Staff Profile | Faculty of Medical Sciences

Dr Arnaud Basle

Macromolecular Molecules X-ray Facilities Manager

Email: arnaud.basle@ncl.ac.uk
Telephone: +44 (0) 191 208 5482
Personal Website: http://sbl.ncl.ac.uk
Address: Newcastle University Biosciences Institute
Medical School
Framlington Place
Newcastle upon Tyne
NE2 4HH
United Kingdom

Publications

Crawshaw AD, Basle A, Salgado PS. A practical overview of molecular replacement: Clostridioides difficile PilA1, a difficult case study. Acta Crystallographica Section D: Structural Biology 2020, 76, 261-271.
Ndeh D, Baslé A, Strahl H, Yates EA, McClurgg UL, Henrissat B, Terrapon N, Cartmell A. Metabolism of multiple glycosaminoglycans by Bacteroides thetaiotaomicron is orchestrated by a versatile core genetic locus. Nature Communications 2020, 11, 646.
Cartmell A, Munoz-Munoz J, Briggs JA, Ndeh DA, Lowe EC, Basle A, Terrapon N, Stott K, Heunis T, Gray J, Yu L, Dupree P, Fernandes PZ, Shah S, Williams SJ, Labourel A, Trost M, Henrissat B, Gilbert HJ. Author Correction: A surface endogalactanase in Bacteroides thetaiotaomicron confers keystone status for arabinogalactan degradation. Nature Microbiology 2019, 4(11), 2021-2023.
Labourel A, Basle A, Munoz-Munoz J, Ndeh D, Booth S, Nepogodiev SA, Field RA, Cartmell A. Structural and functional analyses of glycoside hydrolase 138 enzymes targeting chain A galacturonic acid in the complex pectin rhamnogalacturonan II. Journal of Biological Chemistry 2019, 294(19), 7711-7721.
Barwinska-Sendra A, Basle A, Waldron KJ, Un S. A charge polarization model for the metal-specific activity of superoxide dismutases. Physical Chemistry Chemical Physics 2018, 20(4), 2363-2372.
Cartmell A, Munoz-Munoz J, Briggs JA, Ndeh DA, Lowe EC, Basle A, Terrapon N, Stott K, Heunis T, Gray J, Yu L, Dupree P, Fernandes PZ, Shah S, Williams SJ, Labourel A, Trost M, Henrissat B, Gilbert HJ. A surface endogalactanase in Bacteroides thetaiotaomicron confers keystone status forarabinogalactan degradation. Nature Microbiology 2018, 3, 1314-1326.
Basle A, Hewitt L, Koh A, Lamb HK, Thompson P, Burgess JG, Hall MJ, Hawkins AR, Murray H, Lewis RJ. Crystal structure of NucB, a biofilm-degrading endonuclease. Nucleic Acids Research 2018, 46(1), 473-484.
Abellon-Ruiz J, Zahn M, Basle A, van den Berg B. Crystal structure of the Acinetobacter baumannii outer membrane protein Omp33. Acta Crystallographica Section D: Structural Biology 2018, 74(9), 852-860.
Luis AS, Briggs J, Zhang X, Farnell B, Ndeh D, Labourel A, Baslé A, Cartmell A, Terrapon N, Stott K, Lowe EC, McLean R, Shearer K, Schückel J, Venditto I, Ralet MC, Henrissat B, Martens EC, Mosimann SC, Abbott DW, Gilbert HJ. Dietary pectic glycans are degraded by coordinated enzyme pathways in human colonic Bacteroides. Nature Microbiology 2018, 3(2), 210-219.
Baslé A, El Ghazouani A, Lee J, Dennison C. Insight into Metal Removal from Peptides that Sequester Copper for Methane Oxidation. Chemistry - A European Journal 2018, 24(18), 4515-4518.
Aunkham A, Zahn M, Kesireddy A, Pothula KR, Schulte A, Basle A, Kleinekathofer U, Suginta W, van den Berg B. Structural basis for chitin acquisition by marine Vibrio species. Nature Communications 2018, 9(1), 220.
Kryshtafovych A, Albrecht R, Baslé A, Bule P, Caputo AT, Carvalho AL, Chao KL, Diskin R, Fidelis K, Fontes CMGA, Fredslund F, Gilbert HJ, Goulding CW, Hartmann MD, Hayes CS, Herzberg O, Hill JC, Joachimiak A, Kohring GW, Koning RI, Leggio LL, Mangiagalli M, Michalska K, Moult J, Najmudin S, Nardini M, Nardone V, Ndeh DA, Nguyen TH, Pintacuda G, Postel S, Raaij MJ, Roversi P, Shimon A, Singh AK, Sundberg EJ, Tars K, Zitzmann N, Schwede T. Target highlights from the first post-PSI CASP experiment (CASP12, May-August 2016). Proteins: Structure, Function, and Bioinformatics 2018, 86(S1), 27-50.
Pathania M, Acosta-Gutierrez S, Bhamidimarri SP, Basle A, Ceccarelli M, Winterhalter M, van den Berg B. Unusual constriction zones in the major porins OmpU and OmpT from Vibrio cholerae. Structure 2018, 26(5), 708-721.
Unterlass JE, Baslé A, Blackburn TJ, Tucker J, Turlais F, Cano C, Noble MME, Curtin NJ. Validating and enabling phosphoglycerate dehydrogenase (PHGDH) as a target for fragment-based drug discovery in PHGDH-amplified breast cancer. Oncotarget 2018, 9, 13139-13153.
Temple MJ, Cuskin F, Baslé A, Hickey N, Speciale G, Williams SJ, Gilbert HJ, Lowe EC. A Bacteroidetes locus dedicated to fungal 1,6-β-glucan degradation: unique substrate conformation drives specificity of the key endo-1,6-β-glucanase. Journal of Biological Chemistry 2017, 292(25), 10639-10650.
Munoz-Munoz J, Cartmell A, Terrapon N, Basle A, Henrissat B, Gilbert HJ. An evolutionarily distinct family of polysaccharide lyases removes rhamnose capping of complex arabinogalactan proteins. Journal of Biological Chemistry 2017, 292(32), 13271-13283.
Ndeh D, Rogowski A, Cartmell A, Luis AS, Basle A, Gray J, Venditto I, Briggs J, Yang X, Labourel A, Terrapon N, Buffetto F, Nepogodiev S, Xiao Y, Field RA, Zhu Y, ONeill MA, Urbanowicz BR, York WS, Davies GJ, Abbott DW, Ralet MC, Martens EC, Henrissat B, Gilbert HJ. Complex pectin metabolism by gut bacteria reveals novel catalytic functions. Nature 2017, 544, 65-70.
Cartmell A, Lowe EC, Baslé A, Firbank SJ, Ndeh DA, Murray H, Terrapon N, Lombard V, Henrissat B, Turnbull JE, Czjzek M, Gilbert HJ, Bolam DN. How members of the human gut microbiota overcome the sulfation problem posed by glycosaminoglycans. Proceedings of the National Academy of Sciences of the United States of America 2017, 114(27), 7037-7042.
Abellón-Ruiz J, Kaptan SS, Baslé A, Claudi B, Bumann D, Kleinekathöfer U, van den Berg B. Structural basis for maintenance of bacterial outer membrane lipid asymmetry. Nature Microbiology 2017, 2, 1616-1623.
Glenwright AJ, Pothula KR, Bhamidimarri SP, Chorev DS, Baslé A, Firbank SJ, Zheng H, Robinson CV, Winterhalter M, Kleinekathöfer U, Bolam DN, van den Berg B. Structural basis for nutrient acquisition by dominant members of the human gut microbiota. Nature 2017, 541, 407-411.
Unterlass JE, Wood RJ, Basle A, Tucker J, Cano C, Noble MM, Curtin NJ. Structural insights into the enzymatic activity and potential substrate promiscuity of human 3-phosphoglycerate dehydrogenase (PHGDH). Oncotarget 2017, 8(61), 104478-104491.
Basle A, Platsaki S, Dennison C. Visualizing Biological Copper Storage: The Importance of Thiolate-Coordinated Tetranuclear Clusters. Angewandte Chemie - International Edition 2017, 56(30), 8697-8700.
Vita N, Landolfi G, Basle A, Platsaki S, Lee J, Waldron KJ, Dennison C. Bacterial cytosolic proteins with a high capacity for Cu(I) that protect against copper toxicity. Scientific Reports 2016, 6, 39065.
Vendittoa I, Luis AS, Rydahl M, Schückel J, Fernandes VO, Vidal-Melgosa S, Bule P, Goyal A, Pires VMR, Dourado CG, Ferreira LMA, Coutinho PM, Henrissat B, Knox JP, Baslé A, Najmudin S, Gilbert HJ, Willats WGT, Fontes CMGA. Complexity of the Ruminococcus flavefaciens cellulosome reflects an expansion in glycan recognition. Proceedings of the National Academy of Sciences of the United States of America 2016, 113(26), 7136-7141.
Crouch LI, Cuskin F, Briliute J, Basle A, Bolam DN. Degradation of complex N-glycans by gut Bacteroides species. In: 2016 Annual Meeting of the Society for Glycobiology. 2016, New Orleans, Louisiana: Oxford University Press.
Lowe EC, Cuskin F, Temple MJ, Basle A, Williams SJ, Gilbert HJ. Fungal cell wall glucan metabolism by Bacteroides in the human gut. In: 2016 Annual Meeting of the Society for Glycobiology. 2016, New Orleans, Louisiana: Oxford University Press.
Arunmanee W, Pathania M, Solovyova AS, Le Brun AP, Ridley H, Baslé A, van den Berg B, Lakey JH. Gram-negative trimeric porins have specific LPS binding sites that are essential for porin biogenesis. Proceedings of the National Academy of Sciences of the USA 2016, 113(34), E5034-E5043.
Cuskin F, Crouch LI, Basle A, Bolam DN, Gilbert HJ. Pivotal alpha mannosidase generates specificity for N-glycans through requirement for GlcNac at+2 subsite. In: 2016 Annual Meeting of the Society for Glycobiology. 2016, New Orleans, Louisiana: Oxford University Press.
van den Berg B, Chembath A, Jefferies D, Basle A, Khalid S, Rutherford JC. Structural basis for Mep2 ammonium transceptor activation by phosphorylation. Nature Communications 2016, 7, 11337.
Zahn M, Bhamidimarri SP, Basle A, Winterhalter M, van den Berg B. Structural Insights into Outer Membrane Permeability of Acinetobacter baumannii. Structure 2016, 24(2), 221-231.
Venditto I, Luis AS, Rydahl MG, Schuckel J, Fernandes VO, Melgosa SV, Bule P, Goyal A, Pires VMR, Dourado CG, Ferreira LMA, Coutinho PM, Henrissat B, Knox JP, Basle A, Najmudin S, Gilbert HJ, Willats WG, Fontes CMGA. The complexity of the Ruminococcus flavefaciens cellulosome reflects an expansion in glycan recognition. In: 2016 Annual Meeting of the Society for Glycobiology. 2016, New Orleans, Louisiana: Oxford University Press.
Labourel A, Crouch LI, Bras JLA, Jackson A, Rogowski A, Gray J, Yadav MP, Henrissat B, Fontes CMGA, Gilbert HJ, Najmudin S, Basle A, Cuskin F. The Mechanism by Which Arabinoxylanases Can Recognize Highly Decorated Xylans. Journal of Biological Chemistry 2016, 291(42), 22149-22159.
Vita N, Platsaki S, Basle A, Allen SJ, Paterson NG, Crombie AT, Murrell JC, Waldron KJ, Dennison C. A four-helix bundle stores copper for methane oxidation. Nature 2015, 525(7567), 140-143.
Rogowski A, Briggs JA, Mortimer JC, Tryfona T, Terrapon N, Lowe EC, Baslé A, Morland C, Day AM, Zheng H, Rogers TE, Thompson P, Hawkins AR, Yadav MP, Henrissat B, Martens EC, Dupree P, Gilbert HJ, Bolam DN. Glycan complexity dictates microbial resource allocation in the large intestine. Nature Communications 2015, 6, 7481.
Zahn M, D'Agostino T, Eren E, Baslé A, Ceccarelli M, van den Berg B. Small-Molecule Transport by CarO, an Abundant Eight-Stranded β-Barrel Outer Membrane Protein from Acinetobacter baumannii. Journal of Molecular Biology 2015, 427(14), 2329-2339.
Cuskin F, Baslé A, Ladevèze S, Day AM, Gilbert HJ, Davies GJ, Potocki-Véronèse G, Lowe EC. The GH130 Family of Mannoside Phosphorylases Contains Glycoside Hydrolases That Target β-1,2-Mannosidic Linkages in Candida Mannan. Journal of Biological Chemistry 2015, 290(41), 25023-25033.
Wilson WC, Hornig-Do HT, Bruni F, Chang JC, Jourdain AA, Martinou JC, Falkenberg M, Spåhr H, Larsson NG, Lewis RJ, Hewitt L, Baslé A, Cross HE, Tong L, Lebel RR, Crosby AH, Chrzanowska-Lightowlers ZMA, Lightowlers RN. A human mitochondrial poly(A) polymerase mutation reveals the complexities of post-transcriptional mitochondrial gene expression. Human Molecular Genetics 2014, 23(23), 6345-6355.
Rogowski A, Basle A, Farinas CS, Solovyova A, Mortimer JC, Dupree P, Gilbert HJ, Bolam DN. Evidence That GH115 alpha-Glucuronidase Activity, Which Is Required to Degrade Plant Biomass, Is Dependent on Conformational Flexibility. Journal of Biological Chemistry 2014, 289(1), 53-64.
Kryshtafovych A, Moult J, Basle A, Burgin A, Craig TK, Edwards RA, Fass D, Hartmann MD, Korycinski M, Lewis RJ, Lorimer D, Lupas AN, Newman J, Peat TS, Piepenbrink KH, Prahlad J, van Raaij MJ, Rohwer F, Segall AM, Seguritan V, Sundberg EJ, Singh AK, Wilson MA, Schwede T. Some of the most interesting CASP11 targets through the eyes of their authors. In: Eleventh Meeting on the Critical Assessment of Techniques for Protein Structure Prediction. 2014, Riviera Maya, Mexico: John Wiley and Sons Inc.
Cleverley RM, Barrett JR, Baslé A, Bui NK, Hewitt L, Solovyova A, Xu Z-Q, Daniel RA, Dixon NE, Harry EJ, Oakley AJ, Vollmer W, Lewis RJ. Structure and function of a spectrin-like regulator of bacterial cytokinesis. Nature Communications 2014, 5, 5421.
Badarau A, Basle A, Firbank SJ, Dennison C. Crosstalk between Cu(I) and Zn(II) homeostasis via Atx1 and cognate domains. Chemical Communications 2013, 49(73), 8000-8002.
Badarau A, Baslé A, Firbank SJ, Dennison C. Investigating the Role of Zinc and Copper Binding Motifs of Trafficking Sites in the Cyanobacterium Synechocystis PCC 6803. Biochemistry 2013, 52(39), 6816-6823.
Luis AS, Venditto I, Temple MJ, Rogowski A, Basle A, Xue J, Knox JP, Prates JAM, Ferreira LMA, Fontes CMGA, Najmudin S, Gilbert HJ. Understanding How Noncatalytic Carbohydrate Binding Modules Can Display Specificity for Xyloglucan. Journal of Biological Chemistry 2013, 288(7), 4799-4809.
Cuskin F, Flint JE, Gloster TM, Morland C, Basle A, Henrissat B, Coutinho PM, Strazzulli A, Solovyova AS, Davies GJ, Gilbert HJ. How nature can exploit nonspecific catalytic and carbohydrate binding modules to create enzymatic specificity. Proceedings of the National Academy of Sciences 2012, 109(51), 20889-20894.
Quin MB, Berrisford JM, Newman JA, Baslé A, Lewis RJ, Marles-Wright J. The Bacterial Stressosome: A Modular System that Has Been Adapted to Control Secondary Messenger Signaling. Structure 2012, 20(2), 350-363.
El Ghazouani A, Baslé A, Gray J, Graham DW, Firbank SJ, Dennison C. Variations in methanobactin structure influences copper utilization by methane-oxidizing bacteria. Proceedings of the National Academy of Sciences 2012, 109(22), 8400-8404.
Montanier CY, Correia MA, Flint JE, Zhu Y, Baslé A, McKee LS, Prates JA, Polizzi SJ, Coutinho PM, Lewis RJ, Henrissat B, Fontes CM, Gilbert HJ. A novel, noncatalytic carbohydrate-binding module displays specificity for galactose-containing polysaccharides through calcium-mediated oligomerization. Journal of Biological Chemistry 2011, 286(25), 22499-22509.
El Ghazouani A, Basle A, Firbank SJ, Knapp CW, Gray J, Graham DW, Dennison C. Copper-Binding Properties and Structures of Methanobactins from Methylosinus trichosporium OB3b. Inorganic Chemistry 2011, 50(4), 1378-1391.
Wager B, Baslé A, Delcour A. Disulfide bond tethering of extracellular loops does not affect the closure of OmpF porin at acidic pH. Proteins: Structure, Function and Bioformatics 2010, 78(14), 2886-2894.