Staff Profile

I joined the Wellcome Centre for Mitochondrial Research at Newcastle University in 2013 to complete my PhD with Professor Doug Turnbull, Professor Robert Taylor and Dr Rita Barresi. I completed my PhD in May 2017 and continued as a post-doctoral scientist in the Centre.

In 2019, I was awarded a Sir Henry Wellcome Fellow. My fellowship aims to understand how mitochondrial DNA deletions clonally expand with age and disease, with a focus on the impact of skeletal muscle biology. I also supervise and work on a range of projects investigating mechanisms of mitochondrial dysfunction in skeletal muscle and mitochondrial disease progression.

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Mitochondrial DNA mutations and mitochondrial respiratory chain deficiency arise in a mosaic pattern within the skeletal muscle of patients with mitochondrial myopathy. However, they are also found in a number of other myopathies and in aging skeletal muscle.
My work looks to investigate mitochondria dysfunction and associated pathogenic mechanisms in both mitochondrial and other myopathies. My group and I are doing this in a number of ways:

1) Attempting to understand how mtDNA mutations accumulate in skeletal muscle and the impact of this process on disease progression with age.

2) Looking at the interactions between mitochondrial structure and function and muscle structure and function

3) Looking to understand the impacts of exercise intervention.

I supervise PhD students who are mainly working on understanding the pathogenesis of mitochondrial dysfunction in skeletal muscle. However I am also involved in the supervision of student using 3D Electron microscopy in human brain and developing image analysis and in silico modelling methods for study of mitochondrial disease.

• Bury A, Vincent AE, Turnbull DM, Actis P, Hudson G. Mitochondrial Isolation: When size matters. Wellcome Open Research 2020, 5, 226.
• Mito T, Vincent AE, Faitg J, Taylor RW, Khan N, McWilliam TG, Suomalainen A. Mosaic dysfunction of mitophagy in mitochondrial disease. Cell Metabolism 2022, (ePub ahead of Print).
• Faitg J, Lacefield C, Davey T, White K, Laws R, Kosmidis S, Reeve AK, Kandel ER, Vincent AE, Picard M. 3D neuronal mitochondrial morphology in axons, dendrites, and somata of the aging mouse hippocampus. Cell Reports 2021, 36, 108509.
• Chen C, Mossman E, Malko P, McDonald D, Blain AP, Bone L, Erskine D, Filby A, Vincent AE, Hudson G, Reeve AK. Astrocytic Changes in Mitochondrial Oxidative Phosphorylation Protein Levels in Parkinson's Disease. Movement Disorders 2022, 37(2), 302-314.
• Chen C, McDonald D, Blain A, Sachdeva A, Bone L, Smith ALM, Warren C, Pickett SJ, Hudson G, Filby A, Vincent AE, Turnbull DM, Reeve AK. Imaging mass cytometry reveals generalised deficiency in OXPHOS complexes in Parkinson’s disease. npj Parkinson's Disease 2021, 7(1), 39.
• Gomes TMB, Ng YS, Pickett SJ, Turnbull DM, Vincent AE. Mitochondrial DNA disorders: From pathogenic variants to preventing transmission. Human Molecular Genetics 2021, 30(R2), R245-R253.
• Frazier AE, Vincent AE, Turnbull DM, Thorburn DR, Taylor RW. Assessment of mitochondrial respiratory chain enzymes in cells and tissues. In: Liza A. Pon, Eric A. Schon, ed. Mitochondria, 3rd Edition. London: Academic Press, 2020, pp.121-156.
• Warren C, McDonald D, Capaldi R, Deehan D, Taylor RW, Filby A, Turnbull DM, Lawless C, Vincent AE. Decoding mitochondrial heterogeneity in single muscle fibres by imaging mass cytometry. Scientific Reports 2020, 10(1), 15336.
• Zhang l, Evans A, Von Ruhland C, Shazli Draman M, Edkins S, Vincent A, Berlinguer-Palmini R, Rees D, Haridas A, Morris D, Tee A, Ludgate M, Turnbull D, Karpe F, Dayan C. Distinctive Features of Orbital Adipose Tissue (OAT) in Graves’ Orbitopathy. International Journal of Molecular Sciences 2020, 21(23), 9145.
• Chen C, Vincent AE, Blain AP, Smith AL, Turnbull DM, Reeve AK. Investigation of mitochondrial biogenesis defects in single substantia nigra neurons using post-mortem human tissues. Neurobiology of Disease 2020, 134, 104631.
• Faitg J, Davey T, Turnbull DM, White K, Vincent AE. Mitochondrial morphology and function: two for the price of one!. Journal of Microscopy 2020, 278(2), 89-106.
• Yarnall AJ, Granic A, Waite S, Hollingsworth KG, Warren C, Vincent AE, Turnbull DM, Taylor RW, Dodds RM, Sayer AA. The feasibility of muscle mitochondrial respiratory chain phenotyping across the cognitive spectrum in Parkinson’s disease. Experimental Gerontology 2020, 138, 110997.
• Lawless C, Greaves L, Reeve AK, Turnbull DM, Vincent AE. The rise and rise of mitochondrial DNA mutations. Open biology 2020, 10(5), 200061.
• Trumpff C, Marsland AL, Basualto-Alarcon C, Martin JL, Carroll JE, Sturm G, Vincent AE, Mosharov EV, Gu Z, Kaufman BA, Picard M. Acute psychological stress increases serum circulating cell-free mitochondrial DNA. Psychoneuroendocrinology 2019, 106, 268-276.
• Vincent AE, White K, Davey T, Philips J, Ogden RT, Lawless C, Warren C, Hall MG, Ng YS, Falkous G, Holden T, Deehan D, Taylor RW, Turnbull DM, Picard M. Quantitative 3D Mapping of the Human Skeletal Muscle Mitochondrial Network. Cell Reports 2019, 26(4), 996-1009.e4.
• Lehmann D, Tuppen HAL, Campbell G, Alston CL, Lawless C, Rosa HS, Rocha MC, Reeve AK, Nicholls TJ, Deschauer M, Zierz S, Taylor RW, Turnbull DM, Vincent AE. Understanding mitochondrial DNA maintenance disorders at the single muscle fibre level. Nucleic Acids Research 2019, 47(14), 7430–7443.
• Ahmed ST, Craven C, Russell OM, Turnbull DM, Vincent AE. Diagnosis and Treatment of Mitochondrial Myopathies. Neurotherapeutics 2018, 15(4), 943-953.
• Bacalhau M, Simoes M, Rocha MC, Hardy SA, Vincent AE, Duraes J, Macario MC, Santos MJ, Rebelo O, Lopes C, Pratas J, Mendes C, Zuzarte M, Rego AC, Girao H, Wong LJC, Taylor RW, Grazina M. Disclosing the functional changes of two genetic alterations in a patient with Chronic Progressive External Ophthalmoplegia: Report of the novel mtDNA m.7486G>A variant. Neuromuscular Disorders 2018, 28(4), 350-360.
• Vincent AE, Picard M. Multilevel heterogeneity of mitochondrial respiratory chain deficiency. Journal of Pathology 2018, 246(3), 261-265.
• Vincent AE, Rosa HS, Pabis K, Lawless C, Chen C, Grünewald A, Rygiel K, Rocha MC, Reeve AK, Falkous G, Perissi V, White K, Davey T, Petrof BJ, Sayer AA, Cooper C, Deehan D, Taylor RW, Turnbull DM, Picard M. Subcellular origin of mitochondrial DNA deletions in human skeletal muscle. Annals of Neurology 2018, 84(2), 289-301.
• Vincent AE, Turnbull DM, Eisner V, Hajnóczky G, Picard M. Mitochondrial Nanotunnels. Trends in Cell Biology 2017, 27(11), 787-799.
• Vincent AE, Rosa H, Rygiel KA, Grady JP, Rocha MC, Taylor RW, Picard M, Turnbull DM. Clonal expansion of mtDNA deletions in skeletal muscle: new insights into mechanisms. In: Mitochondria Research Society/United Mitochondrial Disease Foundation Meeting. 2016, Elsevier BV.
• Rygiel KA, Tuppen HA, Grady JP, Vincent A, Blakely EL, Reeve AK, Taylor RW, Picard M, Miller J, Turnbull DM. Complex mitochondrial DNA rearrangements in individual cells from patients with sporadic inclusion body myositis. Nucleic Acids Research 2016, 44(11), 5313-5329.
• Vincent AE, Rosa HS, Alston CL, Grady JP, Rygiel KA, Rocha MC, Barresi R, Taylor RW, Turnbull DM. Dysferlin mutations and mitochondrial dysfunction. Neuromuscular Disorders 2016, 26(11), 782-788.
• Picard M, Vincent AE, Turnbull DM. Expanding Our Understanding of mtDNA Deletions. Cell Metabolism 2016, 24(1), 3-4.
• Cadete VJJ, Deschenes S, Cuillerier A, Brisebois F, Sugiura A, Vincent A, Turnbull D, Picard M, McBride HM, Burelle Y. Formation of mitochondrial-derived vesicles is an active and physiologically relevant mitochondrial quality control process in the cardiac system. Journal of Physiology 2016, 594(18), 5343-5362.
• Vincent AE, Grady JP, Rocha MC, Alston CL, Rygiel KA, Barresi R, Taylor RW, Turnbull DM. Mitochondrial dysfunction in myofibrillar myopathy. Neuromuscular Disorders 2016, 26(10), 691-701.
• Vincent AE, Ng YS, White K, Davey T, Mannella C, Falkous G, Feeney C, Schaefer AM, McFarland R, Gorman GS, Taylor RW, Turnbull DM, Picard M. The Spectrum of Mitochondrial Ultrastructural Defects in Mitochondrial Myopathy. Scientific Reports 2016, 6, 30610.
• Rocha MC, Grady JP, Grünewald A, Vincent A, Dobson PF, Taylor RW, Turnbull DM, Rygiel KA. A novel immunofluorescent assay to investigate oxidative phosphorylation deficiency in mitochondrial myopathy: understanding mechanisms and improving diagnosis. Scientific Reports 2015, 5, 15037.