Staff Profile

I have over 20 years of research and laboratory experience, starting as a Trainee Technician at Newcastle University before completing my PhD at Nottingham. I spent time working in Salisbury and Northern Ireland, before returning to Newcastle University in 2002.

I achieved Registered Scientist (RSci) status in January 2016, am a member of the Institute for Science and Technology (IST), and am a board member for the National Technician Development Centre (NTDC). I recently completed the University's Professional Services Development Programme (PSDP) in Leadership and Management, and have subsequently taken up a new position as Research Technical Team Lead for the Paul O'Gorman and Herschel buildings.

• Articles

  • Uitrakul S, Hutton C, Veal GJ, Jamieson D. A novel imaging flow cytometry method for the detection of histone H4 acetylation in myeloid cells. European Journal of Clinical Investigation 2019, 49(7), e13115.
  • Ogle LF, Orr JG, Willoughby CE, Hutton C, McPherson S, Plummer R, Boddy AV, Curtin NC, Jamieson D, Reeves HL. Imagestream detection and characterisation of circulating tumour cells - a liquid biopsy for hepatocellular carcinoma?. Journal of Hepatology 2016, 65(2), 305-313.
  • Drummond CJ, Esfandiari A, Liu J, Lu X, Hutton C, Jackson J, Bennaceur K, Xu Q, Makimanejavali AR, Bello FD, Piergentili A, Newell DR, Hardcastle IR, Griffin RJ, Lunec J. TP53 mutant MDM2-amplified cell lines selected for resistance to MDM2-p53 binding antagonists retain sensitivity to ionizing radiation. Oncotarget 2016, 7(29), 46203-46218.
  • Blackburn TJ, Ahmed S, Coxon CR, Liu JF, Lu XH, Golding BT, Griffin RJ, Hutton C, Newell DR, Ojo S, Watson AF, Zaytzev A, Zhao Y, Lunec J, Hardcastle IR. Diaryl- and triaryl-pyrrole derivatives: inhibitors of the MDM2-p53 and MDMX-p53 protein-protein interactions. MedChemComm 2013, 4(9), 1297-1304.
  • Hardcastle IR, Liu J, Valeur E, Watson A, Ahmed SU, Blackburn TJ, Bennaceur K, Clegg W, Drummond C, Endicott JA, Golding BT, Griffin RJ, Gruber J, Haggerty K, Harrington RW, Hutton C, Kemp S, Lu X, McDonnell JM, Newell DR, Noble ME, Payne SL, Revill CH, Riedinger C, Xu Q, Lunec J. Isoindolinone Inhibitors of the Murine Double Minute 2 (MDM2)-p53 Protein-Protein Interaction: Structure-Activity Studies Leading to Improved Potency. Journal of Medicinal Chemistry 2011, 54(5), 1233-1243.
  • Hardcastle, I.R., Ahmed, S., Atkins, H., Farnie, G., Golding, B.T., Griffin, R.J., Guyenne, S., Hutton,C., Källblad, P., Kemp, S., Kitching, M.S., Newell, D.R., Norbedo, S., Northen, J.S., Reid, R.J., Saravanan, K., Willems, H., Lunec, J. Small-molecule inhibitors of the MDM2-p53 protein-protein interaction based on an isoindolinone scaffold. Journal of Medicinal Chemistry 2006, 49(21), 6209-6221.
  • Hardcastle I, Ahmed S, Atkins H, Calvert AH, Curtin NJ, Farnie G, Golding BT, Griffin R, Guyenne S, Hutton C, Källblad P, Kemp S, Kitching M, Newell D, Norbedo S, Northen J, Reid R, Saravanan K, Willems H, Lunec J. Isoindolinone-based inhibitors of the MDM2-p53 protein-protein interaction. Bioorganic and Medicinal Chemistry Letters 2005, 15(5), 1515-1520.
  • Kemp, S.J., Hardcastle, I.R, Ahmed, S.U., Atatreh, N.A., Barrett, P., Endicott, J.A., Golding, B.T., Griffin, R.J., Gruber, J, Hutton, C., Lunec, J., Noble, M.E.M., Reid, R.J., Riedinger, C., Smyth, L.A. Isoindolinone based inhibitors of the MDM2-p53 protein-protein interaction. Abstracts of Papers of the American Chemical Society 2005, 230, 2735-2736.
  • Hardcastle, I.R., Ahmed, S.U., Barrett, P.A., Endicott, J.A., Golding, B.T., Griffin, R.J., Gruber, J., Hutton, C., Kemp, S.J., Lunec, J., Noble, M.E., Riedinger, C, Smyth, L.A. Inhibitors of the MDM2-p53 protein-protein interaction based on an isoindolinone scaffold. Clinical Cancer Research 2005, 11(24, Supplement 2), 9053.

• Conference Proceedings (inc. Abstracts)

  • Wyatt N, Hogarth L, Turner D, Patterson M, Jamieson D, Black F, Hutton C, Mulvenna P, Simmons T, Bradshaw A, Kolenda C, Parker C, Martin-Ruiz C, Greystoke A. Circulating Biomarkers of Frailty Are Associated with a Poor Prognosis in Patients with Advanced Non-Small Cell Lung Cancer (NSCLC). In: IASLC 17th World Conference on Lung Cancer. 2016, Vienna, Austria: Elsevier.
  • Watson AF, Golding BT, Griffin RJ, Hutton C, Liu JF, Lug XH, Lunec J, Newell DR, Valeur E, Hardcastle IR. MEDI 147-Isoindolinone-based inhibitors of the MDM2-p53 protein-protein interaction. In: Abstracts of Papers of the American Chemical Society: 236th National Meeting of the American Chemical Society. 2008, Philadelphia, Pennsylvania, USA: American Chemical Society.