Staff Profile

Introduction

I joined joined the structural biology platform in August 2024 as a Scientific Officer, to support researchers with their macromolecular structural biology projects using X-ray technology.

Background

During my PhD and my post-docs I studied is on host/pathogen interactions, focusing on microsporidia, which are fascinating highly specialized eukaryotic I used differents microsporidia/host models coupled with proteomics and genetics to decypher the strategies that pathogens use to attack their hosts and how hosts defend themselves against these attacks.

Academic Appointments

2019-2021: Marie Sklodowska-Curie Fellow, Newcastle University, Newcastle, UK

2016-2019: Postdoctoral Fellow, University of California San Diego, San Diego CA, USA

Professional Education

Ph.D., University of Clermont-Ferrand, France (2015

• Articles

  • Kelly G, Kataura T, Panek J, Gailing M, Salmonowicz H, Davis A, Kendall H, Brookes C, Ayine-Tora DM, Banks P, Nelson G, Dobby L, Pitrez PR, Booth L, Costello L, Richardson GD, Lovat P, Przyborski S, Ferreira L, Greaves L, Szczepanowska K, von Zglinicki T, Miwa S, Brown M, Flagler M, Oblong JE, Bascom CC, Carroll B, Reynisson J, Korolchuk VI. Suppressed basal mitophagy drives cellular aging phenotypes that can be reversed by a p62-targeting small molecule. Developmental Cell 2024, 59(15), 1924-1939.e7.
  • Nicholson D, Salamina M, Panek J, Helena-Bueno K, Brown CR, Hirt RP, Ranson NA, Melnikov SV. Adaptation to genome decay in the structure of the smallest eukaryotic ribosome. Nature communications 2022, 13(1), 591.
  • Panek J, Paris L, Roriz D, Mone A, Dubuffet A, Delbac F, Diogon M, El Alaoui H. Impact of the microsporidian Nosema ceranae on the gut epithelium renewal of the honeybee, Apis mellifera . Journal of Invertebrate Pathology 2018, 159, 121-128.
  • Reddy C, Dror T, Sowa JN, Panek J, Chen K, Lim ES, Wang D, Troemel ER. An intracellular pathogen response pathway promotes proteostasis in C. elegans . Current Biology 2017, 17(22), 3544-3553.e5.
  • Chetouhi C, Panek J, Bonhomme L, El Alaoui H, Texier C, Langin T, De Bekker C, Urbach S, Demettre E, Missé D, Holzmuller P, Hughes DP, Zanzoni A, Brun C, Biron DG. Cross-talk in host–parasite associations: What do past and recent proteomics approaches tell us?. Infection, Genetics and Evolution 2015, 33, 84-94.
  • Parisot N, Pelin A, Gasc X, Polonais V, Belkorchia A, Panek J, El Alaoui H, Biron DG, Brasset E, Vaury C, Peyret P, Corradi N, Peyretaillade E, Lerat E. Microsporidian genomes harbor a diverse array of transposable elements that demonstrate an ancestry of horizontal exchange with metazoans. Genome Biology and Evolution 2014, 6(6), 2289-2300.
  • Panek J, El Alaoui H, Mone A, Urbach S, Demettre E, Texier C, Brun C, Zanzoni A, Peyretaillade E, Parisot N, Lerat E, Peyret P, Delbac F, Biron DG. Hijacking of host cellular functions by an intracellular parasite, the microsporidian Anncaliia algerae. PLoS ONE 2014, 9, e100791.
  • Vidau C, Panek J, Texier C, Biron DG, Belzunces LP, Le Gall M, Broussard C, Delbac F, El Alaoui H. Differential proteomic analysis of midguts from Nosema ceranae-infected honeybees reveals manipulation of key host functions. Journal of Invertebrate Pathology 2014, 121, 89-96.