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Staff Profile

Professor John Common

Prof of Cutaneous Inflamm &Microbiome Bi

Background

Professor John Common is a Principal Investigator in the Dermatology Department at Newcastle University Medical School. He completed his PhD at Queen Mary University of London before moving to Singapore, where he established his independent research group. Now holding a joint appointment between A*STAR Skin Research Labs in Singapore and Newcastle University, his research focuses on skin barrier function, inflammatory skin diseases, and the skin microbiome in both health and disease.



His work investigates host-microbiome and host-environment interactions to uncover how microbes and environmental stimuli contribute to skin health or disease. By exploring the molecular mechanisms underlying these processes, his lab aims to advance our understanding of skin biology and develop translational insights with potential therapeutic applications. A key focus is on how the microbiome interacts with the skin, shaping immune responses and influencing disease progression.

 

Areas of Expertise

  • Epithelial Biology
  • Genodermatoses
  • Inflammatory Skin Diseases
  • Skin Microbiome

 

Google Scholar

Research

Professor John Common’s research is centred on understanding inflammatory skin diseases, with a particular focus on ichthyosis and other disorders affecting the skin barrier. His work combines genetics, immunology, and microbiome research to uncover the molecular mechanisms underlying these conditions. By identifying key genetic mutations and immune pathways involved in skin inflammation, he aims to develop targeted therapies that improve patient outcomes.



Previously based at A*STAR, Professor Common contributed to significant advances in skin biology, including studies on how microbial communities interact with the skin’s immune system. Now at Newcastle University, his research continues to explore how genetic and environmental factors influence skin disease progression. His team employs cutting-edge techniques such as single-cell sequencing, CRISPR-based gene editing, and organoid models to better understand disease pathology and identify novel therapeutic targets.


Beyond fundamental science, Professor Common collaborates with clinicians and industry partners to translate discoveries into potential treatments. His work has implications for a range of skin conditions, from rare genetic disorders to more common inflammatory diseases like eczema and psoriasis. By bridging molecular research and clinical application, he aims to advance precision medicine approaches for dermatological diseases.

Publications