Staff Profile

Since March 2018, is acting Principal Investigator SMAREACH and as Co-Investigator in Clinical Outcome Study in Dysferlinopathy

Research Physiotherapy Lead working with JWMDRC Team to advise on Physiotherapy within Trials

Performs clinical endpoints for many trials in DMD, SMA, Pompe and LGMD

AGM conducts peer reviewed submissions to the journal “Developmental Medicine and Child Neurology” and “Pediatric Physiotherapy” and Neuromuscular Disorders.

AGM is a Core member of an expert group, TREAT-NMD Advisory Committee for Therapeutics (TACT) which is a unique multi-disciplinary international group of well recognized academic and industry drug development experts, who meet twice a year to review and provide guidance on the translation and development path of therapeutics programs in rare neuromuscular diseases.

AGM has had significant involvement in the development and evaluation of key clinical endpoints in NMD including the North Star Ambulatory Assessment for DMD, Performance of Upper Limb Module for DMD, Revised Upper Limb Module for SMA, Revised Hammersmith Scale for SMA, North Star Assessment for Limb Girdle Type Muscular Dystrophies

Anna is involved in training on Outcome measure in DMD, SMA and LGMD

She is a teacher on RCPCH - Early Recognition of Neuromuscular Disorders 

https://www.rcpch.ac.uk/resources/recognising-neuromuscular-disorders-online-learning

She trains on evaluation of clinical endpoints on the TreatNMD Summer School  and on the MSc Module 

She supervisors two PhD students. One at Newcastle, one from Barcelona and  one Masters Student

She has developed of ONLINE Resources for Physiotherapists – https://opentact.net

 to upskill physiotherapists nationally in the community and in tertiary centre of the assessment and management of NMD

• Moore U, Jacobs M, James MK, Mayhew AG, Fernandez-Torron R, Feng J, Cnaan A, Eagle M, Bettinson K, Rufibach LE, Lofra RM, Blamire AM, Carlier PG, Mittal P, Lowes LP, Alfano L, Rose K, Duong T, Berry KM, Montiel-Morillo E, Pedrosa-Hernández I, Holsten S, Sanjak M, Ashida A, Sakamoto C, Tateishi T, Yajima H, Canal A, Ollivier G, DeCostre V, Mendez JB, Praxedes NSA, Thiele S, Siener C, Shierbecker J, Florence JM, Vandevelde B, DeWolf B, Hutchence M, Gee R, Prugel J, Maro E, Hilsden H, Lochmüller H, Grieben U, Spuler S, Rocha CT, Day JW, Jones KJ, Bharucha-Goebel DX, Salort-Campana E, Harms M, Pestronk A, Krause S, Schreiber-Katz O, Walter MC, Paradas C, Hogrel JY, Stojkovic T, Takeda S, Mori-Yoshimura M, Bravver E, Sparks S, Diaz-Manera J, Bello L, Semplicini C, Pegoraro E, Mendell JR, Bushby K, Straub V. Assessment of disease progression in dysferlinopathy – a 1 year cohort study. Neurology 2019, 92(5), e461-e474.
• Muntoni F, Domingos J, Manzur AY, Mayhew A, Guglieri M, Sajeev G, Signorovitch J, Ward SJ. Categorising trajectories and individual item changes of the North Star Ambulatory Assessment in patients with Duchenne muscular dystrophy. PLoS ONE 2019, 14(9), e0221097.
• Murphy AP, Morrow J, Dahlqvist JR, Stijkovic T, Willis TA, Sinclair CDJ, Wastling S, Yousry T, Hanna MS, James MK, Mayhew A, Eagle M, Lee LE, Hogrel JY, Carlier PG, Thornton JS, Vissing J, Hollingsworth KG, Straub V. Natural history of limb girdle musclar dystrophy R9 over 6 years: searching for trial endpoints. Annals of Clinical and Translational Neurology 2019, 6(6), 1033-1045.
• Wood CL, Cheetham TD, Hollingsworth KG, Guglieri M, Ailins-Sahun Y, Punniyakodi S, Mayhew A, Straub V. Observational study of clinical outcomes for testosterone treatment of pubertal delay in Duchenne muscular dystrophy. BMC Pediatrics 2019, 19(1), 131.
• Mayhew AG, Coratti G, Mazzone ES, Klingels K, James M, Pane M, Straub V, Goemans N, Mercuri E, Ricotti V, Muntoni F, Ridout D, Selby V. Performance of Upper Limb module for Duchenne muscular dystrophy. Developmental Medicine and Child Neurology 2019, 62(5), 633-639.
• Pera MC, Coratti G, Mazzone ES, Montes J, Scoto M, De Sanctis R, Main M, Mayhew A, Muni Lofra R, Dunaway Young S, Glanzman AM, Duong T, Pasternak A, Ramsey D, Darras B, Day JW, Finkel RS, De Vivo DC, Sormani MP, Bovis F, Straub V, Muntoni F, Pane M, Mercuri E. Revised upper limb module for spinal muscular atrophy: 12 month changes. Muscle and Nerve 2019, 59(4), 426-430.
• Díaz-Manera J, Fernandez-Torron R, Rossello JL, James M, Mayhew A, Smith FE, Moore U, Blamire A, Carlier PG, Rufibach L, Mittal P, Eagle M, Jacobs M, Hodgson T, Wallace D, Ward L, Smith M, Stramare R, Rampado A, Sato N, Tamaru T, Harwick B, Gala RS, Turk S, Coppenrath EM, Foster G, Bendahan D, Le Fur Y, Fricke ST, Otero HJ, Foster S, Peduto A, Sawyer AM, Hilsden H, Lochmuller L, Grieben U, Spuler S, Rocha CT, Day JW, Jones KJ, Bharucha-Goebel DX, Salort-Campana E, Harms M, Pestronk A, Krause S, Schreiber Katz O, Walter MC, Paradas C, Hogrel JY, Stojkovic T, Takeda S, Mori-Yoshimura M, Bravver E, Sparks S, Bello L, Semplicini C, Pegoraro E, Mendell JR, Bushby K, Straub V. Muscle MRI in dysferlinopathy patients: Pattern recognition and implications for clinical trials. Journal of Neurology, Neurosurgery, and Psychiatry 2018, 89(10), 1071-1081.
• Salazar R, Montes J, Young SD, McDermott MP, Martens W, Pasternak A, Quigley J, Mirek E, Glanzman AM, Civitello M, Gee R, Duong T, Mazzone ES, Main M, Mayhew A, Ramsey D, Muni Lofra R, Coratti G, Fanelli L, De Sanctis R, Forcina N, Chiriboga C, Darras BT, Tennekoon GI, Scoto M, Day JW, Finkel R, Muntoni F, Mercuri E, De Vivo DC. Quantitative Evaluation of Lower Extremity Joint Contractures in Spinal Muscular Atrophy: Implications for Motor Function. Pediatric Physical Therapy 2018, 30(3), 209-215.
• Moore UR, Jacobs M, Fernandez-Torron R, Jang J, James MK, Mayhew A, Rufibach L, Mittal P, Eagle M, Cnaan A, Carlier PG, Blamire A, Hilsden H, Lochmüller H, Grieben U, Spuler S, Rocha CT, Day JW, Jones KJ, Bharucha-Goebel DX, Salort-Campana E, Harms M, Pestronk A, Krause S, Schreiber-Katz O, Walter MC, Paradas C, Hogrel J-Y, Stojkovic T, Takeda S, Mori-Yoshimura M, Bravver E, Sparks S, Diaz-Manera J, Bello L, Semplicini C, Pegoraro E, Mendell JR, Bushby K, Straub V. Teenage exercise is associated with earlier symptom onset in dysferlinopathy: a retrospective cohort study. Journal of Neurology, Neurosurgery and Psychiatry 2018, 89(11), 1224-1226.
• Klingels K, Mayhew AG, Mazzone ES, Duong T, Decostre V, Werlauff U, Vroom E, Mercuri E, Goemans NM, Upper Limb Clinical Outcome Grp. Development of a patient-reported outcome measure for upper limb function in Duchenne muscular dystrophy: DMD Upper Limb PROM. Developmental Medicine & Child Neurology 2017, 59(2), 224-231.
• Moreira S, Wood L, Smith D, Marini-Bettolo C, Guglieri M, McMacken G, Bailey G, Mayhew A, Muni-Lofra R, Eglon G, Williams M, Straub V, Lochmuller H, Evangelista T. Respiratory involvement in ambulant and non-ambulant patients with facioscapulohumeral muscular dystrophy. Journal of Neurology 2017, 264(6), 1271-1280.
• Paradas C, Moore U, James M, Mayhew A, Azzabou N, Torron RF, Reyngoudt H, Smith F, Harris E, Bettinson K, Hilsden H, Jacobs M, Feng J, Cnaan A, Rufibach L, Eagle M, Blamire A, Carlier P, Bushby K. Clinical outcome study for dysferlinopathy: One-year follow-up. In: 21st International Congress of the World Muscle Society. 2016, Granada: Elsevier.
• Landfeldt E, Mayhew A, Eagle M, Lindgren P, Bell CF, Guglieri M, Straub V, Lochmiiller H, Bushby K. Corrigendum to Development and psychometric analysis of the Duchenne muscular dystrophy Functional Ability Self-Assessment Tool (DMDSAT) (vol 25, pg 937, 2015). Neuromuscular Disorders 2016, 26(4-5), 329-329.
• Domingos J, Eagle M, Moraux A, Butler J, Decostre V, Ridout D, Mayhew A, Selby V, Guglieri M, Van der Holst M, Jansen M, Verschuuren J, de Groot I, Niks E, Servais L, Hogrel J, Straub V, Voit T, Ricotti V, Muntoni F. Outcome measures for Duchenne muscular dystrophy from ambulant to non-ambulant: Implications for clinical trials. In: 21st International Congress of the World Muscle Society. 2016, Granada: Elsevier.
• Srinivasan R, Rawlings D, Wood CL, Cheetham T, Moreno ACJ, Mayhew A, Eagle M, Guglieri M, Straub V, Owen C, Bushby K, Sarkozy A. Prophylactic oral bisphosphonate therapy in duchenne muscular dystrophy. Muscle & Nerve 2016, 54(1), 79-85.
• Ramsey D, Scoto M, Mayhew A, Main M, Mazzone E, Montes J, Dunaway S, Salazar R, Glanzman A, Pasternak A, Duong T, Gee R, Civitello M, Bushby K, Day J, Darras B, De Vivo D, Finkel R, Mercuri E, Muntoni F. Revised Hammersmith scale for spinal muscular atrophy: Longitudinal changes over six and twelve months in a large international cohort. In: 21st International Congress of the World Muscle Society. 2016, Granada, Spain: Elsevier Ltd.
• Harris E, Bladen CL, Mayhew A, James M, Bettinson K, Moore U, Smith FE, Rufibach L, Cnaan A, Bharucha-Goebel DX, Blamire AM, Bravver E, Carlier PG, Day JW, Díaz-Manera J, Eagle M, Grieben U, Harms M, Jones KJ, Lochmüller H, Mendell JR, Mori-Yoshimura M, Paradas C, Pegoraro E, Pestronk A, Salort-Campana E, Schreiber-Katz O, Semplicini C, Spuler S, Stokjkovic T, Staub V, Takeda S, Rocha CT, Walter MC, Bushby K. The Clinical Outcome Study for dysferlinopathy: An international multicenter study. Neurology Genetics 2016, 2(4), 2376-7839.
• Landfeldt E, Mayhew A, Eagle M, Lindgren P, Bell CF, Guglieri M, Straub V, Lochmüller H, Bushby K. Development and Psychometric Analysis of the Duchenne Muscular Dystrophy Functional Ability Self-Assessment Tool (DMDSAT). Neuromuscular Disorders 2015, 25(12), 937-944.
• Jimenez C, Moreno, Eagle M, Mayhew A, James M, Straub V, Bushby K. Impact of three decades of improvement in standards of care for Duchenne muscular dystrophy. In: 20th International Congress of the The World Muscle Society. 2015, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND: Elsevier.
• Lynn S, Aartsma-Rus A, Bushby K, Furlong P, Goemans N, De Luca A, Mayhew A, McDonald C, Mercuri E, Muntoni F, Pohlschmidt M, Verschuuren J, Voit T, Vroom E, Wells DJ, Straub V. Measuring clinical effectiveness of medicinal products for the treatment of Duchenne muscular dystrophy. Neuromuscular Disorders 2015, 25(1), 96-105.
• Mayhew A, James M, Eagle M, Bladen C, Lofra RM, Bettinson K, Hilsden H, Harris E, Bushby K, Rufibach L, Jain COS Consortium. Preparation of a disease specific functional measure suitable for trials in dysferlinopathy. In: 20th International Congress of the World Muscle Society. 2015, Brighton, UK: Elsevier.
• Harris EA, Bettinson K, James M, Mayhew A, Eagle M, Bushby K. International Clinical Outcome Study in Dysferlinopathy (COS): Results of screening questionnaires in UK patients. In: 19th International Congress of the World Muscle Society. 2014, Berlin, Germany: Elsevier.
• Willis TA, Hollingsworth KG, Coombs A, Sveen M-L, Andersen S, Stojkovic T, Eagle M, Mayhew A, Loureiro de Sousa P, Dewar L, Morrow JM, Sinclair CDJ, Thornton JS, Bushby K, Lochmuller H, Hanna MG, Hogrel J-Y, Carlier PG, Vissing J, Straub V. Quantitative Magnetic Resonance Imaging in Limb-Girdle Muscular Dystrophy 2I: A Multinational Cross-Sectional Study. PLoS ONE 2014, 9, e90377.
• Eagle M, Mayhew AG, Bettinson K, James MK, Von Rekowski B, Bushby K. Clinical outcome measures for dysferlinopathy: An exploration of reliability and suitability of novel functional rating scales. In: 18th International Congress of the World Muscle Society. 2013, California, USA: Elsevier.
• Mayhew AG, Cano SJ, Scott E, Eagle M, Bushby K, Manzur A, Muntoni F, North Star Clinical Network. Detecting meaningful change using the North Star Ambulatory Assessment in Duchenne muscular dystrophy. Developmental Medicine & Child Neurology 2013, 55(11), 1046-1052.
• Mayhew AG, Eagle M, Mazzone E, Main M, Ash M, James MK, Vandenhauwe M, Klingels K, Duong T, Florence J, Decostre V, Mercuri E, Bushby K. Performance of Upper Limb Scale for use in Duchenne muscular dystrophy - An iterative process to establish its suitability for clinical trials. In: 18th International Congress of the World Muscle Society. 2013, California, USA: Elsevier.
• Willis TA, Hollingsworth KG, Coombs A, Sveen ML, Andersen S, Stojkovic T, Eagle M, Mayhew A, de Sousa PL, Dewar L, Morrow JM, Sinclair CDJ, Thornton JS, Bushby K, Lochmuller H, Hanna MG, Hogrel JY, Carlier PG, Vissing J, Straub V. Quantitative Muscle MRI as an Assessment Tool for Monitoring Disease Progression in LGMD2I: A Multicentre Longitudinal Study. PLoS ONE 2013, 8(8), e70993.
• James MK, Eagle M, Mayhew A, Rose K, Glanzman A, Florence J, Mazzone E, Lowes L, Green E, Jeter B, Jordan M, Morgan A, Wardell C. Clinical Evaluator training for the GSK DEMAND programme. In: 17th International Congress of the World Muscle Society (WMS). 2012, Perth, Australia: Elsevier Ltd.
• Scott E, Eagle M, Mayhew A, Freeman J, Main M, Sheehan J, Manzur A, Muntoni F, The North Star Clinical Network for Paediatric Neuromuscular Disease. Development of a Functional Assessment Scale for Ambulatory Boys with Duchenne Muscular Dystrophy. Physiotherapy Research International 2012, 17(2), 101-109.
• Duong T, Eagle M, Mayhew AG, Mazzone E, Florence J, James M, Main M, Ash M, Klingels K, Van den Hauwe M, Decostre V. Development of an upper limb functional scale in dystrophinopathies. In: 17th International Congress of the World Muscle Society (WMS). 2012, Perth, Australia: Elsevier Ltd.
• Mayhew AG, Eagle M, Steffenson B. Exploratory Rasch analysis of the EK2 scale used in a population of Duchenne muscular dystrophy (DMD). In: 17th International Congress of the World Muscle Society (WMS). 2012, Perth, Australia: Elsevier Ltd.
• Mayhew AG, Eagle M, Scott E, Bushby KMD, Adnan M, Muntoni F, Cano SJ. Trial readiness: Clinical interpretability of change scores of the North Star Ambulatory Assessment in Duchenne muscular dystropy. In: 17th International Congress of the World Muscle Society (WMS). 2012, Perth, Australia: Elsevier Ltd.
• Willis T, Hollingsworth KG, Sveen ML, Morrow JM, Sinclair CDJ, Thornton JS, Vandenheede J, Strojkovic T, Eagle M, Mayhew A, Bushby K, Lochmuller H, Hanna MG, Vissing J, Carliers P, Straub V. Assessing muscle pathology by MRI in LGMD2I. In: Neuromuscular Disorders: United Kingdom Neuromuscular Translational Research Conference. 2011, London, UK: Elsevier Ltd.
• Mayhew AG, Eagle M, Willis TA, Straub V. Exploratory Rasch analysis of adapted North Star ambulatory assessment in LGMD 2I. In: Neuromuscular Disorders: 16th International Congress of the World Muscle Society. 2011, Algarve, Portugal: Elsevier Ltd.
• Mayhew A, Cano S, Scott E, Eagle M, Bushby K, Muntoni F, Straub V (collaborator), Sarkozy A (collaborator), Strehle E (collaborator), Venkateswaran R (collaborator), North Star Clinical Network for Paediatric Neuromuscular Disease. Moving towards meaningful measurement: Rasch analysis of the North Star Ambulatory Assessment in Duchenne muscular dystrophy. Developmental Medicine and Child Neurology 2011, 53(6), 535-542.
• Willis TA, Hollingsworth KG, Sveen ML, Morrow J, Vandenheede J, Strojkovic T, Eagle M, Mayhew A, Bushby K, Lochmuller H, Hanna M, Vissing J, Straub V. Quantitative MRI in LGMD2I; a longitudinal study. In: Neuromuscular Disorders: 16th International Congress of the World Muscle Society. 2011, Algarve, Portugal: Elsevier Ltd.