Staff Profile

I work on senolytic drug discovery, and the use of these compounds in treating therapy induced frailty following cancer therapy.

• Fielder E, Tweedy C, Wilson C, Oakley F, LeBeau FEN, Passos JF, Mann DA, von Zglinicki T, Jurk D. Anti-inflammatory treatment rescues memory deficits during aging in nfkb1−/− mice. Aging Cell 2020, 19(10), e13188.
• Cassidy LD, Young ARJ, Young CNJ, Soilleux EJ, Fielder E, Weigand BM, Lagnado A, Brais R, Ktistakis NT, Wiggins KA, Pyrillou K, Clarke MCH, Jurk D, Passos JF, Narita M. Temporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risk. Nature Communications 2020, 11(1), 307.
• Anderson R, Lagnado A, Maggiorani D, Walaszczyk A, Dookun E, Chapman J, Birch J, Salmonowicz H, Ogrodnik M, Jurk D, Proctor C, Correia-Melo C, Victorelli S, Fielder E, Berlinguer-Palmini R, Owens WA, Greaves L, Kolsky K, Parini A, Douin-Echinard V, LeBrasseur N, Arthur H, Tual-Chalot S, Schafer M, Roos C, Miller J, Robertson N, Mann J, Adams P, Tchkonia T, Kirkland J, Mialet-Perez J, Richardson GD, Passos J. Length‐independent telomere damage drives post‐mitotic cardiomyocyte senescence. The EMBO Journal 2019, 38(5), e100492.
• Chapman J, Fielder E, Passos JF. Mitochondrial dysfunction and cell senescence: deciphering a complex relationship. FEBS Letters 2019, 593(13), 1566-1579.
• Ogrodnik M, Zhu Y, Langhi LGP, Tchkonia T, Krüger P, Fielder E, Victorelli S, Ruswhandi RA, Giorgadze N, Pirtskhalava T, Podgorni O, Enikolopov G, Johnson KO, Xu M, Inman C, Schafer M, Weigl M, Ikeno Y, Burns T, Passos JF, von Zglinicki T, Kirkland JL, Jurk D. Obesity-Induced Cellular Senescence Drives Anxiety And Impairs Neurogenesis. Cell Metabolism 2019, 29(5), 1061-1077.
• CorreiaMelo C, Birch J, Fielder E, Rahmatika D, Taylor J, Chapman J, Lagnado A, Carroll BM, Miwa S, Richardson G, Jurk D, Oakley F, Mann J, Mann DA, Korolchuk V, Passos JF. Rapamycin improves healthspan but not inflammaging in nfkb1-/- mice. Aging Cell 2019, 18(1), e12882.
• Short S, Fielder E, Miwa S, von Zglinicki T. Senolytics and senostatics as adjuvant tumour therapy. EBioMedicine 2019, 41, 683-692.
• Fielder E, Weigand M, Agneessens J, Griffin B, Parker C, Miwa S, von Zglinicki T. Sublethal whole-body irradiation causes progressive premature frailty in mice. Mechanisms of Ageing and Development 2019, 180, 63-69.
• Fielder E, Von Zglinicki T, Jurk D. The DNA Damage Response in Neurons: Die by Apoptosis or Survive in a Senescence-Like State?. Journal of Alzheimer's Disease 2017, 60(s1), S107-S131.
• McParland S, McAleese K, Walker L, Johnson M, Fielder E, Knowles I, Attems J. Tissue microarray in the quantification of hyper-phosphorylated tau, amyloid-beta and alpha-synuclein. In: 114th Meeting of the British Neuropathological Society. 2013, London: Wiley-Blackwell Publishing Ltd.