ralston AH & Penman ID, ed. Davidson's Principles & Practice of Medicine. Churchill Livingstone, 2014.
  • Anstee QM, Smith BC, Thomas HC. Hepatitis B and hepatitis C co-infection. In: Foster, G.R., Rajender Reddy, K, ed. Clinical Dilemmas in Viral Liver Disease. Oxford: Wiley-Blackwell, 2010, pp.192-198.

• Conference Proceedings (inc. Abstracts)

  • Jarvis H, O'Keefe H, Craig D, Stow D, Anstee Q, Hanratty B. People with NAFLD also drink alcohol - how should we advise and manage this expanding group in primary care? A systematic review. In: Society for Academic Primary Care (SAPC) Annual Scientific Meeting 2020. 2020, University of Leeds: Society for Academic Primary Care (SAPC).
  • Breckons M, Doward L, Magdalena Balp M, Twiss J, Oluboyede Y, Vale L, Ternent L, Brass C, Sanyal A, Anstee Q. Evaluating the patient-perceived impact of non-alcoholic steatohepatitis with compensated cirrhosis. In: The Digital International Liver Congress. 2020, Online: EASL.
  • Houghton D, Zalewski P, Cassidy S, Thoma C, Hallsworth K, Avery L, Lukowska AB, Hardy T, Burt AD, Masson S, Day C, McPherson S, Anstee QM, Newton JL, Trenell MI. Autonomic function is impaired across the spectrum of NAFLD. In: The International Liver Congress 2017: 52nd Annual Meeting of the European Association for the Study of the Liver. 2017, Amsterdam, The Netherlands: Elsevier BV.
  • Francque SM, Ratziu V, Harrison S, Anstee QM, Bedossa P, Cordonnier G, Brozek J, Ben Sudrik F, Hum DW, Megnien S, Roudot A, Staels B, Hanf R, Darteil R, Sanyal AJ. Validation of mir-34a, mir-122 and mir-200a as bio-markers for identification of NASH patients eligible for treatment. In: 67th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2016. 2016, Boston, Massachusetts, USA: John Wiley & Sons, Inc.
  • Eddowes PJ, Anstee Q, Guha IN, Sheridan DA, Tsochatzis E, Cobbold J, Allison ME, Paradis V, Bedossa P, Newsome P. Staging fibrosis and excluding advanced fibrosis in patients with NAFLD: comparison of non-invasive markers in an interim analysis from a prospective multicentre study. In: 67th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2016. 2016, Washington DC: Wiley.
  • Eddowes PJ, Anstee Q, Guha IN, Sheridan DA, Tsochatzis E, Cobbold J, Allison ME, de Ledinghen V, Sasso M, Fournier C, Miette V, Paradis V, Bedossa P, Newsome PN. Novel Fibroscan-Based Score to Diagnose NASH and its severity in A Multi-centre UK Cohort of Patients with Suspected NAFLD. In: 67th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2016. 2016, Washington DC: Wiley-Blackwell.
  • Ratziu V, Francque SM, Harrison S, Anstee QM, Bedossa P, Brozek J, Hum DW, Megnien S, Roudot A, Hanf R, Staels B, Sanyal AJ. Improvement in NASH histological activity highly correlates with fibrosis regression. In: 67th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2016. 2016, Boston, Massachusetts, USA: John Wiley & Sons, Inc.
  • de Alwis NMW, Anstee QM, Day CP. How to Diagnose Nonalcoholic Fatty Liver Disease. In: Gut-Liver Interactions: From IBD to NASH. 2016, Innsbruck: S. Karger AG.
  • Houghton DH, Thoma CT, Cassidy SC, Hallsworth KH, Hollingsworth KGH, Taylor RT, Day CPD, Anstee QMA, Trenell MIT. Exercise reduces liver fat and improves body composition but not insulin sensitivity or inflammatory markers in non-alcoholic steatohepatitis. In: Diabetes UK Professional Conference. 2016, Glasgow: Wiley-Blackwell Publishing Ltd.
  • Ratziu V, Harrison SA, Francque S, Bedossa P, Anstee QM, Ben Sudrik F, Roudot A, Megnien S, Hum DW, Hanf R, Staels B, Sanyal AJ. ALT as a non-invasive biomarker of histological response to pharmacotherapy in NASH patients: insights from the elafibranor GOLDEN505 trial. In: 67th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2016. 2016, Washington DC: Wiley-Blackwell.
  • Dhar A, Tschotazis E, Brown R, Manousou P, Millson C, Aldersley M, Forbes S, Aggarwal K, Gera A, Cramp M, Holt A, Mutimer D, McPherson S, Burroughs A, Anstee Q, Goldin R, Thursz MR. Wafarin anticoagulation for liver fibrosis in patients transplanted for hepatitis C (WAFT-C): results at one year. In: 50th Annual Meeting of the European Association for the Study of the Liver. 2015, Vienna, Austria: Elsevier.
  • Anty R, Liu YL, Iannelli A, Patouraux S, Canivet C, Ben-Amor I, Schneck AS, Saint-Paul MC, Gugenheim J, Day C, Daly A, Tran A, Gual P, Anstee Q. The FNDC5 rs3480 is protective on the steatosis and fibrosis in patients with NAFLD. In: 50th Annual Meeting of the European Association for the Study of the Liver. 2015, Vienna, Austria: Elsevier.
  • Donati B, Vanni E, Dongiovanni P, Iavarone M, Rametta R, Rosso C, Carnelutti A, Petta S, Fracanzani AL, Reeves HL, Dofour JF, Miele L, Anstee Q, Bugianesi E, Soardo G, Fargion S, Valenti L. Telomerase reverse transcriptase mutations are associated with hepatocellular carcinoma in nash. In: 50th Annual Meeting of the European Association for the Study of the Liver. 2015, Vienna, Austria: Elsevier.
  • Whitehead A, Ogle L, Patman GL, Anwar G, Tiniakos DG, Anstee QM, Reeves HL, FLIP Investigators FP7 2007-2013 H. Ras and p-ERK in metabolic syndrome associated Hepatocellular Carcinoma (HCC). In: 50th Annual Meeting of the European Association for the Study of the Liver. 2015, Vienna, Austria: Elsevier.
  • Palmer J, Liu YL, Day CP, Daly A, Anstee QM. Mechanistic Study of TM6SF2 in NAFLD pathogenesis: Stably transfected Huh7 cells over-expressing the TM6SF2 E167K variant exhibit greater levels of oxidative stress. In: 50th Annual Meeting of the European Association for the Study of the Liver. 2015, Vienna, Austria: Elsevier.
  • Hardy T, Sharkey V, Zeybel M, Mathers JC, French J, White S, Mann DA, Anstee QM, Mann J. Laser capture microdissection reveals cell-specific DNA methylation signatures in key fibrosis modifier genes in chronic liver disease. In: The International Liver Congress 2015 - 50th Annual meeting of the European Association for the Study of the Liver. 2015, Vienna, Austria: Elsevier BV.
  • McPherson S, Hardy T, Henderson E, Allison M, Ratziu V, Francque S, Burt AD, Day C, Anstee QM. High rate of false positives for advanced fibrosis when simple non-invasive fibrosis tests are used in older patients (>=65 years) with NAFLD. In: 2nd Digestive Disorders Federation Conference. 2015, London, UK: BMJ Group.
  • Houghton D, Thoma C, Hallsworth K, Hollingsworth KG, Day CP, Anstee QM, Trenell MI. Exercise reduces liver fat, visceral fat and circulating triglycerides, but not circulating inflammatory markers in non-alcoholic steatohepatitis. In: The International Liver Congress 2015 - 50th Annual meeting of the European Association for the Study of the Liver. 2015, Vienna, Austria: Elsevier BV.
  • Whitehead A, Patman GL, Deuschle U, Day CP, Kremoser C, Tiniakos DG, Anstee QM, Reeves HL, FLIP Investigators FP7 2007-2013 H. Effects of FXR agonist PX20606 on tumour formation in animal models of non-alcoholic fatty liver disease. In: The International Liver Congress 2015 - 50th Annual meeting of the European Association for the Study of the Liver. 2015, Vienna, Austria: Elsevier.
  • Mcpherson S, Henderson E, Hardy T, Burt A, Day C, Anstee QM. Natural History of NAFLD: A Study of 108 Patients with Paired Liver Biopsies. In: British Society of Gastroenterology Annual General Meeting. 2014, Manchester, UK: BMJ Publishing Group.
  • McPherson S, Henderson E, Hardy T, Burt AD, Day C, Anstee QM. Natural history of NAFLD: A study of 108 patients with paired liver biopsies. In: British Society of Gastroenterology Annual General Meeting. 2014, Manchester, UK: BMJ Group.
  • Zeybel M, Hardy T, Fox C, Masson S, Mann D, Mathers J, Anstee Q, Mann J. Differential DNA methylation of genes involved in fibrosis progression in NAFLD and ALD. In: The International Liver Congress 2014: 49th Annual Meeting of the European Association for the Study of the Liver. 2014, London: Elsevier BV.
  • Cobbold JFL, Wai SN, Stove J, Shojaee-Moradie F, Fitzpatrick J, Thomas EL, Bell JD, Goldin RD, Taylor-Robinson SD, Yee MS, Anstee QM, Thursz MR. Rifaximin in Non-Alcoholic Steatohepatitis: An Open-Label Pilot Study. In: 48th Annual Meeting of the European Association for the Study of the Liver. 2013, Amsterdam, The Netherlands: Elsevier.
  • Patman GL, Televantou D, Whitehead A, Day CP, Oakley F, Mann DA, Burt AD, Anstee QM, Reeves HL, FLIP Investigators FP7-2007-2013. Mild Steatosis and Impaired Glucose Tolerance are Associated with Liver Cancer Development, While Progression to Nash Increases Number/Size in an Animal Model of NAFLD. In: 48th Annual meeting of the European Association for the Study of the Liver. 2013, Amsterdam, Netherlands: Elsevier BV.
  • Wang X, Onjiko RM, Anstee QM, Ratziu V, Liu YL, Cordell HJ, Darlay R, Day CP, Daly AK, Chalasani N, Liu W, FLIP Fatty Liver Inhibition Progression. Mapping Expression Quantitative Traits Loci (EQTL) for PNPLA3 Gene Identifies Additional SNPs Associated with Non-Alcoholic Fatty Liver Disease (NAFLD) Independent of rs738409. In: 48th Annual meeting of the European Association for the Study of the Liver. 2013, Amsterdam, Netherlands: Elsevier BV.
  • Thoma C, Hallsworth K, Hollingsworth K, Anstee Q, Taylor R, Day C, Trenell M. HIGH-INTENSITY INTERMITTENT EXERCISE THERAPY REDUCES LIVER FAT AND IMPROVES BODY COMPOSITION IN ADULTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE. In: 48th Annual Meeting of the European Association for the Study of the Liver. 2013, Amsterdam, The Netherlands: Elsevier BV.
  • Hallsworth K, Thoma C, Moore S, Ploetz T, Anstee QM, Day CP, Trenell MI. Higher Objectively Measured Sedentary Behaviour and Lower Levels of Physical Activity than Matched Healthy Controls. In: 48th Annual meeting of the European Association for the Study of the Liver. 2013, Amsterdam, Netherlands: Elsevier BV.
  • Barrie T, Yeung S, Fathima S, Anstee QM, Masson S, Mcpherson S. Does the Pre-Bone Mineral Density Frax Score Predict Fracture Risk in Patients with Cirrhosis?. In: British Society of Gastroenterology Annual General Meeting. 2013, Glasgow, UK: BMJ Publishing Group.
  • Liu YL, Patman G, Leathart J, Burt A, Day CP, Daly AK, Reeves H, Anstee QM, FLIP Fatty Liver Inhibition Progression. Carriage of PNPLA3 I148M is Associated with an Increased Risk of Non-Alcoholic Fatty Liver Disease Associated Hepatocellular Carcinoma. In: 48th Annual meeting of the European Association for the Study of the Liver. 2013, Amsterdam, Netherlands: Elsevier Science BV.
  • Hallsworth K, Hollingsworth KG, Thoma C, Anstee QM, Day CP, Trenell MI. Cardiac Function Improves Following High Intensity Intermittent Exercise Therapy in Non-Alcoholic Fatty Liver Disease. In: 48th Annual meeting of the European Association for the Study of the Liver. 2013, Amsterdam, Netherlands: Elsevier Science BV.
  • Hallsworth K, Hollingsworth KG, Thoma C, Jakovljevic DG, MacGowan GA, Anstee QM, Day CP, Taylor R, Trenell MI. Cardiac function improves following high intensity intermittent exercise in adults with non-alcoholic fatty liver disease. In: Diabetes UK Annual Professional Conference. 2013, Manchester, UK: Diabetes UK.
  • Whitehead A, Patman GL, Cornell L, Televantou D, Curtin N, Day CP, Burt AD, Piguet AC, Dufour JF, Anstee QM, Reeves HL, FLIP Investigators FP7-2007-2013. A Role for DNA Repair Protein Kinase (DNA-PK) in the Progression of Simple Steatosis to Steatohepatitis (NASH)?. In: 48th Annual meeting of the European Association for the Study of the Liver. 2013, Amsterdam, The Netherlands: Elsevier Science BV.
  • Anstee QM, Darlay R, Leathart J, Liu YL, Tordjman J, Clement K, Aithal G, Valenti L, Van Gaal L, Stickel F, Alison M, Romero-Gomez M, Andrade R, Reeves H, Bedossa P, Pihlajamaki J, Kotronen A, Yki-Jarvinen H, Chalasani N, Kleiner DE, Rotter J, Burt A, Ratziu V, Cordell HJ, Daly AK, Day CP, FLIP Fatty Liver Inhibition, NASH CRN Investigators. A candidate-gene approach to validation of genetic modifier associations using a large cohort with histologically characterised non-alcoholic fatty liver disease. In: The International Liver Congress 2013 – 48th Annual meeting of the European Association for the Study of the Liver. 2013, Amsterdam: Elsevier BV.
  • McPherson S, Griffiths L, Hardy T, Henderson E, Burt A, Day C, Anstee QM. The FIB-4 score reliability excludes advanced fibrosis in a diabetic cohort with NAFLD. In: 47th Annual Meeting of the European Association for the Study of the Liver (EASL). 2012, Barcelona, Spain: Elsevier BV.
  • Petts G, Dhar A, Kudo H, Sadiq F, Anstee QM, Kallis YN, Dorling A, Goldin R, Thursz MR. Targeted inhibition of Tissue Factor suppresses hepatic fibrosis in CCL4 treated mice. In: 63rd Annual Meeting of the American Association for the Study of Liver Diseases (AASLD). 2012, Boston, Massachusetts, USA: John Wiley & Sons, Inc.
  • Petts G, Dhar A, Kudo H, Sadiq F, Anstee QM, Kallis Y, Dorling A, Goldin R, Thursz M. Targeted inhibition of tissue factor and thrombin on CD31 expressing cells supresses hepatic fibrosis in CCL4 treated mice. In: 47th Annual Meeting of the European Association for the Study of the Liver (EASL). 2012, Barcelona, Spain: Elsevier BV.
  • Petts G, Dhar A, Kudo H, Sadiq F, Anstee Q, Kallis Y, Dorling A, Goldin R, Thursz M. Targeted inhibition of tissue factor and thrombin on CD31 expressing cells suppresses hepatic fibrosis in CCl4 treated mice. In: Digestive Disorders Federation Meeting. 2012, Liverpool, UK: BMJ Group.
  • Patman G, Hui KY, Anstee QM, Reeves HL. Oxidative stress induces alternative splicing and nuclear translocation of kruppel like factor 6. In: Digestive Disorders Federation Meeting. 2012, Liverpool, UK: BMJ Group.
  • Cobbold JFL, Peake CM, Anstee QM, Yee MS, Thursz MR. Measuring the effectiveness of a multidisciplinary non-alcoholic fatty liver disease clinic. In: 47th Annual Meeting of the European Association for the Study of the Liver (EASL). 2012, Barcelona, Spain: Elsevier BV.
  • Patman GL, Hui KY, Anstee QM, Reeves HL. Kruppel-like factor 6 splice variant 3 (KLF6-SV3) - The redox sensitive splice variant of KLF6 expressed in non-alcoholic steatohepatitis (NASH). In: 47th Annual Meeting of the European Association for the Study of the Liver (EASL). 2012, Barcelona, Spain: Elsevier BV.
  • Possamai LA, Harrison M, Cox RD, Williams R, Anstee QM, Thursz MR, Cox IJ. H-1-NMR metabolic profiling in germ-free and conventionally housed mouse models of acetaminophen-induced hepatotoxicity. In: 47th Annual Meeting of the European Association for the Study of the Liver (EASL). 2012, Barcelona, Spain: Elsevier BV.
  • Anstee QM, Darlay R, Leathart JB, Clement J, Clement K, Aithal GP, Valenti L, Van Gaal L, Stickel F, Allison ME, Romero-Gomez M, Andrade RJ, Reeves H, Pihlajamaki J, Bedossa P, Kotronen A, Yki-Jarvinen H, Chalasani NP, Kleiner DE, Rotter J, Burt AD, Ratziu V, Cordell HJ, Daly AK, Day CP. Genome-Wide Association Analysis Confirms Importance of PNPLA3 and Identifies Novel Variants Associated With Histologically Progressive Steatohepatitis in NAFLD. In: 63rd Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD). 2012, Boston, Massachusetts, USA: John Wiley & Sons, Inc.
  • Dhar A, Anstee QM, Sadiq F, Levene A, Cobbold J, Petts G, Taylor-Robinson S, Goldin R, Thursz MR. A role for anticoagulation in fibrogenesis: Supression of human hepatic stellate cell contractility and liver fibrosis in vitro and vivo. In: 47th Annual Meeting of the European Association for the Study of the Liver (EASL). 2012, Barcelona, Spain: Elsevier BV.
  • Concas D, Wu B, Kudo H, Levene A, Thomas HC, Goldin RD, Thursz MR, Anstee QM. Vanin-1 activity modulates the steatosis-steatohepatitis transition in progressive non-alcoholic steatohepatitis. In: Journal of Hepatology: 46th Annual Meeting of the European Association for the Study of the Liver (EASL). 2011, Berlin, Germany: Elsevier BV.
  • Patman GL, Anstee Q, Reeves HL. Hepatocellular Carcinoma in NASH: Is there a biological Rationale?. In: 9th Meeting of Therapy in Liver Diseases. 2011, Barcelona, Spain.
  • McPherson S, Anstee QM, Henderson E, Burt AD, Day CP. Are simple non-invasive scoring systems for fibrosis reliable in patients with NAFLD and normal ALT levels?. In: Hepatology: 62nd Annual Meeting of the American Association for the Study of Liver Diseases (AASLD). 2011, San Francisco, California, USA: John Wiley & Sons, Inc.
  • Levene A, Kudo H, Thursz M, Anstee QM, Goldin RD. Activating Autophagocytosis Decreases Fat Within the Liver. In: Journal of Pathology: 199th Scientific Meeting of the Pathological Society of Great Britain and Ireland. 2011, Cambridge, UK: John Wiley & Sons Ltd.
  • Anstee QM, Concas D, Wu B, Potter P, Cox R, Kudo H, Levene A, Goldin RD, Thursz MR, Thomas HC. A novel mouse model of hepatic glycogen storage disease Type 3 identified using a phenotype-driven ethyl-nitrosourea (ENU) mutagensis screen. In: Journal of Hepatology: 46th Annual Meeting of the European Association for the Study of the Liver (EASL). 2011, Berlin, Germany: Elsevier BV.
  • Anstee QM, Possamai LA, Concas D, Wu B, Hassett C, Cox RD, Thomas HC, Thursz MR. Novel quantitative trait locus for acetaminophen-induced hepatotoxicty identified on chromosome 18. In: 45th Annual Meeting of the European Association for the Study of the Liver. 2010, Vienna, Austria: Journal of Hepatology: Elsevier BV.
  • Levene AP, Kudo H, Thursz MR, Anstee QM, Goldin RD. Is oil red-O and digital image analysis the gold standard for quantifying steatosis in the liver?. In: 45th Annual Meeting of the European Association for the Study of the Liver. 2010, Vienna, Austria: Journal of Hepatology: Elsevier BV.
  • Dhar A, Anstee QM, Kudo H, Goldin R, Thursz MR. Coagulation proteins in acute liver injury: a role in initiation and propagation. In: 45th Annual Meeting of the European Association for the Study of the Liver. 2010, Vienna, Austria: Journal of Hepatology: Elsevier BV.
  • Matthews HC, Concas D, Kudo H, Anstee QM, Thomas H, Cox R, Goldin RD, Thursz MR. Cell surface pantetheinase, Vanin-1, increases oxidative damage in acetaminophen-induced liver injury via a reduction in glutathione. In: 45th Annual Meeting of the European Association for the Study of the Liver. 2010, Vienna, Austria: Journal of Hepatology: Elsevier BV.
  • Cobbold JF, Anstee QM, Taylor Robinson SD. The importance of fatty liver disease in clinical practice. In: Annual Meeting of the Nutrition Society and BAPEN. 2009, Cardiff International Arena, Cardiff: Proceedings of the Nutrition Society: Cambridge University Press.
  • Anstee QM, Hoa NT, Sauvage V, Concas D, Levene AP, Thomas H, Thursz MR, Elson D, Goldin R. Autofluorescence: modelling a tool for assessment of steatotic marginal grafts in liver transplantation. In: 60th Annual Meeting of the American Association for the Study of Liver Diseases. 2009, Boston, Massachusetts: Hepatology: John Wiley & Sons, Inc.
  • Knapp S, Hosie AM, Anstee QM, Thomos P, Mortensen M, Martinez A, Tymowska-Lalanne Z, McQuillin A, Gurling HM, Morgan MY, Kuo YT, Herlihy A, Bell JD, Robinson I, Fisher E, Brown S, Stephens D, Smart TG, Thomas HC. Identification of a model of alcohol preference and its similarity to human alcoholism. In: 59th Annual Meeting of the American Association for the Study of Liver Diseases. 2008, San Francisco, California: Hepatology: John Wiley & Sons, Inc.
  • Anstee QM, Goldsworthy M, Goldin R, Thomas HC, Cox R, Thursz M. Microarray analysis demonstrates insulin resistance is central to NASH pathogenesis in the IGT/6 model and suggests a role for CEACAM-1 in disease pathogenesis. In: 42nd Annual Meeting of the European Association for the Study of the Liver. 2007, Barcelona, Spain: Journal of Hepatology: Elsevier BV.
  • Cobbold JF, Chinthaplli S, Anstee QM, Goldin RD, Cox R, Thursz MR, Thomas HC, Taylor-Robinson SD, Cox IJ. Dietary constituents in mice are reflected in the hepatic lipid profile as detected by carbon-13 magic angle spinning magnetic resonance spectroscopy. In: 58th Annual Meeting of the American Association for the Study of Liver Diseases. 2007, Boston, Massachusetts: Hepatology: John Wiley & Sons, Inc.
  • Cobbold JF, Anstee QM, Goldin RD, Cox RD, Thursz MR, Thomas HC, Taylor-Robinson SD, Cox IJ. Can disease progression in non-alcoholic fatty liver disease be predicted by metabolic biomarkers of lipid accumulation and peroxidation?. In: 42nd Annual Meeting of the European Association for the Study of the Liver. 2007, Barcelona, Spain: Journal of Hepatology: Elsevier BV.
  • Anstee QM, Goldsworthy M, Goldin R, Thomas HC, Cox RD, Thursz M. Microarray principal components analysis demonstrates expression of Vanin-1 is a strong determinant of NASH pathogenesis in the IGT/6 model. In: 57th Annual Meeting of the American Association for the Study of Liver Diseases. 2006, Boston, Massachusetts: Hepatology: John Wiley & Sons, Inc.
  • Anstee QM, Wright M, Goldin R, Thomas HC, Thursz M. The factor V Leiden mutation accelerates disease progression in a mouse model of hepatic fibrosis induced by chronic carbon tetrachloride exposure. In: 55th Annual Meeting of the American Association for the Study of Liver Diseases. 2004, Boston, Massachusetts: Hepatology: John Wiley & Sons, Inc.
  • Anstee QM, Goldsworthy M, Haynes A, Hugill A, Goldin R, Thursz M, Cox RD, Thomas H. A novel murine model of non-alcoholic steatohepatitis generated using a sensitised ENU mutagenesis screen. In: 54th Annual Meeting of the American Association for the Study of Liver Diseases. 2003, Boston, Massachusetts: Hepatology: John Wiley & Sons, Inc.

• Editorials

  • Ratziu V, Rinella M, Beuers U, Loomba R, Anstee QM, Harrison S, Francque S, Sanyal A, Newsome PN, Younossi Z. The times they are a-changin' (for NAFLD as well). Journal of Hepatology 2020, 73(6), 1307-1309.
  • Ravaioli F, Anstee QM. Editorial: collagen proportionate area as a prognostic indicator in NAFLD. Alimentary Pharmacology and Therapeutics 2019, 49(11), 1452-1454.
  • Boyle M, Anstee QM. Editorial: hepatocellular carcinoma in non-cirrhotic NASH - a troubling reality. Alimentary Pharmacology and Therapeutics 2018, 48(9), 1021-1023.
  • Patel YA, Imperial JC, Muir AJ, Anstee QM, DeBrota D, Dimick-Santos L, Filozof C, Mehta R, Sanyal AJ, Schabel E, Neuschwander-Tetri BA, Miller V, Anstee QM, Bangma S, Baxter M, Boulos S, Burgess G, Chakravarthy M, Christian R, Coombs A, DeBrota D, Dimick-Santos L, Filozof C, Gannedahl G, Herrmann R, Hum D, Imperial J, Kendrick S, MacConell L, Megnien S, Mehta R, Miller V, Muir A, Neuschwander-Tetri BA, Patel Y, Peres D, Rossi S, Sanyal A, Schabel E, Shapiro D, St Pierre T, Zemel M. Baseline Parameters in Clinical Trials for Nonalcoholic Steatohepatitis: Recommendations From the Liver Forum. Gastroenterology 2017, 153(3), 621-625.e7.
  • McPherson S, Anstee QM. Changing Epidemiology of Chronic Liver Disease Among Ethnic Groups in the United States. Hepatology 2016, 64(6), 1843-1846.
  • Adams LA, Anstee QM. A fatty liver leads to a broken heart?. Journal of Hepatology 2016, 65(1), 14-16.
  • Kahali B, Liu YL, Daly AK, Day CP, Anstee QM, Speliotes EK. TM6SF2: Catch-22 in the Fight Against Nonalcoholic Fatty Liver Disease and Cardiovascular Disease?. Gastroenterology 2015, 148(4), 679-684.
  • Day CP, Anstee QM. Nonalcoholic Fatty Liver Disease: Foreword. Seminars in Liver Disease 2015, 35(3), 203-205.
  • Anstee QM. Animal models in nonalcoholic steatohepatitis research: utility and clinical translation. Liver International 2011, 31(4), 440-442.

• Letters

  • Scragg J, Charman SJ, van Hees VT, Avery L, Taylor GS, Anstee QM, McPherson S, Cassidy S, Hallsworth K. Physical Activity, Inactivity and Sleep in Patients with Significant Non-Alcoholic Fatty Liver Disease. American Journal of the Medical Sciences 2022, 363(1), 80-83.
  • Brandman D, Boyle M, McPherson S, Van Natta ML, Sanyal AJ, Kowdley K, Neuschwander-Tetri B, Chalasani N, Abdelmalek MF, Terrault NA, McCullough A, Bettencourt R, Caussy C, Kleiner DE, Behling C, Tonascia J, Anstee QM, Loomba R. Letter: non-invasive prediction models to exclude cirrhosis in NAFLD—not everyone fits the mould. Authors' reply. Alimentary Pharmacology and Therapeutics 2022, 56(1), 182-183.
  • Vali Y, Anstee QM, Bossuyt PM. Reply to: “Errors in modeling misrepresent the utility of the enhanced liver fibrosis test in the management of non-alcoholic fatty liver disease”. Journal of Hepatology 2020, 73(6), 1582-1583.
  • Lazarus JV, Cortez-Pinto H, Anstee QM. Reply to: “Caveats for the implementation of global strategies against non-alcoholic fatty liver disease”. Journal of Hepatology 2020, 73(1), 221-222.
  • Daly AK, Day CP, Liu YL, Anstee QM. TM6SF2 as a Genetic Risk Factor for Fibrosis. Hepatology 2015, 62(4), 1321-1321.
  • Anstee QM, Liu YL, Day CP, Reeves HL. Reply to: HCC and liver disease risk in homozygous PNPLA3 p.I148M carriers approach monogenic inheritance. Journal of Hepatology 2015, 62(4), 982-983.
  • Anstee QM, Jaques B, Hudson M, Reeves HL. Reply to "Hepatocellular carcinoma and the Newcastle-upon-Tyne area". Journal of Hepatology 2014, 60(6), 1330-1331.
  • Anty R, Anstee QM, Gual P, Tran A. Prophylaxis of bacterial infections in cirrhosis: Is an optimal 25-OH vitamin D level required?. Journal of Hepatology 2014, 61(4), 965-966.
  • Levene AP, Kudo H, Thursz MR, Anstee QM, Goldin RD. Is oil red-O staining and digital image analysis the gold standard for quantifying steatosis in the liver?. Hepatology 2010, 51(5), 1859-1859.

• Notes

  • Pfister D, Nunez N, Sinha A, Weiner A, Deczkowska A, Pinter M, Govaere O, Muller F, Anstee QM, Entgleitner T, Rad R, Pinyol R, Torrecilla S, Dudek M, Knolle P, Weber A, Lengenhagger D, Llovet JM, Amit I, Meissner F, Becher B, Heikenwalder M. Erratum: Adverse effects of PD-1 targeted immunotherapy in NAFLD-triggered HCC. Zeitschrift fur Gastroenterologie 2020, 58(3), e71-e71.
  • Shalapour S, Lin X-J, Bastian IN, Brain J, Burt AD, Aksenov AA, Vrbanac AF, Li W, Perkins A, Matsutani T, Zhong Z, Dhar D, Navas-Molina JA, Xu J, Loomba R, Downes M, Yu RT, Evans RM, Dorrestein PC, Knight R, Benner C, Anstee QM, Karin M. Erratum to: Inflammation-induced IgA⁺ cells dismantle anti-liver cancer immunity (Nature, (2017), 551, 7680, (340-345), 10.1038/nature24302). Nature 2018, 561(7721), E1-E1.
  • Shalapour S, Lin XJ, Bastian IN, Brain J, Burt AD, Aksenov AA, Vrbanac AF, Li W, Perkins A, Matsutani T, Zhong Z, Dhar D, Navas-Molina JA, Xu J, Loomba R, Downes M, Yu RT, Evans RM, Dorrestein PC, Knight R, Benner C, Anstee QM, Karin M. Author correction: Inflammation-induced IgA⁺ cells dismantle anti-liver cancer immunity. Nature 2018, 561, E1.

• Reviews

  • Rasmussen DGK, Anstee QM, Torstenson R, Golding B, Patterson SD, Brass C, Thakker P, Harrison S, Billin AN, Schuppan D, Dufour J-F, Andersson A, Wigley I, Shumbayawonda E, Dennis A, Schoelch C, Ratziu V, Yunis C, Bossuyt P, Karsdal MA. NAFLD and NASH biomarker qualification in the LITMUS consortium – Lessons learned. Journal of Hepatology 2023, epub ahead of print.
  • Pericas JM, Tacke F, Anstee QM, Di Prospero NA, Kjaer MS, Mesenbrink P, Koenig F, Genesca J, Ratziu V. Platform trials to overcome major shortcomings of traditional clinical trials in non-alcoholic steatohepatitis? Pros and cons. Journal of Hepatology 2022, (ePub ahead of Print).
  • Jarvis H, O'Keefe H, Craig D, Stow D, Hanratty B, Anstee QM. Does moderate alcohol consumption accelerate the progression of liver disease in NAFLD? A systematic review and narrative synthesis. BMJ Open 2022, 12(1), e049767.
  • Mak AL, Lee J, van Dijk A-M, Vali Y, Aithal GP, Schattenberg JM, Anstee QM, Brosnan MJ, Zafarmand MH, Ramsoekh D, Harrison SA, Nieuwdorp M, Bossuyt PM, Holleboom AG. Systematic review with meta-analysis: Diagnostic accuracy of Pro-C3 for hepatic fibrosis in patients with non-alcoholic fatty liver disease. Biomedicines 2021, 9(12), 1920.
  • van Dijk A-M, Vali Y, Mak AL, Lee J, Tushuizen ME, Zafarmand MH, Anstee QM, Brosnan MJ, Nieuwdorp M, Bossuyt PM, Holleboom AG. Systematic review with meta-analyses: Diagnostic accuracy of fibrometer tests in patients with non-alcoholic fatty liver disease. Journal of Clinical Medicine 2021, 10(13), 2910.
  • Masoodi M, Gastaldelli A, Hyotylainen T, Arretxe E, Alonso C, Gaggini M, Brosnan J, Anstee QM, Millet O, Ortiz P, Mato JM, Dufour J-F, Oresic M. Metabolomics and lipidomics in NAFLD: biomarkers and non-invasive diagnostic tests. Nature Reviews Gastroenterology and Hepatology 2021, 18, 835-856.
  • Schattenberg JM, Anstee QM, Caussy C, Bugianesi E, Popovic B. Differences between current clinical guidelines for screening, diagnosis and management of nonalcoholic fatty liver disease and real-world practice: a targeted literature review. Expert Review of Gastroenterology and Hepatology 2021, 15(11), 1253-1266.
  • Rinella ME, Tacke F, Sanyal AJ, Anstee QM. Report on the AASLD/EASL joint workshop on clinical trial endpoints in NAFLD. Journal of Hepatology 2019, 71(4), 823-833.
  • Anstee QM, Reeves HL, Kotsiliti E, Govaere O, Heikenwalder M. From NASH to HCC: current concepts and future challenges. Nature Reviews Gastroenterology and Hepatology 2019, 16, 411-428.
  • Scott EJ, Anstee QM. The genetics of alcoholic liver disease and non-alcoholic steatohepatitis. Clinical Medicine 2018, 18(Suppl. 2), s54-s59.
  • Younossi Z, Anstee QM, Marietti M, Hardy T, Henry L, Eslam M, George J, Bugianesi E. Global burden of NAFLD and NASH: Trends, predictions, risk factors and prevention. Nature Reviews Gastroenterology and Hepatology 2018, 15(1), 11-20.
  • Scott E, Anstee QM. Genetics of alcoholic liver disease and non-alcoholic steatohepatitis. Clinical Medicine 2018, 18, s54-s59.
  • Noureddin M, Anstee QM, Loomba R. Review article: emerging anti-fibrotic therapies in the treatment of non-alcoholic steatohepatitis. Alimentary Pharmacology and Therapeutics 2016, 43(11), 1109-1123.
  • Hardy T, Oakley F, Anstee QM, Day CP. Nonalcoholic Fatty Liver Disease: Pathogenesis and Disease Spectrum. Annual Review of Pathology: Mechanisms of Disease 2016, 11, 451-496.
  • Anstee QM, Day CP. The Genetics of Nonalcoholic Fatty Liver Disease: Spotlight on PNPLA3 and TM6SF2. Seminars in Liver Disease 2015, 35(3), 270-290.
  • Dyson JK, Anstee QM, McPherson S. Non-alcoholic fatty liver disease: a practical approach to treatment. Postgraduate Medical Journal 2015, 91(1072), 92-101.
  • Anstee QM, Daly AK, Day CP. Genetics of Alcoholic Liver Disease. Seminars in Liver Disease 2015, 35(4), 361-374.
  • Rowell RJ, Anstee QM. An overview of the genetics, mechanisms and management of NAFLD and ALD. Clinical Medicine, Journal of the Royal College of Physicians of London 2015, 15(6), s77-s82.
  • Rowell RJ, Anstee QM. An overview of the genetics, mechanisms and management of NAFLD and ALD. Clinical medicine 2015, 15(6), s77-s82.
  • Dyson JK, McPherson S, Anstee QM. Non-alcoholic fatty liver disease: non-invasive investigation and risk stratification. Postgraduate Medical Journal 2014, 90(1063), 254-266.
  • Anstee QM, Day CP. The genetics of NAFLD. Nature Reviews Gastroenterology and Hepatology 2013, 10(11), 645-655.
  • Dyson JK, McPherson S, Anstee QM. Non-alcoholic fatty liver disease: non-invasive investigation and risk stratification. Journal of Clinical Pathology 2013, 66(12), 1033-1045.
  • Dongiovanni P, Anstee QM, Valenti L. Genetic predisposition in NAFLD and NASH: impact on severity of liver disease and response to treatment. Current Pharmaceutical Design 2013, 19(29), 5219-5238.
  • Anstee QM, Day CP. S-adenosylmethionine (SAMe) therapy in liver disease: A review of current evidence and clinical utility. Journal of Hepatology 2012, 57(5), 1097-1109.
  • Tripodi A, Anstee QM, Sogaard KK, Primignani M, Valla DC. Hypercoagulability in cirrhosis: causes and consequences. Journal of Thrombosis and Haemostasis 2011, 9(9), 1713-1723.
  • Anstee QM, Daly AK, Day CP. Genetics of alcoholic liver disease and nonalcoholic fatty liver disease. Seminars in Liver Disease 2011, 31(2), 128-146.
  • Anstee QM, Daly AK, Day CP. Genetic modifiers of non-alcoholic fatty liver disease progression. Biochimica et Biophysica Acta: Molecular Basis of Disease 2011, 1812(11), 1557-1566.