Staff Profile

Roles and Responsibilities

Teaching - Curriculum Chair for Pharmacology, module leader, undergraduate teaching on several modules of Biomedical Sciences and Pharmacology programme, supervision of under- and postgraduate researchers

Wolfson Unit radiation protection supervisor 

Qualifications

BSc Applied Biology (upper second class honours) CNAA
PhD (Univ Central Lancs)

Previous Positions

Staff Scientist, Institute of Cellular Medicine (2006-2018)

Scientific Toxicologist, Chemical Hazards and Poisons Division (Newcastle), Health Protection Agency (2004-2006)
Research Associate, School of Clinical and Laboratory Sciences, University of Newcastle (2001-2004)
Research Associate, Dept of Environmental and Occupational Medicine, University of Newcastle (1999-2000)

Memberships

British Toxicology Society (1999 to 2017)
Languages

Some written and spoken French and German

Undergraduate Teaching

Curriculum Chair for Pharmacology since 2017

PED3011 Toxicology module leader

PED2001 Drug disposition and Pharmacokinetics module leader

Undegraduate research project supervision (Pharmacology and Biomedical Sciences)

Deputy Module Leader for CMB3000 (final year dissertation project, Biomedical Sciences)

Postgraduate Teaching

MRes Drug Discovery

MRes Toxicology

MSc in Public Health Research

Research Interests

Dermal absorption, dermal metabolism and dermal toxicology
In vitro methods for dermal absorption and metabolism
Dermal absorption of components from liquid mixtures
Detection of exposure during accidental and deliberate chemical release

Other Expertise

Predictive modelling for dermal absorption and metabolism

Current Work

Decontamination of skin using rapidly deployable methods

Decontamination of hair

Prediction of skin absorption using in silico approaches

Future Research

Research Roles

Theme lead on NIHR Health Protection Research Unit on Emergency Preparedness and Response (skin decontamination)

Postgraduate Supervision

MRes in Toxicology

Currently co-supervisor for PhD student

Esteem Indicators

Member of UK Expert Committee on Pesticides since 2014

Consultancy for L'Oréal 2012-2015

Funding

NIHR HPRU in Emergency Preparedness and Response (2014-2019)

Horizon 2020 BIORAPID (2015-2018)

Industrial Relevance

Dermal absorption of chemicals in the workplace and consequences for health

• Ashrafi P, Sun Y, Davey N, Adams RG, Wilkinson SC, Moss GP. Model fitting for small skin permeability data sets: Hyperparameter optimisation in Gaussian Process Regression. Journal of Pharmacy and Pharmacology 2018, 70(3), 361-373.
• Carroll B, Otten E, Manni D, Stefanatos R, Menzies F, Smith G, Jurk D, Kenneth N, Wilkinson S, Passos J, Attems J, Veal E, Teyssou E, Seilhean D, Millecamps S, Eskelinen E-L, Bronowska A, Rubinsztein DC, Sanz A, Korolchuk V. Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis. Nature Communications 2018, 9, 256.
• Carter H, Weston D, Betts N, Wilkinson S, Amlot R. Public perceptions of emergency decontamination: Effects of intervention type and responder management strategy during a focus group study. PLoS ONE 2018, 13(4), e0195922.
• Kizhedath A, Wilkinson S, Glassey J. Applicability of predictive toxicology methods for monoclonal antibody therapeutics: status Quo and scope. Archives of Toxicology 2017, 91(4), 1595-1612.
• Koogoli R, Hudson L, Naidoo K, Wilkinson S, Chavan B, Birch-Machin M. Bad air gets under your skin. Experimental Dermatology 2017, 26(5), 384-387.
• Wargniez W, Jungman E, Wilkinson S, Seyler N, Gregoire S. Inter-laboratory skin distribution study of 4-n-butyl resorcinol: The importance of liquid chromatography/mass spectrometry (HPLC–MS/MS) bioanalytical validation. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 2017, 1060, 416-423.
• Moss GP, Sun Y, Davey N, Wilkinson SC, Brown MB. Linear or non-linear models for percutaneous absorption?. In: Stratum Corneum VIII Conference - 8th International Symposium. 2015, Cardiff, UK: Wiley-Blackwell Publishing Ltd.
• Moss GP, Gullick DR, Wilkinson SC. Predictive Methods in Percutaneous Absorption. Springer Berlin Heidelberg, 2015.
• Ashrafi P, Moss GP, Wilkinson SC, Davey N, Sun Y. The application of machine learning to the modelling of percutaneous absorption: An overview and guide. SAR and QSAR in Environmental Research 2015, 26(3), 181-204.
• Eilstein J, Lereaux G, Arbey E, Daronnat E, Wilkinson S, Duche D. Xenobiotic metabolizing enzymes in human skin and SkinEthic reconstructed human skin models. Experimental Dermatology 2015, 24(7), 547-549.
• Dodou K, Armstrong A, Kelly I, Wilkinson S, Carr K, Shattock P, Whiteley P. Ex vivo studies for the passive transdermal delivery of low-dose naltrexone from a cream; detection of naltrexone and its active metabolite, 6β-naltrexol, using a novel LC Q-ToF MS assay. Pharmaceutical Development and Technology 2014, 1-8.
• Frasch HF, Dotson GS, Bunge AL, Chen C-P, Cherrie JW, Kasting GB, Kissel JC, Sahmel J, Semple S, Wilkinson S. Analysis of finite dose dermal absorption data: Implications for dermal exposure assessment. Journal of Exposure Science and Environmental Epidemiology 2014, 24(1), 65-73.
• Eilstein J, Léreaux G, Budimir N, Hussler G, Wilkinson S, Duché D. Comparison of xenobiotic metabolizing enzyme activities in ex vivo human skin and reconstructed human skin models from SkinEthic. Archives of Toxicology 2014, 88(9), 1681-1694.
• Mistry T, Staff K, Anjum K, Owen JD, Stair J, Wilkinson SC, Moss GP. Effect of occlusion on the percutaneous absorption of aluminium from antiperspirant products. In: Robert Chilcott, Keith R. Brain, ed. Advances in Dermatological Sciences. Royal Society of Chemistry, 2014, pp.256-264.
• Williams FM, Ravi V, McGarry D, Boulton SJ, Mutch E, Jewell C, Wilkinson SC. Factors influencing expression and specificity of carboxylesterases in skin: Implications for local and systemic paraben ester toxicity. In: Chilcott R Brain K, ed. Advances in Dermatological Sciences. Cambridge, UK: RSC PUblishing, 2014, pp.6-16.
• Binjumah WM, Sun Y, Hewitt M, Adams R, Davey N, Gullick DR, Wilkinson SC, Cronin M, Moss GP. Feature Selection Modelling for Percutaneous Absorption across Synthetic Membranes. In: 2014 IEEE 26th International Conference on Tools with Artificial Intelligence (ICTAI). 2014, Limassol, Cyprus: IEEE.
• Moore CA, Wilkinson SC, Blain PG, Dunn M, Aust GA, Williams FM. Percutaneous absorption and distribution of organophosphates (chlorpyrifos and dichlorvos) following dermal exposure and decontamination scenarios using in vitro human skin model. Toxicology Letters 2014, 229(1), 66-27.
• Moore CA, Wilkinson SC, Blain PG, Dunn M, Aust GA, Williams FM. Use of a human skin in vitro model to investigate the influence of 'every-day' clothing and skin surface decontamination on the percutaneous penetration of organophosphates. Toxicology Letters 2014, 229(1), 257-264.
• Moss GP, Sun Y, Davey N, Adams RG, Wilkinson SC, Gullick DR. The application of gaussian processes in the prediction of permeability across a polydimethlysiloxane membrane. In: Issues in Toxicology. 2013, Royal Society of Chemistry.
• Moss GP, Wilkinson SC, Sun Y. Mathematical modelling of percutaneous absorption. Current Opinion in Colloid & Interface Science 2012, 17(3), 166-172.
• Moss GP, Kyriacou T, Wilkinson SC, Judd A, Gullick DR. Modelling of absorption across skin and silicone membranes using non-linear auto-regressive moving average with exogenous input (NARMAX) methods. In: Stratum Corneum Vll Conference. 2012, Cardiff, UK: Wiley-Blackwell Publishing Ltd.
• Moss GP, Shah AJ, Adams RG, Davey N, Wilkinson SC, Pugh WJ, Sun Y. The application of discriminant analysis and Machine Learning methods as tools to identify and classify compounds with potential as transdermal enhancers. European Journal of Pharmaceutical Sciences 2012, 45(1-2), 116-127.
• Moss GP, Shah AJ, Judd A, Adams RG, Davey N, Wilkinson SC, Pugh WJ, Sun Y. The application of machine learning methods to identify and classify potential transdermal enhancers. In: Stratum Corneum Vll Conference. 2012, Cardiff, UK: Wiley-Blackwell Publishing Ltd.
• Moss GP, Kyriacou T, Wilkinson SC. The application of non-linear auto-regressive moving average with exogenous input (NARMAX) to modelling the absorption across human skin. In: Issues in Toxicology. 2012, La Grande Motte, France: Royal Society of Chemistry.
• Mossa GP, Sun Y, Wilkinson SC, Davey N, Adams R, Martin GP, Prapopopolou M, Brown MB. The application and limitations of mathematical modelling in the prediction of permeability across mammalian skin and polydimethylsiloxane membranes. Journal of Pharmacy and Pharmacology 2011, 63(11), 1411-1427.
• Traynor MJ, Wilkinson SC, Williams FM. Effects of water on the absorption of two glycol ethers through human skin in vitro. In: BTS 2004 Annual Congress. 2004, Edinburgh, Scotland: Toxicology: Elsevier.
• Wilkinson SC, Williams FM. Percutaneous penetration of malathion and parathion: Dose and vehicle effects. In: BTS 2004 Annual Congress. 2004, Heriot Watt University, Edinburgh: Toxicology: Elsevier.
• Wilkinson SC, Williams FM. Effects of experimental conditions on absorption of glycol ethers through human skin in vitro. International Archives of Occupational and Environmental Health 2002, 75(8), 519-527.
• Greaves LC, Wilkinson SC, Williams FM. Factors affecting percutaneous absorption of caffeine in vitro. Toxicology 2002, 178(1), 65-66.
• Wilkinson SC, Williams FM. Dermal absorption of pyridine and some methyl pyridines in vitro. In: British Toxicology Society Annual Congress. 2001, Keele University: Elsevier.
• Sun Y, Hewitt M, Wilkinson SC, Davey N, Adams RG, Gullick DR, Moss GP. Development of a Gaussian Process – feature selection model to characterise (poly)dimethylsiloxane (Silastic®) membrane permeation. Journal of Pharmacy and Pharmacology 2020, 72(7), 873-888.
• Ashrafi P, Sun Y, Davey N, Wilkinson SC, Moss GP. The influence of diffusion cell type and experimental temperature on machine learning models of skin permeability. Journal of Pharmacy and Pharmacology 2020, 72(2), 197-208.
• Kizhedath A, Wilkinson S, Glassey J. Assessment of hepatotoxicity and dermal toxicity of butyl paraben and methyl paraben using HepG2 and HDFn in vitro models. Toxicology in Vitro 2019, 55, 108-115.
• Phatvej W, Datta HK, Wilkinson SC, Mutch E, Daly AK, Horrocks BR. Endocytosis and lack of cytotoxicity of alkyl–capped silicon quantum dots prepared from porous silicon. Materials 2019, 12(10), 1702.