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Staff Profile

Dr Dafni Michalettou

Research Associate - Population Genetics

Background

Position

Postdoctoral Research Associate in Sarah Pickett's lab, part of the Mitochondrial Research Group.


Academic Background

● PhD in Computational Biology (2025). Biosciences Institute, Faculty of Medical Sciences, Newcastle University, UK

● M.Sc. in Bioinformatics (2020). Department of Cell Biology and Biophysics, National and Kapodistrian University of Athens, GR

● B.Sc./M.Sc. in Applied Mathematical and Physical Sciences (2017). School of Applied Mathematical and Physical Sciences, National Technical University of Athens, GR


Research Interests:

Interested in studying the influence of genetics on molecular phenotypes (multi-omics) and complex traits, focusing on mitochondrial disease.


Skills/Techniques:

I am a computational biologist with a multi-disciplinary background and a passion for advancing science, skilled in high throughput data analyses and functional genomics, and experienced in working with large-scale genetic and genomic data in HPC environments.


Population genetics, GWAS, functional genomics, phenotypic association analysis, data pre-processing, LMM, interaction analyses, bioinformatics, R, shell scripting

Research
  • Brown, A.A., Fernandez-Tajes, J.J., Hong, M., Brorsson, C.A., Koivula, R.W., Davtian, D., Dupuis, T., Sartori, A., Michalettou, T.-D., Forgie, I.M., Adam, J., Allin, K.H., Caiazzo, R., Cederberg, H., De Masi, F., Elders, P.J.M., Giordano, G.N., Haid, M., Hansen, T., et al. Genetic analysis of blood molecular phenotypes reveals common properties in the regulatory networks affecting complex traits. Nature Communications 2023, 14(1), p. 5062.
  • Michalettou, T.-D., Michalopoulos, I., Costes, S.V., Hellweg, C.E., Hada, M. & Georgakilas, A.G. A Meta-Analysis of the Effects of High-LET Ionizing Radiations in Human Gene Expression. Life 2021, 11(2), p. 115.
  • Kanakoglou, D.S., Michalettou, T.-D., Vasileiou, C., Gioukakis, E., Maneta, D., Kyriakidis, K.V., Georgakilas, A.G. & Michalopoulos, I. Effects of High-Dose Ionizing Radiation in Human Gene Expression: A Meta-Analysis. Int J Mol Sci 2020, 21(6), 1938.