Staff Profile
Dr Lei Huang
Senior Lecturer
- Email: lei.huang@ncl.ac.uk
- Telephone: 0191 208 2510
- Address: Institute of Cellular Medicine
M3-120, William Leech Bldg.
Newcastle University Medical School
Newcastle upon Tyne,
NE2 4HH
Background
Dr Lei Huang is a Senior Lecturer in the Institute of Cellular Medicines at Newcastle University. His areas of expertise are inflammation, infection, cancer and autoimmunity.
Publications
- Zhu W, Peng Y, Wang L, Hong Y, Li Q, Liu H, Huang L, Wu J, Celis E, Merchen T, Kruse E, He Y. Identification of novel α-fetoprotein specific T cell receptors to redirect T cells for hepatocellular carcinoma immunotherapy. Hepatology 2018, 68(2), 574-589.
- Wang W, Huang L, Jin JY, Jolly S, Zang Y, Wu H, Yan L, Pi W, Li L, Mellor AL, Kong FS. IDO Immune Status after Chemoradiation May Predict Survival in Lung Cancer Patients. Cancer Research 2018, 78(3), 809-816.
- Zhu H, Lemos H, Bhatt B, Islam BN, Singh A, Gurav A, Huang L, Browning DD, Mellor A, Fulzele S, Singh N. Carbidopa, a drug in use for management of Parkinson disease inhibits T cell activation and autoimmunity. PLoS ONE 2017, 12(9), e0183484.
- Mellor AL, Lemos H, Huang L. Indoleamine 2,3-Dioxygenase and tolerance: Where Are We Now?. Frontiers in Immunology 2017, 8, 1360.
- Wu S, Zhu W, Peng Y, Wang L, Hong Y, Huang L, Dong D, Xie J, Merchen T, Kruse E, Guo ZS, Bartlett D, Fu N, He Y. The Antitumor Effects of Vaccine-Activated CD8+ T Cells Associate with Weak TCR Signaling and Induction of Stem-Like Memory T Cells. Cancer Immunology Research 2017, 5(10), 908-919.
- Sivaprakasam S, Gurav A, Paschall AV, Coe GL, Chaudhary K, Cai Y, Kolhe R, Martin P, Browning D, Huang L, Shi H, Sifuentes H, Vijay-Kumar M, Thompson SA, Munn DH, Mellor A, McGaha TL, Shiao P, Cutler CW, Liu K, Ganapathy V, Li H, Singh N. An essential role of Ffar2 (Gpr43) in dietary fibre-mediated promotion of healthy composition of gut microbiota and suppression of intestinal carcinogenesis. Oncogenesis 2016, 5, e238.
- Lemos H, Mohamed E, Huang L, Ou R, Pacholczyk G, Arbab AS, Munn D, Mellor A. STING Promotes the Growth of Tumors Characterized by Low Antigenicity via IDO Activation. Cancer Research 2016, 76(8), 2076-2081.
- Huang L, Ou R, Rabelo de Souza G, Cunha TM, Lemos H, Mohamed E, Li L, Pacholczyk G, Randall J, Munn DH, Mellor AL. Virus Infections Incite Pain Hypersensitivity by Inducing Indoleamine 2,3 Dioxygenase. PLoS Pathogens 2016, 12(5), 1-16.
- Chaudhary K, Shinde R, Liu H, Gnana-Prakasam JP, Veeranan-Karmegam R, Huang L, Ravishankar B, Bradley J, Kvirkvelia N, McMenamin M, Xiao W, Kleven D, Mellor AL, Madaio MP, McGaha TL. Amino Acid Metabolism Inhibits Antibody-Driven Kidney Injury by Inducing Autophagy. Journal of Immunology 2015, 194(12), 5713-5724.
- Lemos H, Huang L, McGaha TL, Mellor AL. STING, nanoparticles, autoimmune disease and cancer: a novel paradigm for immunotherapy?. Expert Review of Clinical Immunology 2015, 11(1), 155-165.
- Sharma MD, Shinde R, McGaha TL, Huang L, Holmgaard RB, Wolchok JD, Mautino MR, Celis E, Sharpe AH, Francisco LM, Yagita H, Mellor AL, Blazar BR, Munn DH. The PTEN pathway in Tregs is a critical driver for the suppressive tumor microenvironment. Science Advances 2015, 1(10), e1500845.
- Lemos H, Huang L, Chandler PR, Mohamed E, Souza GR, Li L, Pacholczyk G, Barber GN, Hayakawa Y, Munn DH, Mellor AL. Activation of the STING Adaptor Attenuates Experimental Autoimmune Encephalitis. The Journal of Immunology 2014, 192(12), 5571-5578.
- Lemos H, Huang L, McGaha TL, Mellor AL. Cytosolic DNA sensing via the stimulator of interferon genes adaptor: Yin and Yang of immune responses to DNA. European Journal of Immunology 2014, 44(10), 2847-2853.
- Liu H, Huang L, Bradley J, Liu K, Bardhan K, Ron D, Mellor AL, Munn DH, McGaha TL. GCN2-dependent metabolic stress is essential for endotoxemic cytokine induction and pathology. Molecular and Cellular Biology 2014, 34(3), 428-438.
- Ding Z-C, Lu X, Yu M, Lemos H, Huang L, Chandler P, Liu K, Walters M, Krasinski A, Mack M, Blazer BR, Mellor AL, Munn DH, Zhou G. Immunosuppressive Myeloid Cells Induced by Chemotherapy Attenuate Antitumor CD4+ T-Cell Responses through the PD-1-PD-L1 Axis. Cancer Research 2014, 74(13), 3441-3353.
- Huang L, Mellor AL. Metabolic control of tumour progression and antitumour immunity. Current Opinion in Oncology 2014, 26(1), 92-99.
- Huang L, Li L, Lemos H, Chandler PR, Pacholczyk G, Baban B, Barber GN, Hayakawa Y, McGaha TL, Ravishankar B, Munn DH, Mellor AL. Cutting Edge: DNA Sensing via the STING Adaptor in Myeloid Dendritic Cells Induces Potent Tolerogenic Responses. The Journal of Immunology 2013, 191(7), 3509-3513.
- Huang L, Li L, Klonowski KD, Tompkins SM, Tripp RA, Mellor AL. Induction and role of indoleamine 2,3 dioxygenase in mouse models of influenza a virus infection. PLoS ONE 2013, 8(6), e66546.
- Fox JM, Sage LK, Huang L, Barber J, Klonowski KD, Mellor AL, Tompkins M, Tripp RA. Inhibition of indoleamine 2,3-dioxygenase enhances the T-cell response to influenza virus infection. Journal of General Virology 2013, 94(7), 1451-61.
- Li L, Huang L, Lemos HP, Mautino M, Mellor AL. Altered tryptophan metabolism as a paradigm for good and bad aspects of immune privilege in chronic inflammatory diseases. Frontiers in Immunology 2012, 3(109).
- McGaha TL, Huang L, Lemos H, Metz R, Mautino M, Prendergast GC, Mellor AL. Amino acid catabolism: a pivotal regulator of innate and adaptive immunity. Immunological Reviews 2012, 249(1), 135-157.
- Huang L, Lemos H, Li L, Li M, Chandler PR, Baban B, McGaha TL, Ravishankar B, Lee J, Munn DH, Mellor AL. Engineering DNA Nanoparticles as Immunomodulatory Reagents that Activate Regulatory T Cells. The Journal of Immunology 2012, 188(10), 4913-4920.