Staff Profile

Roles and Responsibilities

• Development and validation of assays for the quantification of anti-cancer drugs
• Generation of assay validation plans and reports
• Analysis of patient samples collected during clinical trials
• Planning and communication of experimental strategies
• Analysis and interpretation of experimental data

Qualifications

• BSc Biology (Hons), Newcastle University
• Ph.D. (Molecular Biosciences), Newcastle University

I am a Research Associate at the Newcastle University Centre for Cancer, based in the Paul O’Gorman Building. Our research involves investigating the pharmacokinetics of chemotherapeutic agents that are used to treat cancer in both adults and children.

• Barter MJ, Butcher A, Wang H, Tsompani D, Galler M, Rumsby EL, Culley KL, Clark IM, Young DA. HDAC6 regulates NF-κB signalling to control chondrocyte IL-1-induced MMP and inflammatory gene expression. Scientific Reports 2022, 12(1), 6640.
• Byrne DP, Shrestha S, Galler M, Cao M, Daly L, Campbell AE, Eyers CE, Veal EA, Kannan N, Eyers PA. Aurora A regulation by reversible cysteine oxidation reveals evolutionary-conserved redox-control of Ser/Thr protein kinase activity. Science Signaling 2020, 13(639).
• Almeida GS, Bawn CM, Galler M, Wilson I, Thomas HD, Kyle S, Curtin NJ, Newell DR, Maxwell RJ. PARP inhibitor rucaparib induces changes in NAD levels in cells and liver tissues as assessed by MRS. NMR in Biomedicine 2017, 30(9), e3736.
• Harnor SJ, Rennison T, Galler M, Cano C, Griffin RJ, Newell DR, Golding BT. Synthesis of 3 '-deoxy-3'-fluorothymidine (FLT) 5 '-O-glucuronide: a reference standard for imaging studies with [¹⁸F]FLT. MedChemComm 2014, 5(7), 984-988.
• Bui C, Barter MJ, Scott JL, Xu Y, Galler M, Reynard LN, Rowan AD, Young DA. cAMP response element-binding (CREB) recruitment following a specific CpG demethylation leads to the elevated expression of the matrix metalloproteinase 13 in human articular chondrocytes and osteoarthritis. FASEB Journal 2012, 26(7), 3000-3011.