Staff Profile

Introduction

Position: Visiting  Professor of Old Age Psychiatry, Institute of Neuroscience, and Honorary Consultant in Old Age Psychiatry, Northumberland, Tyne and Wear NHS Trust. Also Professor of Old Age Psychiatry at the University of Cambridge.

Roles and Responsibilities

NIHR National Specialty Lead for Dementias
Deputy Editor International Psychogeriatrics
Board Member of the International Psychogeriatric Association
Past-President of the International College for Geriatric Psychoneuropharmacology (ICGP)
Member of Vas-Cog Executive Committee

Research Interests

My research interests include:

• the application of MR, SPECT and PET imaging in dementia and depression

• neurobiological changes (in particular the role of vascular factors) in late-life affective disorders and cognitive impairment

• improving the diagnosis and management of Lewy body dementia
  
  

We are undertaking serial imaging (structural and functional MR, blood flow and ligand SPECT and PET) studies on subjects with Alzheimer’s disease (AD), dementia with Lewy bodies, Parkinson’s disease (PD) and PD dementia to elucidate i) relationships and imaging correlates of diagnosis and symptoms ii) usefulness in improving accuracy of differential diagnosis iii) markers of early diagnosis and iv) how structural and chemical changes alter with disease progression.

Current research projects include a NIHR funded study (DIAMOND-Lewy) aimed at improving the diagnosis and management of Lewy body dementia as well as various studies developing and applying imaging biomarkers to dementia and late life depression

• Colloby SJ, Field RH, Wyper DJ, O'Brien JT, Taylor JP. A spatial covariance ¹²³I-5IA-85380 SPECT study of α4β2 nicotinic receptors in Alzheimer's disease. Neurobiology of Aging 2016, 47, 83-90.
• Firbank MJ, Lloyd JJ, Williams ED, Barber R, Colloby SJ, Barnett NA, Olsen K, Davison C, Donaldson C, Herholz K, O'Brien JT. An evidence based algorithm for the utility of FDG-PET for diagnosing Alzheimer’s disease according to presence of medial temporal lobe atrophy. British Journal of Psychiatry 2016, 208(5), 491-496.
• Khundakar AA, Hanson PS, Erskine D, Lax NZ, Roscamp J, Karyka E, Tsefou E, Singh P, Cockell SJ, Gribben A, Ramsay L, Blain PJ, Mosimann UP, Lett DJ, Elstner M, Turnbull DM, Xiang CC, Brownstein MJ, O'Brien JT, Taylor JP, Attems J, Thomas AJ, McKeith IG, Morris CM. Analysis of primary visual cortex in dementia with Lewy bodies indicates GABAergic involvement associated with recurrent complex visual hallucinations. Acta Neuropathologica Communications 2016, 4, 66.
• Firbank MJ, Yarnall AJ, Lawson RA, Duncan GW, Khoo TK, Petrides GS, O'Brien JT, Barker RA, Maxwell RJ, Brooks DJ, Burn DJ. Cerebral glucose metabolism and cognition in newly diagnosed Parkinson’s disease: ICICLE-PD study. Journal of Neurology, Neurosurgery, and Psychiatry 2017, 88(4), 310-316.
• Colloby SJ, McKeith IG, Burn DJ, Wyper DJ, O'Brien JT, Taylor JP. Cholinergic and perfusion brain networks in Parkinson disease dementia. Neurology 2016, 87(2), 178-185.
• Arnone D, Job D, Selvaraj S, Abe O, Amico F, Cheng YQ, Colloby SJ, O'Brien JT, Frodl T, Gotlib IH, Ham BJ, Kim MJ, Koolschijn PCM, Perico CAM, Salvadore G, Thomas AJ, Van Tol MJ, van der Wee NJA, Veltman DJ, Wagner G, McIntosh AM. Computational meta-analysis of statistical parametric maps in major depression. Human Brain Mapping 2016, 37(4), 1393-1404.
• Su L, Blamire AM, Watson R, He JB, Aribisala B, O'Brien JT. Cortical and Subcortical Changes in Alzheimer's Disease: A Longitudinal and Quantitative MRI Study. Current Alzheimer Research 2016, 13(5), 534-544.
• Vallortigara J, Whitfield D, Quelch W, Alghamdi A, Howlett D, Hortobágyi T, Johnson M, Attems J, O'Brien JT, Thomas A, Ballard CG, Aarsland D, Francis PT. Decreased Levels of VAMP2 and Monomeric Alpha-Synuclein Correlate with Duration of Dementia. Journal of Alzheimer's Disease 2016, 50(1), 101-110.
• Keogh MJ, Kurzawa-Akanbi M, Griffin H, Douroudis K, Ayers KL, Hussein RI, Hudson G, Pyle A, Cordell HJ, Attems J, McKeith IG, O'Brien JT, Burn DJ, Morris CM, Thomas AJ, Chinnery PF. Exome sequencing in dementia with Lewy bodies. Translational Psychiatry 2016, 6, e728.
• Chen A, Akinyemi RO, Hase Y, Firbank MJ, Ndung'u MN, Foster V, Craggs LJL, Washida K, Okamoto Y, Thomas AJ, Polvikoski TM, Allan LM, Oakley AE, O'Brien JT, Horsburgh K, Ihara M, Kalaria RN. Frontal white matter hyperintensities, clasmatodendrosis and gliovascular abnormalities in ageing and post-stroke dementia. Brain 2016, 139(1), 242-258.
• Duncan GW, Firbank MJ, Yarnall AJ, Khoo TK, Brooks DJ, Barker RA, Burn DJ, O'Brien JT. Gray and white matter imaging: A biomarker for cognitive impairment in early Parkinson's disease?. Movement Disorders 2016, 31(1), 103-110.
• Blanc F, Colloby SJ, Cretin B, deSousa PL, Demuynck C, O'Brien JT, Martin-Hunyadi C, Philippi N, Taylor JP. Grey matter atrophy in prodromal stage of dementia with Lewy bodies and Alzheimer's disease. Alzheimer's Research & Therapy 2016, 8(1), 31.
• Peraza LR, Nesbitt D, Lawson RA, Duncan GW, Yarnall AJ, Khoo TK, Kaiser M, Firbank MJ, O'Brien JT, Barker RA, Brooks DJ, Burn DJ, Taylor JP. Intra- and inter-network functional alterations in Parkinson's disease with mild cognitive impairment. Human Brain Mapping 2017, 38(3), 1702-1715.
• Bamford C, Olsen K, Davison C, Barnett N, Lloyd J, Williams D, Firbank M, Mason H, Donaldson C, O'Brien J. Is there a preference for PET or SPECT brain imaging in diagnosing dementia? The views of people with dementia, carers, and healthy controls. International Psychogeriatrics 2016, 28(1), 123-131.
• Firbank MJ, Watson R, Mak E, Aribisala B, Barber R, Colloby SJ, He J, Blamire AM, O'Brien JT. Longitudinal diffusion tensor imaging in dementia with Lewy bodies and Alzheimer’s disease . Parkinsonism and Related Disorders 2016, 24, 76-80.
• Colloby SJ, Cromarty RA, Peraza LR, Johnsen K, Johannesson G, Bonanni L, Onofrj M, Barber R, O'Brien JT, Taylor J-P. Multimodal EEG-MRI in the differential diagnosis of Alzheimer’s disease and dementia with Lewy bodies. Journal of Psychiatric Research 2016, 78, 48-55.
• Chen AQ, Oakley AE, Monteiro M, Tuomela K, Allan LM, Mukaetova-Ladinska EB, O'Brien JT, Kalaria RN. Multiplex analyte assays to characterize different dementias: brain inflammatory cytokines in poststroke and other dementias. Neurobiology of Aging 2016, 38, 56-67.
• Firbank M, Kobeleva X, Cherry G, Killen A, Gallagher P, Burn DJ, Thomas AJ, O'Brien JT, Taylor JP. Neural correlates of attention-executive dysfunction in lewy body dementia and Alzheimer's disease. Human Brain Mapping 2016, 37(3), 1254-1270.
• Cromarty RA, Elder GJ, Graziadio S, Baker M, Bonanni L, Onofrj M, O'Brien JT, Taylor J-P. Neurophysiological biomarkers for Lewy body dementias. Clinical Neurophysiology 2016, 127(1), 349-359.
• Cromarty RA, Elder GJ, Graziadio S, Baker M, Bonanni L, Onofrj M, O'Brien JT, Taylor JP. Neurophysiological biomarkers for Lewy body dementias. Clinical Neurophysiology 2016, 127(1), 349–359.
• Peraza LR, Lawson RA, Firbank JM, Yarnall A, Duncan GW, Khoo TK, Brooks D, O'Brien JT, Barker RA, Burn D, Taylor JP. Principal component discriminant analysis of mild cognitive impairment in Parkinson’s disease reveals early functional changes in the resting state. In: Neuroinformatics 2016 INCF Conference. 2016, Reading, UK: Frontiers Media S.A.
• Peraza LR, Colloby SJ, Deboys L, O'Brien JT, Kaiser M, Taylor JP. Regional functional synchronizations in dementia with Lewy bodies and Alzheimer's disease. International Psychogeriatrics 2016, 28(7), 1143-1151.
• Colloby SJ, Elder GJ, Rabee R, O'Brien JT, Taylor J-P. Structural grey matter changes in the substantia innominata in Alzheimer's disease and dementia with Lewy bodies: a DARTEL-VBM study. International Journal of Geriatric Psychiatry 2017, 32(6), 615-623.
• Watson R, Colloby SJ, Blamire AM, O'Brien JT. Subcortical volume changes in dementia with Lewy bodies and Alzheimer's disease. A comparison with healthy aging. International Psychogeriatrics 2016, 28(4), 529-536.
• Killen A, Flynn D, De Brún A, O'Brien N, O'Brien J, Thomas AJ, McKeith I, Taylor JP. Support and information needs following a diagnosis of dementia with Lewy bodies. International Psychogeriatrics 2016, 28(3), 495-501.
• Firbank MJ, Lloyd J, O'Brien JT. The relationship between hallucinations and FDG-PET in dementia with Lewy bodies. Brain Imaging and Behavior 2016, 10(3), 636-639.
• Mak E, Colloby SJ, Thomas A, O'Brien JT. The segregated connectome of late-life depression: a combined cortical thickness and structural covariance analysis. Neurobiology of Aging 2016, 48, 212-221.
• Taylor JP, Firbank M, O'Brien JT. Visual cortical excitability in dementia with Lewy bodies. British Journal of Psychiatry 2016, 208(5), 497-498.
• Donaghy P, Thomas AJ, O'Brien JT. Amyloid PET Imaging in Lewy Body Disorders. American Journal of Geriatric Psychiatry 2015, 23(1), 23-37.
• Watson R, Colloby SJ, Blamire AM, O'Brien JT. Assessment of Regional Gray Matter Loss in Dementia with Lewy Bodies: A Surface-Based MRI Analysis. American Journal of Geriatric Psychiatry 2015, 23(1), 38-46.
• Mak E, Su L, Williams GB, Firbank MJ, Lawson RA, Yarnall AJ, Duncan GW, Owen AM, Khoo TK, Brooks DJ, Rowe JB, Barker RA, Burn DJ, O'Brien JT. Baseline and longitudinal grey matter changes in newly diagnosed Parkinson's disease: ICICLE-PD study. Brain 2015, 138, 2974-2986.
• Mak E, Su L, Williams G, Lawson R, Yarnall A, Gordon D, Adrian O, Tien K, Brooks D, Rowe J, Barker R, Burn D, O'Brien J. Baseline and longitudinal grey matter changes in newly diagnosed Parkinson's disease: ICICLE-PD study. In: 17th IPA International. 2015, Berlin, Germany: Cambridge University Press.
• Erskine D, Taylor JP, Firbank MJ, Patterson L, Onofrj M, O'Brien JT, McKeith IG, Attems J, Thomas AJ, Morris CM, Khundakar AA. Changes to the lateral geniculate nucleus in Alzheimer's disease but not dementia with Lewy bodies. Neuropathology and Applied Neurobiology 2015, 42(4), 366–376.
• Blanc F, Colloby SJ, Philippi N, de Petigny X, Jung B, Demuynck C, Phillipps C, Anthony P, Thomas A, Bing F, Lamy J, Martin-Hunyadi C, O'Brien JT, Cretin B, McKeith I, Armspach JP, Taylor JP. Cortical Thickness in Dementia with Lewy Bodies and Alzheimer's Disease: A Comparison of Prodromal and Dementia Stages. PLoS ONE 2015, 10(6), e0127396.
• Gillen R, Firbank MJ, Lloyd J, O'Brien JT. CT-based attenuation and scatter correction compared with uniform attenuation correction in brain perfusion SPECT imaging for dementia. Physics in Medicine and Biology 2015, 60(17), 6775-6787.
• Gore RL, Vardy ERLC, O'Brien JT. Delirium and dementia with Lewy bodies: distinct diagnoses or part of the same spectrum?. Journal of Neurology, Neurosurgery & Psychiatry 2015, 86(1), 50-59.
• Peraza LR, Colloby S, Firbank M, McKeith I, O'Brien J, Thomas A, Taylor J-P. Dementia with Lewy Bodies and Parkinson’s Disease Dementia Show No differences in Resting State Functional MRI. In: International Dementia with Lewy Bodies Conference 2015. 2015, Ft. Lauderdale, FL, USA: American Journal of Neurodegenerative Disease.
• Whitfield DR, Vallortigara J, Alghamdi A, Hortobgyi T, Ballard C, Thomas AJ, O'Brien JT, Aarsland D, Francis PT. Depression and Synaptic Zinc Regulation in Alzheimer Disease, Dementia with Lewy Bodies, and Parkinson Disease Dementia. American Journal of Geriatric Psychiatry 2015, 23(2), 141-148.
• Elder GJ, Colloby SJ, Lett DJ, O'Brien JT, Anderson KN, Burn DJ, McKeith IG, Taylor JP. Depressive symptoms are associated with daytime sleepiness and subjective sleep quality in dementia with Lewy bodies. International Journal of Geriatric Psychiatry 2016, 31(7), 765-770.
• Cromarty R, Graziadio S, Colloby S, Killen A, Peraza LR, Elder G, Firbank M, Thomas A, McKeith I, O'Brien J, Taylor J-P. Electrophysiological Correlates of Attentional Dysfunction in Dementia with Lewy Bodies. In: International Dementia with Lewy Bodies Conference 2015. 2015, Ft. Lauderdale, FL, USA: American Journal of Neurodegenerative Disease.
• Chen A, Akinyemi RO, Washida K, Foster V, Firbank MJ, Oakley AE, Okamoto Y, O'Brien JT, Allan LM, Ihara M, Kalaria RN. Frontal white matter clasmatodendrosis and cognitive dysfunction in the elderly. In: 116th Meeting of the British Neuropathological Society Institute of Child Health. 2015, London, UK: Wiley-Blackwell Publishing Ltd.
• Olsen K, Howel D, Barber R, Ford GA, Gallagher P, McAllister-Williams RH, Nilsson J, O'Brien J, Parker J, Thomas A. Lessons from a pilot and feasibility randomised trial in depression (Blood pressure Rapid Intensive Lowering And Normal Treatment for Mood and cognition in persistent depression (BRILiANT mood study)). Pilot and Feasibility Studies 2015, 1(44).
• Mak E, Su L, Williams GB, Watson R, Firbank M, Blamire AM, OBrien JT. Longitudinal assessment of global and regional atrophy rates in Alzheimer's disease and dementia with Lewy bodies. NeuroImage: Clinical 2015, 7, 456-462.
• Stinton C, McKeith I, Taylor JP, Lafortune L, Mioshi E, Mak E, Cambridge V, Mason J, Thomas A, O'Brien JT. Pharmacological Management of Lewy Body Dementia: A Systematic Review and Meta-Analysis. American Journal of Psychiatry 2015, 172(8), 731-742.
• Mukaetova-Ladinska EB, Abdel-All Z, Andrade J, da Silva JA, O'Brien JT, Kalaria RN. Plasma and platelet clusterin ratio is altered in Alzheimer's disease patients with distinct neuropsychiatric symptoms: findings from a pilot study. International Journal of Geriatric Psychiatry 2015, 30(4), 368-375.
• Donaghy PC, O'Brien JT, Thomas AJ. Prodromal dementia with Lewy bodies. Psychological Medicine 2015, 45(2), 259-268.
• Mak E, Sua L, Williams GB, Watson R, Firbank MJ, Blamire AM, O'Brien JT. Progressive cortical thinning and subcortical atrophy in dementia with Lewy bodies and Alzheimer's disease. Neurobiology of Aging 2015, 36(4), 1743-1750.
• Colloby SJ, McKeith IG, Wyper DJ, O'Brien JT, Taylor JP. Regional covariance of muscarinic acetylcholine receptors in Alzheimer's disease using (R, R) [¹²³I]-QNB SPECT. Journal of Neurology 2015, 262(9), 2144-2153.
• Howlett DR, Whitfield D, Johnson M, Attems J, O'Brien JT, Aarsland D, Lai MKP, Lee JH, Chen C, Ballard C, Hortobagyi T, Francis PT. Regional Multiple Pathology Scores Are Associated with Cognitive Decline in Lewy Body Dementias. Brain Pathology 2015, 25(4), 401-408.
• Peraza LR, Colloby SJ, Firbank MJ, Greasy SG, McKeith IG, Kaiser M, O'Brien J, Taylor JP. Resting state in Parkinson’s disease dementia and dementia with Lewy bodies: Commonalities and differences. International Journal of Geriatric Psychiatry 2015, 30(11), 1135-1146.
• Su L, Blamire AM, Watson R, He JB, Aribisala B, O'Brien JT. Tissue microstructural changes in dementia with Lewy bodies revealed by quantitative MRI. Journal of Neurology 2015, 262(1), 165-172.
• O'Brien JT, Thomas A. Vascular dementia. The Lancet 2015, 386(10004), 1698-1706.
• O'Brien JT, Firbank MJ, Davison C, Barnett N, Bamford C, Donaldson C, Olsen K, Herholz K, Williams D, Lloyd J. ¹⁸F-FDG PET and Perfusion SPECT in the Diagnosis of Alzheimer and Lewy Body Dementias. Journal of Nuclear Medicine 2014, 55(12), 1959-1965.
• Davison CM, O'Brien JT. A comparison of FDG-PET and blood flow SPECT in the diagnosis of neurodegenerative dementias: a systematic review. International Journal of Geriatric Psychiatry 2014, 29(6), 551-561.
• O'Donovan J, Watson R, Colloby SJ, Blamire AM, O'Brien JT. Assessment of regional MR diffusion changes in dementia with Lewy bodies and Alzheimer's disease. International Psychogeriatrics 2014, 26(4), 627-635.
• Whitfield DR, Vallortigara J, Alghamdi A, Howlett D, Hortobagyi T, Johnson M, Attems J, Newhouse S, Ballard C, Thomas AJ, O'Brien JT, Aarsland D, Francis PT. Assessment of ZnT3 and PSD95 protein levels in Lewy body dementias and Alzheimer's disease: association with cognitive impairment. Neurobiology of Aging 2014, 35(12), 2836-2844.
• Zanchetti A, Liu L, Mancia G, Parati G, Grassi G, Stramba-Badiale M, Silani V, Bilo G, Corrao G, Zambon A, Scotti L, Zhang X, Wang H, Xhang Y, Xhang X, Guan TR, Berge E, Redon J, Narkiewicz K, Dominiczak A, Nilsson P, Viigimaa M, Laurent S, Agabiti-Rosei E, Wu Z, Zhu D, Rodicio JL, Ruilope LM, Martell-Claros N, Pinto F, Schmieder RE, Burnier M, Banach M, Cifkova R, Farsang C, Konradi A, Lazareva I, Sirenko Y, Dorobantu M, Postadzhiyan A, Accetto R, Jelakovic B, Lovic D, Manolis AJ, Stylianou P, Erdine S, Dicker D, Wei G, Xu C, Xie H, Coca A, O'Brien J, Ford G. Blood pressure and LDL-cholesterol targets for prevention of recurrent strokes and cognitive decline in the hypertensive patient: design of the European Society of Hypertension-Chinese Hypertension League Stroke in Hypertension Optimal Treatment randomized trial. Journal of Hypertension 2014, 32(9), 1888-1897.
• Zanchetti A, Liu L, Mancia G, Parati G, Grassi G, Stramba-Badiale M, Silani V, Bilo G, Corrao G, Zambon A, Scotti L, Zhang X, Wang H, Xhang Y, Xhang X, Guan TR, Berge E, Redon J, Narkiewicz K, Dominiczak A, Nilsson P, Viigimaa M, Laurent S, Agabiti-Rosei E, Wu Z, Zhu D, Rodicio JL, Ruilope LM, Martell-Claros N, Pinto F, Schmieder RE, Burnier M, Banach M, Cifkova R, Farsang C, Konradi A, Lazareva I, Sirenko Y, Dorobantu M, Postadzhiyan A, Accetto R, Jelakovic B, Lovic D, Manolis AJ, Stylianou P, Erdine S, Dicker D, Wei G, Xu C, Xie H, Coca A, O'Brien J, Ford G. Blood pressure and low-density lipoprotein-cholesterol lowering for prevention of strokes and cognitive decline: a review of available trial evidence. Journal of Hypertension 2014, 32(9), 1741-1750.
• Yarnall AJ, Breen DP, Duncan GW, Khoo TK, Coleman SY, Firbank MJ, Nombela C, Winder-Rhodes S, Evans JR, Rowe JB, Mollenhauer B, Kruse N, Hudson G, Chinnery PF, O'Brien JT, Robbins TW, Wesnes K, Brooks DJ, Barker RA, Burn DJ, ICICLE-PD Study Group. Characterizing mild cognitive impairment in incident Parkinson disease The ICICLE-PD Study. Neurology 2014, 82(4), 308-316.
• McAleese KE, Dey M, Firbank M, McParland S, O'Brien JT, Attems J. Cortical neurodegenerative pathology has an influence on white matter integrity. In: 115th Meeting of the British Neuropathological Society. 2014, London, UK: Wiley-Blackwell Publishing Ltd.
• O'Brien JT, Oertel WH, McKeith IG, Grosset DG, Walker Z, Tatsch K, Tolosa E, Sherwin PF, Grachev ID. Diagnostic performance of ioflupane I123 injection (DaTSCAN) in patients with movement disorders and dementia. In: 18th International Congress of Parkinson's Disease and Movemenet Disorders. 2014, Stockholm, Sweden: John Wiley & Sons, Inc.
• O'Brien JT, Oertel WH, McKeith IG, Grosset DG, Walker Z, Tatsch K, Tolosa E, Sherwin PF, Grachev ID. Diagnostic performance of ioflupane I123 injection (DaTSCAN™ Normal 0 false false false EN-GB X-NONE X-NONE ) in patients with movement disorders and dementia. In: Joint Congress of European Neurology. 2014, Istanbul, Turkey: Springer.
• Watson R, Colloby S, Blamire A, Wesnes K, O'Brien J. Does attentional dysfunction predict rapid decline in dementia with Lewy bodies?. In: Australian and New Zealand Society for Geriatric Medicine Annual Scientic Meeting. 2014, Melbourne, Australia: Wiley-Blackwell Publishing Ltd.
• Nombela C, Rowe JB, Winder-Rhodes SE, Hampshire A, Owen AM, Breen DP, Duncan GW, Khoo TK, Yarnall AJ, Firbank MJ, Chinnery PF, Robbins TW, O'Brien JT, Brooks DJ, Burn DJ, Barker RA, ICICLE-PD Study Grp. Genetic impact on cognition and brain function in newly diagnosed Parkinson's disease: ICICLE-PD study. Brain 2014, 137, 2743-2758.
• Duncan GW, Khoo TK, Yarnall AJ, O'Brien JT, Coleman SY, Brooks DJ, Barker RA, Burn DJ. Health-related quality of life in early Parkinson's disease: The impact of nonmotor symptoms. Movement Disorders 2014, 29(2), 195-202.
• Seibyl JP, Kupsch A, Booij J, Grosset DG, Costa DC, Hauser RA, Darcourt J, Bajaj N, Walker Z, Marek K, McKeith I, O'Brien JT, Tatsch K, Tolosa E, Dierckx RA, Grachev ID. Individual-Reader Diagnostic Performance and Between-Reader Agreement in Assessment of Subjects with Parkinsonian Syndrome or Dementia Using ¹²³I-Ioflupane Injection (DaTscan) Imaging. Journal of Nuclear Medicine 2014, 55(8), 1288-1296.
• O'Brien JT, Oertel WH, McKeith IG, Grosset DG, Walker Z, Tatsch K, Tolosa E, Sherwin PF, Grachev ID. Is ioflupane I123 injection diagnostically effective in patients with movement disorders and dementia? Pooled analysis of four clinical trials. BMJ Open 2014, 4(7), e005122.
• Lowther ER, O'Brien JT, Firbank MJ, Blamire AM. Lewy body compared with Alzheimer dementia is associated with decreased functional connectivity in resting state networks. Psychiatry Research: Neuroimaging 2014, 223(3), 192-201.
• Colloby SJ, O'Brien JT, Taylor J-P. Patterns of cerebellar volume loss in dementia with Lewy bodies and Alzheimer's disease: A VBM-DARTEL study. Psychiatric Research: Neuroimaging 2014, 223(3), 187-191.
• Duncan GW, Khoo TK, Coleman SY, Brayne CE, Yarnall AJ, O'Brien JT, Barker RA, Burn DJ. The Incidence of Parkinson's Disease in the North East of England. Age and Ageing 2014, 43(2), 257-263.
• Vann Jones SA, O'Brien JT. The prevalence and incidence of dementia with Lewy bodies: a systematic review of population and clinical studies. Psychological Medicine 2014, 44(4), 673-683.
• Parry SW, Deary V, Finch T, Bamford C, Sabin N, McMeekin P, O'Brien J, Caldwell A, Steen N, Whitney SL, Macdonald C, McColl E. The STRIDE (Strategies to Increase confidence, InDependence and Energy) study: cognitive behavioural therapy-based intervention to reduce fear of falling in older fallers living in the community - study protocol for a randomised controlled trial. Trials 2014, 15, 210.
• Nilsson J, Thomas AJ, O'Brien JT, Gallagher P. White Matter and Cognitive Decline in Aging: A Focus on Processing Speed and Variability. Journal of the International Neuropsychological Society 2014, 20(3), 262-267.
• Watson R, Colloby SJ, Blamire AM, O'Brien JT. Assessment of grey matter loss in dementia with Lewy bodies and Alzheimer's disease using MR surface based analysis. In: Australian and New Zealand Society for Geriatric Medicine Annual Scientific Meeting. 2013, Adelaide: Wiley-Blackwell Publishing Asia.
• Poggesi A, Gouw A, van der Flier W, Pracucci G, Chabriat H, Erkinjuntti T, Fazekas F, Ferro JM, Hennerici M, Langhorne P, O'Brien JT, Visser MC, Wahlund LO, Waldemar G, Wallin A, Scheltens P, Inzitari D, Pantoni L. Cerebral white matter changes are associated with abnormalities on neurological examination in non-disabled elderly: the LADIS study. Journal of Neurology 2013, 260(4), 1014-1021.
• Romeo R, Knapp M, Hellier J, Dewey M, Ballard C, Baldwin R, Bentham P, Burns A, Fox C, Holmes C, Katona C, Lawton C, Lindesay J, Livingston G, McCrae N, Moniz-Cook E, Murray J, Nurock S, O'Brien J, Poppe M, Thomas A, Walwyn R, Wilson K, Banerjee S. Cost-effectiveness analyses for mirtazapine and sertraline in dementia: randomised controlled trial. British Journal of Psychiatry 2013, 202(2), 121-128.
• Taylor JP, Colloby SJ, McKeith IG, O'Brien JT. Covariant perfusion patterns provide clues to the origin of cognitive fluctuations and attentional dysfunction in Dementia with Lewy bodies. International Psychogeriatrics 2013, 25(12), 1917-1928.
• Taylor JP, Colloby SJ, McKeith IG, O'Brien JT. Covariant perfusion patterns provide clues to the origin of cognitive fluctuations and attentional dysfunction in Dementia with Lewy bodies. In: Towards Successful Aging: Harmony of Mental, Physical and Social Life, 16th International Conference. 2013, Seoul, Korea: Cambridge University Press.
• Verdelho A, Madureira S, Moleiro C, Ferro JM, O'Brien JT, Poggesi A, Pantoni L, Fazekas F, Scheltens P, Waldemar G, Wallin A, Erkinjuntti T, Inzitari D, on behalf of the LADIS Study. Depressive symptoms predict cognitive decline and dementia in older people independently of cerebral white matter changes: the LADIS study. Journal of Neurology, Neurosurgery and Psychiatry 2013, 84(11), 1250-1254.
• Vardy ERLC, Ford AH, Gallagher P, Watson R, McKeith IG, Blamire A, O'Brien JT. Distinct cognitive phenotypes in Alzheimer's disease in older people. International Psychogeriatrics 2013, 25(10), 1659-1666.
• O'Donovan J, Watson R, Colloby SJ, Firbank MJ, Burton EJ, Barber R, Blamire AM, O'Brien JT. Does posterior cortical atrophy on MRI discriminate between Alzheimer's disease, dementia with Lewy bodies, and normal aging?. International Psychogeriatrics 2013, 25(1), 111-119.
• Peraza LR, Kaiser M, Firbank M, O'Brien J, Taylor J-P. Functional connectivity in dementia with Lewy bodies: What can the resting state show about visual hallucinations in this disease?. In: BNA Conference 2013. 2013, Barbican Centre, London, UK: BNA.
• Duncan GW, Yarnall AJ, Firbank MJ, Barker RA, O'Brien JT, Burn DJ. Grey matter and CSF amyloid in early non-demented Parkinson's disease: the incidence of cognitive impairment in cohorts with longitudinal evaluation - Parkinson's disease (ICICLE-PD) study. In: Association of British Neurologists Annual Meeting 2013. 2013, Glasgow, UK: Association of British Neurologists.
• Duncan GW, Firbank MJ, Yarnall AJ, Barker RA, O'Brien JT, Burn DJ. Grey matter correlations of cognitive impairment in early Parkinson's disease: the incidence of cognitive impairment in cohorts with longitudinal evaluation - Parkinson's disease (ICICLE-PD) study. In: British Geriatrics Society Spring Meeting. 2013, Belfast: British Geriatrics Society.
• Duncan GW, Firbank MJ, Yarnall AJ, Khoo TK, O'Brien JT, Barker RA, Burn DJ. Grey Matter Correlations of Cognitive Impairment in Early Parkinson's Disease: The Incidence of Cognitive Impairment In Cohorts with Longitudinal Evaluation: Parkinson's Disease (ICICLE-PD) Study. In: Age and Ageing. 2013, Oxford: Oxford University Press.
• Duncan GW, Firbank MJ, Yarnall AJ, Barker RA, O'Brien JT, Burn DJ. Grey Matter Correlations of Cognitive Impairment in Early Parkinson's Disease: The Incidence of Cognitive Impairment in Cohorts with Longitudinal Evaluation-Parkinson's Disease (ICICLE-PD) Study. In: Association of British Neurologists (ABN) Joint Meeting with the Royal College of Physicians (RCP). 2013, London, UK: BMJ Group.
• Wood JS, Watson R, Firbank MJ, Mosimann UP, Barber R, Blamire AM, O'Brien JT. Longitudinal testing of visual perception in dementia with Lewy bodies and Alzheimer’s disease. International Journal of Geriatric Psychiatry 2013, 28(6), 567-572.
• Allan LM, Rowan EN, Thomas AJ, Polvikoski JT, O'Brien JT, Kalaria RN. Long-term incidence of depression and predictors of depressive symptoms in older stroke survivors. British Journal of Psychiatry 2013, n/a, n/a.
• McAleese KE, Firbank M, Hunter D, Sun L, Hall R, Neal JW, Mann DM, Esiri M, Jellinger KA, O'Brien JT, Attems J. Magnetic resonance imaging of fixed post mortem brains reliably reflects subcortical vascular pathology of frontal, parietal and occipital white matter. Neuropathology and Applied Neurobiology 2013, 39(5), 485-497.
• Duncan GW, Firbank MJ, O'Brien JT, Burn DJ. Magnetic resonance imaging: A biomarker for cognitive impairment in Parkinson's disease?. Movement Disorders 2013, 28(4), 425-438.
• Colloby SJ, Taylor J-P, Davison CM, Lloyd JJ, Firbank MJ, McKeith IG, O'Brien JT. Multivariate spatial covariance analysis of ^99mTc-exametazime SPECT images in dementia with Lewy bodies and Alzheimer’s disease: utility in differential diagnosis. Journal of Cerebral Blood Flow & Metabolism 2013, 33(4), 612-618.
• Mukaetova-Ladinska EB, Abdell-All Z, Andrade J, daSilva JA, Boksha I, Burbaeva G, Kalaria RJ, O'Brien JT. Platelet Tau Protein as a Potential Peripheral Biomarker in Alzheimer's disease: An Explorative Study. Current Alzheimer Research 2013, (epub ahead of print).
• Ford AH, Duncan GW, Firbank MJ, Yarnall AJ, Khoo TK, Burn DJ, O'Brien JT. Rapid eye movement sleep behavior disorder in Parkinson's disease: Magnetic resonance imaging study. Movement Disorders 2013, 28(6), 832-836.
• Bohr IJ, Kenny E, Blamire A, O'Brien JT, Thomas AJ, Richardson J, Kaiser M. Resting-state functional connectivity in late-life depression: higher global connectivity and more long distance connections. Frontiers in Psychiatry 2013, 3, 116.
• Kenny ER, O'Brien JT, Firbank MJ, Blamire AM. Subcortical connectivity in dementia with Lewy bodies and Alzheimer's disease. British Journal of Psychiatry 2013, 203(3), 209-214.
• Boucher JJ, Duncan GW, Yarnall AJ, Martin Ruiz C, Barker RA, O'Brien JT, Von Zglinicki T, Burn DJ. Telomere length and cognitive impairment in early Parkinson's disease. In: 49th Annual Meeting of the Irish Neurological Association. 2013, Dublin: Irish Neurological Association.
• Wood JS, Firbank MJ, Mosimann UP, Watson R, Barber R, Blamire AM, O'Brien JT. Testing Visual Perception in Dementia with Lewy Bodies and Alzheimer Disease. American Journal of Geriatric Psychiatry 2013, 21(6), 501-508.
• Duncan GW, Khoo TK, Yarnall AJ, O'Brien JT, Barker RA, Burn DJ. The impact of motor and non-motor symptoms upon health-related quality of life in early Parkinson's disease: the incidence of cognitive impairment in cohorts with longitudinal evaluation: Parkinson's Disease (ICICLE-PD) Study. In: British Geriatrics Society Spring Meeting. 2013, Belfast, Ireland: Oxford University Press.
• Jefferis JM, Clarke MP, Mosimann UP, O'Brien JT, Taylor JP. The influence of two common dementia types on visual symptoms. Acta Ophthalmologica 2013, 91(2), e159-e160.
• Khoo TK, Yarnall AJ, Duncan GW, Coleman S, O'Brien JT, Brooks DJ, Barker RA, Burn DJ. The spectrum of nonmotor symptoms in early Parkinson disease. Neurology 2013, 80(3), 276-281.
• Khoo TK, Duncan GW, Yarnall AJ, Brooks DJ, Barker RA, O'Brien JT, Burn DJ. Apathy in incident Parkinson’s disease. In: The Movement Disorders Society 16th International Congress of Parkinson’s Disease and Movement Disorders. 2012, Dublin, Ireland.
• Kalaria RN, Perry RH, O'Brien J, Jaros E. Atheromatous disease in small intracerebral vessels, microinfarcts and dementia. Neuropathology and Applied Neurobiology 2012, 38(5), 505-508.
• Firbank MJ, Teodorczuk A, O'Brien JT. Authors' Reply: Assessing the role of cerebrovascular disease in the incidence of geriatric depression Reply. British Journal of Psychiatry 2012, 201(5), 412-412.
• Sinha N, Firbank M, O'Brien JT. Biomarkers in dementia with Lewy bodies: a review. International Journal of Geriatric Psychiatry 2012, 27(5), 443-453.
• Watson R, Blamire AM, Colloby SJ, Wood JS, Barber R, He JB, O'Brien JT. Characterizing dementia with Lewy bodies by means of diffusion tensor imaging. Neurology 2012, 79(9), 906-914.
• Frederiksen KS, Garde E, Skimminge A, Barkhof F, Scheltens P, van Straaten ECW, Fazekas F, Baezner H, Verdelho A, Ferro JM, Erkinjuntti T, Jokinen H, Wahlund LO, O'Brien JT, Basile AM, Pantoni L, Inzitari D, Waldemar G, LADIS Study Grp. Corpus Callosum Tissue Loss and Development of Motor and Global Cognitive Impairment: The LADIS Study. Dementia and Geriatric Cognitive Disorders 2012, 32(4), 279-286.
• Khoo TK, Duncan GW, Yarnall AJ, Brooks DJ, Barker RA, O'Brien JT, Burn DJ. Depression and anxiety in incident Parkinson’s disease. In: The Movement Disorders Society 16th International Congress of Parkinson’s Disease and Movement Disorders. 2012, Dublin, Ireland.
• Watson R, O'Brien JT. Differentiating dementia with Lewy bodies and Alzheimer’s disease using magnetic resonance imaging. Neurodegenerative Disease Management 2012, 2(4), 411-420.
• Howard R, McShane R, Lindesay J, Ritchie C, Baldwin A, Barber R, Burns A, Dening T, Findlay D, Holmes C, Hughes A, Jacoby R, Jones R, Jones R, McKeith I, Macharouthu A, O'Brien J, Passmore P, Sheehan B, Juszczak E, Katona C, Hills R, Knapp M, Ballard C, Brown R, Banerjee S, Onions C, Griffin M, Adams J, Gray R, Johnson T, Bentham P, Phillips P. Donepezil and Memantine for Moderate-to-Severe Alzheimer's Disease. New England Journal of Medicine 2012, 366(10), 893-903.
• Duncan GW, Khoo TK, Yarnall AJ, O'Brien JT, Brooks DJ, Barker RA, Burn DJ. Elevated homocysteine levels and cognitive dysfunction in an incident cohort of non-demented Parkinson’s disease patients. In: The Movement Disorders Society 16th International Congress of Parkinson’s Disease and Movement Disorders. 2012, Dublin, Ireland.
• Kenny ER, Blamire AM, Firbank MJ, O'Brien JT. Functional connectivity in cortical regions in dementia with Lewy bodies and Alzheimer's disease. Brain 2012, 135(2), 569-581.
• Gemmell E, Bosomworth H, Allan L, Hall R, Khundakar A, Oakley AE, Deramecourt V, Polvikoski TM, O'Brien JT, Kalaria RN. Hippocampal Neuronal Atrophy and Cognitive Function in Delayed Poststroke and Aging-Related Dementias. Stroke 2012, 43(3), 808-814.
• Mukaetova-Ladinska EB, Abdel-All Z, Andrade J, McNally RJ, James PW, Kalaria RN, O'Brien JT. Increase in platelet immunoglobulin in Alzheimer's disease is lowered following cholinesterase inhibitor treatment: preliminary results. Journal of Alzheimer's Disease 2012, 32(2), 431-436.
• Nombela C, Rowe J, Hampshire A, Owen A, Breen D, Winder-Rhodes S, Khoo T, Firbank M, Yarnall A, Duncan G, O'Brien J, Burn D, Brooks D, Barker R. Inefficiency of fronto-parietal networks in incident Parkinson’s disease. In: 8th Forum of Neuroscience. 2012, Barcelona, Spain.
• McAleese KE, Firbank M, Johnson M, Walker L, Hunter D, Sun L, Hall R, O'Brien JT, Attems J. Magnetic resonance imaging detects subcortical vascular pathology in post mortem brains. In: 113th Meeting of the British Neuropathological Society. 2012, London, UK.
• McAleese KE, Firbank M, Johnson M, Walker L, Hunter D, Sun L, Hall R, O'Brien JT, Attems J. Magnetic resonance imaging detects subcortical vascular pathology in post mortem brains. In: 10th European Congress of Neuropathology. 2012, Edinburgh, Scotland.
• Damangir S, Manzouri A, Oppedal K, Carlsson S, Firbank MJ, Sonnesyn H, Tysnes OB, O'Brien JT, Beyer MK, Westman E, Aarsland D, Wahlund LO, Spulber G. Multispectral MRI segmentation of age related white matter changes using a cascade of support vector machines. Journal of the Neurological Sciences 2012, 322(1-2), 211-216.
• Taylor J-P, O'Brien JT. Neuroimaging of Dementia with Lewy bodies. Neuroimaging Clinics of North America 2012, 22(1), 67-81.
• Firbank MJ, Allan LM, Burton EJ, Barber R, O'Brien JT, Kalaria RN. Neuroimaging predictors of death and dementia in a cohort of older stroke survivors. Journal of Neurology, Neurosurgery and Psychiatry 2012, 83(3), 263-267.
• Colloby SJ, McParland S, O'Brien JT, Attems J. Neuropathological correlates of dopaminergic imaging in Alzheimer's disease and Lewy body dementias. Brain 2012, 135(9), 2798-808.
• Burton EJ, Mukaetova-Ladinska EB, Perry RH, Jaros E, Barber R, O'Brien JT. Neuropathological correlates of volumetric MRI in autopsy-confirmed Lewy body dementia. Neurobiology of Aging 2012, 33(7), 1228-1236.
• Taylor JP, Firbank M, O'Brien J. Occipital transcranial magnetic stimulation in dementia with Lewy bodies Reply. British Journal of Psychiatry 2012, 200(4), 345-346.
• Jordan A, Regnard C, O'Brien JT, Hughes JC. Pain and distress in advanced dementia: Choosing the right tools for the job. Palliative Medicine 2012, 26(7), 873-878.
• Taylor J-P, O'Brien JT. Parkinson’s Disease with Dementia. In: Ebmeier, K.P., O’Brien, J.T., Taylor, J.-P, ed. Psychiatry of Parkinson’s Disease. Basel: Karger, 2012, pp.103-124.
• Watson R, O'Brien JT, Barber R, Blamire AM. Patterns of gray matter atrophy in dementia with Lewy bodies: a voxel-based morphometry study. International Psychogeriatrics 2012, 24(4), 532-540.
• Mukaetova-Ladinska EB, Abdel-All Z, Dodds S, Andrade J, AlvesdaSilva J, Kalaria RN, O'Brien JT. Platelet immunoglobulin and amyloid precursor protein (APP) as potential peripheral biomarkers for Alzheimer’s Disease. Findings from a pilot study. Age and Ageing 2012, 41(3), 408-412.
• Lopes MA, Firbank MJ, Widdrington M, Blamire AM, Kalaria RN, O'Brien JT. Post-stroke dementia: the contribution of thalamus and basal ganglia changes. International Psychogeriatrics 2012, 24(4), 568-576.
• Ebmeier KP, O'Brien JT, Taylor J-P, ed. Psychiatry of Parkinson's disease. Basel: S. Karger AG, 2012.
• Burton EJ, Mukaetova-Ladinska EB, Perry RH, Jaros E, Barber R, O'Brien JT. Quantitative neurodegenerative pathology does not explain the degree of hippocampal atrophy on MRI in degenerative dementia. International Journal of Geriatric Psychiatry 2012, 27(12), 1267-1274.
• Colloby SJ, Firbank MJ, He JB, Thomas AJ, Vasudev A, Parry SW, O'Brien JT. Regional cerebral blood flow in late-life depression: arterial spin labelling magnetic resonance study. British Journal of Psychiatry 2012, 200(2), 150-155.
• Vasudev A, Saxby BK, O'Brien JT, Colloby SJ, Firbank MJ, Brooker H, Wesnes K, Thomas AJ. Relationship Between Cognition, Magnetic Resonance White Matter Hyperintensities, and Cardiovascular Autonomic Changes in Late-Life Depression. American Journal of Geriatric Psychiatry 2012, 20(8), 691-699.
• Firbank MJ, Teodorczuk A, van der Flier WM, Gouw AA, Wallin A, Erkinjuntti T, Inzitari D, Wahlund LO, Pantoni L, Poggesi A, Pracucci G, Langhorne P, O'Brien JT, LADIS Grp. Relationship between progression of brain white matter changes and late-life depression: 3-year results from the LADIS study. British Journal of Psychiatry 2012, 201(1), 40-45.
• Nombela C, Rowe J, Hampshire A, Owen A, Breen D, Khoo T, Firbank M, Yarnall A, Duncan G, O'Brien J, Burn D, Brooks D, Barker R. Spatial planning ability in early stage Parkinson’s disease patients (ICICLE-PD). In: The Movement Disorders Society 16th International Congress of Parkinson’s Disease and Movement Disorders. 2012, Dublin, Ireland.
• Khoo TK, Duncan GW, Yarnall AJ, Brooks DJ, Barker RA, O'Brien JT, Burn DJ. The incidence of Parkinson’s disease in North East England. In: The Movement Disorders Society 16th International Congress of Parkinson’s Disease and Movement Disorders. 2012, Dublin, Ireland.
• Watson R, Blamire AM, Colloby SJ, Wood JS, Barber R, He J, O'Brien JT. Using diffusion tensor imaging to characterise patterns of white matter tract degeneration in dementia with Lewy bodies. In: The Australian and New Zealand Society for Geriatric Medicine Annual Scientific Meetin. 2012, Sydney, Australia: Wiley-Blackwell Publishing Asia.
• Taylor JP, Firbank MJ, He JB, Barnett N, Pearce S, Livingstone A, Vuong Q, McKeith IG, O'Brien JT. Visual cortex in dementia with Lewy bodies: magnetic resonance imaging study. British Journal of Psychiatry 2012, 200(6), 491-498.
• Morris CM, Ballard CG, Allan L, Rowan E, Stephens S, Firbank MJ, Ford GA, Kenny RA, O'Brien JT, Kalaria RN. NOS3 gene rs1799983 polymorphism and incident dementia in elderly stroke survivors. Neurobiology of Aging 2011, 32(3), 554.e1-554.e6.
• Vasudev A, O'Brien JT, Tan MP, Parry SW, Thomas AJ. A study of orthostatic hypotension, heart rate variability and baroreflex sensitivity in late-life depression. Journal of Affective Disorders 2011, 131(1-3), 374-378.
• Firbank MJ, He J, Blamire AM, Singh B, Danson P, Kalaria RN, O'Brien JT. Cerebral blood flow by arterial spin labeling in poststroke dementia. Neurology 2011, 76(17), 1478-1484.
• Colloby SJ, Firbank MJ, Vasudev A, Parry SW, Thomas AJ, O'Brien JT. Cortical thickness and VBM-DARTEL in late-life depression. Journal of Affective Disorders 2011, 133(1-2), 158-164.
• Taylor J-P, O'Brien J. Dementia with Lewy bodies – Clinical Aspects: E-brain module. Joint Neurosciences Council, 2011. Available at: http://www.ebrainjnc.com.
• Howard R, Phillips P, Johnson T, O'Brien J, Sheehan B, Lindesay J, Bentham P, Burns A, Ballard C, Holmes C, McKeith I, Barber R, Dening T, Ritchie C, Jones R, Baldwin A, Passmore P, Findlay D, Hughes A, Macharouthu A, Banerjee S, Jones R, Knapp M, Brown RG, Jacoby R, Adams J, Griffin M, Gray R. Determining the minimum clinically important differences for outcomes in the DOMINO trial. International Journal of Geriatric Psychiatry 2011, 26(8), 812-817.
• Wood JS, Firbank MJ, Mosimann UP, Taylor JP, O'Brien JT. Development of a Novel fMRI Compatible Visual Perception Prototype Battery to Test Older People With and Without Dementia. Journal of Geriatric Psychiatry and Neurology 2011, 24(2), 73-83.
• Firbank MJ, Blamire AM, Teodorczuk A, Teper E, Mitra D, O'Brien JT. Diffusion tensor imaging in Alzheimer's disease and dementia with Lewy bodies. Psychiatry Research: Neuroimaging 2011, 194(2), 176-183.
• Narayan SK, Firbank MJ, Saxby BK, Stansby G, Hansrani M, O'Brien JT, Ford GA. Elevated plasma homocysteine is associated with increased brain atrophy rates in older subjects with mild hypertension. Dementia and Geriatric Cognitive Disorders 2011, 31(5), 341-348.
• Jones EL, Kalaria RN, Sharp SI, O'Brien JT, Francis PT, Ballard CG. Genetic Associations of Autopsy-Confirmed Vascular Dementia Subtypes. Dementia and Geriatric Cognitive Disorders 2011, 31(4), 247-253.
• Allan LM, Rowan EN, Firbank MJ, Thomas AJ, Parry SW, Polvikoski TM, O'Brien JT, Kalaria RN. Long term incidence of dementia, predictors of mortality and pathological diagnosis in older stroke survivors. Brain 2011, 134(12), 3716-3727.
• Lautenschlager N, Burke W, O'Brien J, Ritchie C, Suh GH, Pachana N, Philpot M, Mould J, Hutchins J, Clark J. Meet the Editors of International Psychogeriatrics and the IPA Bulletin or everything you always wanted to know about Editors, but were afraid to ask. In: International Psychogeriatrics: 15th International Congress on International Psychogeriatric Association Reinventing Aging through Innovation. 2011, The Hague, Netherlands: Cambridge University Press.
• Quigley H, Colloby SJ, O'Brien JT. PET imaging of brain amyloid in dementia: a review. International Journal of Geriatric Psychiatry 2011, 26(10), 991-999.
• Narayan SK, Saxby BK, Firbank MJ, O'Brien JT, Harrington F, McKeith IG, Hansrani M, Stansby G, Ford GA. Plasma homocysteine and cognitive decline in older hypertensive subjects. International Psychogeriatrics 2011, 23(10), 1607-1615.
• Colloby SJ, Vasudev A, O'Brien JT, Firbank MJ, Parry SW, Thomas AJ. Relationship of orthostatic blood pressure to white matter hyperintensities and subcortical volumes in late-life depression. British Journal of Psychiatry 2011, 199(5), 404-410.
• Frisoni GB, Winblad B, O'Brien JT. Revised NIA-AA criteria for the diagnosis of Alzheimer's disease: a step forward but not yet ready for widespread clinical use. International Psychogeriatrics 2011, 23(8), 1191-1196.
• Banerjee S, Hellier J, Dewey M, Romeo R, Ballard C, Baldwin R, Bentham P, Fox C, Holmes C, Katona C, Knapp M, Lawton C, Lindesay J, Livingston G, McCrae N, Moniz-Cook E, Murray J, Nurock S, Orrell M, O'Brien J, Poppe M, Thomas A, Walwyn R, Wilson K, Burns A. Sertraline or mirtazapine for depression in dementia (HTA-SADD): a randomised, multicentre, double-blind, placebo-controlled trial. Lancet 2011, 378(9789), 403-411.
• Taylor JP, Firbank M, Barnett N, Pearce S, Livingstone A, Mosimann U, Eyre JA, McKeith IG, O'Brien JT. Visual hallucinations in dementia with Lewy bodies: transcranial magnetic stimulation study. British Journal of Psychiatry 2011, 199(6), 492-500.
• Watson R, O'Brien J, Blamire A, Barber R, Wood J. White matter changes in dementia with Lewy bodies: A diffusion tensor imaging study. In: International Psychogeriatrics: 15th International Congress on International Psychogeriatric Association Reinventing Aging through Innovation. 2011, The Hague, Netherlands: Cambridge University Press.
• Colloby SJ, Firbank MJ, Thomas AJ, Vasudev A, Parry SW, O'Brien JT. White matter changes in late-life depression: A diffusion tensor imaging study. Journal of Affective Disorders 2011, 135(1-3), 216-220.
• Colloby S, Firbank M, Thomas A, O'Brien J, Vasudev A, Parry S. White matter changes in late-life depression: A diffusion tensor imaging study. In: International Psychogeriatrics: 15th International Congress of the International Psychogeriatric Association Reinventing Aging through Innovation. 2011, The Hague, The Netherlands: Cambridge University Press.
• Dubois B, Feldman H, Jacova C, Cummings J, DeKosky S, Barberger-Gateau P, Delacourte A, Frisoni G, Fox N, Galasko D, Gauthier S, Hampel H, Jicha G, Meguro K, O'Brien J, Pasquier F, Robert P, Rossor M, Salloway S, Sarazin M, de Souza L, Stern Y, Visser P, Scheltens P. Revising the definition of Alzheimer's disease: A new lexicon. The Lancet Neurology 2010, 9(11), 1118-1127.
• O'Brien JT, McKeith IG, Walker Z, Tatsch K, Booij J, Darcourt J, Marquardt M, Reininger C, The DLB Study Group. Diagnostic accuracy of ¹²³I-FP-CIT SPECT in possible dementia with Lewy bodies. British Journal of Psychiatry 2009, 194(1), 34-39.
• Watson R, Blamire AM, O'Brien JT. Magnetic Resonance Imaging in Lewy Body Dementias. Dementia and Geriatric Cognitive Disorders 2009, 28(6), 493-506.
• Burton EJ, Barber R, Mukaetova-Ladinska EB, Robson J, Perry RH, Jaros E, Kalaria RN, O'Brien JT. Medial temporal lobe atrophy on MRI differentiates Alzheimer's disease from dementia with Lewy bodies and vascular cognitive impairment: a prospective study with pathological verification of diagnosis. Brain 2009, 132(1), 195-203.
• O'Brien JT, Colloby SJ, Pakrasi S, Perry EK, Pimlott SL, Wyper DJ, McKeith IG, Williams ED. Nicotinic α4β2 receptor binding in dementia with Lewy bodies using 123I-5IA-85380 SPECT demonstrates a link between occipital changes and visual hallucinations. NeuroImage 2008, 40(3), 1056-1063.
• Howard RJ, Juszczak E, Ballard CG, Bentham P, Brown RG, Bullock R, Burns AS, Holmes C, Jacoby R, Johnson T, Knapp M, Lindesay J, O'Brien JT, Wilcock G, Katona C, Jones RW, Decesare J, Rodger M. Donepezil for the treatment of agitation in Alzheimer's disease. New England Journal of Medicine 2007, 357(14), 1382-1392.
• Firbank MJ, Burton EJ, Barber R, Stephens S, Kenny RA, Ballard C, Kalaria RN, O'Brien JT. Medial temporal atrophy rather than white matter hyperintensities predict cognitive decline in stroke survivors. Neurobiology of Aging 2007, 28(11), 1664-1669.
• Pakrasi S, Colloby SJ, Firbank MJ, Perry EK, Wyper DJ, Owens J, McKeith IG, Williams ED, O'Brien JT. Muscarinic acetylcholine receptor status in Alzheimer's disease assessed using (R, R) 123I-QNB SPECT. Journal of Neurology 2007, 254(7), 907-913.
• McKeith I, O'Brien J, Walker Z, Tatsch K, Booij J, Darcourt J, Padovani A, Giubbini R, Bonuccelli U, Volterrani D, Holmes C, Kemp P, Tabet N, Meyer I, Reininger C. Sensitivity and specificity of dopamine transporter imaging with 123I-FP-CIT SPECT in dementia with Lewy bodies: a phase III, multicentre study. Lancet Neurology 2007, 6(4), 305-313.
• O'Brien JT, Colloby SJ, Pakrasi S, Perry EK, Pimlott SL, Wyper DJ, McKeith IG, Williams ED. α4β2 nicotinic receptor status in Alzheimer's disease using 123I-5IA-85380 single-photon-emission computed tomography. Journal of Neurology, Neurosurgery and Psychiatry 2007, 78(4), 356-361.
• Colloby SJ, Pakrasi S, Firbank MJ, Perry EK, Piggott MA, Owens J, Wyper DJ, McKeith IG, Burn DJ, Williams ED, O'Brien JT. In vivo SPECT imaging of muscarinic acetylcholine receptors using (R,R) ¹²³I-QNB in dementia with Lewy bodies and Parkinson's disease dementia. NeuroImage 2006, 33(2), 423-429.
• O'Brien J. [meeting abstract] Neurobiological changes in late life depression: Cause or consequence?. Journal of Affective Disorders 2004, 78(s1), S26-S27.
• O'Brien JT, Lloyd A, McKeith I, Gholkar A, Ferrier N. A Longitudinal Study of Hippocampal Volume, Cortisol Levels, and Cognition in Older Depressed Subjects. American Journal of Psychiatry 2004, 161(11), 2081-2090.
• Ballard CG, Morris CM, Rao H, O'Brien JT, Barber R, Stephens S, Rowan E, Gibson A, Kalaria RN, Kenny RA. APOE ε4 and cognitive decline in older stroke patients with early cognitive impairment. Neurology 2004, 63(8), 1399-1402.
• Molloy S, O'Brien JT, McKeith IG, Burn DJ. Can parkinsonian phenotype be used to predict levodopa response in extrapyramidal syndromes with and without dementia?. In: Journal of Neurology, Neurosurgery and Psychiatry: Spring Meeting of the Association of British Neurologists. 2004, London, UK: BMJ Group.
• Kenny RA, Shaw FE, O'Brien JT, Scheltens PH, Kalaria R, Ballard C. Carotid sinus syndrome is common in dementia with Lewy bodies and correlates with deep white matter lesions. Journal of Neurology, Neurosurgery and Psychiatry 2004, 75(7), 966-971.
• Burton EJ, Karas G, Paling SM, Williams ED, Ballard CG, McKeith IG, Scheltens P, Barkhof F, O'Brien JT. Cerebral atrophy in dementia with Lewy bodies studied using voxel-based morphometry. In: 2nd Meeting of the Alzheimers Imaging Consortium. 2004, Stockholm, Sweden: Neurobiology of Aging: Elsevier.
• Burton EJ, McKeith IG, Burn DJ, Williams ED, O'Brien JT. Cerebral atrophy in Parkinson's disease with and without dementia: A comparison with Alzheimer's disease, dementia with Lewy bodies and controls. Brain 2004, 127(4), 791-800.
• Minett TS, Dean JL, Firbank M, English P, O'Brien JT. Cerebral white matter lesions and subjective memory complaints in the elderly. In: 9th International Conference on Alzheimers Disease and Related Disorders. 2004, Philadelphia, PA: Neurobiology of Aging: Elsevier.
• Ballmaier M, O'Brien JT, Burton EJ, Thompson PM, Rex DE, Narr KL, McKeith IG, DeLuca H, Toga AW. Comparing gray matter loss profiles between dementia with Lewy bodies and Alzheimer's disease using cortical pattern matching: Diagnosis and gender effects. NeuroImage 2004, 23(1), 325-335.
• Fernando MS, O'Brien JT, Perry RH, English P, Forster G, McMeekin W, Slade JY, Golkhar A, Matthews FE, Barber R, Kalaria RN, Ince PG. Comparison of the pathology of cerebral white matter with post-mortem magnetic resonance imaging (MRI) in the elderly brain. Neuropathology and Applied Neurobiology 2004, 30(4), 385-395.
• Burn DJ, Perry EK, O'Brien JT, et al. Dementia with Lewy Bodies. In: Charney, D.S., Nestler, E.J, ed. Neurobiology of Mental Illness. Oxford, UK: Oxford University Press, 2004, pp.881-895.
• O'Brien JT, Colloby S, Fenwick J, Williams ED, Firbank M, Burn D, Aarsland D, McKeith IG. Dopamine transporter loss visualized with FP-CIT SPECT in the differential diagnosis of dementia with lewy bodies. Archives of Neurology 2004, 61(6), 919-925.
• Thomas AJ, Davis S, Ferrier IN, Kalaria RN, O'Brien JT. Elevation of cell adhesion molecule immunoreactivity in the anterior cingulate cortex in bipolar disorder. Biological Psychiatry 2004, 55(6), 652-655.
• Colloby S, O'Brien J. Functional imaging in Parkinson's disease and dementia with Lewy bodies. Journal of Geriatric Psychiatry and Neurology 2004, 17(3), 158-163.
• Wiseman RM, Saxby BK, Burton EJ, Barber R, Ford GA, O'Brien JT. Hippocampal atrophy, whole brain volume, and white matter lesions in older hypertensive subjects. Neurology 2004, 63(10), 1892-1897.
• Lloyd AJ, Ferrier IN, Barber R, Gholkar A, Young AH, O'Brien JT. Hippocampal volume change in depression: Late- and early-onset illness compared. British Journal of Psychiatry 2004, 184(6), 488-495.
• O'Brien JT, Colloby S, Pakrasi S, Burn D, Williams D, Wyper D, Owens J, McKeith I. I-123-QNB SPECT demonstrates loss of cholinergic muscarinic receptors in Alzheimer's disease, but occipital increases in dementia with lewy bodies and Parkinson's disease dementia. In: Neurobiology of Aging: 9th International Conference on Alzheimers Disease and Related Disorders. 2004, Philadelphia, Pennsylvania, USA: Elsevier Inc.
• Coulthard EJ, Firbank M, English PT, Birchall D, Welch J, O'Brien J, Griffiths D. Magnetic resonance spectroscopy as a diagnostic tool in frontotemporal dementia. In: Journal of Neurology, Neurosurgery and Psychiatry: Annual Meeting of the British Neuropsychiatry Association. 2004, London, UK: BMJ Group.
• Ince PG, Fernando MS, Matthews F, Brayne C, O'Brien JT. Molecular pathology and vascular morphology of 'incidental' MRI white matter lesions in the ageing brain indicate an ischaemic origin. In: Stroke: 5th World Stroke Congress. 2004, Vancouver, Canada: Lippincott Williams & Wilkins.
• Hendricksen M, Thomas AJ, Ferrier IN, Ince P, O'Brien JT. Neuropathological study of the dorsal raphe nuclei in late-life depression and Alzheimer's disease with and without depression. American Journal of Psychiatry 2004, 161(6), 1096-1102.
• Ballard CG, Jacoby R, Del Ser T, Khan MN, Munoz DG, Holmes C, Nagy Z, Perry EK, Joachim C, Jaros E, O'Brien JT, Perry RH, McKeith IG. Neuropathological Substrates of Psychiatric Symptoms in Prospectively Studied Patients With Autopsy- Confirmed Dementia With Lewy Bodies. American Journal of Psychiatry 2004, 161(5), 843-849.
• Ballard CG, Burton EJ, Barber R, Stephens S, Kenny RA, Kalaria RN, O'Brien JT. NINDS AIREN neuroimaging criteria do not distinguish stroke patients with and without dementia. Neurology 2004, 63(6), 983-988.
• Colloby SJ, Fenwick JD, Paling S, Lobotesis K, Ballard C, McKeith I, Williams ED, O'Brien JT. Tc-99m-HMPAO SPECT image analysis in dementia with Lewy bodies and Alzheimer's disease using Statistical Parametric Mapping. In: 2nd Meeting of the Alzheimers Imaging Consortium. 2004, Stockholm, Sweden: Neurobiology of Aging: Elsevier.
• Paling SM, Williams ED, Barber R, Burton EJ, Crum WR, Fox NC, O'Brien JT. The application of serial MRI analysis techniques to the study of cerebral atrophy in late-onset dementia. Medical Image Analysis 2004, 8(1), 69-79.
• Colloby SJ, O'Brien JT, Fenwick JD, Firbank MJ, Burn DJ, McKeith IG, Williams ED. The application of statistical parametric mapping to I-123-FP-CIT SPECT in dementia with Lewy bodies, Alzheimer's disease and Parkinson's disease. NeuroImage 2004, 23(3), 956-966.
• Mosimann UP, Mather G, Wesnes KA, O'Brien JT, Burn DJ, McKeith IG. Visual perception in Parkinson disease dementia and dementia with Lewy bodies. Neurology 2004, 63(11), 2091-2096.
• Burton EJ, Kenny RA, O'Brien J, Stephens S, Bradbury M, Rowan E, Kalaria R, Firbank M, Wesnes K, Ballard C. White matter hyperintensities are associated with impairment of memory, attention, and global cognitive performance in older stroke patients. Stroke 2004, 35(6), 1270-1275.
• Ballard C, O'Brien J, Reichelt K, Perry E. [abstract] A Randomized controlled trial of aromatherapy for dementia. International Psychogeriatrics 2003, 15(s2), 96-97.
• O'Brien J. [abstract] Behavioral symptoms in vascular cognitive impairment and vascular dementia. International Psychogeriatrics 2003, 15(s2), 133-138.
• O'Brien JT. [abstract] Does depression damage the brain?. International Psychogeriatrics 2003, 15(s2), 158-158.
• Thomas A, O'Brien JT, Harrison R, Davis S, Jackson E. [abstract] Increase in serum interleukin-1b in late-life depression. International Psychogeriatrics 2003, 15(s2), 167-168.
• Aarsland D, Ballard C, Larsen JP, McKeith I, O'Brien J, Perry R. [abstract] Marked neuroleptic sensitivity in dementia with Lewy bodies and Parkinson's disease. Nordic Journal of Psychiatry 2003, 57(2), 94.
• O'Brien JT. [abstract] Neuroimaging changes in Lewy body disorders. International Psychogeriatrics 2003, 15(s2), 103.
• O'Brien JT, Burton EJ, Kalaria R, Kenny RA, Ballard C. [abstract] Neuroimaging changes in vascular mild cognitive impairment (MCI). International Psychogeriatrics 2003, 15(s2), 50-51.
• Thomas A, Kalaria R, Perry R, O'Brien JT. [abstract] Neuropathological changes in late life depression. International Psychogeriatrics 2003, 15(s2), 159.
• Mosimann UP, Felblinger J, Muri RM, Allan L, Pakrasi S, Bowman LC, O'Brien JT. [abstract] Saccadic eye movements in dementia with Lewy bodies. International Psychogeriatrics 2003, 15(s2), 349-350.
• Firbank MJ, Minett T, O'Brien JT. Changes in DWI and MRS associated with white matter hyperintensities in elderly subjects. Neurology 2003, 61(7), 950-954.
• Wiseman RM, Burton EJ, Saxby BK, O'Brien JT, Ford GA. Increased brain atrophy rate in older hypertensive subjects. In: Journal of Hypertension: 13th European Meeting on Hypertension. 2003, Milan, Italy: Lippincott Williams & Wilkins, Ltd.
• Wiseman RM, Burton EJ, Barber R, O'Brien JT, Ford GA. Reduced whole brain volumes, increased white matter lesions but normal hippocampal volume in older hypertensive subjects. In: Journal of Hypertension: 13th European Meeting on Hypertension. 2003, Milan, Italy: Lippincott Williams & Wilkins, Ltd.
• O'Brien J, Reisberg B, Erkinjuntti T. Vascular burden of the brain. International Psychogeriatrics 2003, 15(s1), 7-10.
• O'Brien JT, Erkinjuntti T, Reisberg B, Roman G, Sawada T, Pantoni L, Bowler JV, Ballard C, DeCarli C, Gorelick PB, Rockwood K, Burns A, Gauthier S, DeKosky ST. Vascular cognitive impairment. Lancet Neurology 2003, 2(2), 89-98.
• O'Brien J. Ageism in the NHS. Journal of the British Menopause Society 2002, 8(2), 47.
• Thomas AJ, Ferrier IN, Kalaria RN, Davis S, O'Brien JT, Porter RJ, Marshall EF, Barnett NA, Idey A, McGuckin EA. Cell adhesion molecule expression in the dorsolateral prefrontal cortex and anterior cingulate cortex in major depression in the elderly Effects of rapid tryptophan depletion on salivary and plasma cortisol in Alzheimer's disease and the healthy elderly Effects of hydrocortisone administration on cognitive function in the elderly. British Journal of Psychiatry 2002, 181(1), 129-134.
• Burton EJ, Paling SM, Ballard CG, McKeith IG, O'Brien JT, Karas G, Scheltens P, Barkhof F, Williams ED. Cerebral atrophy in dementia with Lewy bodies studied using voxel-based morphometry. In: Neurobiology of Aging. 2002, Elsevier Inc.
• O'Brien JT, Wiseman R, Burton EJ, Barber B, Wesnes K, Saxby B, Ford GA. Cognitive associations of subcortical white matter lesions in older people. In: Alzheimer's Disease: Vascular Etiology and Pathology. 2002, Kyoto, Japan: New York Academy of Sciences.
• O'Brien JT. Early diagnosis of Alzheimer's Disease. International Journal of Geriatric Psychiatry 2002, 17(3), 293-293.
• Lloyd AJ, McGuckin EA, Barnett NA, Gholkar A, McKeith IG, Young AH, Ferrier IN, O'Brien JT. Increased salivary cortisol in late- but not early-onset depression: Relationship with hippocampal volume. In: Journal of Psychopharmacology: Summer Meeting of the British Association for Psychopharmacology. 2002, Harrogate: Sage Publications Ltd.
• Perry EK, Burn DJ, McKeith IG, O'Brien J, Perry R. Lewy body diseases. In: Davis, K.L., Charney, D., Coyle, J.T., Nemeroff, C, ed. Neuropsychopharmacology: The Fifth Generation of Progress. Philadelphia: Lippincott Williams & Wilkins, 2002, pp.1301-1316.
• Ballard C, Stephens S, McLaren A, Wesnes K, Kenny RA, Burton E, O'Brien J, Kalaria R. Neuropsychological deficits in older stroke patients. In: Alzheimer's Disease: Vascular Etiology and Pathology. 2002, Kyoto, Japan: New York Academy of Sciences.
• Thomas AJ, Perry R, Barber R, Kalaria RN, O'Brien JT. Pathologies and pathological mechanisms for white matter hyperintensities in depression. In: Alzheimer's Disease: Vascular Etiology and Pathology. 2002, Kyoto, Japan: New York Academy of Sciences.
• Karas G, Rombouts SARB, van Schijndel RA, Powels P, Scheltens P, Barkhof F, Burton EJ, Paling SM, O'Brien JT. Patterns of cerebral atrophy detected by voxel-based morphometry (VBM) in Alzheimer's disease. In: Neurobiology of Aging. 2002, Elsevier Inc.
• Colloby S, Paling SM, Lobotesis K, Ballard C, McKeith IG, O'Brien JT, Fenwick JD, Williams ED. Tc-99m HMPAO SPECT image analysis in dementia with Lewy bodies and Alzheimer's disease using statistical paramentric mapping. In: Neurobiology of Aging. 2002, Elsevier Inc.
• O'Brien JT, Ballard CG. Drugs for Alzheimer's disease. British Medical Journal 2001, 323(7305), 123-124.
• O'Brien J. Hormones gender and the aging brain: The endocrine basis of geriatric psychiatry. Journal of Psychosomatic Research 2001, 50(6), 343-343.
• Kalaria RN, Ballard CG, Ince PG, Kenny RA, McKeith IG, Morris CM, O'Brien JT, Perry EK, Perry RH, Edwardson JA. Multiple substrates of late-onset dementia: Implications for brain protection. Ageing Vulnerability: Causes and Interventions: Novartis Foundation Symposium 235 2001, 235, 49-65.
• Wiseman RM, Barber R, O'Brien J, Ford GA. White matter lesions on magnetic resonance imaging in older hypertensives and normotensives. In: Journal of the American Geriatrics Society. 2001, Wiley-Blackwell Publishing, Inc.
• Fernando M, O'Brien J, Gholkar A, Esiri M, Rossi M, Lowe J, Xuereb J, Ince P. Evaluation of white matter lesions in a large community derived sample of demented and non-demented elderly people. In: Neuropathology 2000 - XIVth International Congress of Neuropathology. 2000, Birmingham, England.
• Paling S, Williams ED, LLoyd A, Barber R, Burton EJ, Gholkar A, Crum WR, Fox NC, McKeith I, Ballard C, O'Brien JT. Serial MR image registration and analysis techniques applied to studies of differential cerebral atrophy in late-onset dementia. In: International Conference on Mathematics and Engineering Techniques in Medicine and Biological Sciences. 2000, Las Vegas, Nevada, USA: CSREA PRESS.
• Potkins D, Bradley S, Shrimanker J, O'Brien J, Swann A, Ballard C. Symptoms of striatofrontal dysfunction contribute to disability in geriatric depression. International Journal of Geriatric Psychiatry 2000, 15(11), 992-999.
• O'Brien J, Porter R, Lunn B, Walker L, Gray J, Ballard C. The role of serotonin and the effects of acute dietary depletion of tryptophan on cognitive and non-cognitive symptoms in Alzheimer's disease. In: 40th Annual Meeting of the Scandinavian Society for Psychopharmacology. 1999, Copenhagen, Denmark: Informa Healthcare.
• Donaghy PC, Firbank MJ, Thomas AJ, Lloyd J, Petrides G, Barnett N, Olsen K, O'Brien JT. Clinical and imaging correlates of amyloid deposition in dementia with Lewy bodies. Movement Disorders 2018, 33(7), 1130-1138.
• Kane JPM, Surendranathan A, Bentley A, Barker SAH, Taylor J-P, Thomas AJ, Allan LM, McNally RJ, James PW, McKeith IG, Burn DJ, O'Brien JT. Clinical prevalence of Lewy body dementia. Alzheimer's Research & Therapy 2018, 10, 19.
• Pink J, O'Brien J, Robinson L, Longson D. Dementia: Assessment, management and support: Summary of updated NICE guidance. BMJ 2018, 361, k2438.
• Thomas A, Donaghy P, Roberts G, Colloby SJ, Barnett NA, Petrides G, Lloyd J, Olsen K, Taylor J-P, McKeith I, O'Brien JT. Diagnostic Accuracy of Dopaminergic Imaging in Prodromal Dementia with Lewy Bodies. Psychological Medicine 2019, 49(3), 396-402.
• Croall ID, Tozer DJ, Moynihan B, Khan U, O'Brien JT, Morris RG, Cambridge VC, Barrick TR, Blamire AM, Ford GA, Markus HS. Effect of Standard vs Intensive blood pressure control on cerebral blood flowin small vessel disease the preserve randomized clinical trial. JAMA Neurology 2018, 75(6), 720-727.
• Peraza LR, Cromarty RA, Kobeleva X, Firbank MJ, Killen A, Graziadio S, Thomas AJ, O'Brien JT, Taylor J-P. Electroencephalographic derived network differences in Lewy body dementia compared to Alzheimer’s disease patients. Scientific Reports 2018, 8, 4637.
• Schumacher J, Peraza LR, Firbank MJ, Thomas AJ, Kaiser M, Gallagher P, O'Brien JT, Blamire AM, Taylor J-T. Functional connectivity in dementia with Lewy bodies: A within- and between-network analysis. Human Brain Mapping 2018, 39(3), 1118-1129.
• Firbank MJ, O'Brien JT, Taylor JP. Long reaction times are associated with delayed brain activity in lewy body dementia. Human Brain Mapping 2018, 39(2), 633–643.
• Donaghy PC, Taylor JP, O'Brien JT, Barnett N, Olsen K, Colloby SJ, Lloyd J, Petrides G, McKeith IG, Thomas AJ. Neuropsychiatric symptoms and cognitive profile in mild cognitive impairment with Lewy bodies. Psychological Medicine 2018, 48(14), 2384-2390.
• King E, O'Brien JT, Donaghy P, Morris C, Barnett N, Olsen K, Martin-Ruiz C, Taylor J-P, Thomas AJ. Peripheral inflammation in prodromal Alzheimer’s and Lewy body dementias. Journal of Neurology, Neurosurgery and Psychiatry 2018, 89(4), 339-345.
• Skrobot OA, Black SE, Chen C, DeCarli C, Erkinjuntti T, Ford GA, Kalaria RN, O'Brien J, Pantoni L, Pasquier F, Roman GC, Wallin A, Sachdev P, Skoog I, VICCCS group, Ben-Shlomo Y, Passmore AP, Love S, Kehoe PG. Progress toward standardized diagnosis of vascular cognitive impairment: Guidelines from the Vascular Impairment of Cognition Classification Consensus Study. Alzheimer's and Dementia 2018, 14(3), 280-292.
• Stylianou M, Murphy N, Peraza LR, Graziadio S, Cromarty R, Killen A, O'Brien JT, Thomas AJ, LeBeau FEN, Taylor J-P. Quantitative electroencephalography as a marker of cognitive fluctuations in dementia with Lewy bodies and aid to differential diagnosis. Clinical Neurophysiology 2018, 129(6), 1209-1220.
• Thomas AJ, Attems J, Colloby SJ, O'Brien JT, McKeith I, Walker R, Lee L, Burn D, Lett DJ, Walker Z. Author response: Autopsy validation of 123 I-FP-CIT dopaminergic neuroimaging for the diagnosis of DLB. Neurology 2017, 89(7), 751-751.
• Thomas AJ, Attems J, Colloby SJ, O'Brien JT, Mckeith I, Walker R, Lee L, Burn D, Lett DJ, Walker Z. Autopsy validation of ¹²³ I-FP-CIT dopaminergic neuroimaging for the diagnosis of DLB. Neurology 2017, 88(3), 276-283.
• Webster L, Groskreutz D, Grinbergs-Saull A, Howard R, O'Brien JT, Mountain G, Banerjee S, Woods B, Perneczky R, Lafortune L, Roberts C, McCleery J, Pickett J, Bunn F, Challis D, Charlesworth G, Featherstone K, Fox C, Goodman C, Jones R, Lamb S, Moniz-Cook E, Schneider J, Shepperd S, Surr C, Thompson-Coon J, Ballard C, Brayne C, Burns A, Clare L, Garrard P, Kehoe P, Passmore P, Holmes C, Maidment I, Robinson L, Livingston G. Core outcome measures for interventions to prevent or slow the progress of dementia for people living with mild to moderate dementia: Systematic review and consensus recommendations. PLoS ONE 2017, 12(6), e0179521.
• Knapp M, King D, Romeo R, Adams J, Baldwin A, Ballard C, Banerjee S, Barber R, Bentham P, Brown RG, Burns A, Dening T, Findlay D, Holmes C, Johnson T, Jones R, Katona C, Lindesay J, Macharouthu A, McKeith I, McShane R, O'Brien JT, Phillips PPJ, Sheehan B, Howard R. Cost-effectiveness of donepezil and memantine in moderate to severe Alzheimer's disease (the DOMINO-AD trial). International Journal of Geriatric Psychiatry 2017, 32(12), 1205-1216.
• Webster L, Groskreutz D, Grinbergs-Saull A, Howard R, O'Brien JT, Mountain G, Banerjee S, Woods B, Perneczky R, Lafortune L, Roberts C, McCleery J, Pickett J, Bunn F, Challis D, Charlesworth G, Featherstone K, Fox C, Goodman C, Jones R, Lamb S, Moniz-Cook E, Schneider J, Shepperd S, Surr C, Thompson-Coon J, Ballard C, Brayne C, Burke O, Burns A, Clare L, Garrard P, Kehoe P, Passmore P, Holmes C, Maidment I, Murtagh F, Robinson L, Livingston G. Development of a core outcome set for disease modification trials in mild to moderate dementia: A systematic review, patient and public consultation and consensus recommendations. Health Technology Assessment 2017, 21(26).
• Thomas AJ, Taylor JP, Mckeith I, Bamford C, Burn D, Allan L, O'Brien J. Development of assessment toolkits for improving the diagnosis of the Lewy body dementias: Feasibility study within the DIAMOND Lewy study. International Journal of Geriatric Psychiatry 2017, 32(12), 1280-1304.
• McKeith IG, Boeve BF, Dickson DW, Halliday G, Taylor J-P, Weintraub D, Aarsland D, Galvin J, Attems J, Ballard CG, Bayston A, Beach TG, Blanc F, Bohnen N, Bonanni L, Bras J, Brundin P, Burn D, Chen-Plotkin A, Duda JE, El-Agnaf O, Feldman H, Ferman TJ, Ffytche D, Fujishiro H, Galasko D, Goldman JG, Gomperts SN, Graff-Radford NR, Honig LS, Iranzo A, Kantarci K, Kaufer D, Kukull W, Lee VMY, Leverenz JB, Lewis S, Lippa C, Lunde A, Masellis M, Masliah E, McLean P, Mollenhauer B, Montine TJ, Moreno E, Mori E, Murray M, O'Brien JT, Orimo S, Postuma RB, Ramaswamy S, Ross OA, Salmon DP, Singleton A, Taylor A, Thomas A, Tiraboschi P, Toledo JB, Trojanowski JQ, Tsuang D, Walker Z, Yamada M, Kosaka K. Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium. Neurology 2017, 89(1), 88-100.
• Watson R, Colloby SJ, Blamire AM, Wesnes KA, Wood J, O'Brien JT. Does attentional dysfunction and thalamic atrophy predict decline in dementia with Lewy bodies?. Parkinsonism and Related Disorders 2017, 45, 69-74.
• Mak E, Su L, Williams GB, Firbank MJ, Lawson RA, Yarnall AJ, Duncan GW, Mollenhauer B, Owen AM, Khoo TK, Brooks DJ, Rowe JB, Barker RA, Burn DJ, O'Brien JT. Longitudinal whole-brain atrophy and ventricular enlargement in nondemented Parkinson's disease. Neurobiology of Aging 2017, 55, 78-90.
• Donaghy PC, Barnett N, Olsen K, Taylor J-P, McKeith IG, O'Brien JT, Thomas AJ. Symptoms associated with Lewy body disease in mild cognitive impairment. International Journal of Geriatric Psychiatry 2017, 32(11), 1163-1171.
• Hodgetts S, Gallagher P, Stow D, Ferrier IN, O'Brien JT. The impact and measurement of social dysfunction in late-life depression: an evaluation of current methods with a focus on wearable technology. International Journal of Geriatric Psychiatry 2017, 32(3), 247-255.
• Elder GJ, Mactier K, Colloby SJ, Watson R, Blamire AM, O'Brien JT, Taylor J-P. The influence of hippocampal atrophy on the cognitive phenotype of dementia with Lewy bodies. International Journal of Geriatric Psychiatry 2017, 32(11), 1182-1189.
• Croall ID, Lohner V, Moynihan B, Khan U, Hassan A, O'Brien JT, Morris RG, Tozer DJ, Cambridge VC, Harkness K, Werring DJ, Blamire AM, Ford GA, Barrick TR, Markus HS. Using DTI to assess white matter microstructure in cerebral small vessel disease (SVD) in multicentre studies. Clinical Science 2017, 131(12), 1361-1373.
• McAleese K, Firbank M, Dey M, Colloby SJ, Walker L, Johnson M, Beverley JR, Taylor JP, Thomas AJ, O'Brien JT, Attems J. Cortical tau load is associated with white matter hyperintensities. Acta Neuropathologica Communications 2015, 3, 60.
• Vallortigara J, Rangarajan S, Whitfield D, Alghamdi A, Howlett D, Hortobagyi T, Johnson M, Attems J, Ballard C, Thomas A, O'Brien J, Aarsland D, Francis P. Dynamin1 concentration in the prefrontal cortex is associated with cognitive impairment in Lewy body dementia. F1000Research 2014, 3, 108.