Staff Profile

As we age, the “environment” that surrounds our cells changes, altering the activity of the DNA and affecting the molecules in our cells. We study what this means for our chances of developing disease, with the hope this knowledge will lead to better treatments. For this we combine genotyping, RNA sequencing, proteomics and metabolomics technologies with statistical genetics methods to investigate how the relationships between molecules and DNA are affected by ageing. As the amount of information we can collect now is staggering, our research requires the use of modern compute resources, together with the development of new software to put it all together.

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Keywords: computational biology, genomics, quantitative genetics, complex traits, diabetes, ageing, metabolic diseases, multi-omics datasets.

Previous positions:

2014 - 2020: Postdoctoral Researcher, Department of Genetic Medicine and Development, University of Geneva (Switzerland).

2011–2014: Postdoctoral Researcher, Twin Research Department and Genetic Epidemiology. King’s College London (UK).

2008-2011: PhD candidate Department of Nematology, Wageningen University (The Netherlands).

Group members:

Dafni-Theodora Michalettou (PhD candidate)

Visiting researchers:

Gerard Temprano Sagrera (Sant Pau Hospital, Barcelona, Spain)

Amy Roberts (King's Collegue London, UK)

Former Group members:

Sulaiman Lawal (Postdoctoral Researcher)

Dr Viñuela is a regular contributor to the MRes courses on Genetics of Common Disease (MMB8014), Diabetes (MMB8035) and Bioinformatics for Biomedical Scientists (MMB8052) and BSc (BMS3025).

Her group also host BSc and MRes students for their final year projects. 

• Articles

  • Allesoe RL, Lundgaard AT, Hernandez Medina R, Aguayo-Orozco A, Johansen J, Nissen JN, Brorsson C, Mazzoni G, Niu L, Biel JH, Brasas V, Webel H, Benros ME, Pedersen AG, Chmura PJ, Jacobsen UP, Mari A, Koivula R, Mahajan A, Vinuela A, Tajes JF, Sharma S, Haid M, Hong M-G, Musholt PB, De Masi F, Vogt J, Pedersen HK, Gudmundsdottir V, Jones A, Kennedy G, Bell J, Thomas EL, Frost G, Thomsen H, Hansen E, Hansen TH, Vestergaard H, Muilwijk M, Blom MT, 't Hart LM, Pattou F, Raverdy V, Brage S, Kokkola T, Heggie A, McEvoy D, Mourby M, Kaye J, Hattersley A, McDonald T, Ridderstrale M, Walker M, Forgie I, Giordano GN, Pavo I, Ruetten H, Pedersen O, Hansen T, Dermitzakis E, Franks PW, Schwenk JM, Adamski J, McCarthy MI, Pearson E, Banasik K, Rasmussen S, Brunak S, Froguel P, Thomas CE, Haussler R, Beulens J, Rutters F, Nijpels G, van Oort S, Groeneveld L, Elders P, Giorgino T, Rodriquez M, Nice R, Perry M, Bianzano S, Graefe-Mody U, Hennige A, Grempler R, Baum P, Staerfeldt H-H, Shah N, Teare H, Ehrhardt B, Tillner J, Dings C, Lehr T, Scherer N, Sihinevich I, Cabrelli L, Loftus H, Bizzotto R, Tura A, Dekkers K, van Leeuwen N, Groop L, Slieker R, Ramisch A, Jennison C, McVittie I, Frau F, Steckel-Hamann B, Adragni K, Thomas M, Pasdar NA, Fitipaldi H, Kurbasic A, Mutie P, Pomares-Millan H, Bonnefond A, Canouil M, Caiazzo R, Verkindt H, Holl R, Kuulasmaa T, Deshmukh H, Cederberg H, Laakso M, Vangipurapu J, Dale M, Thorand B, Nicolay C, Fritsche A, Hill A, Hudson M, Thorne C, Allin K, Arumugam M, Jonsson A, Engelbrechtsen L, Forman A, Dutta A, Sondertoft N, Fan Y, Gough S, Robertson N, McRobert N, Wesolowska-Andersen A, Brown A, Davtian D, Dawed A, Donnelly L, Palmer C, White M, Ferrer J, Whitcher B, Artati A, Prehn C, Adam J, Grallert H, Gupta R, Sackett PW, Nilsson B, Tsirigos K, Eriksen R, Jablonka B, Uhlen M, Gassenhuber J, Baltauss T, de Preville N, Klintenberg M, Abdalla M, Leal Rodríguez C. Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models. Nature Biotechnology 2023, 41, 399–408.
  • Wesolowska-Andersen A, Brorsson CA, Bizzotto R, Mari A, Tura A, Koivula R, Mahajan A, Vinuela A, Tajes JF, Sharma S, Haid M, Prehn C, Artati A, Hong M-G, Musholt PB, Kurbasic A, De Masi F, Tsirigos K, Pedersen HK, Gudmundsdottir V, Thomas CE, Banasik K, Jennison C, Jones A, Kennedy G, Bell J, Thomas L, Frost G, Thomsen H, Allin K, Hansen TH, Vestergaard H, Hansen T, Rutters F, Elders P, t'Hart L, Bonnefond A, Canouil M, Brage S, Kokkola T, Heggie A, McEvoy D, Hattersley A, McDonald T, Teare H, Ridderstrale M, Walker M, Forgie I, Giordano GN, Froguel P, Pavo I, Ruetten H, Pedersen O, Dermitzakis E, Franks PW, Schwenk JM, Adamski J, Pearson E, McCarthy MI, Brunak S. Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals: An IMI DIRECT study. Cell Reports Medicine 2022, 3(1), 100477.
  • Bizzotto R, Jennison C, Jones AG, Kurbasic A, Tura A, Kennedy G, Bell JD, Thomas EL, Frost G, Eriksen R, Koivula RW, Brage S, Kaye J, Hattersley AT, Heggie A, McEvoy D, 't Hart LM, Beulens JW, Elders P, Musholt PB, Ridderstrale M, Hansen TH, Allin KH, Hansen T, Vestergaard H, Lundgaard AT, Thomsen HS, De Masi F, Tsirigos KD, Brunak S, Vinuela A, Mahajan A, McDonald TJ, Kokkola T, Forgie IM, Giordano GN, Pavo I, Ruetten H, Dermitzakis E, McCarthy MI, Pedersen O, Schwenk JM, Adamski J, Franks PW, Walker M, Pearson ER, Mari A. Processes Underlying Glycemic Deterioration in Type 2 Diabetes: An IMI DIRECT Study. Diabetes Care 2021, 44(2), 511-518.
  • Deshmukh HA, Madsen AL, Vinuela A, Have CT, Grarup N, Tura A, Mahajan A, Heggie AJ, Koivula RW, De Masi F, Tsirigos KK, Linneberg A, Drivsholm T, Pedersen O, Sorensen TIA, Astrup A, Gjesing AAP, Pavo I, Wood AR, Ruetten H, Jones AG, Koopman ADM, Cederberg H, Rutters F, Ridderstrale M, Laakso M, McCarthy MI, Frayling TM, Ferrannini E, Franks PW, Pearson ER, Mari A, Hansen T, Walker M. Genome-Wide Association Analysis of Pancreatic Beta-Cell Glucose Sensitivity. The Journal of Clinical Endocrinology & Metabolism 2021, 106(1), 80-90.
  • Gudmundsdottir V, Pedersen HK, Mazzoni G, Allin KH, Artati A, Beulens JW, Banasik K, Brorsson C, Cederberg H, Chabanova E, De Masi F, Elders PJ, Forgie I, Giordano GN, Grallert H, Gupta R, Haid M, Hansen T, Hansen TH, Hattersley AT, Heggie A, Hong M-G, Jones AG, Koivula R, Kokkola T, Laakso M, Longreen P, Mahajan A, Mari A, McDonald TJ, McEvoy D, Musholt PB, Pavo I, Prehn C, Ruetten H, Ridderstrale M, Rutters F, Sharma S, Slieker RC, Syed A, Tajes JF, Thomas CE, Thomsen HS, Vangipurapu J, Vestergaard H, Vinuela A, Wesolowska-Andersen A, Walker M, Adamski J, Schwenk JM, McCarthy MI, Pearson E, Dermitzakis E, Franks PW, Pedersen O, Brunak S. Whole blood co-expression modules associate with metabolic traits and type 2 diabetes: an IMI-DIRECT study. Genome Medicine 2020, 12(1), 109.
  • Koivula RW, Atabaki-Pasdar N, Giordano GN, White T, Adamski J, Bell JD, Beulens J, Brage S, Brunak S, De Masi F, Dermitzakis ET, Forgie IM, Frost G, Hansen T, Hansen TH, Hattersley A, Kokkola T, Kurbasic A, Laakso M, Mari A, McDonald TJ, Pedersen O, Rutters F, Schwenk JM, Teare HJA, Thomas EL, Vinuela A, Mahajan A, McCarthy MI, Ruetten H, Walker M, Pearson E, Pavo I, Franks PW. The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes: an IMI DIRECT study. Diabetologia 2020, 63(4), 744-756.
  • Oliva M, Muñoz-Aguirre M, Kim-Hellmuth S, Wucher V, Gewirtz ADH, Cotter DJ, Parsana P, Kasela S, Balliu B, Viñuela A, Castel SE, Mohammadi P, Aguet F, Zou Y, Khramtsova EA, Skol AD, Garrido-Martín D, Reverter F, Brown A, Evans P, Gamazon ER, Payne A, Bonazzola R, Barbeira AN, Hamel AR, Martinez-Perez A, Soria JM, Pierce BL, Stephens M, Eskin E, Dermitzakis ET, Segrè AV, Im HK, Engelhardt BE, Ardlie KG, Montgomery SB, Battle AJ, Lappalainen T, Guigó R, Stranger BE. The impact of sex on gene expression across human tissues. Science 2020, 369(6509), eaba3066.
  • Aguet F, Barbeira AN, Bonazzola R, Brown A, Castel SE, Jo B, Kasela S, Kim-Hellmuth S, Liang Y, Oliva M, Flynn ED, Parsana P, Fresard L, Gamazon ER, Hamel AR, He Y, Hormozdiari F, Mohammadi P, Muñoz-Aguirre M, Park Y, Saha A, Segrè AV, Strober BJ, Wen X, Wucher V, Ardlie KG, Battle A, Brown CD, Cox N, Das S, Dermitzakis ET, Engelhardt BE, Garrido-Martin D, Gay NR, Getz GA, Guigó R, Handsaker RE, Hoffman PJ, Im HK, Kashin S, Kwong A, Lappalainen T, Li X, MacArthur DG, Montgomery SB, Rouhana JM, Stephens M, Stranger BE, Todres E, Viñuela A, Wang G, Zou Y, Anand S, Gabriel S, Graubert A, Hadley K, Huang KH, Meier SR, Nedzel JL, Nguyen DT, Balliu B, Conrad DF, Cotter DJ, deGoede OM, Einson J, Eskin E, Eulalio TY, Ferraro NM, Gloudemans MJ, Hou L, Li X, Mangul S, Nachun DC, Nobel AB, Park Y, Rao AS, Reverter F, Sabatti C, Skol AD, Teran NA, Wright F, Ferreira PG, Li G, Mele M, Yeger-Lotem E, Barcus ME, Bradbury D, Krubit T, McLean JA, Qi L, Robinson K, Roche NV, Smith AM, Tabor DE, Undale A, Bridge J, Brigham LE, Foster BA, Gillard BM, Hasz R, Hunter M, Johns C, Johnson M, Karasik E, Kopen G, Leinweber WF, McDonald A, Moser MT, Myer K, Ramsey KD, Roe B, Shad S, Thomas JA, Walters G, Washington M, Wheeler J, Jewell SD, Rohrer DC, Valley DR, Davis DA, Mash DC, Sobin L, Sobin L, Barker LK, Gardiner HM, Mosavel M, Siminoff LA, Flicek P, Haeussler M, Juettemann T, Kent WJ, Lee CM, Powell CC, Rosenbloom KR, Ruffier M, Sheppard D, Taylor K, Trevanion SJ, Zerbino DR, Abell NS, Akey J, Chen L, Demanelis K, Doherty JA, Feinberg AP, Hansen KD, Hickey PF, Hou L, Jasmine F, Jiang L, Kaul R, Kellis M, Kellis M, Kibriya MG, Li JB, Li Q, Lin S, Linder SE, Pierce BL, Rizzardi LF, Smith KS, Snyder M, Stamatoyannopoulos J, Tang H, Wang M, Branton PA, Branton PA, Carithers LJ, Guan P, Koester SE, Little AR, Moore HM, Nierras CR, Rao AK, Vaught JB, Volpi S. The GTEx Consortium atlas of genetic regulatory effects across human tissues. Science 2020, 369(6509), 1318-1330.
  • Atabaki-Pasdar N, Ohlsson M, Viñuela A, Frau F, Pomares-Millan H, Haid M, Jones AG, Thomas EL, Koivula RW, Kurbasic A, Mutie PM, Fitipaldi H, Fernandez J, Dawed AY, Giordano GN, Forgie IM, McDonald TJ, Rutters F, Cederberg H, Chabanova E, Dale M, De Masi F, Thomas CE, Allin KH, Hansen TH, Heggie A, Hong M-G, Elders PJM, Kennedy G, Kokkola T, Pedersen HK, Mahajan A, McEvoy D, Pattou F, Raverdy V, Häussler RS, Sharma S, Thomsen HS, Vangipurapu J, Vestergaard H, ‘t Hart LM, Adamski J, Musholt PB, Soren B, Brunak S, Dermitzakis E, Frost G, Hansen T, Laakso M, Pedersen O, Ridderstråle M, Ruetten H, Hattersley AT, Walker M, Beulens JWJ, Mari A, Schwenk JM. Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts. PLoS Medicine 2020, 17(6), e1003149.
  • Obura M, Beulens JWJ, Slieker R, Koopman ADM, Hoekstra T, Nijpels G, Elders P, Koivula RW, Kurbasic A, Laakso M, Hansen TH, Ridderstrale M, Hansen T, Pavo I, Forgie I, Jablonka B, Ruetten H, Mari A, McCarthy MI, Walker M, Heggie A, McDonald TJ, Perry MH, De Masi F, Brunak S, Mahajan A, Giordano GN, Kokkola T, Dermitzakis E, Vinuela A, Pedersen O, Schwenk JM, Adamski J, Teare HJA, Pearson ER, Franks PW, 't Hart LM, Rutters F. Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes: An IMI-DIRECT study. PLoS ONE 2020, 15(11), e0242360.
  • Viñuela A, Varshney A, van de Bunt M, Prasad RB, Asplund O, Bennett A, Boehnke M, Brown AA, Erdos MR, Fadista J, Hansson O, Hatem G, Howald C, Iyengar AK, Johnson P, Krus U, MacDonald PE, Mahajan A, Manning Fox JE, Narisu N, Nylander V, Orchard P, Oskolkov N, Panousis NI, Payne A, Stitzel ML, Vadlamudi S, Welch R, Collins FS, Mohlke KL, Gloyn AL, Scott LJ, Dermitzakis ET, Groop L, Parker SCJ, McCarthy MI. Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D. Nature Communications 2020, 11(1), 4912.
  • Eriksen R, Perez IG, Posma JM, Haid M, Sharma S, Prehn C, Thomas LE, Koivula RW, Bizzotto R, Mari A, Giordano GN, Pavo I, Schwenk JM, De Masi F, Tsirigos KD, Brunak S, Vinuela A, Mahajan A, McDonald TJ, Kokkola T, Rutter F, Teare H, Hansen TH, Fernandez J, Jones A, Jennison C, Walker M, McCarthy MI, Pedersen O, Ruetten H, Forgie I, Bell JD, Pearson ER, Franks PW, Adamski J, Holmes E, Frost G. Dietary metabolite profiling brings new insight into the relationship between nutrition and metabolic risk: An IMI DIRECT study. EBioMedicine 2020, 58, 102932.
  • Kim-Hellmuth S, Aguet F, Oliva M, Muñoz-Aguirre M, Kasela S, Wucher V, Castel SE, Hamel AR, Viñuela A, Roberts AL, Mangul S, Wen X, Wang G, Barbeira AN, Garrido-Martin D, Nadel BB, Zou Y, Bonazzola R, Quan J, Brown A, Martinez-Perez A, Soria JM, Getz G, Dermitzakis ET, Small KS, Stephens M, Xi HS, Im HK, Guigó R, Segrè AV, Stranger BE, Ardlie KG, Lappalainen T, Anand S, Gabriel S, Getz GA, Graubert A, Hadley K, Handsaker RE, Huang KH, Kashin S, Li X, MacArthur DG, Meier SR, Nedzel JL, Nguyen DT, Todres E, Balliu B, Battle A, Brown CD, Conrad DF, Cotter DJ, Cox N, Das S, de Goede O, Einson J, Engelhardt BE, Eskin E, Eulalio TY, Ferraro NM, Flynn ED, Fresard L, Gamazon ER, Gay NR, Gloudemans MJ, Hame AR, He Y, Hoffman PJ, Hormozdiari F, Hou L, Jo B, Kellis M, Kwong A, Li X, Liang Y, Mohammadi P, Montgomery SB, Nachun DC, Nobel AB, Park Y, Park Y, Parsana P, Rao AS, Reverter F, Rouhana JM, Sabatti C, Saha A, Skol AD, Strober BJ, Teran NA, Wright F, Ferreira PG, Li G, Melé M, Yeger-Lotem E, Barcus ME, Bradbury D, Krubit T, McLean JA, Qi L, Robinson K, Roche NV, Smith AM, Sobin L, Tabor DE, Undale A, Bridge J, Brigham LE, Foster BA, Gillard BM, Hasz R, Hunter M, Johns C, Johnson M, Karasik E, Kopen G, Leinweber WF, McDonald A, Moser MT, Myer K, Ramsey KD, Roe B, Shad S, Thomas JA, Walters G, Washington M, Wheeler J, Jewell SD, Rohrer DC, Valley DR, Davis DA, Mash DC, Branton PA, Barker LK, Gardiner HM, Mosavel M, Siminoff LA, Flicek P, Haeussler M, Juettemann T, Kent WJ, Lee CM, Powell CC, Rosenbloom KR, Ruffier M, Sheppard D, Taylor K, Trevanion SJ, Zerbino DR, Abell NS, Akey J, Chen L, Demanelis K, Doherty JA, Feinberg AP, Hansen KD, Hickey PF, Jasmine F, Jiang L, Kaul R, Kibriya MG, Li JB, Li Q, Lin S, Linder SE, Pierce BL, Rizzardi LF, Smith KS, Snyder M, Stamatoyannopoulos J, Tang H, Wang M, Carithers LJ, Guan P, Koester SE, Little AR, Moore HM, Nierras CR, Rao AK, Vaught JB, Volpi S. Cell type–specific genetic regulation of gene expression across human tissues. Science 2020, 369(6509).
  • Wilman HR, Parisinos CA, Atabaki-Pasdar N, Kelly M, Thomas EL, Neubauer S, Jennison C, Ehrhardt B, Baum P, Schoelsch C, Freijer J, Grempler R, Graefe-Mody U, Hennige A, Dings C, Lehr T, Scherer N, Sihinecich I, Pattou F, Raverdi V, Caiazzo R, Torres F, Verkindt H, Mari A, Tura A, Giorgino T, Bizzotto, Froguel P, Bonneford A, Canouil M, Dhennin V, Brorsson C, Brunak S, De Masi F, Gudmundsdottir V, Pedersen H, Banasik K, Thomas C, Sackett P, Staerfeldt H-H, Lundgaard A, Nilsson B, Nielsen A, Mazzoni G, Karaderi T, Rasmussen S, Johansen J, Allesoe R, Fritsche A, Thorand B, Adamski J, Grallert H, Haid M, Sharma S, Troll M, Adam J, Ferrer J, Eriksen H, Frost G, Haussler R, Hong M-G, Schwenk J, Uhlen M, Nicolay C, Pavo I, Steckel-Hamann B, Thomas M, Adragni K, Wu H, Hart L, Roderick S, van Leeuwen N, Dekkers K, Frau F, Gassenhuber J, Jablonka B, Musholt P, Ruetten H, Tillner J, Baltauss T, Bernard Poenaru O, de Preville N, Rodriquez M, Arumugam M, Allin K, Engelbrechtsen L, Hansen T, Hansen T, Forman A, Jonsson A, Pedersen O, Dutta A, Vogt J, Vestergaard H, Laakso M, Kokkola T, Kuulasmaa T, Franks P, Giordano N, Pomares-Millan H, Fitipaldi H, Mutie P, Klintenberg M, Bergstrom M, Groop L, Ridderstrale M, Atabaki Pasdar N, Deshmukh H, Heggie A, Wake D, McEvoy D, McVittie I, Walker M, Hattersley A, Hill A, Jones A, McDonald T, Perry M, Nice R, Hudson M, Thorne C, Dermitzakis E, Vinuela A, Cabrelli L, Loftus H, Dawed A, Donnelly L, Forgie I, Pearson E, Palmer C, Brown A, Koivula R, Wesolowska-Andersen A, Abdalla M, McRobert N, Fernandez J, Jiao Y, Robertson N, Gough S, Kaye J, Mourby M, Mahajan A, McCarthy M, Shah N, Teare H, Holl R, Koopman A, Rutters F, Beulens J, Groeneveld L, Bell J, Thomas L, Whitcher B, Hingorani AD, Patel RS, Hemingway H, Franks PW, Bell JD, Banerjee R, Yaghootkar H. Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration. Journal of Hepatology 2019, 71(3), 594-602.
  • Koivula RW, Forgie IM, Kurbasic A, Vinuela A, Heggie A, Giordano GN, Hansen TH, Hudson M, Koopman ADM, Rutters F, Siloaho M, Allin KH, Brage S, Brorsson CA, Dawed AY, De Masi F, Groves CJ, Kokkola T, Mahajan A, Perry MH, Rauh SP, Ridderstrale M, Teare HJA, Thomas EL, Tura A, Vestergaard H, White T, Adamski J, Bell JD, Beulens JW, Brunak S, Dermitzakis ET, Froguel P, Frost G, Gupta R, Hansen T, Hattersley A, Jablonka B, Kaye J, Laakso M, McDonald TJ, Pedersen O, Schwenk JM, Pavo I, Mari A, McCarthy MI, Ruetten H, Walker M, Pearson E, Franks PW. Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium. Diabetologia 2019, 62(9), 1601-1615.
  • Tsai P-C, Glastonbury CA, Eliot MN, Bollepalli S, Yet I, Castillo-Fernandez JE, Carnero-Montoro E, Hardiman T, Martin TC, Vickers A, Mangino M, Ward K, Pietilainen KH, Deloukas P, Spector TD, Vinuela A, Loucks EB, Ollikainen M, Kelsey KT, Small KS, Bell JT. Smoking induces coordinated DNA methylation and gene expression changes in adipose tissue with consequences for metabolic health 06 Biological Sciences 0604 Genetics. Clinical Epigenetics 2018, 10(1), -.
  • Small KS, Todorcevic M, Civelek M, El-Sayed Moustafa JS, Wang X, Simon MM, Fernandez-Tajes J, Mahajan A, Horikoshi M, Hugill A, Glastonbury CA, Quaye L, Neville MJ, Sethi S, Yon M, Pan C, Che N, Vinuela A, Tsai P-C, Nag A, Buil A, Thorleifsson G, Raghavan A, Ding Q, Morris AP, Bell JT, Thorsteinsdottir U, Stefansson K, Laakso M, Dahlman I, Arner P, Gloyn AL, Musunuru K, Lusis AJ, Cox RD, Karpe F, McCarthy MI. Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition. Nature Genetics 2018, 50(4), 572-580.
  • Vinuela A, Brown AA, Buil A, Tsai P-C, Davies MN, Bell JT, Dermitzakis ET, Spector TD, Small KS. Age-dependent changes in mean and variance of gene expression across tissues in a twin cohort. Human Molecular Genetics 2018, 27(4), 732-741.
  • Bryois J, Buil A, Ferreira PG, Panousis NI, Brown AA, Vinuela A, Planchon A, Bielser D, Small K, Spector T, Dermitzakis ET. Time-dependent genetic effects on gene expression implicate aging processes. Genome Research 2017, 27(4), 545-552.
  • Brown AA, Viñuela A, Delaneau O, Spector TD, Small KS, Dermitzakis ET. Predicting causal variants affecting expression by using whole-genome sequencing and RNA-seq from multiple human tissues. Nature Genetics 2017, 49(12), 1747-1751.
  • Odhams CA, Cortini A, Chen L, Roberts AL, Vinuela A, Buil A, Small KS, Dermitzakis ET, Morris DL, Vyse TJ, Cunninghame Graham DS. Mapping eQTLs with RNA-seq reveals novel susceptibility genes, non-coding RNAs and alternative-splicing events in systemic lupus erythematosus. Human Molecular Genetics 2017, 26(5), 1003-1017.
  • Law MH, Medland SE, Zhu G, Yazar S, Vinuela A, Wallace L, Shekar SN, Duffy DL, Bataille V, Glass D, Spector TD, Wood D, Gordon SD, Barbour JM, Henders AK, Hewitt AW, Montgomery GW, Sturm RA, Mackey DA, Green AC, Martin NG, MacGregor S. Genome-Wide Association Shows that Pigmentation Genes Play a Role in Skin Aging. Journal of Investigative Dermatology 2017, 137(9), 1887-1894.
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• Note

  • Small KS, Todorcevic M, Civelek M, El-Sayed Moustafa JS, Wang X, Simon MM, Fernandez-Tajes J, Mahajan A, Horikoshi M, Hugill A, Glastonbury CA, Quaye L, Neville MJ, Sethi S, Yon M, Pan C, Che N, Vinuela A, Tsai P-C, Nag A, Buil A, Thorleifsson G, Raghavan A, Ding Q, Morris AP, Bell JT, Thorsteinsdottir U, Stefansson K, Laakso M, Dahlman I, Arner P, Gloyn AL, Musunuru K, Lusis AJ, Cox RD, Karpe F, McCarthy MI. Erratum to: Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition (Nature Genetics, (2018), 50, 4, (572-580), 10.1038/s41588-018-0088-x). Nature Genetics 2018, 50(9), 1342.