Introduction

I am currently Principal Research Associate with the Stroke Research Group. A clinician by background, I worked as a junior doctor in and around the Oxford area prior to moving to Newcastle upon Tyne. In Newcastle, I have worked in medical teaching and research, joining the Stroke Research Group in 2006.

Qualifications

MD                                                                           Newcastle University 2010

Postgraduate Certificate in Clinical Education               Newcastle University 2006

MRCP                                                                       Royal College of Physicians 2001

BM BCh                                                                    Oxford University 1998

BSc (Hons) 1st class                                                  St Andrews University 1995

Previous positions

Teaching and Education Fellow, Northumbria Healthcare NHS Foundation Trust

Specialist Registrar, Oxford Deanery

Senior House Officer posts, Oxford and London

House Officer posts, Oxford region

Research expertise

I have worked as a researcher in stroke medicine since July 2006. During this time I have built up knowledge and expertise in the design, management and analysis of clinical trials. For my MD, I co-ordinated a 12 centre randomised controlled trial which evaluated the effectiveness of botulinum toxin for the treatment of upper limb spasticity after stroke. Since completion of my MD (2010) I have been involved in the design, conduct and analysis of further clinical trials to evaluate stroke care.

Current research

I have input into the following on-going research projects:  

1. A trial to Evaluate an eXTended RehAbilitation service for Stroke patients (EXTRAS). This is a multicentre randomised controlled trial led by Professor Helen Rodgers and funded by NIHR HTA. http://research.ncl.ac.uk/extrastrial/

2. Robot Assisted Training for the Upper Limb after Stroke (RATULS). This is a multicentre randomised controlled trial led by Professor Helen Rodgers and funded by NIHR HTA. http://research.ncl.ac.uk/ratuls/

3. Paramedic Acute Stroke Treatment Assessment (PASTA). This is a multicentre randomised controlled trial led by Dr Chris Price and funded by NIHR Programme Grants for Applied Research. https://research.ncl.ac.uk/pasta/

4. Protocol development and clinical trial feasibility evaluation of a wrist-worn accelerometer to monitor, prompt and report impaired upper limb activity during self-supervised rehabilitation after stroke. This project is led by Dr Chris Price and funded by The Stroke Association.

5. Development and clinical trial feasibility evaluation of auditory rhythmical cueing to improve gait and physical activity in community dwelling stroke survivors. This project is led by Dr Sarah Moore and funded by The Stroke Association.

6. Purines for Rapid Identification of Stroke Mimics (PRISM). The project is led by Dr Chris Price and funded by Innovate UK.

7. Electrical bioimpedence cerebral spectroscopy detection of large vessel occlusion amoungst patients with symptoms of acute stroke. This project is led by Dr Chris Price and funded by MRC Confidence in Concepts.

8. Development of a standardised set of metrics for monitoring performance in randomised controlled trials. This project is led by Professor Diane Whitham from Nottingham University.

Current research grants held

1. A trial to Evaluate an eXTended RehAbilitation service for Stroke patients (EXTRAS).

Chief Investigator: Helen Rodgers.

Co-investigators: Robin Cant, Mark Deverill, Avril Drummond, Gary Ford, Anne Forster, Denise Howel, Anne-Marie Laverty, Chris McKevitt, Peter McMeekin, Chris Price, Lisa Shaw

Funding: NIHR HTA 01.10.2012 – 28.02.2018

2. Robot Assisted Training for the Upper Limb after Stroke (RATULS).

Chief Investigator: Helen Rodgers.

Co-investigators: Lydia Aird, Sree Andole, David Cohen, Jesse Dawson, Janet Eyre, Tracy Finch, Gary Ford, Steven Hogg, Denise Howel, Niall Hughes, Hermano Igo Krebs, Anne-Marie Laverty, Chris Price, Lynn Rochester, Lisa Shaw, Laura Ternent, Duncan Turner, Luke Vale, Frederike van Wijck, Scott Wilkes.

Funding: NIHR HTA 01.01.2014 – 31.08.2019

3. Protocol development and clinical trial feasibility evaluation of a wrist-worn accelerometer to monitor, prompt and report impaired upper limb activity during self-supervised rehabilitation after stroke.

Chief Investigator: Chris Price

Co-investigators: Madeline Balaam, Katie Brittain, Lianne Brkic, Thomas Ploetz, Helen Rodgers, Lisa Shaw, Frederike van Wijck. 

Funding: The Stroke Association 01.01.2015 - 31.12.2017  

4. Development and clinical trial feasibility evaluation of auditory rhythmical cueing to improve gait and physical activity in community dwelling stroke survivors.

Chief Investigator: Sarah Moore

Co-investigators: Alan Godfrey, Allen Lambert, Sue Lord, Chris Price, Lynn Rochester, Helen Rodgers, Lisa Shaw.

Funding: The Stroke Associate 01.07.2017 - 30.06.2020

5. Purines for Rapid Identification of Stroke Mimics (PRISM).

Chief Investigator: Dr Chris Price

Co-investigators: Nick Dale, Gary Ford, Sara Graziadio, Chris Imray, Dennis Lendrem, Everad Mascarenhas, Peter McMeekin, Christine Roffe, Lisa Shaw, Craig Smith.

Funding: Innovate UK 01.08.2017 - 31.07.2020

6. Electrical Bioimpedence Cerebral Spectroscopy detection of large vessel occlusion amoungst patients with symptoms of acute stroke.

Chief Investigator: Dr Chris Price

Co-investigators: Anand Dixit, Dip Mitra, Helen Rodgers, Lisa Shaw, Philip White

Funding: MRC Confidence in Concepts 01.04.2018 - 31.12.2018

Other professional activities

Council member and treasurer for the Society for Research in Rehabilitation

Associate Editor for the journal 'Trials'

• McClelland G, Wilson N, Shaw L, Grayling M, Haworth D, Price C. Ambulance documentation of stroke symptoms during the UK COVID-19 ‘Stay at home’ message . Emergency Medicine Journal 2020.
• Rodgers H, Bosomworth H, Krebs H, van Wijck F, Howel D, Wilson N, Finch T, Alvarado N, Ternent L, Fernandez-Garcia C, Aird L, Andole S, Cohen D, Dawson J, Ford G, Francis R, Hogg S, Hughes N, Price C, Turner D, Vale V, Wilkes S, Shaw L. Robot-assisted training compared with an enhanced upper limb therapy programme and with usual care for upper limb functional limitation after stroke: the RATULS three-group RCT. Health Technology Assessment 2020, 24(54).
• Bosomworth H, Rodgers H, Shaw L, Smith L, Aird L, Howel D, Wilson N, Alvarado N, Andole S, Cohen D, Dawson J, Fernandez-Garcia C, Finch T, Ford G, Francis R, Hogg S, Hughes N, Price C, Ternent L, Turner D, Vale V, Wilkes S, Krebs H, van Wijck F. Evaluation of the enhanced upper limb therapy programme within the Robot-Assisted Training for the Upper Limb after Stroke trial: descriptive analysis of intervention fidelity, goal selection and goal achievement. Clinical Rehabilitation 2020, epub ahead of print.
• Lally J, Vaittinen A, McClelland G, Price C, Shaw L, Ford GA, Flynn D, Exley C. Paramedic experiences of using an enhanced stroke assessment during cluster randomised controlled trial; a qualitatve thematic analysis. Emergency Medicine Journal 2020, (ePub ahead of Print).
• Shaw L, Bhattarai N, Cant R, Drummond A, Ford GA, Forster A, Francis R, Hills K, Howel D, Lavery AM, McKevitt C, Price C, Stamp E, Stevens E, Vale L, Rodgers H. An extended stroke rehabilitation service for people who have had a stroke: the EXTRAS RCT. Health Technology Assessment 2020, 24(24).
• McCue P, Del Din S, Hunter H, Lord S, Price CIM, Shaw L, Rodgers H, Rochester L, Moore SA. Auditory rhythmical cueing to improve gait and physical activity in community dwelling stroke survivors (ACTIVATE): study protocol for a pilot randomised controlled trial. Pilot and Feasibility Studies 2020, 6(1), 68.
• Lumley HA, Flynn D, Shaw L, McClelland G, Ford GA, White P, Price C. A Scoping Review of Pre-hospital Technology to Assist Ambulance Personnel with Patient Diagnosis or Stratification during the Emergency Assessment of Suspected Stroke. BMC Emergency Medicine 2020, 20, 30.
• Price CI, Shaw L, Islam S, Javanbakht M, Watkins A, McMeekin P, Snooks S, Flynn D, Francis R, Lakey R, Sutcliffe L, McClelland G, Lally J, Exley C, Rodgers H, Russell I, Vale L, Ford GA. Effect of an Enhanced Paramedic Acute Stroke Treatment Assessment (PASTA) on Thrombolysis Delivery During Emergency Stroke Care: A Cluster Randomised Clinical Trial. JAMA Neurology 2020, (ePub ahead of Print).
• Price CI, Shaw L, Dixit A, Graziadio S, Lendrem C, Mitra D, Rodgers H, Sutcliffe L, White P. Asymmetrical Bioimpedance in the Anterior Circulation for Urgent Stratification of suspected Stroke (ABACUS Stroke): study protocol for a diagnostic accuracy study. Diagnostic and Prognostic Research 2020, 4, 2.
• Rodgers H, Bosomworth H, van Wijck F, Krebs HI, Shaw L. Usual care: the big but unmanaged problem of rehabilitation evidence – Authors' reply. The Lancet 2020, 395(10221), 337-338.
• Rodgers H, Howel D, Bhattarai N, Cant R, Drummond A, Ford GA, Forster A, Francis R, Hills K, Laverty A-M, McKevitt C, McMeekin P, Price CIM, Stamp E, Stevens E, Vale L, Shaw L. Evaluation of an Extended Stroke Rehabilitation Service (EXTRAS): A Randomized Controlled Trial and Economic Analysis. Stroke 2019, 50(12), 3561-3568.
• Rodgers H, Bosomworth H, Krebs HI, van Wijck F, Howel D, Wilson N, Aird L, Alvarado N, Andole S, Cohen DL, Dawson J, Fernandez-Garcia C, Finch T, Ford GA, Francis R, Hogg S, Hughes N, Price CI, Ternent L, Turner DL, Vale L, Wilkes S, Shaw L. Robot Assisted Training for the Upper Limb after Stroke (RATULS): a multi-centre randomised controlled trial comparing robot-assisted training; an enhanced upper limb therapy programme; and usual care. Lancet 2019, 394(10192), 51-62.
• Da-Silva RH, Moore SA, Rodgers H, Shaw L, Sutcliffe L, van Wijck F, Price CI. Wristband Accelerometers to motiVate arm Exercises after Stroke (WAVES): a pilot randomized controlled trial. Clinical Rehabilitation 2019, 33(8), 1391-1403.
• Price CI, Shaw L, Dodd P, Exley C, Flynn D, Francis R, Islam S, Javanbakht M, Lakey R, Lally J, McClelland G, McMeekin P, Rodgers H, Snooks H, Sutcliffe L, Tyrell P, Vale L, Watkins A, Ford GA. Paramedic Acute Stroke Treatment Assessment (PASTA): study protocol for a randomised controlled trial. Trials 2019, 20, 121.
• Lumley H, Flynn D, Ford GA, Inskip A, McClelland G, Shaw L, White PM, Price CIM. A Review of Technology to Assist with Patient Stratification during the Emergency Assessment of Suspected Stroke. PROSPERO 2018 2018, CRD42018087611.
• Whitham D, Turzanski J, Bradshaw L, Clarke M, Culliford L, Duley L, Shaw L, Skea Z, Treweek S, Walker K, Williamson P, Montgomery A. Development of a standardised set of metrics for monitoring site performance inmulticentre randomised trials: a Delphi study. Trials 2018, 19, 557.
• Da-Silva R, van Wijck F, Shaw L, Rodgers H, Balaam M, Brkic L, Ploetz T, Jackson D, Ladha K, Price CI. Prompting arm activity after stroke: a clinical proof of concept study of wrist-worn accelerometers with a vibrating alert function. Journal of Rehabilitation and Assistive Technologies Engineering 2018, 5, 1-8.
• Rodgers H, Shaw L, Bosomworth H, Aird L, Alvarado N, Andole S, Cohen DL, Dawson J, Eyre J, Finch T, Ford GA, Hislop J, Hogg S, Howel D, Hughes N, Krebs HI, Price C, Rochester L, Stamp E, Ternent L, Turner D, Vale L, Warburton E, van Wijck F, Wilkes S. Robot Assisted Training for the Upper Limb after Stroke (RATULS): study protocol for a randomised controlled trial. Trials 2017, 18(1), 340.
• Brkic L, Shaw L, vanWijck F, Francis R, Price C, Forster A, Langhorne P, Watkins C, Rodgers H. Repetitive arm functional tasks after stroke (RAFTAS): a pilot randomised controlled trial. Pilot and Feasibility Studies 2016, 2, 50.
• Moore SA, Da Silva R, Balaam M, Brkic L, Jackson D, Jamieson D, Ploetz T, Rodgers H, Shaw L, van Wijck F, Price C. Wristband Accelerometers to motiVate arm Exercise after Stroke (WAVES): study protocol for a pilot randomized controlled trial. Trials 2016, 17, 508.
• Rodgers H, Shaw L, Cant R, Drummond A, Ford GA, Forster A, Hills K, Howel D, Laverty A, McKevitt C, McMeekin P, Price C. Evaluating an extended rehabilitation service for stroke patients (EXTRAS): study protocol for a randomised controlled trial. Trials 2015, 16, 205.
• Buck D, Shaw LC, Price CI, Ford GA. Reperfusion Therapies for Wake-Up Stroke Systematic Review. Stroke 2014, 45(6), 1869-1875.
• Shaw L, Price C, McLure S, Howel D, McColl E, Younger P, Ford GA. Paramedic Initiated Lisinopril For Acute Stroke Treatment (PIL-FAST): results from the pilot randomised controlled trial. Emergency Medicine Journal 2014, 31(12), 994-999.
• Pandyan AD, Radford K, Ashford S, Bateman A, Burton C, Connell L, Gibson A, Harris N, Hoffman K, Nair R, Shaw L, Turton A, Tyson SF, van Wijck F. NICE on rehabilitation: New guidelines on rehabilitation likely to restrict practices and stifle innovation. BMJ 2013, 347, f4876.
• Shackley P, Shaw L, Price C, VanWijck F, Barnes M, Graham L, Ford G, Steen N, Rodgers H. Cost-effectiveness of treating upper limb spasticity due to stroke with botulinum toxin A: results from the botulinum toxin for the upper limb after stroke (BoTULS) trial. Toxins 2012, 4(12), 1415-1426.
• Shaw L, Price C, McLure S, Howel D, McColl E, Ford GA. Paramedic Initiated Lisinopril for Acute Stroke Treatment (PIL-FAST): study protocol for a pilot randomised controlled trial. Trials 2011, 12(1), 152.
• Shaw LC, Barnes MP, Rodgers H. Response to Letter by Munin et al Regarding Article, "Botulinum Toxin for the Upper Limb After Stroke (BoTULS) Trial: Effect on Impairment, Activity Limitation, and Pain". Stroke 2011, 42(7), E413.
• Shaw LC, Price CIM, van Wijck FMJ, Shackley P, Steen N, Barnes MP, Ford GA, Graham LA, Rodgers H. Botulinum Toxin for the Upper Limb After Stroke (BoTULS) Trial: Effect on Impairment, Activity Limitation, and Pain. Stroke 2011, 42(5), 1371-1379.
• Shaw L, Rodgers H, Price C, van Wijck F, Shackley P, Steen N, Barnes M, Ford G, Graham L, BoTULS Investigators. BoTULS: a multicentre randomised controlled trial to evaluate the clinical effectiveness and cost-effectiveness of treating upper limb spasticity due to stroke with botulinum toxin type A. Health Technology Assessment 2010, 14(26), 1-142.
• Shaw L, Rodgers H. Botulinum toxin to treat spasticity after stroke. Stroke Matters 2010, (6), 12-13.
• Shaw L, Rodgers H. Botulinum toxin type A for upper limb spasticity after stroke. Expert Review of Neurotherapeutics 2009, 9(12), 1713-1725.
• Rodgers H, Shaw L, Price C, Wijck Fvan, Barnes M, Graham L, Ford GA, Shackley P, Steen N. Study design and methods of the BoTULS trial: a randomised controlled trial to evaluate the clinical effect and cost effectiveness of treating upper limb spasticity due to stroke with botulinum toxin type A. Trials 2008, 9(1), 59.