Staff Profile

Role and Responsibilities

Professor of Immunobiology and Dean of Postgraduate Research

Qualifications

BA Biochemistry; 1st Class hons.
DPhil Immunopathology

Previous Positions

BHF Fellow
Lecturer in Transplant Immunology
Senior Lecturer in Transplant Immunology
Reader in Immunobiology

Memberships

International Transplantation Society
British Transplantation Society
British Society for Immunology
Editorial Board of 'Transplantation'
Editorial Board of 'Transplant Immunology'

Current Research Interests

ORCID iD:   0000-0003-2543-4131

Scopus Id:   7202384212

My primary research interest is focused on the Immunobiology of tissue injury during inflammatory diseases. These include active projects in the autoimmune diseases rheumatoid arthritis, primary biliary cirrhosis and inflammatory bowel diseases. However, given the uncertain timeline of clinically relevant autoimmunity, I have focused most of my research on investigation of mechanisms of allograft rejection. Newcastle is one of the UK’s leading centres for organ transplantation, allowing investigation of the complete timeline of human inflammation from the earliest innate responses following donor brain death and transplantation through T cell-mediated acute rejection to chronic allograft failure and organ fibrosis.

Specific interests have focused on:

1.       Chemokine function within extracellular matrix (protein-heparan sulphate interactions)

2.       Strategies to inhibit inflammatory chemokines

3.       Growth factor biology including the activation of TGF-β

4.       T cell differentiation (including Th1, Th17 and Treg biology)

5.       Regulation of immune cell chemotaxis and adhesion

6.       T cell-epithelial cell interactions mediated by CD103 and E-cadherin

7.       Epithelial cell biology including de-differentiation, autophagy, senescence and mesenchymal transition.

8.       The role of donor-specific antibody in allograft rejection.

9.       The biology of sphingosine-1-phosphate in T cell biology and inflammation.

Postgraduate Supervision

 More than 60 PhD, MD and MPhil students have graduated from my research group since 1996.

Funding

Arthritis Research-UK

Wellcome Trust

MRC

Kidney Research-UK

British Heart Foundation

Roche Organ Transplantation Research Fund

Northern Counties Kidney Research Fund

Marie Curie EST programme (EU FP6).

Postgraduate Teaching

Most of my teaching is at postgraduate level. 

I have supervised 80 research students to degree completion.

I lecture extensively in the Applied Immunobiology and Transplantation Science modules of the MRes programme. 

As Dean of Postgraduate Studies I contribute a range of kills Development sessions for Postgraduate Research Students. 

• Martinez-Burgo B, Cobb S, Pohl E, Kashanin D, Paul T, Kirby JA, Sheerin N, Ali S. A C-terminal CXCL8 peptide based on chemokine-glycosaminoglycan interactions reduces neutrophil adhesion and migration during inflammation. Immunology 2019, 157(2), 173-184.
• Lamb CA, Mansfield JC, Kirby JA, Keir ME. The Importance of Molecular Immune Investigation in Therapeutic Clinical Development for Biomarker Assessment. Journal of Crohn's and Colitis 2019, 13(7), 956-957.
• Ichikawa R, Lamb CA, Eastham-Anderson J, Scherl A, Raffals L, Faubion WA, Bennett MR, Long AK, Mansfield JC, Kirby JA, Keir ME. AlphaE Integrin Expression Is Increased in the Ileum Relative to the Colon and Unaffected by Inflammation. Journal of Crohn's & Colitis 2018, 12(10), 1191-1199.
• del Molino del Barrio I, Wilkins GC, Meeson A, Ali S, Kirby JA. Breast Cancer: An Examination of the Potential of ACKR3 to Modify the Response of CXCR4 to CXCL12. International Journal of Molecular Sciences 2018, 19(11), 3592.
• Lamb CA, Kirby JA. Donor intravascular monocyte trafficking: A potential therapeutic target for primary graft dysfunction following lung transplantation?. Thorax 2018, 73(4), 303-304.
• Carbone M, Nardi A, Flack S, Carpino G, Varvaropoulou N, Gavrila C, Spicer A, Badrock J, Bernuzzi F, Cardinale V, Ainsworth HF, Heneghan MA, Thorburn D, Bathgate A, Jones R, Neuberger JM, Battezzati PM, Zuin M, Taylor-Robinson S, Donato MF, Kirby J, Mitchell-Thain R, Floreani A, Sampaziotis F, Muratori L, Alvaro D, Marzioni M, Miele L, Marra F, Giannini E, Gaudio E, Ronca V, Bonato G, Cristoferi L, Malinverno F, Gerussi A, Stocken DD, Cordell HJ, Hirschfield GM, Alexander GJ, Sandford RN, Jones DE, Invernizzi P, Mells GF, Thomas C, Rahman M, Yapp T, Lye Ch'ng C, Harrison M, Sturgess R, Galaska R, Healey C, Whiteman J, Czaijkowski M, Gray C, Gunasekera A, Gyawli P, Premchand P, Mann S, Elliott K, Kapur K, Watson A, Foster G, Trembling P, Subhani J, Harvey R, McCorry R, Adgey C, Hobson L, Mulvaney-Jones C, Evans R, Mathialahan T, Ramanaden D, Gasem J, Van Duyvenvoorde G, Shorrock C, Seward K, Southern P, Tibble J, Penn R, Gorard D, Maiden J, Damant R, Palegwala A, Jones S, Alexander G, Mells G, Sandford R, Whiteman J, Dolwani S, Prince M, Silvestre V, Foxton M, Dungca E, Mitchison H, Wheatley N, Gooding I, Doyle H, Karmo M, Kent M, Saksena S, Braim D, Patel M, Lord S, Ede R, Paton A, Austin A, Lancaster N, Sayer J, Gibbins A, Hogben K, Hovell C, Fisher N, Carter M, Koss K, Musselwhite J, Muscariu F, Piotreowicz A, McKay A, Grimley C, Neal D, Ting Tan L, Lim G, Brighton J, Foale C, Ala A, Saeed A, Flahive K, Wood G, Townshend P, Ford C, Brown J, Kordula J, Bowles J, Wilkinson M, Palmer C, Ramage J, Gordon H, Featherstone J, Ridpath J, Ngatchu T, Levi S, Shaukat S, Sadeghian J, Shidrawi R, Williams B, Abouda G, Jones S, Duggan C, Hynes A, Narain M, Rees I, Salam I, Crossey M, Taylor-Robinson S, Brown A, MacNicol C, Williams S, Wilhelmsen E, Banim P, Raymode P, Chilton A, Das D, Lee H-J, Curtis H, Heneghan M, Gess M, Durant E, Drake IM, Bishop R, Davies M, Jones R, Aldersley M, Ncube N, McNair A, Srirajaskanthan R, Sen S, Casey R, Bird G, Mendall M, Cowley C, Barnardo A, Kitchen P, Yoong K, Amore K, Sirdefield D, Orpe J, Mathew R, MacFaul G, Wrigth A, Shah A, Evans C, Keggans J, Bird B, Baxter G, Saha S, Pollock K, Hughes M, Bramley P, Grieve E, Young K, Fraser A, Mukhopadhya A, Ocker K, Mills P, Hines F, Shallcross C, Wilkins J, Grellier L, Campbell S, Martin K, Bathgate A, Innes C, Shepherd A, Rushbrook S, Valliani T, Przemioslo R, Fairlamb H, Macdonald C, Eastick A, Metcalf J, Tanqueray E, Shmueli U, Holbrook B, Davis A, Browning J, Naqvi A, Walker K, Lee T, Verheyden J, Slininger S, Ryder SD, Chapman R, Collier J, O'Donnell D, Stafford L, Williamson K, Kent L, Klass H, Ninkovic M, March L, Cramp M, Simpson D, Dickson C, Sharer N, Hayes M, Goggin P, Quinne M, Pearson S, Hoeroldt B, Jones L, Wright A, Booth J, Loftus A, Lipscomb G, Dewhurst H, Gunter E, Williams E, Fouracres A, Farrington L, Graves L, Hussaini H, Stableforth B, Marriott S, Ayres R, Leoni M, Burroughs A, Marshall E, Thorburn D, Tyrer D, Martin K, Lombard M, Patanwala I, Dali-Kemmery L, Lambourne V, Maltby J, Vyas S, Colley J, Shinder B, Singhal S, Jones J, Mills M, Gleeson D, Carnahan M, Butterworth J, Boulton K, Taylor N, George K, Harding T, Tregonning J, Douglass A, Brown C, Clifford G, Panter S, Gocher D, Shearman J, Bray G, Hamilton M, Butcher G, Forton D, Mclindon J, Curtis J, Das D, Shewan T, Cowan M, Whatley G, Nasseri M, Grover B, Sivaramakrishnan N, Ducker S, Houghton K, Jones D, Griffiths L, Tripoli S, Pitcher M, Shpuza E, White N, Ghosh D, Douds A, Green M, Brookes M, Cumlat L, Wong VS, Warner K, Netherton K, Mandal A, Jain S, Gupta H, Sanghi P, Pereira S, Neuberger J, Gunson B, Hirschfield G, Lim RT, Gallagher S, Clement D, Brind A, Watts G, Mupudzi M, Wright M, Gitahi J, Gordon F, Gocher D, Unitt E, Pateman H, Batham S, Delahooke T, Grant A, Conder J, Higham A, Cox M, O'Donohoe L, Currie L, King A, Oblak M, Collins C, Whalley S, Quinn M, Baird Y, Amey I, Fraser J, Li A, Cotterill D, Bell A, Watson A, Singhal A, Gee I, Greer S, Ang Y, Ransford R, Allison J, Gotto J, Dyer S, Sweeting H, Millson C, Invernizzi P, Carbone M, Cristoferi L, Bonato G, Malinverno F, Bernuzzi F, Alvaro D, Labbadia G, Bragazzi MC, Andreone P, Muratori L, Azzaroli F, Floreani A, Galli A, Tarocchi M, Giannini E, Miele L, Gasbarrini A, Grieco A, Marrone G, Donato MF, Valenti L, Marra F, Marzioni M, Maroni L, Rigamonti C, Zuin M, Battezzati PM, Picciotto A. Pretreatment prediction of response to ursodeoxycholic acid in primary biliary cholangitis: development and validation of the UDCA Response Score. The Lancet Gastroenterology and Hepatology 2018, 3(9), 626-634.
• Lamb CA, Mansfield JC, Tew GW, Gibbons D, Long AK, Irving P, Diehl L, Eastham-Anderson J, Price MB, O'Boyle G, Jones DEJ, O'Byrne S, Hayday A, Keir ME, Egen JG, Kirby JA. aEß7 Integrin Identifies Subsets of Pro-Inflammatory Colonic CD4+ T Lymphocytes in Ulcerative Colitis. Journal of Crohn's and Colitis 2017, 11(5), 610-620.
• Barker CE, Thompson S, O'Boyle G, Lortat-Jacob H, Sheerin NS, Ali S, Kirby JA. CCL2 nitration is a negative regulator of chemokine-mediated inflammation. Scientific Reports 2017, 7, 44384.
• Embleton ND, Berrington JE, Dorling J, Ewer AK, Juszczak E, Kirby JA, Lamb CA, Lanyon CV, McGuire W, Probert CS, Rushton SP, Shirley MD, Stewart CJ, Cummings SP. Mechanisms Affecting the Gut of Preterm Infants in Enteral Feeding Trials. Frontiers in Microbiology 2017, 4, 14.
• Thompson S, Martinez-Burgo B, Sepuru KM, Rajarathnam K, Kirby JA, Sheerin NS, Ali S. Regulation of chemokine function: The roles of GAG-binding and post-translational nitration. International Journal of Molecular Sciences 2017, 18(8), 1692.
• Anderson AE, Swan DJ, Wong OY, Buck M, Eltherington O, Harry RA, Patterson AM, Pratt AG, Reynolds G, Doran JP, Kirby JA, Isaacs JD, Hilkens CM. Tolerogenic dendritic cells generated with dexamethasone and vitamin D3 regulate rheumatoid arthritis CD4⁺ T-cells partly via TGF-β1. Clinical & Experimental Immunology 2017, 187(1), 113-123.
• Tew GW, Hackney JA, Gibbons D, Lamb CA, Luca D, Egen JG, Diehl L, Anderson JE, Vermeire S, Mansfield JC, Feagan BG, Panes J, Baumgart DC, Schreiber S, Dotan I, Sandborn WJ, Kirby JA, Irving PM, De Hertogh G, Van Assche GA, Rutgeerts P, O'Byrne S, Hayday A, Keir ME. Association Between Response to Etrolizumab and Expression of Integrin alpha E and Granzyme A in Colon Biopsies of Patients With Ulcerative Colitis. Gastroenterology 2016, 150(2), 477-487.e9.
• Lawrence H, Deehan DJ, Holland JP, Anjum SA, Mawdesley AE, Kirby JA, Tyson-Capper AJ. Cobalt ions recruit inflammatory cells in vitro through human Toll-like receptor 4. Biochemistry and Biophysics Reports 2016, 7, 374-378.
• Anjum SA, Lawrence H, Holland JP, Kirby JA, Deehan DJ, Tyson-Capper AJ. Effect of cobalt-mediated Toll-like receptor 4 activation on inflammatory responses in endothelial cells. Oncotarget 2016, 7(47), 76471-76478.
• Lawrence H, Mawdesley AE, Holland JP, Kirby JA, Deehan DJ, Tyson-Capper AJ. Targeting Toll-like receptor 4 prevents cobalt-mediated inflammation. Oncotarget 2016, 7(7), 7578-7585.
• del Barrio ID, Kirby J, Ali S. The Role of Chemokine and Glycosaminoglycan Interaction in Chemokine-Mediated Migration In Vitro and In Vivo. Methods in Enzymolgy 2016, 570, 309-333.
• Speight RA, Davey T, White K, Kirby JA, Mansfield JC. Activation of the bile acid receptor, farnesoid-x receptor, maintains gut epithelial cell morphology, possibly via inhibition of myosin light chain kinase expression. In: 2nd Digestive Disorders Federation Conference 2015. 2015, London, UK: BMJ Group.
• Speight RA, Whitehead A, Patman G, Mansfield JC, Reeves H, Kirby JA. Activation of the bile acid receptor, Farnesoid-X Receptor, may reduce Ileal Inflammatory Cytokine expression in an animal model of diet-induced obesity. In: 2nd Digestive Disorders Federation Conference 2015. 2015, London, UK: BMJ Group.
• Ferreras L, Sheerin NS, Kirby J, Ali S. Mechanisms of renal graft chronic injury and progression to interstitial fibrosis. Current Transplantation Reports 2015, 2, 259-268.
• Keir M, Tew GW, Luca D, Eastham-Anderson J, Diehl L, Egen JG, Vermeire S, Mansfield JC, Lamb CA, Panes J, Baumgart DC, Schreiber S, Dotan I, Sandborn WJ, De Hertogh G, Kirby JA, Van Assche G, Rutgeerts P, O'Byrne S. AlphaE integrin expression as a predictive biomarker for induction of clinical remission by etrolizumab: Analysis of a phase II trial in moderate-to-severely active ulcerative colitis. In: 9th Congress of ECCO. 2014, Copenhagen, Denmark: Oxford University Press.
• Douglass A, Meeson AP, Overbeck-Zubrzycka D, Brain JG, Bennett MR, Lamb CA, Lennard TWJ, Browell D, Ali S, Kirby JA. Breast cancer metastasis: demonstration that FOXP3 regulates CXCR4 expression and the response to CXCL12. The Journal of Pathology 2014, 234(1), 74-85.
• Lawrence H, Deehan DJ, Holland JP, Kirby JA, Tyson-Capper AJ. Can cobalt from metal-on-metal joints activate human TLR4 and cause an inflammatory response?. Bone and Joint Journal 2014, 96-B(Supp 11), 292-292.
• Mallini P, Lennard T, Kirby J, Meeson A. Epithelial-to-mesenchymal transition: What is the impact on breast cancer stem cells and drug resistance. Cancer Treatment Reviews 2014, 40(3), 341-348.
• Vermeire S, O'Byrne S, Keir M, Williams M, Lu TT, Mansfield JC, Lamb CA, Feagan BG, Panes J, Salas A, Baumgart DC, Schreiber S, Dotan I, Sandborn WJ, Tew GW, Luca D, Tang MT, Diehl L, Eastham-Anderson J, De Hertogh G, Perrier C, Egen JG, Kirby JA, van Assche G, Rutgeerts P. Etrolizumab as induction therapy for ulcerative colitis: a randomised, controlled, phase 2 trial. Lancet 2014, 384(9940), 309-318.
• Thompson S, Redgrave R, Kirby J, Arthur H, Ali S. Modulation of wound healing post-myocardial infarction. In: British Society for Immunology Annual Congress. 2014, Brighton, UK: Wiley-Blackwell.
• Alhasan AA, Spielhofer J, Kusche-Gullberg M, Kirby JA, Ali S. Role of 6-O-Sulfated Heparan Sulfate in Chronic Renal Fibrosis. Journal of Biological Chemistry 2014, 289(29), 20295-20306.
• Lawrence H, Deehan D, Holland J, Kirby JA, Tyson-Capper AJ. The immunobiology of cobalt: demonstration of a potential aetiology for inflammatory pseudotumours after metal-on-metal replacement of the hip. Bone & Joint Journal 2014, 96-B(9), 1172-1177.
• Barker CE, Ali S, O'Boyle G, Kirby JA. Transplantation and inflammation: implications for the modification of chemokine function. Immunology 2014, 143(2), 138-145.
• Pitts AC, Palmer JM, Dyson JK, Ducker S, Griffiths L, Jones DEJ, Kirby JA. Understanding the mechanisms underpinning treatment non-response in Primary Biliary Cirrhosis: a tool for treatment stratification. In: The International Liver Congress 2014: 49th Annual Meeting of the European Association for the Study of the Liver. 2014, London: Elsevier BV.
• Pitts AC, Palmer JM, Jones DE, Dyson JK, Griffiths L, Ducker S, Kirby JA. Understanding the Mechanisms Underpinning Treatment Non-Response in Primary Biliary Cirrhosis: A Tool for Treatment Stratification. In: British Society of Gastroenterology Annual General Meeting. 2014, Manchester, UK: BMJ Publishing Group.
• Naemi FMA, Carter V, Kirby JA, Ali S. Anti-Donor HLA Class I Antibodies: Pathways to Endothelial Cell Activation and Cell-Mediated Allograft Rejection. Transplantation 2013, 96(3), 258-266.
• Brain JG, Robertson H, Thompson EH, Humphreys E, Gardner A, Booth TA, Jones DEJ, Afford SC, von Zglinicki T, Burt AD, Kirby JA. Biliary Epithelial Senescence and Plasticity in Acute Cellular Rejection. American Journal of Transplantation 2013, 13(7), 1688-1702.
• O'Boyle G, Ali S, Kirby JA. Comment on "CXCL19 causes heterologous desensitization of CXCL12-mediated memory T cell activation". Journal of Immunology 2013, 191(2), 525.
• Thompson E, Burt AD, Barker CE, Kirby JA, Brain JG. Development of a robust protocol for gene expression analysis using formalin-fixed, paraffin-embedded liver transplant biopsy specimens. Journal of Clinical Pathology 2013, 66(9), 815-818.
• Douglass S, Ali S, Meeson AP, Browell D, Kirby JA. Erratum to: The role of FOXP₃ in the development and metastatic spread of breast cancer (vol 31, pg 843, 2012). Cancer and Metastasis Reviews 2013, 32(3-4), 763-763.
• Saleki M, Colgin N, Kirby JA, Cobb SL, Ali S. Evaluation of two cyclic di-peptides as inhibitors of CCL2 induced chemotaxis. MedChemComm 2013, 4(5), 860-864.
• Hudson AS, Kirby JA, Ali S, Colgin N, Caron L, Cobb SL. From Di-peptides to Whole Proteins: Exploiting Peptide Chemistry in the Rational Design of New Chemokine Inhibitors. In: 23rd American Peptide Symposium. 2013, Hawaii: Wiley-Blackwell.
• Willet JDP, Pichitsiri W, Jenkinson SE, Brain JG, Wood K, Alhasan AA, Spielhofer J, Robertson H, Ali S, Kirby JA. Kidney transplantation: analysis of the expression and T cell-mediated activation of latent TGF-β. Journal of Leukocyte Biology 2013, 93(4), 471-478.
• Okonkwo A, Ladak S, Ali S, Kirby J. Kidney transplantation: chronic molecular signatures in acute kidney injury. In: Annual Congress of the British Society for Immunology. 2013, Liverpool: Wiley-Blackwell Publishing Ltd.
• Tyson-Capper AJ, Lawrence H, Holland JP, Deehan DJ, Kirby JA. Metal-on-metal hips: cobalt can induce an endotoxin-like response. Annals of the Rheumatic Diseases 2013, 72(3), 460-461.
• Pekalski M, Jenkinson SE, Willet JDP, Poyner EFM, Alhamidi AH, Robertson H, Ali S, Kirby JA. Renal allograft rejection: Examination of delayed differentiation of Treg and Th17 effector T cells. Immunobiology 2013, 218(3), 303-310.
• Giannoudaki E, Kirby JA, Ali S. Sphingosine 1-phosphate in ischemia-reperfusion injury: effects on trans-endothelial migration of neutrophils. In: Annual Congress of the British Society for Immunology. 2013, Liverpool, UK: Wiley-Blackwell.
• Tyson-Capper AJ, Lawrence H, Holland JP, Deehan DJ, Kirby JA. The Molecular Mechanism of Cell Activation by Cobalt Ions. Comment on Ninomiya et al.: Metal Ions Activate Vascular Endothelial Cells and Increase Lymphocyte Chemotaxis and Binding. Journal of Orthopaedic Research 2013, 31(11), 1859.
• O'Boyle G, Fox CR, Walden HR, Willet JD, Mavin ER, Hine DW, Palmer JM, Barker CE, Lamb CA, Ali S, Kirby JA. Chemokine receptor CXCR3 agonist prevents human T-cell migration in a humanized model of arthritic inflammation. Proceedings of the National Academy of Sciences 2012, 109(12), 4598-4603.
• Gorowiec MR, Borthwick LA, Parker SM, Kirby JA, Saretzki GC, Fisher AJ. Free radical generation induces epithelial-to-mesenchymal transition in lung epithelium via a TGF-beta 1-dependent mechanism. Free Radical Biology & Medicine 2012, 52(6), 1024-1032.
• Swan DJ, Kirby JA, Ali S. Post-Transplant Immunosuppression: Regulation of the Efflux of Allospecific Effector T Cells from Lymphoid Tissues. PLoS One 2012, 7(9), e45548.
• Miller B, Shelleh A, Kirby JA, Robson SC, Tyson-Capper AJ. Preterm Birth: A Modulatory Role for HMGB1?. In: 59th Annual Scientific Meeting of the Society for Gynecologic Investigation. 2012, Sage.
• Sultan J, Griffin SM, Di Franco F, Kirby JA, Shenton BK, Seal CJ, Davis P, Viswanath YKS, Preston SR, Hayes N. Randomized clinical trial of omega-3 fatty acid-supplemented enteral nutrition versus standard enteral nutrition in patients undergoing oesophagogastric cancer surgery. British Journal of Surgery 2012, 99(3), 346-355.
• Douglass S, Ali S, Meeson AP, Browell D, Kirby JA. The role of FOXP3 in the development and metastatic spread of breast cancer. Cancer and Metastasis Reviews 2012, 31(3-4), 843-854.
• Naemi FMA, Ali S, Kirby JA. Antibody-mediated allograft rejection: The emerging role of endothelial cell signalling and transcription factors. Transplantation Immunology 2011, 25(2-3), 96-103.
• Ciechomska M, Lennard TWJ, Kirby JA, Knight AM. B lymphocytes acquire and present intracellular antigens that have relocated to the surface of apoptotic target cells. European Journal of Immunology 2011, 41(7), 1850-1861.
• Britton KM, Kirby JA, Lennard TWJ, Meeson AP. Cancer Stem Cells and Side Population Cells in Breast Cancer and Metastasis. Cancers 2011, 3(2), 2106-2130.
• O'Boyle G, Ali S, Kirby JA. Chemokines in transplantation: what can atypical receptors teach us about anti-inflammatory therapy?. Transplantation Reviews 2011, 25(4), 136-144.
• Kirby JA, O'Boyle G. Lung Transplantation: The Yin and Yang of Mesenchymal Stem Cells. Transplantation 2011, 92(2), 129-130.
• Bradford L, Marshall H, Robertson H, Kirby JA, Graham G, Ali S, O'Boyle G. Cardiac Allograft Rejection: Examination of the Expression and Function of the Decoy Chemokine Receptor D6. Transplantation 2010, 89(11), 1411-1416.
• Rostron AJ, Cork DMW, Avlonitis VS, Fisher AJ, Dark JH, Kirby JA. Contribution of Toll-Like Receptor Activation to Lung Damage After Donor Brain Death. Transplantation 2010, 90(7), 732-739.
• Borthwick LA, McIlroy EI, Gorowiec MR, Brodlie M, Johnson GE, Ward C, Lordan JL, Corris PA, Kirby JA, Fisher AJ. Inflammation and Epithelial to Mesenchymal Transition in Lung Transplant Recipients: Role in Dysregulated Epithelial Wound Repair. American Journal of Transplantation 2010, 10(3), 498-509.
• Nilsson J, Ali S, Harvey I, Kirby J, Meeson A. Stem cell therapy: a role for CXCR4 in homing bone marrow side population cells to areas of myocardial damage. International Journal of Cardiology 2010, 145(3), 554-555.
• Rygiel KA, Robertson H, Willet JDP, Brain JG, Burt AD, Jones DEJ, Kirby JA. T Cell-Mediated Biliary Epithelial-to-Mesenchymal Transition in Liver Allograft Rejection. Liver Transplantation 2010, 16(5), 567-576.
• Ali S, O'Boyle G, Hepplewhite P, Tyler JR, Robertson H, Kirby JA. Therapy with Nonglycosaminoglycan-Binding Mutant CCL7: A Novel Strategy to Limit Allograft Inflammation. American Journal of Transplantation 2010, 10(1), 47-58.
• Avlonitis VS, Wigfield CH, Kirby JA, Dark JH. Treatment of the brain-dead lung donor with aprotinin and nitric oxide. Journal of Heart and Lung Transplantation 2010, 29(10), 1177-1184.
• Swan DJ, Kirby JA, Ali S. Vascular biology: the role of sphingosine 1-phosphate in both the resting state and inflammation. Journal of Cellular and Molecular Medicine 2010, 14(9), 2211-2222.
• O'Boyle G, Mellor P, Kirby JA, Ali S. Anti-inflammatory therapy by intravenous delivery of non-heparan sulfate-binding CXCL12. FASEB Journal 2009, 23(11), 3906-3916.
• Borthwick LA, Parker SM, Brougham KA, Johnson GE, Gorowiec MR, Ward C, Lordan JL, Corris PA, Kirby JA, Fisher AJ. Epithelial to mesenchymal transition (EMT) and airway remodelling after human lung transplantation. Thorax 2009, 64(9), 770-777.
• Lewis AJM, Rostron AJ, Cork DMW, Kirby JA, Dark JH. Norepinephrine and Arginine Vasopressin Increase Hepatic but Not Renal Inflammatory Activation During Hemodynamic Resuscitation in a Rodent Model of Brain-dead Donors. Experimental and Clinical Transplantation 2009, 7(2), 119-123.
• Charnley R, Sewpaul A, French J, Khoo T, Kernohan M, Kirby J. Soluble E-cadherin: An early marker of severity in acute pancreatitis. HPB Surgery 2009, article ID: 397375.
• Newton P, O'Boyle G, Jenkins Y, Ali S, Kirby JA. T cell extravasation: Demonstration of synergy between activation of CXCR3 and the T cell receptor. Molecular Immunology 2009, 47(2-3), 485-492.
• Brain JG, Rostron AJ, Dark JH, Kirby JA. Activation and modulation of cardiac poly-adenosine diphosphate ribose polymerase activity in a rat model of brain death. Transplantation 2008, 85(9), 1348-1350.
• Avlonitis VS, Wigfield CH, Golledge HDR, Rostron AJ, Kirby JA, Dark JH. Brain stem auditory evoked response for confirmation of brain death in the rat. Transplantation 2008, 86(5), 745-746.
• Dovedi SJ, Kirby JA, Davies BR, Leung H, Kelly JD. Celecoxib has Potent Antitumour Effects as a Single Agent and in Combination with BCG Immunotherapy in a Model of Urothelial Cell Carcinoma. European Urology 2008, 54(3), 621-630.
• Kirby JA, Robertson H, Marshall H, Rygiel KA, Hudson M, Jones DEJ, Burt AD. Epithelial to mesenchymal transition in primary sclerosing cholangitis. Liver International 2008, 28(8), 1176-1177.
• Kirby JA, Robertson H, Marshall HL, Rygiel KA, Hudson M, Jones DEJ, Burt AD. Epithelial to mesenchymal transition in primary sclerosing cholangitis. Liver International 2008, 28(8), 1176-1177.
• Rygiel KA, Robertson H, Marshall HL, Pekalski M, Zhao L, Booth TA, Jones DEJ, Burt AD, Kirby JA. Epithelial-mesenchymal transition contributes to portal tract fibrogenesis during human chronic liver disease. Laboratory Investigation 2008, 88(2), 112-123.
• Rostron AJ, Avlonitis VS, Cork DMW, Grenade DS, Kirby JA, Dark JH. Hemodynamic Resuscitation With Arginine Vasopressin Reduces Lung Injury After Brain Death in the Transplant Donor. Transplantation 2008, 85(4), 597-606.
• Ali S, Jenkins Y, Kirkley M, Dagkalis A, Manivannan A, Crane IJ, Kirby JA. Leukocyte extravasation: An immunoregulatory role for α-L-Fucosidase?. Journal of Immunology 2008, 181(4), 2407-2413.
• Ahmed I, Harvey JR, Ali S, Kirby JA, Lennard TWJ. Mouse mammary tumor virus: a cause of breast cancer in humans?. Cancer Therapy 2008, 6, 537-544.
• Al-Hamidi A, Pekalski M, Robertson H, Ali S, Kirby JA. Renal allograft rejection: The contribution of chemokines to the adhesion and retention of αE(CD103)β7 integrin-expressing intratubular T cells. Molecular Immunology 2008, 45(15), 4000-4007.
• Jones DEJ, Palmer JM, Burt AD, Kirby JA. The specificity of liver inflammation in mouse models of primary biliary cirrhosis. Hepatology 2008, 48(4), 1353-1354.
• Walden HR, Kirby JA, Yeaman SJ, Gray J, Jones DE, Palmer JM. Xenobiotic Incorporation into Pyruvate Dehydrogenase Complex Can Occur Via the Exogenous Lipoylation Pathway. Hepatology 2008, 48(6), 1874-1884.
• Ali S, O'Boyle G, Mellor P, Kirby JA. An apparent paradox: Chemokine receptor agonists can be used for anti-inflammatory therapy. Molecular Immunology 2007, 44(7), 1477-1482.
• Robertson H, Kirby JA, Yip WW, Jones DEJ, Burt AD. Biliary epithelial-mesenchymal transition in posttransplantation recurrence of primary biliary cirrhosis. Hepatology 2007, 45(4), 977-981.
• O'Boyle G, Brain JG, Kirby JA, Ali S. Chemokine-mediated inflammation: Identification of a possible regulatory role for CCR2. Molecular Immunology 2007, 44(8), 1954-1963.
• Avlonitis VS, Wigfield CH, Golledge HDR, Kirby JA, Dark JH. Early hemodynamic injury during donor brain death determines the severity of primary graft dysfunction after lung transplantation. American Journal of Transplantation 2007, 7(1), 83-90.
• Rostron AJ, Avlonitis VS, Kirby JA, Dark JH. Hemodynamic resuscitation of the brain-dead organ donor and the potential role of vasopressin. Transplantation Reviews 2007, 21(1), 34-42.
• Ratanamart J, Huggins CG, Kirby JA, Shaw J. In vitro and in vivo evaluation of intrinsic immunogenicity of reporter and insulin gene therapy plasmids. Journal of Gene Medicine 2007, 9(8), 703-714.
• Harvey, J., Mellor, P., Eldaly, H., Lennard, T.W.J., Kirby, J., Ali, S. Inhibition of CXCR4-mediated breast cancer metastasis: A potential role for heparinoids?. Clinical Cancer Research 2007, 13(5), 1562-1570.
• Mellor, P., Harvey, J., Murphy, K, Pye, D., O'Boyle, G, Lennard, T.W.J., Kirby, J., Ali, S. Modulatory effects of heparin and short-length oligosaccharides of heparin on the metastasis and growth of LMD MDA-MB 231 breast cancer cells in vivo. British Journal of Cancer 2007, 97(6), 761-768.
• Smyth LJC, Kirby JA, Cunningham AC. Role of the mucosal integrin αE(CD103)β7 in tissue-restricted cytotoxicity. Clinical and Experimental Immunology 2007, 149(1), 162-170.
• Tyler JR, Robertson H, Booth TA, Burt AD, Kirby JA. Chronic allograft nephropathy: Intraepithelial signals generated by transforming growth factor-β and bone morphogenetic protein-7. American Journal of Transplantation 2006, 6(6), 1367-1376.
• Avlonitis VS, Kirby JA, Dark JH. Donor treatment with nitric oxide does not improve reperfusion injury after transplantation of lungs damaged by brain death. The Journal of Heart and Lung Transplantation 2006, 25(2), S64.
• Birraux J, Kirby JA, Thomason JM, Taylor JJ. The effect of cyclosporin on cell division and apoptosis in human oral keratinocytes. Journal of Periodontal Research 2006, 41(4), 297-302.
• Broad A, Jones DEJ, Kirby JA. Toll-like receptor (TLR) response tolerance: A key physiological "damage limitation" Effect and an important potential opportunity for therapy. Current Medicinal Chemistry 2006, 13(21), 2487-2502.
• Broad A, Kirby JA, Jones DEJ. Toll-like receptor interactions: Tolerance of MyD88-dependent cytokines but enhancement of MyD88-independent interferon-β production. Immunology 2006, 120(1), 103-111.
• Natarajan A, Kirby JA. A guide to oral presentaiton skills. Student BMJ 2005, 13, 353-396.
• Robe AJ, Kirby JA, Jones DEJ, Palmer JM. A key role for autoreactive B cells in the breakdown of T-cell tolerance to pyruvate dehydrogenase complex in the mouse. Hepatology 2005, 41(5), 1106-1112.
• Robe AJ, Kirby JA, Jones DEJ, Palmer JM. A key role for autoreactive B cells in the breakdown of T-cell tolerance to pyruvate dehydrogenase complex in the mouse. Hepatology 2005, 41(5), 1106-1112.
• Ali S, Robertson H, Wain JH, Isaacs JD, Malik G, Kirby JA. A non-glycosaminoglycan-binding variant of CC chemokine ligand 7 (monocyte chemoattractant protein-3) antagonizes chemokine-mediated inflammation. Journal of Immunology 2005, 175(2), 1257-1266.
• Dovedi SJ, Kirby JA, Atkins H, Davies BR, Kelly JD. Cyclooxygenase-2 inhibition: A potential mechanism for increasing the efficacy of bacillus Calmette-Guerin immunotherapy for bladder cancer. The Journal of Urology 2005, 174(1), 332-337.
• Ward C, Forrest IA, Murphy DM, Johnson GE, Robertson H, Cawston TE, Fisher AJ, Dark JH, Lordan JL, Kirby JA, Corris PA. Phenotype of airway epithelial cells suggests epithelial to mesenchymal cell transition in clinically stable lung transplant recipients. Thorax 2005, 60(10), 865-871.
• Ali S, Malik G, Burns A, Robertson H, Kirby JA. Renal transplantation: Examination of the regulation of chemokine binding during acute rejection. Transplantation 2005, 79(6), 672-679.
• Avlonitis VS, Wigfield CH, Kirby JA, Dark JH. The hemodynamic mechanisms of lung injury and systemic inflammatory response following brain death in the transplant donor. American Journal of Transplantation 2005, 5(4 I), 684-693.
• Macdonald P, Palmer J, Kirby JA, Jones DEJ. Apoptosis as a mechanism for cell surface expression of the autoantigen pyruvate dehydrogenase complex. Clinical and Experimental Immunology 2004, 136(3), 559-567.
• Robertson H, Ali S, McDonnell BJ, Burt AD, Kirby JA. Chronic Renal Allograft Dysfunction: The Role of T Cell-Mediated Tubular Epithelial to Mesenchymal Cell Transition. Journal of the American Society of Nephrology 2004, 15(2), 390-397.
• Palmer JM, Robe AJ, Burt AD, Kirby JA, Jones DEJ. Covalent modification as a mechanism for the breakdown of immune tolerance to pyruvate dehydrogenase complex in the mouse. Hepatology 2004, 39(6), 1583-1592.
• Hardy LA, Booth TA, Lau EK, Handel TM, Ali S, Kirby JA. Examination of MCP-1 (CCL2) partitioning and presentation during transendothelial leukocyte migration. Laboratory Investigation 2004, 84(1), 81-90.
• Chishti AD, Shenton BK, Kirby JA, Baudouin SV. Neutrophil chemotaxis and receptor expression in clinical septic shock. Intensive Care Medicine 2004, 30(4), 605-611.
• Ellis JS, Morgan CL, Kirby JA, Taylor JJ, Thomason JM. Plasma TGF-β1 as a risk factor for gingival overgrowth. Journal of Clinical Periodontology 2004, 31(10), 863-868.
• Dowsland, M., Harvey, J., Lennard, T.W.J., Kirby, J.A., Ali, S. Chemokines and breast cancer: A gateway to revolutionary targeted cancer treatments?. Current Medicinal Chemistry 2003, 10(7), 579-592.
• Carter NM, Ali S, Kirby JA. Endothelial inflammation: The role of differential expression of N-deacetylease/N-sulphotransferase enzymes in alteration of the immunological properties of heparan sulphate. Journal of Cell Science 2003, 116(17), 3591-3600.
• Rao JN, Clark SC, Ali S, Kirby J, Flecknell PA, Dark JH. Improvements in lung compliance after pulmonary transplantation: Correlation with interleukin 8 expression. European Journal of Cardio-thoracic Surgery 2003, 23(4), 497-502.
• Aitchison JD, Orr HE, Flecknell PA, Kirby JA, Dark JH. Nitric oxide during perfusion improves posttransplantation function of non-heart-beating donor lungs. Transplantation 2003, 75(12), 1960-1964.
• Atkins H, Davies BR, Kirby JA, Kelly JD. Polarisation of a T helper cell immune response by CpG-containing oligonucleotides: A potential immunotherapy for bladder cancer. British Journal of Cancer 2003, 89(12), 2312-2319.
• Atkins H, Davies BR, Kirby JA, Kelly JD. Polarisation of a T-helper cell immune response by activation of dendritic cells with CpG-containing oligonucleotides: A potential therapeutic regime for bladder cancer immunotherapy. British Journal of Cancer 2003, 89(12), 2312-2319.
• Robertson H, Kirby JA. Post-transplant renal tubulitis: The recruitment, differentiation and persistence of intra-epithelial T cells. American Journal of Transplantation 2003, 3(1), 3-10.
• Avlonitis VS, Fisher AJ, Kirby JA, Dark JH. Pulmonary transplantation: The role of brain death in donor lung injury. Transplantation 2003, 75(12), 1928-1933.
• Wain JH, Palmer JM, Kirby JA, Ali S. Rapid site-directed mutagenesis of chemokines and their purification from a bacterial expression system. Journal of Immunological Methods 2003, 279(1-2), 233-249.
• Kirby JA, Bone M, Robertson H, Hudson M, Jones DEJ. The number of intraepithelial T cells decreases from ascending colon to rectum [1]. Journal of Clinical Pathology 2003, 56(2), 158-.
• Ali S, Hardy LA, Kirby JA. Transplant immunobiology: A crucial role for heparan sulfate glycosaminoglycans?. Transplantation 2003, 75(11), 1773-1782.
• Wong WK, Robertson H, Carroll H, Ali S, Kirby JA. Tubulitis in renal allograft rejection: role of TGFb and IL-15 in development and maintenance of CD103+T cells. Transplantation 2003, 75(4), 505-514.
• Wong WK, Robertson H, Carroll HP, Ali S, Kirby JA. Tubulitis in renal allograft rejection: Role of transforming growth factor-β and interleukin-15 in development and maintenance of CD103+ intraepithelial T cells. Transplantation 2003, 75(4), 505-514.
• Robe AJ, Palmer JM, Kirby JA, Bassendine MF, Jones DEJ. [abstract] Characterisation of liver infiltrating T-cell antigen specificity in a mouse model of primary biliary cirrhosis (PBC). Gut 2002, 50(s2), A116 abstract no. 428.
• Cresswell J, Wong W, Henry MJ, Robertson H, Neal DE, Kirby JA. Adhesion of lymphocytes to bladder cancer cells: The role of the αEβ7 integrin. Cancer Immunology, Immunotherapy 2002, 51(9), 483-491.
• Wigfield CH, Golledge HDR, Shenton BK, Kirby JA, Dark JH. Ameliorated reperfusion injury in lung transplantation after reduction of brain death induced inflammatory graft damage in the donor. Journal of Heart and Lung Transplantation 2002, 21(1), 57.
• Jones DEJ, Palmer JM, Burt AD, Walker C, Robe AJ, Kirby JA. Bacterial motif DNA as an adjuvant for the breakdown of immune self-tolerance to pyruvate dehydrogenase complex. Hepatology 2002, 36(3), 679-686.
• Macdonald P, Kirby JA, Jones DE. Cell-surface expression of pyruvate dehydrogenase complex during apoptosis: A possible route for autoantigen presentation in primary biliary cirrhosis. In: Hepatology: 53rd Annual Meeting of the Association for the Study of Liver Diseases. 2002, Boston, Massachusetts, USA: John Wiley & Sons, Inc.
• Robe A, Palmer J, Kirby J, Jones D. Characterisation of liver infiltrating T-cell antigen specificity in a mouse model of primary biliary cirrhosis (PBC). In: Journal of Hepatology. 2002, Elsevier BV.
• Ali S, Fritchley SJ, Chaffey BT, Kirby JA. Contribution of the putative heparan sulfate-binding moif BBXB of RANTES to transendothelial migrationwth factor beta(a) expression and rejection grade. Glycobiology 2002, 12(9), 535-543.
• Ali S, Fritchley SJ, Chaffey BT, Kirby JA. Contribution of the putative heparan sulfate-binding motif BBXB of RANTES to transendothelial migration. Glycobiology 2002, 12(9), 535-543.
• Kirby J, Menzies FM, Cookson MR, Bushby K, Shaw PJ. Differential gene expression in a cell culture model of SOD1-related familial motor neurone disease. Human Molecular Genetics 2002, 11(17), 2061-2075.
• Pettit SJ, Neal DE, Kirby JA. Evaluation of dendritic cell immunogenicity after activation and chemical fixation: A mixed lymphocyte reaction model. Journal of Immunotherapy 2002, 25(2), 152-161.
• Dowsland MH, Ali SA, Kirby JA, Lennard TWJ. Heparin blocks stromal derived factor-1 induced migration via CXCR4 in breast cancer cells. British Journal of Surgery 2002, 89(Supplement 1), 40-40.
• Jones DEJ, Palmer JM, Bennett K, Robe AJ, Yeaman SJ, Robertson H, Bassendine MF, Burt AD, Kirby JA. Investigation of a mechanism for accelerated breakdown of immune tolerance to the primary biliary cirrhosis-associated autoantigen, pyruvate dehydrogenase complex. Laboratory Investigation 2002, 82(2), 211-219.
• Wain JH, Kirby JA, Ali S. Leucocyte chemotaxis: Examination of mitogen-activated protein kinase and phosphoinositide 3-kinase activation by Monocyte Chemoattractant Proteins-1, -2, -3 and -4. Clinical and Experimental Immunology 2002, 127(3), 436-444.
• Jones DEJ, Palmer JM, Robe A, Kirby JA. Oral tolerisation to pyruvate dehydrogenase complex as a potential therapy for primary biliary cirrhosis. Autoimmunity 2002, 35(8), 537-544.
• French JJ, Cresswell J, Wong WK, Seymour K, Charnley RM, Kirby JA. T cell adhesion and cytolysis of pancreatic cancer cells: A role for E-cadherin in immunotherapy?. British Journal of Cancer 2002, 87(9), 1034-1041.
• French JJ, Cresswell J, Wong WK, Seymour K, Charnley RM, Kirby JA. T-cell adhesion and cytolysis of pancreatic cancer cells: a role for E-cadherin in immunotherapy. British Journal of Surgery 2002, 89, 43-43.
• Palmer JM, Kirby JA, Jones DEJ. The immunology of primary biliary cirrhosis: The end of the beginning?. Clinical and Experimental Immunology 2002, 129(2), 191-197.
• Carroll HP, Ali S, Kirby JA. Accelerating the induction of Fas-mediated T cell apoptosis: A strategy for transplant tolerance?. Clinical and Experimental Immunology 2001, 126(3), 589-597.
• Chishti A, Kirby J, Baudouin SV. CXC chemokine receptor expression in severe sepsis in man. Intensive Care Medicine 2001, 27, 7.
• Cresswell J, Robertson H, Neal DE, Griffiths TRL, Kirby JA. Distribution of lymphocytes of the αEβ7 phenotype and E-cadherin in normal human urothelium and bladder carcinomas. Clinical and Experimental Immunology 2001, 126(3), 397-402.
• Jones DE, Robe AJ, Palmer JM, Kirby JA. Exploration of the immunogenicity of the primary biliary cirrhosis autoantigen pyuvate dehydrogenase complex. Hepatology 2001, 34, 730.
• Chishti AD, Dark JH, Kesteven P, Powell H, Snowden C, Shenton BK, Kirby JA, Baudouin SV. Expression of chemokine receptors CXCR1 and CXCR2 during cardiopulmonary bypass. Journal of Thoracic and Cardiovascular Surgery 2001, 122(6), 1162-1166.
• Aitchison JD, Orr HE, Flecknell PA, Kirby JA, Dark JH. Functional assessment of non-heart-beating donor lungs: Prediction of post-transplant function. European Journal of Cardio-thoracic Surgery 2001, 20(1), 187-194.
• Bassendine MF, Palmer JM, Yeaman SJ, Kirby JA, Jones DEJ. Immunological aspects of chronic cholestatic liver diseases. In "FALK Workshop on Hepatobiliary Diseases: Cholestasis and Gallstones" pp 32-41 Eds. Acalovschi and Paumgartner Pub. Kluwer Academic Publishers<br>(Chapter) 2001.
• Balupuri S, Strong A, Hoernich N, Snowden C, Mohamed M, Manas D, Kirby J, Talbot D. Machine perfusion for kidneys: How to do it at minimal cost. Transplant International 2001, 14(2), 103-107.
• Ali S, Palmer ACV, Fritchley SJ, Maley Y, Kirby JA. Multimerization of monocyte chemoattractant protein-1 is not required for glycosaminoglycan-dependent transendothelial chemotaxis. Biochemical Journal 2001, 358(3), 737-745.
• Chishti A, Kirby J, Baudouin SV. Neutrophil CXC chemokine receptor expression in sepsis. In: British Journal of Anaesthesia. 2001, Oxford University Press.
• Robe AJ, Palmer JM, Kirby JA, Jones DE. No role for autoreactive antibody in the breakdown of T-cell tolerance to pyruvate dehydrogenase complex, the autoantigen in primary biliary cirrhosis. In: Hepatology. 2001, John Wiley & Sons, Inc.
• Robertson H, Wong WK, Burt AD, Mohamed MAS, Talbot D, Kirby JA. Relationship between TGF beta(1), intratubular CD103 positive T cells and acute renal allograft rejection. Transplantation Proceedings 2001, 33(1-2), 1159-1159.
• Robertson H, Kirby JA. Renal allograft rejection: The development and function of tubulitis. Transplantation Reviews 2001, 15(3), 109-128.
• Mohammed MAS, Burt AD, Robertson H, Kirby JA, Talbot D. TGF-β expression in protocol transplant liver biopsies: a comparative study between cyclosporine-A (CyA) and tacrolimus (FK 506) immunosuppression. Transplantation Proceedings 2001, 33(1), 1378-1380.
• Mohamed MAS, Burt A, Robertson H, Kirby JA, Talbot D. TGF-β expression in protocol transplant liver biopsies: A comparative study between cyclosporine-A (CyA) and tacrolimus (FK 506) immunosuppression. Transplantation Proceedings 2001, 33(1-2), 1378-1380.
• Dowsland MH, Ali S, Kirby JA, Lennard TWJ. TNF-alpha affects CXCR4 gene expression and apoptosis in the breast cancer cell line MCF-7. Clinical Cancer Research 2001, 7(11), 3758S-3758S.
• Mohamed MAS, Robertson H, Kirby J, Talbot D. Transforming growth factor-beta 1 plasma levels in stable renal allograft recipients under different immunosuppression - Response. Transplantation 2001, 71(4), 587-587.
• Robertson H, Keong Wong W, Talbot D, Burt AD, Kirby JA. Tubulitis after renal transplantation: Demonstration of an association between CD103+ T cells, transforming growth factor β1 expression and rejection grade. Transplantation 2001, 71(2), 306-313.
• Mohamed MAS, Robertson H, Booth TA, Balupuri S, Gerstenkorn C, Kirby JA, Talbot D. Active TGF-β1 expression in kidney transplantation: A comparative study of cyclosporin-A (CyA) and tacrolimus (FK506). Transplant International 2000, 13(S1), S295-S298.
• Balupuri S, Buckley P, Mohamed M, Cornell C, Mantle D, Kirby J, Manas DM, Talbot D. Assessment of non-heart-beating donor (NHBD) kidneys for viability on machine perfusion. Clinical Chemistry and Laboratory Medicine 2000, 38(11), 1103-1106.
• Yeamon SJ, Kirby JA, Jones DEJ. Autoreactive responses to pyruvate dehydrogenase complex in the pathogenesis of primary biliary cirrhosis. Immunological Reviews 2000, 174(1), 238-249.
• Balupuri S, Talbot D, El-Sheikh M, Snowden C, Manas DM, Kirby J, Mantle D. Comparison of proteolytic enzymes and glutathione S-transferase levels in non-heart-beating donors' (NHBD) kidney perfusates. Clinical Chemistry and Laboratory Medicine 2000, 38(11), 1099-1102.
• Ali S, Palmer ACV, Banerjee B, Fritchley SJ, Kirby JA. Examination of the function of RANTES, MIP-1α, and MIP-1β following interaction with heparin-like glycosaminoglycans. Journal of Biological Chemistry 2000, 275(16), 11721-11727.
• Jones DEJ, Palmer JM, Kirby JA, De Cruz DJ, McCaughan GW, Sedgwick JD, Yeaman SJ, Burt AD, Bassendine MF. Experimental autoimmune cholangitis: A mouse model of immune-mediated cholangiopathy. Liver 2000, 20(5), 351-356.
• Armstrong F, Kirby J, Higgins CA, Coaker J, Mathers JC. High dose Hylon VII increases tumourigenesis and decreases lymphocyte proliferation in Min mice. In: PROCEEDINGS OF THE NUTRITION SOCIETY. 2000.
• Burt AD, Jones DEJ, Palmer JM, Kirby JA, Cruz DeDJ, McCaughan GW, Sedgewick JD, Yeaman SJ, Bassendine MF. Histopathology of experimental autoimmune cholangitis - a mouse model of primary biliary cirrhosis. Journal of Pathology 2000, 190, 3A-3A.
• Pettit SJ, Seymour K, O'Flaherty E, Kirby JA. Immune selection in neoplasia: towards a microevolutionary model of cancer development. British Journal of Cancer 2000, 82(12), 1900-1906.
• Bennett KM, Robertson H, Bone M, Burt AD, Kirby JA, Jones DE. Immunohistochemical analaysis of portal tract changes in experimental autoimmune cholangitis, a murine model of non-suppurative destructive cholangitis (NSDC). In: HEPATOLOGY. 2000.
• Milne DS, Moy JV, Corris PA, Robertson H, De Soyza A, Kirby JA, Cunningham AC. Intragraft Proliferating T Lymphocytes are associated with Moderate Acute Pulmonary Rejection 1. Transplantation 2000, 69(9), 1981-1984.
• Balupuri S, Mantle DM, Mohamed M, Shenton BK, Gok MA, Soomro NA, Manas DM, Kirby JA, Talbot D. Machine perfusion and viability assessment of non-heart-beating donor kidneys: A single-centre result. In: XVIII International Congress of the Transplantation Society. 2000, Rome, Italy: Transplantation Proceedings: Elsevier.
• Balupuri S, Buckley P, Mantle D, Snowden C, Cornell C, Manas DM, Kirby J, Talbot D, Laskowski IA, Tilney NL. Non-heart-beating kidney donors (multiple letters). Clinical Transplantation 2000, 14(3), 266-267.
• O'Flaherty E, Wong WK, Pettit SJ, Seymour K, Ali S, Kirby JA. Regulation of T-cell apoptosis: a mixed lymphocyte reaction model. Immunology 2000, 100(3), 289-299.
• Robertson H, Morley AR, Talbot D, Callanan K, Kirby JA. Renal allograft rejection: β-Chemokine involvement in the development of tubulitis. Transplantation 2000, 69(4), 684-687.
• Palmer JM, Doshi M, Kirby JA, Yeaman SJ, Bassendine MF, Jones DEJ. Secretory autoantibodies in primary biliary cirrhosis (PBC). Clinical and Experimental Immunology 2000, 122(3), 423-428.
• Seymour K, Pettit SJ, Kirby JA. Selection of metastatic tumour phenotypes - Reply. The Lancet 2000, 355(9204), 655-656.
• Morgan CL, Robertson H, Thomason JM, Kirby JA, Taylor JJ. TGF beta 1 in drug-induced gingival overgrowth: activation or synthesis?. In: Symposia/Behavioural Sciences & Health Services Research. 2000, Washington, USA: Sage Publications.
• Mohamed MAS, Robertson H, Booth TA, Balupuri S, Kirby JA, Talbot D. TGF-β expression in renal transplant biopsies - A comparative study between cyclosporin-A and tacrolimus. Transplantation 2000, 69(5), 1002-1005.
• Fritchley SJ, Kirby JA, Ali S. The antagonism of interferon-gamma (IFN-γ) by heparin: Examination of the blockade of class II MHC antigen and heat shock protein-70 expression. Clinical and Experimental Immunology 2000, 120(2), 247-252.
• Gerstenkorn C, Balupuri S, Mohamed MA, Manas DM, Ali S, Kirby J, Talbot D. The impact of cytomegalovirus serology for 7-year graft survival in cadaveric kidney transplantation - The Newcastle experience. Transplant International 2000, 13(1), S372-S374.
• Cresswell J, Robertson H, Kirby JA, Neal DE. The relationship between lymphocytes of the CD103 phenotype and E-cadherin expressing bladder cancers. In: BRITISH JOURNAL OF CANCER. 2000.
• Jones DE, Robe AJ, Palmer JM, Yeaman SJ, Kirby JA. The role played by gender in breakdown of immune tolerance in experimental autoimmune cholangitis: A mouse model of primary biliary cirrhosis. In: HEPATOLOGY. 2000.
• Balupuri S, Buckley P, Snowden C, Sen MMB, Griffiths P, Hannon M, Manas D, Kirby J, Talbot D. The trouble with kidneys derived from the non heart-beating donor: A single center 10-year experience. Transplantation 2000, 69(5), 842-846.
• Bone MH, Jones DE, Kirby JA, Robertson H, Burt AD, Jawahari A, Hudson M. Ulcerative colitis: An investigation of the potential role played by a B-E(7) +VE T-cells. Gastroenterology 2000, 118(4), A1334-A1334.
• Jones DE, Palmer JM, Yeaman SJ, Kirby JA, Bassendine MA. Bacterial motif DNA as ad adjuvant for the development of autoimmunity in primary biliary cirrhosis (PBC). Gut 1999, 44, TH390.
• Pettit SJ, Ali S, O'Flaherty E, Griffiths TRL, Neal DE, Kirby JA. Bladder cancer immunogenicity: expression of CD80 and CD86 is insufficient to allow primary CD4(+) T cell activation in vitro. Clinical and Experimental Immunology 1999, 116(1), 48-56.
• Pettit SJ, Ali S, Griffiths TRL, Neal DE, Kirby JA. Bladder cancer immunogenicity: expression of CD80 and CD86 is insufficient to allow primary CD4+T cell activation in vitro. Clinical and Experimental Immunology 1999, 116(1), 48-56.
• Jones DEJ, Palmer JM, Yeaman SJ, Kirby JA, Bassendine ME. Breakdown of tolerance to pyruvate dehydrogenase complex in experimental autoimmune cholangitis: A mouse model of primary biliary cirrhosis. Hepatology 1999, 30(1), 65-70.
• Palmer JM, Kirby JA, Yeaman SJ, Doshi M, Jones DE. Persistence of secretory autoantibodies in PBC patients post-liver transplant: a potential mechanism for disease recurrence?. In: Hepatology. 1999, John Wiley & Sons, Inc.
• Seymour K, Pettit S, O'Flaherty E, Charnley RM, Kirby JA. Selection of metastatic tumour phenotypes by host immune systems. Lancet 1999, 354(9194), 1989-1991.
• Morgan CL, Robertson H, Thomason JM, Kirby JA, Taylor JJ. TGF-beta 1 associated with gingival overgrowth in transplant patients medicated with cyclosporin A. In: British Society for Dental Research 47th Annual Meeting. 1999, Leeds, United Kingdom: Sage Publications, Inc.
• Mohamed MAS, Walmsley M, Robertson H, Kirby JA, Talbot D. The effect of cyclosporin A and Tacrolimus on cultured human epithelial cells: The role of TGF-β. In: XVIIth World Congress of the Transplantation-Society. 1999, Montreal, Canada: Elsevier.
• Jones DE, Palmer JM, Yeaman SJ, Kirby JA, Bassendine MF, Burt AD. The time-course of bile duct lesion development in experimental autoimmune cholangitis (A mouse model of primary biliary cirrhosis -PBC). In: HEPATOLOGY. 1999.
• Jones DE, Palmer JM, Yeaman SJ, Kirby JA, Bassendine MF, Burt AD. The time-course of bile duct lesion development in experimental autoimmune cholangitis (a mouse model of primary biliary cirrhosis-PBC). In: HEPATOLOGY. 1999.
• S. J. Pettit, E. O'Flaherty, S. Ali, T. R. L. Griffiths, D. E. Neal and J. A. Kirby. Antigen presentation and induction of lymphocyte apoptosis by a transitional cell carcinoma line. British Journal of Cancer 1998, 78, P52.
• H. Robertson, J. Wheeler, A. R. Morley, T. A. Booth, D. Talbot and J. A. Kirby. beta-chemokine expression and distribution in paraffin-embedded transplant renal biopsy sections: analysis by scanning laser confocal microscopy. Histochemistry and Cell Biology 1998, 110, 207-213.
• Jones DEJ, Palmer JM, Yeaman SJ, Kirby JA and Bassendine MF. Breakdown cholangitis (EAC), a murine model of primary biliary cirrhosis. Hepatology 1998, 28, 963.
• Zhang J.G., Walmsley M.W., Moy J.V., Cunningham A.C., Talbot D., Dark J.H. and Kirby J.A. Differential effects of cyclosporin A and tacrolimus on the production of TGF-beta: implication for the development of obliterative bronchiolitis after lung transplantation. Transplant International 1998, 11910, S325-327.
• E. O'Flaherty, S. Ali, S. J. Pettit and J. A. Kirby. Examination of the sensitivity of T cells to Fas ligation - Induction of allospecific apoptosis. Transplantation 1998, 66, 1067-1073.
• I. E. Nichol, S. M. Plusa, C. Marshall, J. Kirby, B. K. Shenton and J. S. Varma. Proinflammatory effects of colitic mucosa on neutrophil adhesion. British Journal of Surgery 1998, 85, 13-13.
• Palmer JM, Jones DEJ, Doshi M, Yeaman SJ, Bassendine MF and Kirby JA. Secretory IgA anti-PDC in saliva in primary biliary cirrhosis: A novel mechanism for tissue damage?. Hepatology 1998, 28, 1513.
• Robertson H., Morley A. and Kirby J.A. Study of chemokine expression in rejecting renal allograft tissue by confocal microscopy. Histochem Cell Biol 1998, 110, 207-213.
• I. E. Nichol, S. M. Plusa, J. Kirby, B. K. Shenton, D. A. Browell, W. J. Cunliffe and J. S. Varma. The role of interleukin - 8 in the inflammatory response of ulcerative colitis. Gut 1998, 42, TW189.
• A. C. Cunningham, J. G. Zhang, J. V. Moy, S. Ali and J. A. Kirby. A comparison of the antigen-presenting capabilities of class II MHC-expressing human lung epithelial and endothelial cells. Immunology 1997, 91, 458-463.
• C. Marshall, L. Gray, D. Lambert, B. Shenton, S. M. Plusa and J. A. Kirby. A novel flow-cytometric assay to assess neutrophil adhesion in whole blood. Biochemical Society Transactions 1997, 25, 740-743.
• S. C. Clark, J. H. Dark and J. A. Kirby. An assay of neutrophil adhesion to fibronectin and its attenuation by pentoxifylline and nitric oxide. Biochemical Society Transactions 1997, 25, S199-S199.
• M. S. Douglas, D. A. Rix and J. A. Kirby. Antigen presentation by endothelium: heparin reduces the immunogenicity of interferon-gamma-treated endothelial cells. Transplant Immunology 1997, 5, 233-235.
• M. S. Douglas, D. A. Rix, A. Larnkjaer, J. H. Dark, D. Talbot and J. A. Kirby. Blockade of the interaction between interferon-gamma and endothelial glycosaminoglycans: A novel strategy for immunosuppression?. Transplantation Proceedings 1997, 29, 1086-1088.
• J. A. Kirby, M. P. Leon, M. S. Douglas and D. A. Rix. Development of a flow-cytometric assay to identify and quantify lymphocytes that bind to endothelial and epithelial cells. Biochemical Society Transactions 1997, 25, 736-740.
• D. A. Rix, M. S. Douglas, M. P. Leon, S. Ali, D. Talbot and J. A. Kirby. Endothelial cells: Heparin modulates the induction of functional antigen presentation by IFN-gamma. Biochemical Society Transactions 1997, 25, S195-S195.
• M. S. Douglas, S. Ali, D. A. Rix, J. G. Zhang and J. A. Kirby. Endothelial production of MCP-1: modulation by heparin and consequences for mononuclear cell activation. Immunology 1997, 92, 512-518.
• Douglas M.S., Ali S., Rix D.A., Zhang J.G. and Kirby J.A. Endothelial production of MCP-1: modulation by heparin and consequences for mononuclear cell activation. Immunology 1997, 92, 512-518.
• M. S. Douglas, D. A. Rix, J. H. Dark, D. Talbot and J. A. Kirby. Examination of the mechanism by which heparin antagonizes activation of a model endothelium by interferon-gamma (IFN- gamma). Clinical and Experimental Immunology 1997, 107, 578-584.
• M. S. Douglas, J. G. Zhang, D. A. Rix, J. V. Moy and J. A. Kirby. Heparin modulates endothelial production of monocyte chemotactic peptide-1 following interferon-gamma stimulation. Biochemical Society Transactions 1997, 25, S194-S194.
• M. P. Leon, M. F. Bassendine, P. Gibbs, M. Thick and J. A. Kirby. Immunogenicity of biliary epithelium: Study of the adhesive interaction with lymphocytes. Gastroenterology 1997, 112, 968-977.
• S. C. Clark, B. K. Shenton, J. H. Dark and J. A. Kirby. An assay of neutrophil adhesion to fibronectin and its attenuation by pentoxifylline. Immunology 1996, 89, WI417-WI417.
• A. C. Cunningham, J. G. Zhang, J. V. Moy and J. A. Kirby. Can alveolar epithelial cells activate CD4+ lymphocytes?. Immunology 1996, 89, OJ100-OJ100.
• M. P. Leon, J. A. Kirby, P. Gibbs, M. Thick and M. F. Bassendine. Cytotoxic immune lysis of human intrahepatic biliary epithelial cells: Modulation by ICAM-1 blockade. Hepatology 1996, 23, T41-T41.
• L. V. P. Korlipara, M. P. Leon, D. A. Rix, M. S. Douglas, P. Gibbs, M. F. Bassendine and J. A. Kirby. Development of a flow cytometric assay to quantify lymphocyte adhesion to cytokine-stimulated human endothelial and biliary epithelial cells. Journal of Immunological Methods 1996, 191, 121-130.
• J. A. Kirby, M. P. Leon, M. S. Douglas and D. A. Rix. Development of a flow cytometric assay to quantify lymphocyte adhesion to endothelial and epithelial cells. Immunology 1996, 89, SI35-SI35.
• M. R. Azari, F. M. Williams, J. Kirby, P. Kelly, J. W. Edwards and P. G. Blain. Effects of nitrogen oxides on natural killer cells in glass craftsmen and braziers. Occupational and Environmental Medicine 1996, 53, 248-251.
• D. A. Rix, M. S. Douglas, M. P. Leon, S. Ali, D. Talbot and J. A. Kirby. Endothelial cells: Heparin modulates the induction of functional antigen presentation by IFN-gamma. Immunology 1996, 89, ORH2-ORH2.
• M. S. Douglas, J. G. Zhang, D. A. Rix, J. V. Moy and J. A. Kirby. Heparin modulates endothelial production of monocyte chemotactic peptide-1 following interferon-gamma stimulation. Immunology 1996, 89, ORH1-ORH1.
• Leon M.P., Bassendine M.F., Thick M., Gibbs P., Burt A.D. and Kirby J.A. Hepatic allograft rejection: regulation of the immunogenicity of human intrahepatic biliary epithelial cells. J Liver Transpl and Surg 1996, 2, 37-45.
• M.P. Leon, M.F. Bassendine, P.A. Gibbs, A.D.Burt, M. Thick, J.A. Kirby. Hepatic allograft rejection: regulation of the immunogenicity of human intrahepatic biliary epithelial cells. Liver Transplantation and Surgery 1996, 2, 37-45.
• M. P. Leon, M. F. Bassendine, J. L. Wilson, S. Ali, M. Thick and J. A. Kirby. Immunogenicity of biliary epithelium: Investigation of antigen presentation to CD4(+) T cells. Hepatology 1996, 24, 561-567.
• Bliss R, Kirby J, Browell D, Lennard TWJ. Inhibition of endothelial adhesion and invasion by breast carcinoma cells may contribute towards the anti-metastatic effects of tamoxifen. European Journal of Surgical Oncology 1996, 22(1), 27-33.
• C. Marshall, D. Lambert, S. M. Plusa, J. A. Kirby and B. K. Shenton. Intravascular adhesion: A novel assay to assess binding by neutrophils in whole blood. Immunology 1996, 89, SI36-SI36.
• M. P. Leon, M. F. Bassendine, J. Wilson, P. Gibbs, M. Thick and J. A. Kirby. Mixed biliary lymphocyte culture: Allostimulation of CD4(+) T cells by human intrahepatic biliary epithelial cells. Hepatology 1996, 23, T40-T40.
• H. Robertson, J. Wheeler, J. A. Kirby and A. R. Morley. Renal allograft rejection - In situ demonstration of cytotoxic intratubular cells. Transplantation 1996, 61, 1546-1549.
• D. A. Rix, M. S. Douglas, D. Talbot, J. H. Dark and J. A. Kirby. Role of glycosaminoglycans (GAGs) in regulation of the immunogenicity of human vascular endothelial cells. Clinical and Experimental Immunology 1996, 104, 60-65.
• Bliss RD, Kirby JA, Browell DA, Lennard TWJ. The role of beta-1 integrins in adhesion of 2 breast carcinoma cell lines to a model endothelium. Clinical & Experimental Metastasis 1995, 13(3), 173-183.
• Bliss RD, Kirby JA, Browell DA, Lennard TWJ. Effect of menstrual phase on surgical treatment of breast cancer. Lancet 1994, 344(8919), 403-404.
• Brotherick I, Shenton BK, Kirby JA, Rigg KM, Palmer JM, Yeaman SJ, Lennard TWJ. Production of immunosuppressive factors by a cultured tumor cell line and their effect on lymphocyte proliferation and cells cycle response. Surgical Oncology 1993, 2(4), 241-248.
• Ikuta S, Kirby JA, Shenton BK, Givan AL, Lennard TWJ. Human endothelial cells: effect of TNF-alpha on peripheral blood mononuclear cell adhesion. Immunology 1991, 73(1), 71-76.
• Kirby JA, Morgan JC, Shenton BK, Lennard TWJ, Proud G, Taylor RMR. Renal allograft rejection: functional impairment of kidney epithelial cell monolayers mediated by lymphokine activated killer cells and by antibody. Transplantation 1991, 51(4), 891-895.
• Kirby JA, Ikuta S, Clark K, Proud G, Lennard TWJ, Taylor RMR. Renal allograft rejection: investigation of alloantigen presentation by cultured human renal epithelial cells. Immunology 1991, 72(3), 411-417.
• Clark KR, Kirby JA, Baker N, Givan AL, Shenton BK, Proud G, Lennard TWJ, Taylor RMR. Renal epithelium: reversal of cytotoxic damage by addition of anti-thymocyte globulin. Transplant International 1991, 4(4), 210-214.
• Kirby JA, Givan AL, Shenton BK, Talbot D, Forsythe JLR, Lennard TWJ, Proud G, Taylor RMR. Renal allograft rejection: possible involvement of antibody dependent cell mediated cytotoxicity. Transplantation 1990, 50(2), 225-229.