Roles and Responsibilities

Research

Research supervision

Qualifications

BSc (Hons), Exon; PhD (Genetics), Cantab.

Previous Positions

Senior Demonstrator, Department of Biochemistry, University of Liverpool (1982-83)
Post-doctoral Research Fellow, Dept. Molecular Biology, University of Edinburgh (1980-1982).

Memberships

Honours and Awards

Bernard Tucker Medal (British Trust for Ornithology)

Languages

I can count to ten in Spanish, German and French.

Research Interests

Main research interests concern the role of retinoids (vitamin A and derivatives) and ligand-dependent transcription factors in cellular signalling processes, particularly relating to differentiation, apoptosis and cell stress. I am particularly interested in the use of systems biology to understand the dynamics of cell signalling. Related interests includes the role of thiopurines in cell signalling and immunosuppression.

Other Expertise

Ornithology- ringing and tagging with electronic devices as monitoring and research tools

Current Work

The mechanism of retinoids in inducing survival pathways in response to cell stress, and interactions between retinoid and arachidonic acid signalling. The role and mechanisms of retinoic acid receptors in transducing retinoid signals in relation to the differentiation and apoptosis of neuroblastoma cells. Interactions between retinoids and stress signalling pathways with respect to the induction of tumour cell death. Inhibition of protein disulphide isomerase as a therapeutic strategy for cancer. Graphene as a biological platform for drug delivery and cell sensors.

Research Roles

Principle Investigator & Group Leader

Postgraduate Supervision

PhD students, Post-doctoral Research Associates.

Esteem Indicators

External Advisor for EU Horizon 2020 project: ER Stress in Health & Disease (TRAIN-ERS Network), National University of Ireland in Galway.

Scientific Committee of 2016 Conference on Computational Modelling with COPASI, Manchester, May 2016

Editor: Ringing & Migration

Funding

Cancer Research UK
SPARKS
Neuroblastoma Society
Newcastle Healthcare

Undergraduate Teaching

Biology Degree Programme (Vertebrate biology)

Postgraduate Teaching

Systems biology

Research supervision of PhD students and Masters projects

• Buckingham L, Bogdanova MI, Green JA, Dunn RE, Wanless S, Bennett S, Bevan RM, Call A, Canham M, Corse CJ, Harris MP, Heward CJ, Jardine DC, Lennon J, Parnaby D, Redfern CPF, Scott L, Swann RL, Ward RM, Weston ED, Furness RW, Daunt F. Interspecific variation in non-breeding aggregation: a multi-colony tracking study of two sympatric seabirds. Marine Ecology Progress Series 2022, 684, 181-197.
• Redfern CPF, Bevan RM. The Arctic Tern Sterna paradisaea: consistency and variability in spatial use at a global oceanographic scale. Marine Ecology Progress Series 2022, M 14054. In Press.
• Toyonaga K, Kobayashi T, Kuronuma S, Ueno A, Kiyohara H, Okabayashi S, Takeuchi O, Redfern CPF, Terai H, Ozaki R, Sagami S, Nakano M, Coulthard SA, Tanaka Y, Hibi T. Increased DNA-incorporated thiopurine metabolite as a possible mechanism for leukocytopenia through cell apoptosis in inflammatory bowel disease patients with NUDT15 mutation. Journal of Gastroenterology 2021, epub ahead of print.
• Redfern CPF. Pair bonds during the annual cycle of a long‑distance migrant, the Arctic Tern (Sterna paradisaea). Avian Research 2021, 12, 1-8.
• Redfern CPF, Kinchin-Smith D, Newton S, Morrison P, Bolton M, Piec D. Upwelling systems in the migration ecology of Roseate Terns (Sterna dougallii) breeding in northwest Europe. Ibis 2021, 163(2), 549-565.
• Redfern CPF, Bevan RM. Use of sea ice by arctic terns Sterna paradisaea in Antarctica and impacts of climate change. Journal of Avian Biology 2020, 51(2), e02318.
• Khatib T, Müller B, Whiting A, Chisholm DR, Redfern C, McCaffery P. A Bioluminescence Reporter Assay for Retinoic Acid Control of Translation of the GluR1 Subunit of the AMPA Glutamate Receptor. Molecular Neurobiology 2019, 56, 7074-7084.
• Boothby C, Redfern C, Schroeder J. An evaluation of canes as management technique to reduce predation by gulls on ground nesting seabirds. Ibis 2019, 161(2), 453-458.
• Whitworth CL, Redfern CPF, Cheek TR. Differentiation-induced remodelling of store-operated calcium entry is independent of neuronal or glial phenotype but modulated by cellular context. Molecular Neurobiology 2019, 56(2), 857-872.
• Chisholm D, Tomlinson C, Zhou G-L, Holden C, Affleck V, Lamb R, Newling K, Ashton P, Valentine R, Redfern C, Erostyák J, Makkai G, Ambler C, Whiting A, Pohl E. Fluorescent retinoic acid analogues as probes for biochemical and intracellular characterization of retinoid signaling pathways. ACS Chemical Biology 2019, 14(3), 369-377.
• Khatib T, Marini P, Nunna S, Chisholm DR, Whiting A, Redfern C, Greig I, McCaffery P. Genomic and non-genomic pathways are both crucial for peak induction of neurite outgrowth by retinoids. Cell Communication and Signalling 2019, 17, 40.
• Morgan EA, Hassall C, Redfern CPF, Bevan RM, Hamer KC. Individuality of foraging behaviour in a short-ranging benthic marine predator: Incidence and implications. Marine Ecology Progress Series 2019, 609, 209-219.
• Redfern CPF, Bevan RM. Overland movement and migration phenology in relation to breeding of Arctic Terns Sterna paradisaea. Ibis 2019, 162(2), 373-380.
• Wilson J, Caletrio J, Redfern C. The timing of departure of Reed Warblers from northern England. Ringing and Migration 2019, 34(1), epub ahead of print.
• Zaferanloo B, Pepper SA, Coulthard SA, Redfern CPF, Palombo EA. Metabolites of endophytic fungi from Australian native plants as potential anticancer agents. FEMS Microbiology Letters 2018, 365(9), fny078.
• Haffez HR, Khatib T, McCaffery P, Przyborski S, Redfern C, Whiting A. Neurogenesis in Response to Synthetic Retinoids at Different Temporal Scales. Molecular Neurobiology 2018, 55(3), 1942-1950.
• Haffez H, Chisholm DR, Tatum NJ, Valentine R, Redfern C, Pohl E, Whiting A, Przyborski S. Probing biological activity through structural modelling of ligand-receptor interactions of 2,4-disubstituted thiazole retinoids. Bioorganic & Medicinal Chemistry 2018, 26(8), 1560-1572.
• Coulthard SA, McGarrity S, Sahota K, Berry P, Redfern CPF. Three Faces of Mercaptopurine Cytotoxicity in vitro: Methylation, Nucleotide Homeostasis and Deoxythioguanosine in DNA. Drug Metabolism and Disposition 2018, 46(8), 1191-1199.
• Coulthard SA, Berry P, McGarrity S, McLaughlin S, Ansari A, Redfern CPF. Azathioprine with Allopurinol: Lower Deoxythioguanosine in DNA and Transcriptome Changes Indicate Mechanistic Differences to Azathioprine Alone. Inflammatory Bowel Diseases 2017, 23(6), 946-955.
• Haffez H, Chisholm DR, Valentine R, Pohl E, Redfern C, Whiting A. The molecular basis of the interactions between synthetic retinoic acid analogues and the retinoic acid receptors. MedChemComm 2017, 8(3), 578-592.
• Coulthard S, Berry P, McGarrity S, Redfern C. A Novel Assay for The Direct Detection of Deoxythioguanosine (DTG) in DNA from Patients On Azathioprine Using Liquid Chromatography and Tandem Mass Spectrometry (LC-MS/MS). In: Annual General Meeting of the British Society of Gastroenterology. 2016, Liverpool: BMJ Publishing Group.
• Coulthard S, Berry P, McGarrity S, Kobayashi T, Toyonaga T, Ansari A, Redfern C. Deoxythioguanosine (DTG) in DNA as a Pharmacological Endpoint of Thiopurine Treatment in Inflammatory Bowel Disease Patients. In: British Society of Gastroenterology Annual General Meeting. 2016, Liverpool: BMJ Publishing Group.
• Coulthard SA, Berry P, McGarrity S, Ansari A, Redfern CPF. Liquid chromatography-mass spectrometry for measuring deoxythioguanosine in DNA from thiopurine-treated patients. Journal of Chromatography B 2016, 1028, 175-180.
• Coulthard SA, Berry P, McGarrity S, Ansari A, Redfern CPF. Liquid chromatography-mass spectrometry for measuring deoxythioguanosine in DNA from thiopurine-treated patients. Journal of Chromatography B 2016, 1028, 175-180.
• Armstrong JL, Hill DS, McKee CS, Hernandez-Tiedra S, Lorente M, Lopez-Valero I, Anagnostou ME, Babatunde F, Corazzari M, Redfern CPF, Velasco V, Lovat PE. Exploiting Cannabinoid-Induced Cytotoxic Autophagy to Drive Melanoma Cell Death. Journal of Investigative Dermatology 2015, 135(6), 1629-1637.
• Swierczewski R, Hedley J, Redfern CPF. High-resolution micromechanical measurement in real time of forces exerted by living cells. Cell Adhesion & Migration 2015, 10(3), 322-330.
• Nicholson L, Evans C, Matheson E, Minto L, Keilty C, Sanichar M, Case M, Schwab C, Williamson D, Rainer J, Harrison C, Kofler R, Hall AG, Rednern CPF, Wheaton AD, Irving JAE. Quantitative proteomic analysis reveals maturation as a mechanism underlying glucocorticoid resistance in B lineage ALL and re-sensitization by JNK inhibition. British Journal of Haematology 2015, 171(4), 595–605.
• Redfern CPF, Bevan RM. A comparison of foraging behaviour in the North Sea by Black-legged Kittiwakes Rissa tridactyla from an inland and a maritime colony. Bird Study 2014, 61(1), 17-28.
• Martin S, Lovat PE, Redfern CPF. Cell-Type Variation in Stress Responses as a Consequence of Manipulating GRP78 Expression in Neuroectodermal Cells. Journal of Cellular Biochemistry 2014, 116(3), 438-449.
• Bell E, Ponthan F, Whitworth C, Tweddle DA, Lunec J, Redfern CPF. COX2 expression in neuroblastoma increases tumorigenicity but does not affect cell death in response to the COX2 inhibitor celecoxib. Clinical & Experimental Metastasis 2014, 31(6), 651-659.
• Swierczewski R, Vázquez J, Hedley J, Birch M, Redfern C. A microsystem for real time high resolution measurement of cell forces. IEEE Sensors Journal 2013, 13(5), 1602-1609.
• Bell E, Ponthan F, Whitworth C, Thomas H, Redfern CPF. Cell Survival Signalling through PPARδ and Arachidonic Acid Metabolites in Neuroblastoma. PLoS One 2013, 8(7), e68859.
• Łastowska M, Al-Afghani H, Al-Balool HH, Sheth H, Mercer E, Coxhead JM, Redfern CPF, Peters H, Burt AD, Santibanez-Koref M, Bacon CM, Chesler L, Rust AG, Adams DJ, Williamson D, Clifford SC, Jackson MS. Identification of a neuronal transcription factor network involved in medulloblastoma development. Acta Neuropathologica Communications 2013, 1, 35.
• Martin S, Lamb HK, Brady C, Lefkove B, Bonner MY, Thompson P, Lovat PE, Arbiser JL, Hawkins AR, Redfern CPF. Inducing apoptosis of cancer cells using small-molecule plant compounds that bind to GRP78. British Journal of Cancer 2013, 109(2), 433-443.
• McKee CS, Hill DS, Redfern CPF, Armstrong JL, Lovat PE. Oncogenic BRAF signalling increases Mcl-1 expression in cutaneous metastatic melanoma. Experimental Dermatology 2013, 22(11), 767-769.
• Bell N, Hann V, Redfern CPF, Cheek TR. Store-operated Ca²⁺ entry in proliferating and retinoic acid-differentiated N- and S-type neuroblastoma cells. Biochimica et Biophysica Acta: Molecular Cell Research 2013, 1833(3), 643-651.
• Gomaa MS, Bridgens CE, Illingworth NA, Veal GJ, Redfern CPF, Brancale A, Armstrong JL, Simons C. Novel retinoic acid 4-hydroxylase (CYP26) inhibitors based on a 3-(1H-imidazol- and triazol-1-yl)-2,2-dimethyl-3-(4-(phenylamino)phenyl)propyl scaffold. Bioorganic & Medicinal Chemistry 2012, 20(14), 4201-4207.
• Gomaa MS, Lim AST, Wilson-Lau SC, Watts AM, Illingworth NA, Bridgens CE, Veal GJ, Redfern CPF, Brancale A, Armstrong JL, Simons C. Synthesis and CYP26A1 inhibitory activity of novel methyl 3-[4-(arylamino)phenyl]-3-(azole)-2,2-dimethylpropanoates. Bioorganic & Medicinal Chemistry 2012, 20(20), 6080-6088.
• Armstrong JL, Martin S, Illingworth NA, Jamieson D, Neilson A, Lovat PE, Redfern CPF, Veal GJ. The impact of retinoic acid treatment on the sensitivity of neuroblastoma cells to fenretinide. Oncology Reports 2012, 27(1), 293-298.
• Myers GW, Redfern CPF. Change in body mass during breeding in Barn Swallows Hirundo rustica. Bird Study 2011, 58(3), 248-256.
• Coulthard SA, Redfern CPF, Vikingsson S, Lindqvist-Appell M, Skoglund K, Jakobsen-Falk I, Hall AG, Taylor GA, Hogarth LA. Increased Sensitivity to Thiopurines in Methylthioadenosine Phosphorylase-Deleted Cancers. Molecular Cancer Therapeutics 2011, 10(3), 495-504.
• Armstrong JL, Corazzari M, Martin S, Pagliarini V, Falasca L, Hill DS, Ellis N, Al Sabah S, Redfern CPF, Fimia GM, Piacentini M, Lovat PE. Oncogenic B-RAF Signaling in Melanoma Impairs the Therapeutic Advantage of Autophagy Inhibition. Clinical Cancer Research 2011, 17(8), 2216-2226.
• Carr-Wilkinson J, Griffiths R, Elston R, Goranov B, Redfern CPF, Gamble LD, Lunec J, Tweddle DA. Outcome of the p53-mediated DNA damage response in neuroblastoma is determined by morphological subtype and MYCN expression. Cell Cycle 2011, 10(21), 3778-3787.
• Nicholson L, Evans C, Matheson EC, Minto L, Keilty C, Schwab C, Harrison CJ, Hall AG, Redfern C, Whetton A, Irving J. Quantitative Proteomic Analysis Reveals Maturation As a Mechanism Underlying Glucocorticoid Resistance in Childhood Acute Lymphoblastic Leukemia and PAX5 As a Re-Sensitising Therapeutic Target. In: Blood: 53rd Annual Meeting and Exposition of the American Society of Hematology (ASH). 2011, San Diego, California, USA: American Society of Hematology.
• Gomaa MS, Bridgens CE, Aboraia AS, Veal GJ, Redfern CPF, Brancale A, Armstrong JL, Simons C. Small Molecule Inhibitors of Retinoic Acid 4-Hydroxylase (CYP26): Synthesis and Biological Evaluation of Imidazole Methyl 3-(4-(aryl-2-ylamino)phenyl)propanoates. Journal of Medicinal Chemistry 2011, 54(8), 2778-2791.
• Gomaa MS, Bridgens CE, Veal GJ, Redfern CPF, Brancale A, Armstrong JL, Simons C. Synthesis and Biological Evaluation of 3-(1H-Imidazol- and Triazol-1-yl)-2,2-dimethyl-3-[4-(naphthalen-2-ylamino)phenyl]propyl Derivatives as Small Molecule Inhibitors of Retinoic Acid 4-Hydroxylase (CYP26). Journal of Medicinal Chemistry 2011, 54(19), 6803-6811.
• Redfern CPF. Brood-patch development and female body mass in passerines. Ringing and Migration 2010, 25(1), 33-41.
• Redfern CPF. Impact and value. Ringing and Migration 2010, 25(1), 1-2.
• Nicholson L, Hall AG, Redfern CP, Irving J. NF kappa B modulators in a model of glucocorticoid resistant, childhood acute lymphoblastic leukemia. Leukemia Research 2010, 34(10), 1366-1373.
• Armstrong JL, Flockhart R, Veal GJ, Lovat PE, Redfern CPF. Regulation of Endoplasmic Reticulum Stress-induced Cell Death by ATF4 in Neuroectodermal Tumor Cells. Journal of Biological Chemistry 2010, 285(9), 6091-6100.
• Rowbotham SE, Boddy AV, Redfern CPF, Veal GJ, Daly AK. Relevance of non-synonymous CYP2C8 polymorphisms to 13-cis retinoic acid and paclitaxel hydroxylation. Drug Metabolism and Disposition 2010, 38(8), 1261-1266.
• Martin S, Hill DS, Paton JC, Paton AW, Birch-Machin MA, Lovat PE, Redfern CPF. Targeting GRP78 to enhance melanoma cell death. Pigment Cell and Melanoma Research 2010, 23(5), 675-682.
• Hiscutt EL, Hill DS, Martin S, Kerr R, Harbottle A, Birch-Machin M, Redfern CPF, Fulda S, Armstrong JL, Lovat PE. Targeting X-Linked Inhibitor of Apoptosis Protein to Increase the Efficacy of Endoplasmic Reticulum Stress-Induced Apoptosis for Melanoma Therapy. Journal of Investigative Dermatology 2010, 130(9), 2250-2258.
• Hill DS, Martin S, Armstrong JL, Flockhart R, Tonison JJ, Simpson DG, Birch-Machin MA, Redfern CPF, Lovat PE. Combining the endoplasmic reticulum stress-inducing agents bortezomib and fenretinide as a novel therapeutic strategy for metastatic melanoma. Clinical Cancer Research 2009, 15(4), 1192-1198.
• Syed AA, Halpin C, Irving JAE, Unwin NC, White M, Bhopal RS, Redfern CPF, Weaver JU. A common intron 2 polymorphism of the glucocorticoid receptor gene is associated with insulin resistance in men. Clinical Endocrinology 2008, 68(6), 879-884.
• Moore HC, Wood KM, Jackson MS, Lastowska MA, Hall D, Imrie H, Redfern CPF, Lovat PE, Ponthan FM, O'Toole KT, Lunec J, Tweddle DA. Histological profile of tumours from MYCN transgenic mice. Journal of Clinical Pathology 2008, 61(10), 1098-1103.
• Syed AA, Redfern CPF, Weaver JU. In vivo and in vitro glucocorticoid sensitivity in obese people with cushingoid appearance. Obesity 2008, 16(10), 2374-2378.
• Lovat PE, Corazzari M, Armstrong JL, Martin S, Pagliarini V, Hill DS, Brown A, Piacentini M, Birch-Machin MA, Redfern CPF. Increasing melanoma cell death using inhibitors of protein disulfide isomerases to abrogate survival responses to endoplasmic reticulum stress. Cancer Research 2008, 68(13), 5363-5369.
• Gomaa MS, Armstrong JL, Bobillon B, Veal GJ, Brancale A, Redfern CPF, Simons C. Novel azolyl-(phenylmethyl)]aryl/heteroarylamines: Potent CYP26 inhibitors and enhancers of all-trans retinoic acid activity in neuroblastoma cells. Bioorganic and Medicinal Chemistry 2008, 16(17), 8301-8313.
• Christie V, Barnard J, Batsanov A, Bridgens C, Cartmell E, Collings J, Maltman D, Redfern CPF, Marder T, Przyborski S, Whiting A. Synthesis and evaluation of synthetic retinoid derivatives as inducers of stem cell differentiation. Organic and Biomolecular Chemistry 2008, 6(19), 3497-3507.
• Hogarth LA, Redfern CPF, Teodoridis J, Hall AG, Anderson HL, Case MC, Coulthard SA. The effect of thiopurine drugs on DNA methylation in relation to TPMT expression. Biochemical Pharmacology 2008, 76(8), 1024-1035.
• Ponthan F, Wickström M, Gleissman H, Fuskevåg O, Segerström L, Sveinbjörnsson B, Redfern CPF, Eksborg S, Kogner P, Johnsen J. Celecoxib prevents neuroblastoma tumor development and potentiates the effect of chemotherapeutic drugs in vitro and in vivo. Clinical Cancer Research 2007, 13(3), 1036-1044.
• Riddoch, F.C., Brown, A.M., Rowbotham, S.E., Redfern, C.P.F., Cheek, T.R. Changes in functional properties of the caffeine-sensitive Ca2+ store during differentiation of human SH-SY5Y neuroblastoma cells. Cell Calcium 2007, 41(3), 195-206.
• Armstrong J, Taylor GA, Thomas HD, Boddy AV, Redfern C, Veal GJ. Molecular targeting of retinoic acid metabolism in neuroblastoma: The role of the CYP26 inhibitor R116010 in vitro and in vivo. British Journal of Cancer 2007, 96(11), 1675-1683.
• Armstrong, J.L., Veal, G.J., Redfern, C.P.F., Lovat, P.E. Role of Noxa in p53-independent fenretinide-induced apoptosis of neuroectodermal tumours. Apoptosis 2007, 12(3), 613-622.
• Corazzari, M., Lovat, P.E., Armstrong, J.L., Fimia, G.M., Hill, D.S., Birch-Machin, M.A., Redfern, C.P.F., Piacentini, M. Targeting homeostatic mechanisms of endoplasmic reticulum stress to increase susceptibility of cancer cells to fenretinide-induced apoptosis: The role of stress proteins ERdj5 and ERp57. British Journal of Cancer 2007, 96(7), 1062-1071.
• Syed, A.A., Irving, J.A.E., Redfern, C.P.F., Hall, A.G., Unwin, N.C., White, M.J.R., Bhopal, R.S., Weaver, J.U. Association of glucocorticoid receptor polymorphism A3669G in exon 9β with reduced central adiposity in women. Obesity 2006, 14(5), 759-764.
• Coiffait L, Bevan RM, Newton J, Redfern CPF, Wolff K. Elucidating the movements of migratory birds through the combined use of stable isotope ‘signatures’ and DNA markers. In: Boere, G.C.; Galbraith, C.A.; Stroud, D.A, ed. Waterbirds Around the World. Edinburgh: The Stationery Office, 2006, pp.506-507.
• Goranov B, Campbell-Hewson Q, Pearson ADJ, Redfern CPF. Overexpression of RARγ increases death of SH-SY5Y neuroblastoma cells in response to retinoic acid but not fenretinide [3]. Cell Death and Differentiation 2006, 13(4), 676-679.
• Thaxter, C., Redfern, C.P.F., Bevan, R.M. Survival rates of adult Reed Warblers Acrocephalus scirpaceus at a northern and southern site in England. Ringing and Migration 2006, 23(2), 65-79.
• Armstrong, J.L., Redfern, C.P.F., Veal, G.J. 13-cis Retinoic acid and isomerisation in paediatric oncology - Is changing shape the key to success?. Biochemical Pharmacology 2005, 69(9), 1299-1306.
• Corazzari, M., Lovat, P.E., Oliverio, S., Di Sano, F., Donnorso, R., Redfern, C.P.F., Piacentini, M. Fenretinide: A p53-independent way to kill cancer cells. Biochemical and Biophysical Research Communications 2005, 331(3), 810-815.
• Armstrong, J., Ruiz, M., Boddy, A. V., Redfern, C., Pearson, A. D. J., Veal, G. J. Increasing the intracellular availability of all-trans retinoic acid in neuroblastoma cells. British Journal of Cancer 2005, 92(4), 696-704.
• Brown, A.M., Riddoch, F.C, Robson, A., Redfern, C.P.F., Cheek, T.R. Mechanistic and functional changes in Ca2+ entry after retinoic acid-induced differentiation of neuroblastoma cells. Biochemical Journal 2005, 388(3), 941-948.
• Myatt, S., Redfern, C.P.F., Burchill, S. p38MAPK-dependent sensitivity of Ewing's sarcoma family of tumors to fenretinide-induced cell death. Clinical Cancer Research 2005, 11(8), 3136-3148.
• Riddoch, F.C., Rowbotham, S.E., Brown, A.M., Redfern, C.P.F., Cheek, T.R. Release and sequestration of Ca2+ by a caffeine- and ryanodine-sensitive store in a sub-population of human SH-SY5Y neuroblastoma cells. Cell Calcium 2005, 38(2), 111-120.
• Campbell-Hewson, Q., Lovat, P.E., Corazzari, M., Catterall, J.B., Redfern, C.P.F. The NF-κB pathway mediates fenretinide-induced apoptosis in SH-SY5Y neuroblastoma cells. Apoptosis 2005, 10(3), 493-498.
• Lovat, P.E., Corazzari, M., Di Sano, F., Piacentini, M., Redfern, C.P.F. The role of gangliosides in fenretinide-induced apoptosis of neuroblastoma. Cancer Letters 2005, 228(1-2), 105-110.
• Syed AA, Redfern CP, Weaver JU. Aldosterone revisited. New England Journal of Medicine 2004, 351(20), 2131-2133.
• Goranov BB, Redfern CPF. Cytogenetic differences and neuroblastoma cell interconversion. Cancer Genetics and Cytogenetics 2004, 149(2), 173-174.
• Goranov, B., Redfern, C.P.F., Cohen, N, Betts, D., Rechavi, G., Amariglio, N., Trakhtenbrot, L. Cytogenetic differences and neuroblastoma cell interconversion [1] (multiple letters). Cancer Genetics and Cytogenetics 2004, 149(2), 173-175.
• Redfern, C.P.F., Topp, V.J., Jones, P. Fat and pectoral muscle in migrating Sedge Warblers Acrocephalus schoenobaenus. Ringing and Migration 2004, 22(1), 24-34.
• Lovat, P.E., Di Sano, F., Corazzari, M., Fazi, B., Donnorso, R., Pearson, A.D.J., Hall, A.G., Redfern, C.P.F., Piacentini, M. Gangliosides link the acidic sphingomyelinase-mediated induction of ceramide to 12-lipoxygenase-dependent apoptosis of neuroblastoma in response to fenretinide. Journal of the National Cancer Institute 2004, 96(17), 1288-1299.
• Syed, A.A., Irving, J.A.E., Redfern, C.P.F., Hall, A.G., Unwin, N.C., White, M., Bhopal, R., Alberti, K., Weaver, J.U. Low Prevalence of the N363S Polymorphism of the Glucocorticoid Receptor in South Asians Living in the United Kingdom. Journal of Clinical Endocrinology and Metabolism 2004, 89(1), 232-235.
• Lovat PE, Corazzari M, Goranov B, Piacentini M, Redfern CPF. Molecular mechanisms of fenretinide-induced apoptosis of neuroblastoma cells. In: Signal Transduction and Communication in Cancer Cells. 2004, Erice, Sicily: New York Academy of Sciences.
• Lovat, P.E., Corazzari, M., Goranov, B., Piacentini, M., Redfern, C.P.F. Molecular mechanisms of fenretinide-induced apoptosis of neuroblastoma cells. Annals of the New York Academy of Sciences 2004, 1028, 81-89.
• Lovat, P.E., Oliverio, S, Corazzari, M., Rodolfo, C., Ranalli, M., Goranov, B., Melino, G., Redfern,C.P.F., Piacentini, M. Bak: A Downstream Mediator of Fenretinide-Induced Apoptosis of SH-SY5Y Neuroblastoma Cells. Cancer Research 2003, 63(21), 7310-7313.
• Roberts, R.G., Redfern, C.P.F., Goodship, T.H.J. Effect of insulin upon protein degradation in cultured human myocytes. European Journal of Clinical Investigation 2003, 33(10), 861-867.
• Armstrong, J. L., Veal, G. J., Redfern, C. P. F., Boddy, A. V. Effects of ketoconazole and acitretin on retinoid isomerisation and metabolism in neuroblastoma. British Journal of Cancer 2003, 88(supplement 1), S67 P168.
• Corazzari, M., Lovat, P.E., Oliverio, S., Pearson, A.D.J., Piacentini, M., Redfern, C.P.F. Growth and DNA Damage-Inducible Transcription Factor 153 Mediates Apoptosis in Response to Fenretinide but Not Synergy between Fenretinide and Chemotherapeutic Drugs in Neuroblastoma. Molecular Pharmacology 2003, 64(6), 1370-1378.
• Lovat, P.E., Oliverio, S., Corazzari, M., Ranalli, M., Pearson, A.D.J., Melino, G., Piacentini, M., Redfern, C.P.F. Induction of GADD153 and Bak: Novel molecular targets of fenretinide-induced apoptosis of neuroblastoma. Cancer Letters 2003, 197(1-2), 157-163.
• Lovat, P.E., Ranalli, M., Corazzari, M., Raffaghello, L., Pearson, A.D.J., Ponzoni, M., Piacentini, M., Melino, G., Redfern, C.P.F. Mechanisms of free-radical induction in relation to fenretinide-induced apoptosis of neuroblastoma. Journal of Cellular Biochemistry 2003, 89(4), 698-708.
• Rana, B., Veal,G.J., Pearson, A.D.J., Redfern, C.P.F. Retinoid X receptors and retinoid response in neuroblastoma cells. Journal of Cellular Biochemistry 2002, 86(1), 67-78.
• Lovat, P.E., Oliverio, S., Ranalli, M., Corazzari, M., Rodolfo, C., Bernassola, F., Aughton, K., Maccarrone, M., Campbell-Hewson, Q., Pearson, A.D.J., Melino, G., Piacentini, M., Redfern, C.P.F. GADD153 and 12-lipoxygenase mediate fenretinide-induced apoptosis of neuroblastoma. Cancer Research 2002, 62(18), 5158-5167.
• Veal, G. J., Errington, J., Redfern, C., Pearson, A. D. J., Boddy, A. V. Influence of isomerisation on the growth inhibitory effects and cellular activity of 13-cis and all-trans retinoic acid in neuroblastoma cells. Biochemical Pharmacology 2002, 63(2), 207-215.
• Redfern, C.P.F., Douglas, G., Halliday, T. Intestine length and mass relative to fat in migrating Redwings Turdus iliacus. Ardea 2002, 90(2), 285-292.
• Campbell-Hewson, Q., Lovat, P.E., Pearson, A.D.J., Redfern, C.P.F. Retinoid signalling and gene expression in neuroblastoma cells: RXR agonist and antagonist effects on CRABP-II and RARβ expression. Journal of Cellular Biochemistry 2002, 87(3), 284-291.
• Rana B, Veal GJ, Pearson ADJ, Redfern CPF. Retinoid X receptors and retinoid response in neuroblastoma cells. Journal of Cellular Biochemistry 2002, 86(1), 67-78.
• Jagoe, R.T., Redfern, C.P.F., Roberts, R.G., Gibson, G.J., Goodship, T.H.J. Skeletal muscle mRNA levels for cathepsin B, but not components of the ubiquitin-proteasome pathway, are increased in patients with lung cancer referred for thoracotomy. Clinical Science 2002, 102(3), 353-361.
• Roberts, R.G., Redfern, C.P.F., Graham, K.A., Bartlett, K., Wilkinson, R., Goodship, T.H.J. Sodium bicarbonate treatment and ubiquitin gene expression in acidotic human subjects with chronic renal failure. European Journal of Clinical Investigation 2002, 32(7), 488-492.
• Coulthard, S.A., Hogarth, L.A., Little, M.A., Matheson, E., Redfern, C.P.F., Minto, C.L.J., Hall, A.G. The effect of thiopurine methyltransferase expression on sensitivity to thiopurine drugs. Molecular Pharmacology 2002, 62(1), 102-109.
• Annicchiarico-Petruzzelli, M., Bernassola, F., Lovat, P.E., Redfern, C.P.F., Pearson, A.D.J., Melino, G. Apoptosis in neuroblastomas induced by interferon-gamma involves the CD95/CD95L pathway. Medical and Pediatric Oncology 2001, 36(1), 115-117.
• Lovat, P.E., Dobson, M., Malcolm, A.J., Pearson, A.D.J., Redfern, C.P.F. Differential gene regulation by 9-cis and all-trans retinoic acid in neuroblastoma cells. Medical and Pediatric Oncology 2001, 36(1), 135-138.
• Veal, G. J., Errington, J., Redfern, C. P. F., Pearson, A. D. J., Boddy, A. V. Influence of retinoid isomerisation on the cellular activity of 13-cis retinoic acid in neuroblastoma. British Journal of Cancer 2001, 85(1), 93-97.
• Rana, B., Pearson, A.D.J., Redfern, C.P.F. RXRβ isoforms in neuroblastoma cells and evidence for a novel 3′-end transcript. FEBS Letters 2001, 506(1), 39-44.
• Dobson, M.G., Redfern, C.P.F., Unwin, N.C., Weaver, J.U. The N363S polymorphism of the glucocorticoid receptor: Potential contribution to central obesity in men and lack of association with other risk factors for coronary heart disease and diabetes mellitus. Journal of Clinical Endocrinology and Metabolism 2001, 86(5), 2270-2274.
• Bailey, S., Hall, A. G., Pearson, A. D. J., Redfern, C. P. F. The role of AP-1 in glucocorticoid resistance in leukaemia. Leukemia 2001, 15(3), 391-397.
• Ponthan FM, Borgstrom P, Hassan M, Wassberg E, Redfern CPF, Kogner P. The vitamin A analogues: 13-cis retinoic acid, 9-cis retinoic acid, and Ro 13-6307 inhibit neuroblastoma tumour growth in vivo. Medical and Pediatric Oncology 2001, 36(1), 127-131.
• Lovat, P.E., Ranalli, M., Bernassola, F., Tilby, M., Malcolm, A.J., Pearson, A.D.J., Piacentini, M., Melino, G., Redfern, C.P.F. Distinct properties of fenretinide and CD437 lead to synergistic responses with chemotherapeutic reagents. Medical and Pediatric Oncology 2000, 35(6), 663-668.
• Lovat, P.E., Ranalli, M., Annichiarrico-Petruzzelli, M., Bernassola, F., Piacentini, M., Malcolm, A.J., Pearson, A.D.J., Melino, G., Redfern, C.P.F. Effector mechanisms of fenretinide-induced apoptosis in neuroblastoma. Experimental Cell Research 2000, 260(1), 50-60.
• Redfern, C.P.F., Slough, A., Dean, B., Brice, J., Jones, P. Fat and body condition migrating Redwings Turdus iliacus. Journal of Avian Biology 2000, 31(2), 197-205.
• Campbell-Hewson, Q., Lovat, P.E., Malcolm, A.J., Pearson, A.D.J., Redfern, C.P.F. Receptor mechanisms mediating differentiation and proliferation effects of retinoids on neuroblastoma cells. Neuroscience Letters 2000, 279(2), 113-116.
• Lovat, P.E., Ranalli, M., Bernassola, F., Tilby, M.J., Malcolm, A.J., Pearson, A.D.J., Piacentini, M, Melino, G., Redfern, C.P.F. Synergistic induction of apoptosis of neuroblastoma by fenretinide or CD437 in combination with chemotherapeutic drugs. International Journal of Cancer 2000, 88(6), 977-985.
• Lovat, P.E., Annicchiarico-Petruzzelli, M., Corazzari, M., Dobson, M., Malcolm, A.J., Pearson, A.D.J., Melino, G., Redfern, C.P.F. Differential effects of retinoic acid isomers on the expression of nuclear receptor co-regulators in neuroblastoma. FEBS Letters 1999, 445(2-3), 415-419.
• Bailey, S., Hall, A.G., Pearson, A.D.J., Reid. M., Redfern, C.P.F. Glucocorticoid resistance and the AP-1 transcription factor in leukaemia. Advances in Experimental Medicine and Biology 1999, 457, 615-619.
• Matthews, C.J., McEwan, G.T.A., Redfern, C.P.F., Thomas, E.J., Hirst, B.H. Absorptive apical amiloride-sensitive Na+ conductance in human endometrial epithelium. Journal of Physiology 1998, 513(2), 443-452.
• Redfern CPF. Retinoic acid receptors. British Journal of Pharmacology 1998, 124(Supplement), U78-U78.
• Irving, H., Lovat, P.E., Campbell-Hewson, Q., Malcolm, A., Pearson, A.D.J., Redfern, C.P.F. Retinoid-induced differentiation of neuroblastoma: Comparison between LG69, an RXR-selective analogue and 9-cis retinoic acid. European Journal of Cancer 1998, 34(1), 111-117.
• Redfern, C.P.F. The analysis of primary moult using feather mass. Ringing and Migration 1998, 19(1), 39-40.
• Lovat, P.E., Irving, H., Malcolm, A.J., Pearson, A.D.J., Redfern, C.P.F. 9-cis retinoic acid - A better retinoid for the modulation of differentiation, proliferation and gene expression in human neuroblastoma. Journal of Neuro-Oncology 1997, 31(1-2), 85-91.
• Lovat, P.E., Irving, H., Annicchiarico-Petruzzelli, M., Bernassola, F., Malcolm, A.J., Pearson, A.D.J., Melino, G., Redfern, C.P.F. Apoptosis of N-type neuroblastoma cells after differentiation with 9- cis-retinoic acid and subsequent washout. Journal of the National Cancer Institute 1997, 89(6), 446-452.
• Lovat PE, Irving H, Annicchiarico-Petruzzelli M, Bernassola F, Malcolm AJ, Pearson ADJ, Melino G, Redfern CPF. Retinoids in neuroblastoma therapy: Distinct biological properties of 9- cis- and all-trans-retinoic acid. European Journal of Cancer 1997, 33(12), 2075-2080.
• Kumarendran, M., Loughney, A., Prentice, A., Thomas, E., Redfern, C.P.F. Nuclear retinoid receptor expression in normal human endometrium throughout the menstrual cycle. Molecular Human Reproduction 1996, 2(2), 123-129.
• Redfern, C.P.F., Alker, P.J. Plumage development and post-juvenile moult in the Sedge Warbler Acrocephalus schoenobaenus. Journal of Avian Biology 1996, 27(2), 157-163.
• Loughney, A.D., Redfern, C.P.F. Menstrual-cycle related differences in the proliferative responses of cultured human endometrial stromal cells to retinoic acid

   . Journal of Reproduction and Fertility 1995, 105(1), 153-159.

• Redfern CPF, Lovat PE, Malcolm AJ, Pearson ADJ. Gene expression and neuroblastoma cell differentiation in response to retinoic acid: differential effects of 9-cis and all-trans retinoic acid. European Journal of Cancer 1995, 31A(4), 486-494.
• Loughney AD, Kumarendran MK, Thomas EJ, Redfern CPF. Molecular aspects of implantation: Variation in the expression of cellular retinoid binding proteins in human endometrium throughout the menstrual cycle. Human Reproduction 1995, 10(5), 1297-1304.
• Siddiqui, N.A., Thomas, E.J., Dunlop, W., Redfern, C.P.F. Retinoic acid receptors and retinoid binding proteins in endometrial adenocarcinoma: Differential expression of cellular retinoid binding proteins in endometrioid tumours. International Journal of Cancer 1995, 64(4), 253-263.
• Siddiqui NA, Loughney AD, Thomas EJ, Dunlop W, Redfern CPF. Cellular retinoid binding proteins and nuclear retinoic acid receptors in endometrial epithelial cells. Human Reproduction 1994, 9(8), 1410-1416.
• Sharpe GR, Fisher C, Redfern CPF. Changes in oncogene mRNA expression during human keratinocyte differentiation. Archives of Dermatological Research 1994, 286(8), 476-480.
• Lovat PE, Lowis SP, Pearson ADJ, Malcolm AJ, Redfern CPF. Concentration-dependent effects of 9-cis retinoic acid on neuroblastoma differentiation and proliferation in vitro. Neuroscience Letters 1994, 182(1), 29-32.
• Redfern CPF, Lovat PE, Malcolm AJ, Pearson ADJ. Differential effects of 9-cis and all-trans retinoic acid on the induction of retinoic acid receptor-beta and cellular retinoic acid-binding protein II in human neuroblastoma cells. Biochemical Journal 1994, 304(part 1), 147-154.
• Redfern CPF. Molecular markers of retinoid activity in skin. Journal of Investigative Dermatology 1994, 102(1), 11-12.
• Kumarendran MK, Matthews CJ, Levasseur M, Prentice A, Thomas EJ, Redfern CPF. Oestrogen and progesterone do not regulate the expression of retinoic acid receptors and retinoid 'X' receptors in human endometrial stromal cells in vitro. Human Reproduction 1994, 9(2), 229-234.
• Frith SE, Hoenich NA, Redfern CPF, Goodship THJ. Production of interleukin 1 receptor antagonist and interleukin 1 during haemodialysis with cellulose membranes. International Journal of Artificial Organs 1994, 17(9), 478-487.
• Matthews CJ, Redfern CPF, Thomas EJ, Hirst BH. Bombesin and gastrin-releasing peptide stimulate electrogenic ion transport in cultured human endometrial epithelial cell layers. Experimental Physiology 1993, 78(5), 715-718.
• Matthews CJ, McEwan GTA, Redfern CPF, Thomas EJ, Hirst BH. Bradykinin stimulation of electrogenic ion transport in epithelial layers of cultured human endometrium. Pflügers Archiv European Journal of Physiology 1993, 422(4), 401-403.
• Matthews CJ, Thomas EJ, Redfern CPF, Hirst BH. Ion transport by human endometrial epithelia in vitro. Human Reproduction 1993, 8(10), 1570-1575.
• Redfern CPF, Wilson KE. Ligand binding properties of human cellular retinoic acid binding protein II expressed in E. coli as a glutathione-S-transferase fusion protein. FEBS Letters 1993, 321(2-3), 163-168.
• Lovat PE, Pearson ADJ, Malcolm AJ, Redfern CPF. Retinoic acid receptor expression during the in vitro differentiation of human neuroblastoma. Neuroscience Letters 1993, 162(1-2), 109-113.
• Braverman IM, Redfern CPF. Transformation in cutaneous T-cell lymphoma. Journal of Investigative Dermatology 1993, 101(3), 249-251.
• Redfern CPF. Retinoic acid receptors. Pathobiology 1992, 60(5), 254-263.
• Matthews CJ, Redfern CPF, Hirst BH, Thomas EJ. Characterization of human purified epithelial and stromal cells from endometrium and endometriosis in tissue culture. Fertility and Sterility 1992, 57(5), 990-997.
• Matthews CJ, Redfern CPF, Hirst BH, Thomas EJ. Epitopes for endometrial cells - Reply. Fertility and Sterility 1992, 58(6), 1267-1268.
• Redfern CPF, Todd C. Retinoic acid receptor expression in human skin keratinocytes and dermal fibroblasts in vitro. Journal of Cell Science 1992, 102(1), 113-121.
• Randall VA, Thornton MJ, Hamada K, Redfern CPF, Nutbrown M, Ebling FJG, Messenger AG. Androgens and the hair follicle: Cultured human dermal papilla cells as a model system. Annals of the New York Academy of Sciences 1991, 642, 355-375.
• Randall VA, Thornton MJ, Redfern CPF. Dermal papilla cells from human hair follicles express mRNA for retinoic acid receptors in culture. Annals of the New York Academy of Sciences 1991, 642, 457-458.
• Redfern CPF, Daly AK. Cellular retinoic acid-binding protein from neonatal rat skin: Purification and analysis. Methods in Enzymology 1990, 189, 307-314.
• Daly AK, Redfern CPF, Martin B. Identification and analysis of retinoic acid-binding proteins and receptors from nuclei of mammalican cells. Methods in Enzymology 1990, 189, 239-247.
• Redfern CPF, Daly AK, Latham JAE, Todd C. The biological activity of retinoids in melanoma cells: Induction of expression of retinoic acid receptor-β by retinoic acid in S91 melanoma cells. FEBS Letters 1990, 273(1-2), 19-22.
• Rees JL, Daly AK, Redfern CPF. Differential expression of the alpha and beta retinoic acid receptors in tissues of the rat. Biochemical Journal 1989, 259(3), 917-919.
• Latham, J.A.E. , Redfern, C.P.F., Thody, A.J., Dekrester, T.A. Immunohistochemical markers of human sebaceous gland differentiation. Journal of Histochemistry and Cytochemistry 1989, 37(5), 729-734.
• Daly AK, Rees JL, Redfern CPF. Nuclear retinoic acid binding proteins and receptors in retinoic acid responsive cell lines. Experimental Cell Biology 1989, 57(6), 339-345.
• Daly, A.K., Redfern, C.P.F. Purification and properties of cellular retinois acid-binding protein from neonatal rat skin. Biochimica et Biophysica Acta 1988, 965(2-3), 118-126.
• Redfern CPF, Todd C. The effects of retinoic acid on rat epidermal cells in vitro: Changes in patterns of protein phosphorylation in relation to growth and differentation. Experimental Cell Research 1988, 174(2), 367-377.
• Daly AK, Redfern CPF. Characterisation of a retinoic-acid-binding component from F9 embryonal-carcinoma-cell nuclei. European Journal of Biochemistry 1987, 168(1), 133-139.