Staff Profile
Laura Wilson
Technician
- Email: laura.wilson5@ncl.ac.uk
- Address: Paul O’Gorman Building
Medical School
Newcastle University
Framlington Place
Newcastle upon Tyne
NE2 4HH
UK
Background
I have worked for the University for over 10 years as a Research Technician working in the Solid Tumour Target Discovery group, my main research focus is in Prostate cancer and Stem cells.
I am experienced in a range of laboratory techniques, specialising in molecular pathology and bio-imaging, specifically; Immunohistochemistry, immunofluorescence, Microtomy and FACS. I also run the Aperio virtual pathology imaging system, providing training in automated analysis of stained tissue slides.
I have been a registered scientist since 2015 and now I am an assessor for the IST and the science council.
I have established and co-ordinate the 6th form work experience programme, designed to show 6th form students what it is like working in a lab.
Publications
- Blackwood JK, Williamson SC, Greaves LC, Wilson L, Rigas AC, Sandher R, Pickard RS, Robson CN, Turnbull DM, Taylor RW, Heer R. In situ lineage tracking of human prostatic epithelial stem cell fate reveals a common clonal origin for basal and luminal cells. Journal of Pathology 2011, 225(2), 181-188.
- Williamson C, Blackwood JK, Greaves L, Wilson L, Pickard RS, Lako M, Robson CN, Turnbull DM, Taylor RW, Heer R. Lineage tracking in situ: Where are the prostate stem cells? What are they doing?. In: Annual Meeting of the Society of Academic and Research Surgery. 2012, Nottingham, UK: John Wiley & Sons Ltd.
- Williamson SC, Hepburn AC, Wilson L, Coffey K, Ryan-Munden CA, Pal D, Leung HY, Robson CN, Heer R. Human α2β1HI CD133+VE Epithelial Prostate Stem Cells Express Low Levels of Active Androgen Receptor. PLoS One 2012, 7(11), e48944.
- Moad M, Pal D, Hepburn AC, Williamson SC, Wilson L, Lako M, Armstrong L, Hayward SW, Franco O, Cates J, Fordham SE, Przyborski S, Carr-Wilkinson J, Robson CN, Heer R. A novel model of urinary tract differentiation, tissue regeneration, and disease: Reprogramming human prostate and bladder cells into induced pluripotent stem cells. European Urology 2013, 64(5), 753-761.
- Williamson C, Hepburn AC, Mantilla A, Wilson L, Leung HY, Robson CN, Heer R. Stockpiling testosterone; A unique mechanism of progression to castrate resistant disease. In: Annual Meeting of the Society of Academic and Research Surgery. 2013, London, UK: Wiley-Blackwell.
- Williamson SC, Mitter R, Hepburn AC, Wilson L, Mantilla A, Leung HY, Robson CN, Heer R. Characterisations of human prostate stem cells reveal deficiency in class I UGT enzymes as a novel mechanism for castration-resistant prostate cancer. British Journal of Cancer 2013, 109(4), 950-956.
- Williamson SC, Wilson L, Williamson GA, Greaves L, Tuppen H, Pickard R, Wright NA, Robson CN, Turnbull DM, Taylor RW, Heer R. Finding a niche. The location of human prostate stem cells. In: Annual Meeting of the Society-of-Academic-and-Research-Surgery. 2014, Univ Cambridge, Robinson Coll, Cambridge, ENGLAND: John Wiley & Sons Ltd.
- Wade MA, Jones D, Wilson L, Stockley J, Coffey K, Robson CN, Gaughan L. The histone demethylase enzyme KDM3A is a key estrogen receptor regulator in breast cancer. Nucleic Acids Research 2015, 43(1), 196-207.
- Moad M, Hannezo E, Buczacki SJ, Wilson L, ElSherif A, Sims D, Pickard R, Wright NA, Williamson SC, Turnbull DM, Taylor RW, Greaves L, Robson CN, Simons BD, Heer R. Multipotent Basal Stem Cells, Maintained in Localized Proximal Niches, Support Directed Long-Ranging Epithelial Flows in Human Prostates. Cell Reports 2017, 20(7), 1609-1622.
- Grey J, Jones D, Wilson L, Nakjang S, Clayton J, Temperley R, Clark E, Gaughan L, Robson C. Differential regulation of the androgen receptor by protein phosphatase regulatory subunits. Oncotarget 2018, 9(3), 3922-3935.
- McClurg UL, Nabbi A, Ricordel C, Korolchuk S, McCracken S, Heer R, Wilson L, Butler LM, Irving-Hooper BK, Pedeux R, Robson CN, Riabowol KT, Binda O. Human ex vivo prostate tissue model system identifies ING3 as an oncoprotein. British Journal of Cancer 2018, 118, 713-726.
- Hepburn AC, Steele RE, Veeratterapillay R, Wilson L, Kounatidou EE, Barnard A, Berry P, Cassidy JR, Moad M, El-Sherif A, Gaughan L, Mills IG, Robson CN, Heer R. Correction: The induction of core pluripotency master regulators in cancers defines poor clinical outcomes and treatment resistance (Oncogene, (2019), 10.1038/s41388-019-0712-y). Oncogene 2019, 38, 4425.
- Jones D, Wilson L, Thomas H, Gaughan L, Wade MA. The histone demethylase enzymes KDM3A and KDM4B co-operatively regulate chromatin transactions of the estrogen receptor in breast cancer. Cancers 2019, 11(8), 1122.
- Hepburn AC, Steele RE, Veeratterapillay R, Wilson L, Kounatidou EE, Barnard A, Berry P, Cassidy JR, Moad M, El-Sherif A, Gaughan L, Mills IG, Robson CN, Heer R. The induction of core pluripotency master regulators in cancers defines poor clinical outcomes and treatment resistance. Oncogene 2019, 38, 4412-4424.
- Bainbridge A, Walker S, Smith J, Patterson K, Dutt D, Ng YM, Thomas HD, Wilson L, McCullough B, Jones D, Maan A, Banks P, McCracken SRC, Gaughan L, Robson CN, Coffey K. IKBKE activity enhances AR levels in advanced prostate cancer via modulation of the Hippo pathway. Nucleic Acids Research 2020, 48(10), 5366-5382.
- Hepburn AC, Curry EL, Moad M, Steele RE, Franco OE, Wilson L, Singh P, Buskin A, Crawford SE, Gaughan L, Mills IG, Hayward SW, Robson CN, Heer R. Propagation of human prostate tissue from induced pluripotent stem cells. Stem Cells Translational Medicine 2020, 9(7), 734-745.